scholarly journals Protocol of the VICTORIA study: personalized vitamin D supplementation for reducing or preventing fatigue and enhancing quality of life of patients with colorectal tumor - randomized intervention trial

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ben Schöttker ◽  
Sabine Kuznia ◽  
Dana Clarissa Laetsch ◽  
David Czock ◽  
Annette Kopp-Schneider ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Colorectal Tumor ◽  
Intervention Trial ◽  
Randomized Intervention

scholarly journals THE ROLE OF VITAMIN D SUPPLEMENTATION FOR HEAD AND NECK CANCER : A LITERATURE REVIEW

2019 ◽  
Vol 6 (1) ◽  
pp. 59
Author(s):  
Dewi Kania Intan Permatasari ◽  
Irna Sufiawati
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Head And Neck Cancer ◽  
Literature Review ◽  
Head And Neck ◽  
Vitamin D Deficiency ◽  
Neck Cancer ◽  
Active Form ◽  
Vitamin D Supplementation

Background: Vitamin D has several roles, namely physiological function of calcium and bone metabolism, cell growth and differentiation, immune and cardiovascular function. Vitamin D deficiency can cause the risk of cancer. Head and neck cancer is one of the cancers that occur due to vitamin D deficiency in the body. This literature review was to asses and evaluate the impact and benefits of vitamin D supplementation for head and neck cancer.Discussion: A study found an association between vitamin D supplementation and a low risk of recurrence in conditions of high total vitamin D levels. Another study found a significant increase in quality of life (QOL). The primary mechanism of vitamin D action is mediated through binding of either 1,25(OH)2D3 (active form) or 25(OH)D (less active form) to the VDR, which is a member of the nuclear receptor superfamily of steroid and thyroid hormones with gene-regulatory and consequent anti-proliferative properties.Conclusions: Vitamin D supplementation provides a role in improving the condition of patients with head and neck cancer. Both in terms of suppressing recurrence and in terms of increasing quality of life

Effect of vitamin D supplementation on asthma control in patients with vitamin D deficiency: the ACVID randomised clinical trial

Thorax ◽  
2020 ◽  
pp. thoraxjnl-2019-213936
Author(s):  
Rubén Andújar-Espinosa ◽  
Lourdes Salinero-González ◽  
Fátima Illán-Gómez ◽  
Manuel Castilla-Martínez ◽  
Chunshao Hu-Yang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Asthma Control ◽  
Intervention Group ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Asthmatic Patients ◽  
Secondary Endpoints

BackgroundThe relationship between asthma and vitamin D deficiency has been known for some time. However, interventional studies conducted in this regard have shown conflicting results.ObjectiveTo evaluate the efficacy of vitamin D supplementation in asthmatic patients in improving the degree of control of asthma.MethodsRandomised, triple-blind, placebo-controlled, parallel-group study in adult asthmatic patients with serum 25-hydroxyvitamin-D3 <30 ng/mL. The intervention group received oral supplementation with 16 000 IU of calcifediol per week, and the control group had placebo added to their usual asthma treatment. The study period was 6 months. The primary endpoint was the degree of asthma control as determined by the asthma control test (ACT). Secondary endpoints included quality of life measured using the mini Asthma Quality of Life Questionnaire, the number of asthma attacks, oral corticosteroid cycles, the dose of inhaled corticosteroids, number of emergency visits, unscheduled consultations with the primary care physician and hospitalisations for asthma.ResultsOne hundred and twelve patients were randomised (mean age 55 years, with 87 (78%) being women). Of the 112 patients, 106 (95%) completed the trial. Half the patients (56) were assigned to the intervention group and the other half to the control group. A statistically significant clinical improvement was observed in the intervention group (+3.09) compared with the control group (−0.57) (difference 3.66 (95% CI 0.89 to 5.43); p<0.001) as measured using ACT scores. Among the secondary endpoints, a significant improvement in the quality of life was found in the intervention group (5.34), compared with the control group (4.64) (difference 0.7 (95% CI 0.15 to 1.25); p=0.01).ConclusionAmong adults with asthma and vitamin D deficiency, supplementation with weekly oral calcifediol compared with placebo improved asthma control over 6 months. Further research is needed to assess long-term efficacy and safety.Trial registration numberNCT02805907.

scholarly journals Vitamin D Supplementation Improves Health Related Quality of Life in Children with Sickle Cell Disease

2018 ◽  
Vol 50 (5S) ◽  
pp. 729-730 ◽  
Author(s):  
Kelly A. Dougherty ◽  
Chiara Bertolaso ◽  
Joan I. Schall ◽  
Kim Smith-Whitley ◽  
Virginia A. Stallings
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Vitamin D Supplementation ◽  
Health Related Quality ◽  
Cell Disease ◽  
Related Quality ◽  
Health Related

Effects of Vitamin D Supplementation on Nonspecific Musculoskeletal Pain, Quality of Life, Self-Related Health and Sexual Satisfaction: A Randomized Control Trial

2018 ◽  
Vol 17 (1) ◽  
pp. 17-22
Author(s):  
Mottaghi Peyman ◽  
Miraghajani Maryam ◽  
Hajianfar Hossein ◽  
Abadi Rayehe Shekl
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sexual Satisfaction ◽  
Intervention Group ◽  
Vitamin D Supplementation ◽  
Unknown Etiology ◽  
Self Rated Health ◽  
Pain Scores

Non-specific musculoskeletal pains (CNMP) are common problem with unknown etiology which has become a major concern because of their negative impact on health. The aim of the present study was to investigate the effect of vitamin D supplementation on pain scores, quality of life, self-rated health and sexual satisfaction among CNMP patients with vitamin D deficiency. In this clinical trial study, sixty-six patients (18–50 years in both sex) with CNMP and vitamin D deficiency were randomly assigned to consume 50000 IU vitamin D, once every week for 8 weeks in the intervention group or placebo in the control condition. Clinical examination, pain scores, quality of life (QoL), self-rated health and sexual satisfaction were measured at the beginning and at the end of study. Patients in the vitamin D group had a significant pain relief after 8 weeks compared to the placebo group (p = 0.04 vs. p = 0.42). Also, they had increased QoL scores and sexual satisfaction compared with placebo (p < 0.0001 and p = 0.01, respectively). We observed a significant effect on improvement of quality of life, sexual satisfaction and pain in patients with CNMP after administration of therapeutic doses of vitamin D. Such findings could be considered to implement informative interventional programs to control CNMP complications and develop practical policies to improve the diet quality among CNMP patients. Further studies are needed to determine whether vitamin D supplementation lead to significant modifications in CNMP complications with consideration of confounding factors in different population.

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