Influence of weight status on bone mineral content measured by DXA in children

Abstract Introduction Childhood obesity is a public health problem with repercussions in later life. As tissue formation peaks in childhood we determined how weight status influences bone mineral content. Material and methods We studied 553 children aged 4–18 years over 10 years (46.8% girls). We measured age, weight, height and through bone densitometry (DXA), bone mineral content (BMC), bone mineral density (BMD), and waist, arm and hip circumferences. The patients were divided into groups using the body mass index z-score: underweight, normal weight, overweight, obese and very obese. Results BMC and BMD values were highest in the normal-weight and overweight groups. Logistic regression showed bone mineralization was inversely associated with waist circumference, the association being positive for weight and age. No differences were found according to sex. Discussion Studies of the relationship between weight and bone mineralization report contradictory results, often because of different study designs. Moreover, studies in children are either few or with small samples. Our findings in a large sample show the importance of weight status in bone mineralization given the risk of bone fractures or osteoporosis. Conclusions Weight status influenced bone mineralization. BMC and BMD decreased in children with a higher degree of obesity. Waist circumference correlated negatively with bone mineralization.

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Effect of single neonatal vitamin D3 treatment (hormonal imprinting) on the bone mineralization of adult non-treated and dexamethasone treated rats

Human & Experimental Toxicology ◽

10.1177/096032719801700803 ◽

1998 ◽

Vol 17 (8) ◽

pp. 424-429 ◽

Cited By ~ 6

Author(s):

Cs Karabélyos ◽

Cs Horváth ◽

I Holló ◽

G Csaba

Keyword(s):

Vitamin D ◽

Body Weight ◽

Bone Mineral ◽

Mineral Content ◽

Bone Mineralization ◽

The Body ◽

Mineral Density ◽

Hormonal Imprinting ◽

Old Rats ◽

Old Females

Hormonal imprinting (the first encounter between the hormone and receptor after birth) is needed for the normal development of receptor. Presence of the appropriate hormone in excess, or its absence, as well as presence of hormone-like molecules able to bind to the maturing receptor in this time, can cause faulty imprinting. In this experiment the effect of neonatal treatment with a single dose of 0.05 mg cholecalciferol (vitamin D3) was studied by bone densitometry. The treatment caused significant decrease of body weight in 3-month old females and also significant reduction of bone mineral density (BMD) and bone mineral content (BMC) in males. Dexamethasone treatment of 3-month old rats for 10 days increased BMD in males and BMC in females without affecting body weight. The double treatment (vitamin D neonatally and dexamethasone when adult) decreased the body weight of both sexes and increased BMD in males, and BMC, BMD/bw and BMC/bw in both sexes, related to the control or the only vitamin D treated groups. Considering the hormonal imprinting effect of neonatal vitamin D treatment at glucocorticoid receptorial level in other experiments, similar effects also can be supposed for vitamin D itself, manifested in the changes of bone mineralization.

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Influence of the weight status on bone mineral content and bone mineral density in a group of Lebanese adolescent girls

Joint Bone Spine ◽

10.1016/j.jbspin.2009.10.004 ◽

2009 ◽

Vol 76 (6) ◽

pp. 680-684 ◽

Cited By ~ 12

Author(s):

Rawad El Hage ◽

Christophe Jacob ◽

Elie Moussa ◽

Carole Groussard ◽

Jean-Claude Pineau ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral Content ◽

Bone Mineral ◽

Adolescent Girls ◽

Weight Status ◽

Mineral Content ◽

Mineral Density

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Influence of anthropometric parameters on assessment of paediatric bone mineral density and bone mineral content

Bone Abstracts ◽

10.1530/boneabs.2.p18 ◽

2013 ◽

Author(s):

N Hangartner Thomas ◽

F Short David ◽

Gilsanz Vicente ◽

J Kalkwarf Heidi ◽

M Lappe Joan ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Mineral Density ◽

Anthropometric Parameters

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Intra-Bone Marrow Administration of Mesenchymal Stem/Stromal Cells Is a Promising Approach for Treating Osteoporosis

Stem Cells International ◽

10.1155/2019/4214281 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Hideki Agata ◽

Yoshinori Sumita ◽

Tatsuro Hidaka ◽

Mayumi Iwatake ◽

Hideaki Kagami ◽

...

Keyword(s):

Bone Marrow ◽

Bone Mineral Content ◽

Bone Mineral ◽

Intravenous Administration ◽

Stromal Cells ◽

Mineral Content ◽

Bone Diseases ◽

Research Progress ◽

Bone Thickness ◽

Mineral Density

Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and efficacy of intra-bone marrow and intravenous administration of MSCs for the treatment of ovariectomy- (OVX-) induced osteoporosis. Cells capable of forming bone were isolated from the murine compact bones and expanded in culture. Relatively pure MSCs possessing increased potential for cell proliferation, osteogenic differentiation, and inhibition of osteoclastogenesis were obtained by magnetic-activated cell sorting with the anti-Sca-1 antibody. Sca-1-sorted MSCs were administered to OVX mice, which were sacrificed 1 month later. We observed that 22% of the mice died after intravenous administration, whereas none of the mice died after intra-bone marrow administration. With respect to efficacy, intravenous administration improved bone mineral density (BMD) by increasing bone mineral content without affecting bone thickness, whereas intra-bone marrow administration improved BMD by increasing both bone mineral content and bone thickness. These results indicate that intra-bone marrow administration of pure MSCs is a safer and more effective approach for treating osteoporosis.

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The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105365 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5365

Author(s):

Annie M. Constable ◽

Josie E. Porter ◽

Danielle Benger ◽

Dimitris Vlachopoulos ◽

Alan R. Barker ◽

...

Keyword(s):

Physical Activity ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Vigorous Physical Activity ◽

Normal Weight ◽

Cross Sectional ◽

Prepubertal Children ◽

Total Body ◽

The Relationship

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

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Effects of One-Year Adjuvant Treatment with Tamoxifen on Bone Mineral Density in Postmenopausal Breast Cancer Women

Tumori Journal ◽

10.1177/030089169608200114 ◽

1996 ◽

Vol 82 (1) ◽

pp. 65-67 ◽

Cited By ~ 10

Author(s):

Sandro Barni ◽

Paolo Lissoni ◽

Gabriele Tancini ◽

Antonio Ardizzoia ◽

Marina Cazzaniga

Keyword(s):

Breast Cancer ◽

Bone Mineral Density ◽

Alkaline Phosphatase ◽

Bone Mineral Content ◽

Bone Mineral ◽

Adjuvant Treatment ◽

Mineral Content ◽

Postmenopausal Breast Cancer ◽

Mineral Density ◽

One Year

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.

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