Knowledge, attitude, and practices on intestinal schistosomiasis among primary schoolchildren in the Lake Victoria basin, Rorya District, north-western Tanzania

Abstract Background Intestinal schistosomiasis is highly endemic in Tanzania and mass drug administration (MDA) using praziquantel is the mainstay of the control program. However, the MDA program covers only school aged children and does not include neither adult individuals nor other public health measures. The Ijinga schistosomiasis project examines the impact of an intensified treatment protocol with praziquantel MDA in combination with additional public health interventions. It aims to investigate the feasibility of eliminating intestinal schistosomiasis in a highly endemic African setting using an integrated community-based approach. In preparation of this project, we report about baseline data on S.mansoni prevalence, intensity of infection, related hepatosplenic morbidities and their associated factors. Methods A cross sectional study was conducted among 930 individuals aged 1–95 years living at Ijinga Island, north-western Tanzania in September 2016. Single stool and urine samples were collected from each study participant and processed using Kato Katz (KK) technique and point-of-care Circulating Cathodic (POC-CCA) antigen test for detection of S.mansoni eggs and antigen respectively. Ultrasonographical examination for S.mansoni hepatosplenic morbidities was done to all participants. For statistical analyses Fisher’s exact test, chi-square test, student-t-test, ANOVA and linear regression were used where applicable. Results Overall based on KK technique and POC-CCA test, 68.9% (95%CI: 65.8–71.8) and 94.5% (95%CI: 92.8–95.8) were infected with S.mansoni. The overall geometrical mean eggs per gram (GMepg) of faeces was 85.7epg (95%CI: 77.5–94.8). A total of 27.1, 31.2 and 51.9% of the study participants had periportal fibrosis (PPF-grade C-F), splenomegaly and hepatomegaly. Risk factors for PPF were being male (aRR = 1.08, 95%CI: 1.02–1.16, P < 0.01), belong to the age group 16–25 years (aRR = 1.23, 95%CI: 105–1.44, P < 0.01), 26–35 years (aRR = 1.42, 95%CI: 1.21–1.67, P < 0.001), 36–45 years (aRR = 1.56, 95%CI:1.31–1.84, P < 0.001) and ≥ 46 years (aRR = 1.64, 95%CI:1.41–1.92, P < 0.001). The length of the left liver lobe was associated with being female (P < 0.03), belong to the age group 1–5 years (P < 0.013), 6–15 years (P < 0.04) and S.mansoni intensity of infection (P < 0.034). Male sex (aRR = 1.15, 95%CI:1.06–1.24, P < 0.001) and belonging to the age groups 16–25 years (aRR = 1.27, 95%CI:1.05–1.54, P < 0.02) or 26–35 years (aRR = 1.32, 95%CI:108–1.61, P < 0.01) were associated with splenomegaly. Conclusion Schistosoma mansoni infection and its related morbidities (hepatomegaly, splenomegaly, periportal fibrosis) are common in the study area. Age, sex and intensity of infection were associated with periportal fibrosis. The prevalence of S.mansoni was above 50% in each age group and based on the observed prevalence, we recommend MDA to the entire community.

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Prevalence of HIV infection and uptake of HIV/AIDS services among fisherfolk in landing Islands of Lake Victoria, north western Tanzania

BMC Health Services Research ◽

10.1186/s12913-018-3784-4 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 2

Author(s):

Anthony Kapesa ◽

Namanya Basinda ◽

Elias C. Nyanza ◽

Martha F. Mushi ◽

Ola Jahanpour ◽

...

Keyword(s):

Hiv Infection ◽

Lake Victoria ◽

North Western ◽

Western Tanzania ◽

Hiv Aids

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Malacological survey to identify transmission sites for intestinal schistosomiasis on Ijinga Island, Mwanza, north-western Tanzania

Acta Tropica ◽

10.1016/j.actatropica.2019.105289 ◽

2020 ◽

Vol 203 ◽

pp. 105289 ◽

Cited By ~ 1

Author(s):

Antje Fuss ◽

Humphrey Deogratias Mazigo ◽

Andreas Mueller

Keyword(s):

Intestinal Schistosomiasis ◽

North Western ◽

Western Tanzania

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Reduced-representation sequencing identifies small effective population sizes of Anopheles gambiae in the north-western Lake Victoria basin, Uganda

Malaria Journal ◽

10.1186/s12936-018-2432-0 ◽

2018 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Rachel M. Wiltshire ◽

Christina M. Bergey ◽

Jonathan K. Kayondo ◽

Josephine Birungi ◽

Louis G. Mukwaya ◽

...

Keyword(s):

Anopheles Gambiae ◽

Lake Victoria ◽

Lake Victoria Basin ◽

Effective Population ◽

Reduced Representation ◽

The North ◽

Western Lake ◽

Population Sizes ◽

North Western ◽

Reduced Representation Sequencing

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Schistosoma mansoni Infections, Undernutrition and Anaemia among Primary Schoolchildren in Two Onshore Villages in Rorya District, North-Western Tanzania

PLoS ONE ◽

10.1371/journal.pone.0167122 ◽

2016 ◽

Vol 11 (12) ◽

pp. e0167122 ◽

Cited By ~ 7

Author(s):

David Zadock Munisi ◽

Joram Buza ◽

Emmanuel A. Mpolya ◽

Safari M. Kinung’hi

Keyword(s):

Schistosoma Mansoni ◽

Primary Schoolchildren ◽

North Western ◽

Western Tanzania

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Intestinal schistosomiasis of Ijinga Island, north-western Tanzania: Prevalence, intensity of infection, hepatosplenic morbidities and their associated factors

10.21203/rs.2.10130/v2 ◽

2019 ◽

Author(s):

Andreas Mueller ◽

Antje Fuss ◽

Uwe Ziegler ◽

Godfrey M. Kaatano ◽

Humphrey D. Mazigo

Keyword(s):

Public Health ◽

Associated Factors ◽

Age Group ◽

Intensity Of Infection ◽

Left Liver Lobe ◽

Periportal Fibrosis ◽

Intestinal Schistosomiasis ◽

The Impact ◽

North Western ◽

Western Tanzania

Abstract Background: Intestinal schistosomiasis is highly endemic in Tanzania and mass drug administration (MDA) using praziquantel is the mainstay of control. MDA covers only school aged children and does not include other public health measures. The Ijinga schistosomiasis project examines the impact of an intensified MDA protocol combined with additional public health interventions. It aims to investigate the feasibility of eliminating intestinal schistosomiasis in a highly endemic African setting using an integrated community-based approach. We report baseline data on S.mansoni prevalence, intensity of infection, related hepatosplenic morbidities and their associated factors. Methods: A cross sectional study was conducted among 930 individuals aged 1-95 years on Ijinga Island, north-western Tanzania in September 2016. Single stool and urine samples were collected and processed using Kato Katz (KK) technique and point-of-care Circulating Cathodic (POC-CCA) antigen test for detection of S.mansoni eggs and antigen respectively. All participants received ultrasonography for S.mansoni hepatosplenic morbidities. For statistical analyses Fisher’s exact test, chi-square test, student-t-test, ANOVA and linear regression were used where applicable. Results: Based on KK technique and POC-CCA test, 68.9% and 94.5% respectively were infected with S.mansoni . The overall geometrical mean eggs per gram (GMepg) of faeces was 85.7epg. A total of 27.1%, 31.2% and 51.9% of the participants had periportal fibrosis (PPF-grade C-F), splenomegaly and hepatomegaly. Risk factors for PPF were being male (aRR=1.08, P <0.01), belong to the age group 16-25 years (aRR=1.23, P <0.01), 26-35 years (aRR=1.42, P <0.001), 36-45 years (aRR=1.56, P <0.001) and ≥ 46 years (aRR=1.64, P <0.001). The length of the left liver lobe was associated with being female ( P <0.03), the age group 1-5 years ( P <0.013), 6-15 years ( P <0.04) and S.mansoni intensity of infection ( P <0.034). Male sex (aRR=1.15, P <0.001) and the age groups 16-25 years (aRR=1.27, P <0.02) or 26-35 years (aRR=1.32, P <0.01) were associated with splenomegaly. Conclusion : Schistosoma mansoni infection and related morbidities are common in the study area. Age, sex and intensity of infection were associated with periportal fibrosis. With a prevalence of >50% in each age group we recommend MDA to the entire community.

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Intestinal schistosomiasis of Ijinga Island, north-western Tanzania: Prevalence, intensity of infection, hepatosplenic morbidities and their associated factors

10.21203/rs.2.10130/v1 ◽

2019 ◽

Author(s):

Andreas Mueller ◽

Antje Fuss ◽

Uwe Ziegler ◽

Godfrey M. Kaatano ◽

Humphrey D. Mazigo

Keyword(s):

Public Health ◽

Associated Factors ◽

Study Participant ◽

Age Group ◽

Intensity Of Infection ◽

Left Liver Lobe ◽

Intestinal Schistosomiasis ◽

Group 16 ◽

North Western ◽

Western Tanzania

Abstract Background: Intestinal schistosomiasis is highly endemic in Tanzania and mass drug administration (MDA) using praziquantel is the mainstay of the control program. However, the MDA program covers only school aged children and does not include neither adult individuals nor other public health measures. The Ijinga schistosomiasis project aims to introduce an intensified treatment protocol using a MDA approach combined with other public health interventions to demonstrate the feasibility of eliminating intestinal schistosomiasis in a highly endemic African setting. In preparation of this project, we report about baseline data on S.mansoni prevalence, intensity of infection, related hepatosplenic morbidities and their associated factors. Methods: A cross sectional study was conducted among 930 individuals aged 3-95 years living at Ijinga Island, north-western Tanzania. Single stool and urine samples were collected from each study participant and processed using Kato Katz (KK) technique and point-of-care Circulating Cathodic (POC-CCA) antigen test for detection of S.mansoni eggs and antigen. Ultrasonographical examination for S.mansoni hepatosplenic morbidities was done to all participants. Results: Overall based on KK technique and POC-CCA test, 68.9% (95%CI: 65.8-71.8) and 94.5% (95%CI: 92.8-95.8) were infected with S.mansoni. The overall geometrical mean eggs per gram (GMepg) of faeces was 85.7epg (95%CI: 77.5-94.8). A total of 27.1%, 31.2% and 51.9% of the study participants had periportal fibrosis (PPF-grade C-F), splenomegaly and hepatomegaly. Risk factors for PPF were being male (aRR=1.08, 95%CI: 1.02-1.16, P<0.01), belong to the age group 16-25 years (aRR=1.23, 95%CI: 105-1.44, P<0.01), 26-35 years (aRR=1.42, 95%CI: 1.21-1.67, P<0.001), 36-45 years (aRR=1.56, 95%CI:1.31-1.84, P<0.001) and ≥ 46 years (aRR=1.64, 95%CI:1.41-1.92, P<0.001). The length of the left liver lobe was associated with being female (P<0.03), belong to the age group 1-5 years (P<0.013), 6-15 years (P<0.04) and S.mansoni intensity of infection (P<0.034). Similarly, being male (aRR=1.15, 95%CI:1.06-1.24, P<0.001), belonging to the age group 16-25 years (aRR=1.27, 95%CI:1.05-1.54, P<0.02), 26-35 years (aRR=1.32, 95%CI:108-1.61, P<0.01) were associated with splenomegaly. Conclusion: Schistosoma mansoni infection and its related morbidities are common in the study area. The prevalence of S.mansoni was above 50% in each age group and based on the observed prevalence, we recommend MDA to the entire community.

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Prevalence and intensity ofSchistosoma mansoniinfection in pediatric populations on antiretroviral therapy in north-western Tanzania: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2019-029749 ◽

2019 ◽

Vol 9 (7) ◽

pp. e029749 ◽

Cited By ~ 1

Author(s):

Humphrey D Mazigo ◽

Laurence Kirway ◽

Emmanuela Ausebio Ambrose

Keyword(s):

Antiretroviral Therapy ◽

Point Of Care ◽

Rapid Test ◽

Paediatric Population ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Intestinal Schistosomiasis ◽

North Western ◽

Western Tanzania

BackgroundIn areas where HIV and intestinal schistosomiasis are highly endemic, co-infections of the two diseases in a single human host are frequent. Evidence in adult populations indicates that HIV and intestinal schistosomiasis are associated with negative health impacts. However, the topic of HIV and schistosomiasis in paediatric populations has received little attention. The present study determined the prevalence and intensity ofSchistosoma mansoniinfection in a paediatric population on antiretroviral therapy (ART) in north-western Tanzania.Design, settings and participantsA cross-sectional study was conducted among HIV-infected children aged 1–16 years on ART attending a Care and Treatment Clinic at Ukerewe Designated District Hospital, north-western Tanzania.Main outcome measuresSingle stool and urine samples were collected and screened forS. mansonieggs and circulating cathodic antigen (CCA), using the Kato-Katz (KK) technique and point-of-care CCA (POC-CCA) rapid urine test, respectively.ResultsA total of 134 children with a median age of 10 years (IQR 7–12 years) participated in the study. Of these, 44.8% (60/134) and 55.2% (74/134) were female and male, respectively. The overall prevalence ofS. mansonibased on the KK technique and POC-CCA rapid test were 10.7% (95% CI 5.9% to 18.4%) and 33.8% (95% CI 26.2% to 42.4%), respectively. The overall geometrical mean eggs per gram of faeces was 293.9 GM-epg (95% CI 123.3 to 700.9). A small proportion of the children had moderate (4.9%, 5/103) and heavy (3.8%, 4/103) intensity of infection.ConclusionPaediatric populations on ART are co-infected withS. mansoniinfection. Screening and treatment of intestinal schistosomiasis at initiation of ART is recommended to reduce the risk of developing hepatosplenic disease, schistosomiasis-related immune reconstitution inflammatory syndrome and the possible adverse effect of schistosomiasis on outcome of ART.

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