scholarly journals Trends in cervical cancer mortality in China from 1989 to 2018: an age-period-cohort study and Joinpoint analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Menghan Guo ◽  
Juan Xu ◽  
Jiayue Du
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Protective Factor ◽  
Statistical Significance ◽  
Cervical Screening ◽  
Large Population ◽  
Cohort Effect ◽  
International Agency ◽  
Period Effect ◽  
Cervical Cancer Mortality

Abstract Background Worldwide, cervical cancer is the second-most-common malignancy of the female reproductive system. Due to its large population, China accounted for 11.9% of cervical cancer deaths, and 12.3% of global cervical cancer DALYs in 2017. In 2009, China launched a nationwide screening program, yet mortality from cervical cancer has shown an upward trend in recent years. The aim of this study was to explore factors affecting cervical cancer mortality rates in China, and contribute to their future reduction. Methods In this descriptive study, a Joinpoint regression analysis and age-period-cohort (APC) model based on the intrinsic estimator (IE) algorithm were utilized. Data from the period 1989–2018 were extracted from the International Agency for Research on Cancer (IARC) Database of WHO (1989–2000) and China Health Statistical Yearbook database (2002–2018). Results Our study found mortality from cervical cancer to have initially declined, but increase thereafter over the entire observation period in both rural and urban China. The influence of age, period and cohort effect on the mortality rate had statistical significance. The effect of age increased with years, becoming a contributing factor in women aged over 45 years countrywide. Conversely, the cohort effect became a protective factor for women born after 1938 in urban areas, and for women born after 1958 in rural areas. The period effect was relatively less impactful. Conclusions The study indicates that organized cervical screening projects facilitated the identification of potential patients, or patients with comorbidities. Correspondingly, mortality was found to increase with incidence, particularly among elderly women, indicating that newly diagnosed patients were at an advanced stage of cervical cancer, or were not receiving appropriate treatment. Therefore, the coverage of cervical cancer screening should be improved, and women’s health awareness promoted. Early diagnosis and treatment is critical to reduce the disease burden and improve outcomes.

scholarly journals Evolução Temporal da Mortalidade por Cancro do Colo do Útero em Portugal

2019 ◽  
Vol 32 (6) ◽  
pp. 427 ◽  
Author(s):  
Cristina Teixeira ◽  
Ana Maria Pereira ◽  
Eugénia Anes ◽  
Carina Rodrigues ◽  
Maria José Castanheira
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Negative Impact ◽  
Cervical Screening ◽  
Age Groups ◽  
Mortality Rates ◽  
International Agency ◽  
Therapeutic Approaches ◽  
Time Period ◽  
Cervical Cancer Mortality

Introduction: The mortality rate due to cervical cancer is higher in Portugal compared to other European countries. This study aimed to evaluate the time-trends in cervical cancer mortality rates observed in Portugal over the last six decades.Material and Methods: Age-standardized cervical cancer mortality rates reported in Portugal between 1955 and 2014, were collected from the International Agency for Research on Cancer (IARC). Joinpoint regression analysis was used to identify significant changes in mortality rates by assessing the percentage of annual variation (%AV) of the rate and respective 95% confidence interval (95%CI) according to the age groups.Results: Among women with 30–39 years, cervical cancer mortality decreased 1.9% per year (95%CI: –2.3; –1.4) throughout the time-period, reaching 0.5/100 000 in 2014. Among women aged 40–49 years, CC mortality decreased between 1971 and 1981 (%AV = –11.6; IC 95%: –14.6; –8.6). Rates then increased by 2.4% per year (95%CI: 1.0; 3.8) until 2001 and such trend reverted from 2001 onwards (%AV = –5.2; IC 95%: –7.7; –2.6), reaching 3.0/100 000 in 2014. In women aged 50–64, 65–74 and 75 years or older, cervical cancer mortality rates decreased from 29.2 to 6.7/100 000, from 34.3 to 7.7/100 000 and from 24.7 to 9.2/100 000. The decline in mortality rates in these three age groups occurred mainly between 1970 and 1980, and there have been no significant changes in the last three decades.Discussion: In Portugal, the most impressive decline in cervical cancer mortality rates occurred in the 1970s concurrently with changes in the National Healthcare System. The most important changes were the increased access to early diagnosis and the improvement in therapeutic approaches. The plateau that we observed among older women over the last three decades can be partially explained by factors with negative impact on adherence to cervical screening.Conclusion: There was a marked decrease in mortality due to CC among all age groups. However, we observed a plateau of this indicator in more advanced age groups over the last three decades. These findings suggest the need of promoting adherence to cervical screening in Portugal.

scholarly journals Effectiveness of Cervical Cancer Screening Over Cervical Cancer Mortality Among Japanese Women

2006 ◽  
Vol 36 (8) ◽  
pp. 511-518 ◽  
Author(s):  
Khandoker Aklimunnessa ◽  
Mitsuru Mori ◽  
M. M. H. Khan ◽  
Fumio Sakauchi ◽  
Tatsuhiko Kubo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Cancer Mortality ◽  
Japanese Women ◽  
Cervical Cancer Mortality

European trends in cervical cancer mortality in relation to national screening programs, 1985–2014

2021 ◽  
Vol 74 ◽  
pp. 102002
Author(s):  
Ingrid Salciccioli ◽  
Charlie D. Zhou ◽  
Emeka C. Okonji ◽  
Joseph Shalhoub ◽  
Justin D. Salciccioli ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Screening Programs ◽  
Cervical Cancer Mortality

scholarly journals Analysis of cervical cancer mortality rate trends in Natal-RN, Brazil, between 2000 and 2012

2019 ◽  
Vol 21 (2) ◽  
pp. 161-167
Author(s):  
Paulo Roberto Medeiros Azevedo ◽  
Joyce Bezerra Rocha ◽  
Thales Allyrio Araújo de Medeiros Fernandes ◽  
José Veríssimo Fernandes
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Empirical Bayes ◽  
Family Income ◽  
Screening Program ◽  
Mortality Rates ◽  
P Value ◽  
Average Family ◽  
Historical Series ◽  
Cervical Cancer Mortality

Objective To describe cervical cancer mortality rates and their corresponding trends, and to analyze the spatial correlations of this type of cancer in Natal-RN, Brazil, between 2000 and 2012.Materials and Methods The simple linear regression model, the empirical Bayes method and the Global Moran's index were used for the statistical analysis.Results The mortality coefficient of cervical cancer in Natal, standardized by age range, was 5.5 per 100 000 women. All historical series for the coefficients studied were classifiedas stable. The Global Moran's index obtained was 0.048, with a p-value for the spatial test correlation between neighborhoods of 0.300. The average family income by neighborhood showed no significant correlation to cervical cancer mortality rates.Conclusion This study found a temporal stabilization and spatial independence trend of cervical cancer mortality rates in women from Natal, as well as the absence of correlationbetween these rates and the average family income of the of the participating women distributed by neighborhoods. In view of this, changes in the public policies should be made aimed at preventing the disease; adopting these measures could positively impact the screening program, improving the coverage of Pap smears and immunization campaigns against HPV, in order to reverse this trend and achieve a reduction of mortality rates.

scholarly journals All-Cause and Cancer Mortality Trends in Macheng, China (1984–2013): An Age-Period-Cohort Analysis

2018 ◽  
Vol 15 (10) ◽  
pp. 2068
Author(s):  
Chunhui Li ◽  
Songbo Hu ◽  
Chuanhua Yu
Keyword(s):  
Cancer Mortality ◽  
Disease Surveillance ◽  
Cohort Analysis ◽  
Cohort Effect ◽  
Age Effect ◽  
Mortality Data ◽  
Period Effect ◽  
Mortality Trends ◽  
All Cause Mortality ◽  
Males And Females

The aim was to study the variation trends of all-cause and cancer mortality during 1984–2013 in Macheng City, China. The mortality data were collected from Macheng City disease surveillance points system and Hubei Center for Disease Control and Prevention. The model life table system was used to adjust mortality rates due to an under-reporting problem. An age-period-cohort model and intrinsic estimator algorithm were used to estimate the age effect, period effect, and cohort effect of all-cause mortality and cancer mortality for males and females. Age effect of all-cause mortality for both sexes increased with age, while the age effect of cancer mortality for both sexes reached a peak at the age group of 55–59 years old and then decreased. The relative risks (RRs) of all-cause mortality for males and females declined with the period and decreased by 51.13% and 63.27% during the whole study period, respectively. Furthermore, the period effect of cancer mortality in both sexes decreased at first and then increased. The cohort effect of all-cause and cancer mortality for both sexes born after 1904 presented the pattern of “rise first and then fall,” and decreased by 82.18% and 90.77% from cohort 1904–1908 to 1989–1993, respectively; especially, the risk of all-cause and cancer mortality for both sexes born before 1949 was much higher than that for those born after 1949.

Relations of cervical cancer mortality with the population's number and distribution in Republics, located in Siberia (2007-2018)

2020 ◽  
pp. 46-49
Author(s):  
I.V. Kononova ◽  
M.P. Kirillina ◽  
S.I. Sofronova ◽  
P.V. Nikiforov ◽  
V.A. Alekseev ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Cervical Cancer Mortality

Trends in cervical cancer mortality

The Lancet ◽  
1991 ◽  
Vol 338 (8774) ◽  
pp. 1081-1082 ◽  
Author(s):  
Mike Murphy ◽  
Ruairidh Milne
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Cervical Cancer Mortality
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