scholarly journals Vitamin D deficiency associations with metabolic, bone turnover and adverse general health markers in community free living adults

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Salah Gariballa ◽  
Javed Yasin ◽  
Ghada Abluwi ◽  
Awad Al Essa
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
United Arab Emirates ◽  
Multiple Logistic Regression Analysis ◽  
Health Impact ◽  
Clinical Markers ◽  
Free Living ◽  
Cross Sectional ◽  
Older Subjects

Abstract Background Although there is some evidence that vitamin D deficiency is highly prevalent in the Middle East, however its health impact is still not clear. The aim of this study was to assess the prevalence, causes and health implications of vitamin D deficiency in local United Arab Emirates (UAE) citizens. Methods A cross-sectional study was conducted on community free living adults living in the city of Al Ain, UAE. Following informed written consent eligible subject’s blood and urine samples were taken for measurements of vitamin D [25(OH)D], metabolic and bone turnover markers. Clinical assessment that includes general and self-rated health, muscle health, and physical activity were also performed. Results A total of 648 subjects (491 female) were included in this analysis. Their mean (SD) age was 38 (12) years. Mean 25(OH)D was 24 ng/ml (range: 4–67) with 286 (44%) subjects found to have vitamin D deficiency (< 20 ng/ml), 234 (36%) subjects have insufficiency (20-32 ng/ml) and 128 (20%) subjects have optimal concentrations (> 32 ng/ml). 25(OH)D concentrations were significantly higher in local indigenous UAE subjects compared to other Arab expatriates (p = 0.071). Although there were no statistically significant differences in clinical markers between groups, however, utra-sensitive C-reactive protein (us-CRP), parathyroid hormone (PTH), body mass index (BMI) and the bone markers U-PYD and PYD/CR were higher in vitamin D deficient older subjects aged ≥50 years and female subjects younger than 50 years respectively compared to those with insufficiency or optimal concentrations (p value < 0.05. Multiple logistic regression analysis revealed significant and independent association between 25(OH)D status and age and sex (p < 0.05). Conclusion Older subjects with vitamin D deficiency have increased BMI, inflammation and PTH compared with those with insufficiency or optimal concentrations. Co-existence of obesity and vitamin D deficiency may have increased adverse health effects.

scholarly journals Vitamin D Deficiency and Its Determinants in Adults: A Sample from Community-Based Settings in the United Arab Emirates

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Wegdan Bani-issa ◽  
Kamal Eldeirawi ◽  
Sondos Harfil ◽  
Randa Fakhry
Keyword(s):  
Public Health ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
United Arab Emirates ◽  
Associated Factors ◽  
Diabetes Type 2 ◽  
Health Concern ◽  
Community Based ◽  
Cross Sectional ◽  
Healthcare Settings

Background.Vitamin D deficiency (VDD) is a public health concern in adults worldwide. This study aims to explore the extent of VDD and its associated factors among adults in the United Arab Emirates (UAE).Subjects and Methods.Quantitative, cross-sectional research was used to assess VDD and its associated factors in 216 adults recruited from randomly selected community-based healthcare settings over a six-month period. Recent values of vitamin D and glycated hemoglobin (HbA1c) were abstracted from medical records, followed by interviews with participants to obtain information on factors related to VDD and other covariates and to measure their heights and weights.Results.A total of 74% of participants demonstrated VDD (vitamin D serumlevel≤30 nmol/L). Emirati participants had higher odds of having VDD compared to non-Emiratis (OR: 2.95; 95% CI: 1.58–5.52), with also significantly increased odds of the condition appearing in older, less educated, and employed adults. Diabetes type 2 (HbA1c≥6.5%), depression, and obesity were significantly associated with an increased likelihood of VDD after accounting for other covariates.Conclusion.VDD is a significant problem for UAE adults and requires attention by public health policy makers. Diabetes, obesity, and depression need to be considered when screening for vitamin D.

scholarly journals KNOWLEDGE AND PERCEPTIONS OF VITAMIN D DEFICIENCY AMONG THE UNITED ARAB EMIRATES POPULATION

2019 ◽  
pp. 183-186 ◽  
Author(s):  
OSAMA MOHAMED IBRAHIM ◽  
NOOR KIFAH AL-TAMEEMI ◽  
DALIA DAWOUD
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Blood Level ◽  
United Arab Emirates ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Abu Dhabi ◽  
Sectional Study ◽  
Cross Sectional

Objectives: The purpose of this study is to assess the Vitamin D deficiency awareness and perceptions between the United Arab Emirates (UAE) population. Methods: A cross-sectional study was done among the population of two emirates at the UAE: Abu Dhabi and Sharjah. Results: Overall, 434 participants completed the survey. Majority of people were aware of phenomenon of Vitamin D deficiency, but only 21.4% of them knew that sunlight is considered the main source of Vitamin D. Moreover, less than half of participants check their Vitamin D blood level regularly and around 55% of them follow-up with their physicians after completing the treatment. High proportion of participant females spend <1 h outdoors (60%) and use sunscreen daily (55%) that cause higher prevalence of Vitamin D deficiency among females than males (83% vs. 42%). Conclusion: This research gives some insights regarding the UAE population’s awareness and perceptions of Vitamin D insufficiency. Decreased awareness of sunlight exposure as a major source of Vitamin D, in addition to lifestyle, contributed to Vitamin D deficiency problem among the UAE population, in general, and in females, in particular.

scholarly journals Interplay between Vitamin D, Obesity, and Other Metabolic Factors in a Multiethnic Adult Cohort

2020 ◽  
pp. 1-6
Author(s):  
Khadeeja Mohammed Khalid Mansoor ◽  
Sumaiya Iqbal ◽  
Nowfala Nowshad ◽  
Dima Abdelmannan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
United Arab Emirates ◽  
Cross Sectional Study ◽  
Metabolic Factors ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
Prevalence Of Obesity ◽  
Study Population

<b><i>Introduction:</i></b> Vitamin D deficiency and obesity have been classified as pandemic issues worldwide with high prevalence of both the risk factors in the United Arab Emirates. In recent years, obesity has been associated with vitamin D deficiency, but very few studies have been published about the correlation between them in the UAE population. <b><i>Subjects and Methods:</i></b> This is a cross-sectional study designed to find a correlation between vitamin D deficiency and obesity along with other metabolic factors. Data were collected from electronic medical records of 300 subjects ranging from 15 to 85 years of age of various ethnic origins residing in Dubai. <b><i>Results:</i></b> The study showed a high prevalence of obesity (44.9%) and vitamin D deficiency (40.1) in our study population. There is no evidence of a relation between vitamin D level and the obesity; 40.1% of the subjects were vitamin D deficient, out of which 46.7% were obese. However, a statistically significant relationship was found between cholesterol levels and vitamin D levels. Similarly, a significant relation was found between decreasing Vitamin D levels and increasing age but no relationship was detected with gender. <b><i>Conclusions:</i></b> The present study revealed an alarming prevalence of obesity and vitamin D deficiency. Further steps need to be taken to tackle this growing problem.

scholarly journals Prevalence and Determinants of a Blunted Parathyroid Hormone Response in Young Saudi Women with Vitamin D Deficiency: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hanan Al Kadi
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Deficiency ◽  
Serum Calcium ◽  
Multiple Logistic Regression Analysis ◽  
Secondary Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Saudi Women

Vitamin D deficiency is highly prevalent among the Saudi population. Increased parathyroid hormone (PTH) secretion is an appropriate homeostatic response to correct the resultant hypocalcemia. However, not all vitamin D deficiency patients have increased PTH levels. This study determined the prevalence of a blunted PTH response to vitamin D deficiency among apparently healthy young Saudi women and assessed anthropometric and biochemical factors associated with this response by performing a secondary analysis of data obtained from a cross-sectional study conducted at the “Center of Excellence for Osteoporosis research.” Overall, 315 women (aged 20–45 years) with vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) levels <30 nmol/L) were included. They were divided into two groups according to the laboratory cutoff value of PTH (<7 or ≥7 pmol/L), and anthropometric and biochemical characteristics of both groups were compared. Women with a blunted PTH response (n = 62, 19.7%) had a significantly lower body mass index (BMI) ( P < 0.001 ) and smaller waist circumference ( P = 0.001 ). They also had significantly higher serum 25(OH)D ( P = 0.001 ), corrected serum calcium ( P < 0.001 ), and phosphate ( P = 0.003 ) levels than those with an elevated PTH response (n = 253, 80.3%). Multiple logistic regression analysis showed that lower BMI (OR = 0.925; 95% CI: 0.949–0.987) and higher 25(OH)D (OR = 1.068; 95% CI: 1.014–1.124) and serum calcium (OR = 8.600; 95% CI: 1.614–45.809) levels were significantly associated with a blunted PTH response (R2 = 0.178). A blunted PTH response to vitamin D deficiency is mainly observed among women with lower BMI. Higher serum calcium and 25(OH)D levels and lower BMI were significant predictors of a blunted PTH response, which may indicate that these subjects are adapting to lower 25(OH)D levels and maintaining normal calcium levels without the need to increase PTH secretion. The mechanisms underlying this adaptation are unclear, and future studies to explore these mechanisms are warranted.

scholarly journals Biochemical Markers of Bone Turnover in Patients withβ-Thalassemia Major: A Single Center Study from Southern Pakistan

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sadia Sultan ◽  
Syed Mohammed Irfan ◽  
Syed Ijlal Ahmed
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
Biochemical Markers ◽  
Demographic Data ◽  
Thalassemia Major ◽  
Cross Sectional ◽  
Children And Adolescent ◽  
Markers Of Bone Turnover ◽  
25 Oh Vitamin D

Objectives. Skeletal complications inβ-homozygous thalassemic patients are uncommon but often debilitating, even amongst children and adolescent patients with well maintained transfusion and chelation therapy. The aim is to evaluate the biochemical markers of bone turnover in regularly transfused thalassemic patients and its possible correlations with demographic data and hematological and biochemical markers.Methods. In this prospective cross-sectional study, 36β-thalassemia major patients were enrolled from March 2012 to March 2014. All patients underwent complete blood counts, LFTs, serum ferritin, serum calcium, phosphorus, serum albumin, alkaline phosphatase, 25-OH vitamin D, and parathormone (PTH) levels.Results. There were 17 males and 19 females with mean age of 12.56 ± 5.9 years. Hypocalcemia and hypophosphatemia were seen in 66.6% and 19.4%, respectively, while 25-OH vitamin D deficiency was present in 72.2% of thalassemic children and adolescents. Hypoparathyroidism was seen in 13.8% while hyperparathyroidism was detected in 8.3% of patients. There was direct correlation between serum phosphorus and ferritin levels (P<0.05). No correlation was found between indirect bilirubin and skeletal parameters, calcium and parathyroid hormone (P>0.05).Conclusions. Biochemical profile is significantly altered in patients withβ-thalassemia major and bone associated biochemical abnormalities like hypocalcaemia, 25-OH vitamin D deficiency, and hypophosphatemia are not uncommon in Pakistani patients with thalassemia major.

scholarly journals Welfare receipt and the risk of vitamin D deficiency in Japanese patients on maintenance hemodialysis: a cross-sectional, retrospective study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Keisuke Yoshida ◽  
Tomoki Yonaha ◽  
Masayuki Yamanouchi ◽  
Hirofumi Sumi ◽  
Yasuhiro Taki ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Multiple Logistic Regression Analysis ◽  
Significant Risk ◽  
Welfare Recipients ◽  
Maintenance Hemodialysis ◽  
Vitamin D Status ◽  
Welfare Receipt ◽  
Cross Sectional ◽  
Increased Risk

Abstract Background Vitamin D deficiency is often observed in patients undergoing maintenance hemodialysis and is associated with significantly increased risk of overall mortality. Despite reports of poor nutrition/intake, vitamin D status among patients on maintenance hemodialysis receiving welfare remains unknown. This study investigated the vitamin D status in welfare recipients undergoing maintenance hemodialysis. Methods This cross-sectional study investigated vitamin D status among 106 outpatients undergoing maintenance hemodialysis at two medical facilities in Japan. Patients were divided into welfare and non-welfare groups based on their status as of September 2018. Patients were divided into two categories: serum vitamin D deficiency, defined as serum 25(OH)D concentrations < 12 ng/mL, or non-deficiency. Vitamin D deficiency was used as a dependent variable, while welfare receipt was used as the main predictor variable. Results Mean [± standard deviation] patient age, median [interquartile range] body mass index, and hemodialysis duration were 66.9 [± 10.8] years, 21.5 [19.6, 24.3] kg/m2, and 7.9 [2.9, 12.3] years, respectively. Among 106 patients, 45 were women (42.5%) and 16 (15.1%) were receiving welfare. The welfare group had a higher diabetes prevalence (P = 0.003) and significantly lower median serum 25-hydroxyvitamin D concentrations (11.5 [8.7, 14.0] vs. 14.8 [11.2, 19.9] ng/mL, P = 0.005). Multiple logistic regression analysis revealed that welfare receipt was a significant risk factor for vitamin D deficiency (odds ratio [95% confidence interval], 4.41 [1.08, 18.07]). Conclusions Welfare recipients undergoing maintenance hemodialysis are at significantly increased risks of vitamin D deficiency compared with patients not receiving welfare.

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