Changes from 1986 to 2018 in the Prevalence of Obesity and Overweight, Metabolic Control and Treatment in Children with Type 1 Diabetes Mellitus

Abstract Background: In recent decades, a global increase in the prevalence of childhood overweight and obesity has been observed in children and adolescents with type 1 diabetes.Methods: This retrospective, cross-sectional, population study examined three groups (1986, 2007, and 2018) of children and adolescents aged <16 years diagnosed with type 1 diabetes. Overweight and obesity were defined according to the World Health Organization recommendations.Results: The prevalence of overweight and obesity in diabetic children and adolescents was 30.2% (95% CI: 23.1-38.3). There was a significant increase from 1986 to 2007 (11.9% to 41.7%, p=0.002) and from 1986 to 2018 (11.9% to 34.8%, p=0.012), but no significant differences were found from 2007 to 2018 (41.7% to 34.8%, p=0.492). The age at diagnosis was lower in the group with excess body mass (p=0.037). No significant differences were observed in age (p=0.690), duration of diabetes (p=0.163), distribution according to sex (p=0.452), metabolic control (HbA1c, p=0.909), or insulin units kg/day (p=0.566), in diabetic patients with overweight or obesity. From 2007 to 2018, the use of insulin analogs (p=0.009) and a higher number of insulin doses (p=0.007) increased significantly, with no increase in the prevalence of overweight and obesity.Conclusions: The evolution of the prevalence of overweight and obesity in diabetic children and adolescents during the study period is a reflection of the epidemic of childhood obesity in a global obesogenic environment.

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Prevalence of dental caries in children and adolescents with type 1 diabetes: a systematic review and meta-analysis

BMC Oral Health ◽

10.1186/s12903-019-0903-5 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Yan Wang ◽

Lin Xing ◽

Hui Yu ◽

LiJuan Zhao

Keyword(s):

Type 1 Diabetes ◽

Dental Caries ◽

Children And Adolescents ◽

Metabolic Control ◽

Meta Analysis ◽

Preventive Treatment ◽

Diabetic Patients ◽

China National Knowledge Infrastructure ◽

Pooled Prevalence

Abstract Background Dental caries and type 1 diabetes are responsible for a large burden of global disease; however, the exact prevalence of dental caries among children and adolescents with type 1 diabetes remains controversial, and no quantitative meta-analysis exists. Thus, we performed a meta-analysis to evaluate the prevalence of dental caries among children and adolescents with type 1 diabetes. Methods We performed a systematic search strategy using PubMed, EMBASE and China National Knowledge Infrastructure for relevant studies investigating the prevalence of dental caries in children and adolescents with type 1 diabetes from July 1971 until December 2018. The pooled prevalence with 95% confidence intervals (95%CIs) and subgroup analyses were calculated using a random effects model. Results After screening 358 non-duplicated articles, a total of 10 articles involving 538 individuals were included. The overall prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI: 0.56–0.77%; I2 = 83%). The prevalence was highest in South America (84%) and lowest in diabetic patients with good metabolic control (47%). Conclusions The prevalence of dental caries was high among children and adolescents with type 1 diabetes. Screening and preventive treatment should be included in dental clinical routines for diabetic children and adolescents, especially in those with poor metabolic control.

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Associations Among Taste Perception, Food Neophobia and Preferences in Type 1 Diabetes Children and Adolescents: A Cross-Sectional Study

Nutrients ◽

10.3390/nu11123052 ◽

2019 ◽

Vol 11 (12) ◽

pp. 3052

Author(s):

Chiara Mameli ◽

Camilla Cattaneo ◽

Luisa Lonoce ◽

Giorgio Bedogni ◽

Francesca Chiara Redaelli ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Cross Sectional Study ◽

Taste Perception ◽

Diabetic Patients ◽

Sectional Study ◽

Cross Sectional ◽

Food Neophobia ◽

Product Categories

Type 1 diabetes (T1D) is one of the most common systemic diseases in childhood which predisposes the patient to serious short-term and long-term complications, affecting all body systems. Taste and olfactory impairments were first described a long time ago in adult patients affected by diabetes (both type 1 and type 2 diabetes). However, studies evaluating taste perception, behavioral attitudes (e.g., food neophobia), and preferences toward foods in children and adolescents affected by T1D are globally lacking. Therefore, the purpose of this study was to assess taste sensitivity, food neophobia, and preferences among children and adolescents affected by T1D and healthy controls in a cross-sectional study. T1D patients presented a significantly lower ability in general to correctly identify taste qualities, especially bitter and sour tastes. Moreover, they were characterized by fewer fungiform papillae compared to controls, as well as a lower responsiveness to the bitter compound 6-n-propylthiouracil (PROP). There were no significant differences in food neophobia scores between the two groups, but differences were observed in the mean hedonic ratings for some product categories investigated. Diabetic patients showed a greater liking for certain type of foods generally characterized by sourness and bitterness, an observation probably linked to their impaired ability to perceive taste stimuli, e.g., sourness and bitterness. These results may help to enhance the understanding of these relationships in populations with elevated diet-related health risks.

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The Association between Treatment Modality, Lipid Profile, Metabolic Control in Children with Type 1 Diabetes and Celiac Disease—Data from the International Sweet Registry

Nutrients ◽

10.3390/nu13124473 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4473

Author(s):

Monica Marino ◽

Alexander J. Eckert ◽

Shoshana Tell ◽

Nevena Krnic ◽

Grazyna Deja ◽

...

Keyword(s):

Type 1 Diabetes ◽

Celiac Disease ◽

Lipid Profile ◽

Metabolic Control ◽

Treatment Modality ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

Diabetes Duration ◽

Cross Sectional

Background and Aims: A higher frequency of dyslipidemia is reported in children with type 1 diabetes (T1D) and celiac disease (CD). Recently, continuous subcutaneous insulin infusion (CSII) has been associated with better lipid profiles in patients with T1D. The aim of this study was to investigate the association between treatment modality and lipid profile, metabolic control, and body mass index (BMI)-SDS in children with both T1D and CD. Methods: Cross-sectional study in children registered in the international SWEET database in November 2020. Inclusion criteria were children (2–18 years) with T1D and CD with available data on treatment modality (CSII and injections therapy, IT), triglyceride, total cholesterol, HDL, LDL, dyslipidemia, HbA1c, and BMI-SDS. Overweight/obesity was defined as > +1 BMI-SDS for age. Data were analyzed by linear and logistical regression models with adjustment for age, gender, and diabetes duration. Results: In total 1009 children with T1D and CD (female 54%, CSII 54%, age 13.9 years ±3.6, diabetes duration 7.2 years ±4.1, HbA1c 7.9% ±1.4) were included. Significant differences between children treated with CSII vs. IT were respectively found; HDL 60.0 mg/dL vs. 57.8 mg/dL, LDL 89.4 mg/dL vs. 94.2 mg/dL, HbA1c 7.7 vs. 8.1%, BMI-SDS 0.4 vs. 0.6, overweight and obesity 17% vs. 26% (all p < 0.05). Conclusions: CSII is associated with higher HDL and lower LDL, HbA1c, BMI-SDS, and percentage of overweight and obesity compared with IT in this study. Further prospective studies are required to determine whether CSII improves lipid profile, metabolic control and normalize body weight in children with both T1D and CD.

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The Prevalence of Childhood Underweight, Overweight, and Obesity based on Four Different Criteria

Journal of Nutrition and Food Security ◽

10.18502/jnfs.v5i4.4434 ◽

2020 ◽

Author(s):

Mojgan Amiri ◽

Nastaran Ahmadi ◽

Mohammad Reza Mohammadi ◽

Seyed Ali Mostafavi ◽

Mahla Zahedifard ◽

...

Keyword(s):

Children And Adolescents ◽

Task Force ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

The Body ◽

High Rate ◽

World Health ◽

Cross Sectional ◽

Health Organization ◽

Iranian Children

Background: Childhood/adolescence under- and over-nutrition are among the major public concerns worldwide. This study aimed to determine the prevalence of underweight, overweight, and obesity among children living in Yazd, Iran using different criteria. Methods: This community-based cross-sectional study was conducted among children and adolescents aged 6-18 years. Body weight, height, waist, and hip circumference were measured. Furthermore, the body mass index (BMI) and waist to hip ratio were calculated. Afterwards, BMI was classified according to four criteria including the US center for disease control and prevention (CDC), world health organization (WHO), the international obesity task force (IOTF), and Iranian national cut-points. Results: The mean age of the included children was 11.32 ± 3.89 years. Overall, the highest rate of underweight was estimated by IOTF %16.9 and the lowest rate was estimated by the national criteria %1.2. Furthermore, the highest and the lowest rates for overweight were obtained by CDC2000 %19.0 and WHO criteria %12.2, respectively. The highest and lowest rates for obesity were obtained by the national %22.3 and the CDC2000 criteria %11.3, respectively. The selected criteria were significantly different in estimating underweight, overweight, and obesity (P < 0.05). Conclusions: All the mentioned criteria showed high rate of overweight and obesity among children and adolescents in Yazd. Furthermore, the highest rate of obesity was detected by national criteria. The national distribution of BMI in Iranian children is skewed to overweight and obesity.

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Glycemic Control and Knowledge among Children and Adolescents with Type 1 Diabetes Mellitus; A Cross-sectional Study

Journal of Scientific Research in Medical and Biological Sciences ◽

10.47631/jsrmbs.v2i1.149 ◽

2021 ◽

Vol 2 (1) ◽

pp. 1-9

Author(s):

Nosaiba Ahmed Hussein Abdelseed

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type 1 Diabetes Mellitus ◽

Children And Adolescents ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Diabetic Children

Purpose: The aim of this study is to evaluate the long-term glycemic control by glycosylated hemoglobin level (HbA1c) and to assess knowledge about the diabetic regimen. The results of glycemic control in this study were compared with the results of a study conducted in 2018 that targeted almost a similar population. Study Design: A Cross-Sectional Study. Subjects and Methods: The study was conducted in October 2012 to December 2012 in a major referral Diabetic Centre. Diabetic children aged 8 to 18 years old who were attending the referral diabetic clinics were included in the study (n = 90). Knowledge of diabetes management was evaluated by using a semi-structured questionnaire and HbA1c results were obtained from medical records, available for only 71. Later, these Glycated Hemoglobin HbA1c results were compared with the results of a recent study carried out among Sudanese diabetic children and adolescents in 2018. Results: Out of 71 diabetic children 78.9% were of poor glycemic control with mean HbA1c 10.36±2.14. On the other hand, the majority had good knowledge about the diabetic treatment including insulin administration, its storage conditions, and also the effect of exercise on blood glucose. However, almost 18.8% of studied participants did not know hypoglycemia symptoms, and about 11% of these patients were unaware of hypoglycemia management. Conclusion: The study has indicated that a significant percentage of studied diabetic children and adolescents had poor glycemic control. Although children’s knowledge about insulin therapy was good, further study must be conducted to investigate factors related to glycemic control among children with type 1 diabetes mellitus (T1DM).

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The Prevalence of Weight Disorders in Children and Adolescents in Lorestan Province: Comparison of Three Different Criteria in A Cross-sectional Study

Journal of Nutrition and Food Security ◽

10.18502/jnfs.v6i4.7619 ◽

2021 ◽

Author(s):

Hedayat Nazari ◽

Mohamad Reza Mohammadi ◽

Seyed-Ali Mostafavi ◽

Ali Khaleghi ◽

Nastaran Ahmadi ◽

...

Keyword(s):

Children And Adolescents ◽

Rural Areas ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

World Health ◽

Cluster Sampling ◽

Cross Sectional ◽

Total Prevalence ◽

Urban And Rural Areas ◽

Health Organization

Background: Anthropometric studies in children and adolescents are important to screen changes in growth and puberty. Hence, standard percentiles and cutoffs are set by the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), and Iranian national criteria. This study aimed to examine and compare the prevalence of weight disorders in children and adolescents in Lorestan province according to different criteria. Methods: Children and adolescents (6–18 years) were randomly selected from the urban and rural areas by the multistage stratified cluster sampling method. All Iranian citizens aged who resided in Lorestan province for at least one year were eligible to participate in this study. After obtaining consent forms, researchers gathered the accurate anthropometrics and body mass index (BMI) measurements. Results: A total of 866 children and adolescents took part in the study, 447(51.6%) of whom were girls and 419 (48.4%) were boys. The overall prevalence of overweight and obesity was 17% in boys and 12.5% in girls. The prevalence of underweight in girls was 5.8%; while in boys it was 4.5%. The total prevalence rate of underweight according to the national criteria was 5.2%. However, this rate increased to 12% and 12.6% by using WHO and CDC cut-off points, respectively. The highest prevalence of overweight was obtained by CDC (15.8%), followed by WHO (13%); while national cut-off points resulted in 9.7%. Furthermore, 9.2% of the studied population was found to be obese by WHO; while this rate was 4.2%, and 5% by CDC and national cut-off points. Conclusion: This study indicated the coexisting prevalence of underweight and obesity and high prevalence of overweight among children and adolescents in Lorestan province. Furthermore, using the WHO and CDC criteria leads to overestimating the prevalence of weight disorder compared to the national cut-off points in Iran.

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Prevalence of Metabolic Syndrome in Children and Adolescents with Type 1 Diabetes Mellitus and Possibilities of Prevention and Treatment: A Systematic Review

Nutrients ◽

10.3390/nu13061782 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1782

Author(s):

Monika Grabia ◽

Renata Markiewicz-Żukowska ◽

Katarzyna Socha

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Type 1 Diabetes ◽

Children And Adolescents ◽

Treatment Options ◽

Overweight And Obesity ◽

Excess Body Weight ◽

Healthy Population ◽

Prevention And Treatment

Overweight and obesity are an increasingly common problem, not only among the healthy population, but also in adolescents with type 1 diabetes (T1DM). Excess body weight is related to many cardiometabolic complications as well as a high risk of metabolic syndrome (MetS). The purpose of this systematic review is to provide a concise and critical overview of the prevalence of MetS in children and adolescents with T1DM and, ultimately, to discuss prevention and treatment options. The study was conducted in accordance with PRISMA guidelines. This review shows that, apart from the growing percentage of overweight and obese children and adolescents with T1DM (on average 20.1% and 9.5%, respectively), the problem of the increasing incidence of MetS (range from 3.2 to 29.9%, depending on the criteria used) is one of the most important phenomena of our time. One of the methods of prevention and treatment is a combined approach: changing eating habits and lifestyle, but there are also reports about the beneficial effects of the gut microflora.

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Secular Trends of Underweight, Overweight, and Obesity in Children and Adolescents from Ukraine

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063302 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3302

Author(s):

Katarzyna Dereń ◽

Justyna Wyszyńska ◽

Serhiy Nyankovskyy ◽

Olena Nyankovska ◽

Marta Yatsula ◽

...

Keyword(s):

Children And Adolescents ◽

Age Groups ◽

Overweight And Obesity ◽

The Body ◽

World Health ◽

Public Health Issue ◽

Significant Difference ◽

Significant Public Health ◽

Health Organization ◽

Obesity In Children

Overweight and obesity, as well as underweight in children and adolescents, pose a significant public health issue. This study aimed to investigate the secular trend of the incidence of underweight, overweight, and obesity in children from Ukraine in 2013/2014 and 2018/2019. The studies were conducted in randomly selected primary and secondary schools in Ukraine. In total, 13,447 children (6468 boys and 6979 girls) participated in the study in 2013/2014 and 18,144 children (8717 boys and 9427 girls) participated in 2018/2019. Measurements of body weight and height were performed in triplicate. Underweight, overweight, and obesity were diagnosed according to the standards of the World Health Organization (WHO). In the group of girls, a significant difference between 2013/2014 and 2018/2019 measurements was found only among 7-year-olds. The percentage of girls at this age exceeding the body mass index (BMI) norm was lower in the 2018/2019 study. In boys, a significant difference was also found in 7-year-olds, and, as in girls, a lower share of overweight and obesity was found in 2018/2019. But for the ages of 12, 13, and 15, the significant differences had a different character—more overweight or obese boys were found in the 2018/2019 study. The proportion of underweight children was similar for the majority of age groups in both genders and did not differ in a statistically significant way.

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