scholarly journals Fatalism in breast cancer and performing mammography on women with or without a family history of breast cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Maryam Molaei-Zardanjani ◽  
Mitra Savabi-Esfahani ◽  
Fariba Taleghani
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Positive Family History ◽  
Screening Method ◽  
Cross Sectional Study ◽  
Data Collection Tool ◽  
Cross Sectional ◽  
History Of ◽  
The Mean ◽  
Spss Software

Abstract Background Breast cancer is the most prevalent cancer in women, and in those with a positive family history, it is important to perform mammography. One of the probable barriers in doing mammography is fatalism. Methods This is a descriptive/cross-sectional study conducted on 400 women residing in Isfahan, Iran, randomly selected in 2017. Sampling was done randomly among the enrolled women in Health Integrity System. The data collection tool was a questionnaire regarding the demographic-fertility information and fatalism. The data analysis was done by SPSS software. A P-value < 0.05 was considered statistically significant. Results The results showed that the mean rate of fatalism was 59.5 ± 23.2 in women with the experience of mammography, and 65.9±18.7 in women without the experience. Moreover, the mean rate of fatalism was 73.1±15.2 in subjects with a family history of breast cancer, and 59.3 ± 22.5 in those no family history related to this condition. Accordingly, fatalism was statistically significant associated (P < 0.001) with a family history of breast cancer and experience of mammography. There was no significant relationship between demographic information and fatalism (P > 0.05). Conclusion The results indicated that fatalism in women with no experience of mammography was higher than in those with a positive history. Regarding the necessity of mammography in women with a family history of breast cancer, the required interventions seem to be essential to changing the viewpoints of women regarding the importance and effect of mammography as a screening method for breast cancer.

scholarly journals Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Micro Rna ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

scholarly journals Knowledge towards breast cancer, and breast self-examination practices and its barriers among university female students in Bangladesh: Findings from a cross-sectional study

2021 ◽  
Author(s):  
Rumpa Sarker ◽  
Md. Saiful Islam ◽  
Mst. Sabrina Moonajilin ◽  
Mahmudur Rahman ◽  
Hailay Abrha Gesesew ◽  
...  
Keyword(s):  
Breast Cancer ◽  
University Students ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Female Students ◽  
Sectional Study ◽  
Cross Sectional ◽  
Breast Self Examination ◽  
The Mean ◽  
Self Examination

Early diagnosis of breast cancer is the best approach towards its control that may result in alleviating related mortality and morbidity. This study aimed to evaluate knowledge about breast cancer and both practices and perceived barriers to breast self-examination among female university students in Bangladesh. A cross-sectional study was carried out with 400 female students of Jahangirnagar University, Bangladesh. Participants were sampled from female dormitories at the university from January to April 2020. Proportionate stratified random sampling was conducted to calculate the study sample from each dormitory. A pre-tested, semi-structured self-reported questionnaire was employed to collect data from participants during the survey periods. The questionnaire consists of demographic variables, items about knowledge about breast cancer, breast self-examination practices and its barriers. We applied descriptive and inferential statistics, and data were analyzed using SPSS. Participants aged between 18-26 years and comprised university students of 1st year (20%), 2nd year (24%), 3rd year (22%), 4th year (21%) and Masters (14.%). 18% of them had reported positive family history (mother, aunt, sister/cousin, grandmother) of breast cancer. The overall mean score of total knowledge items was 15 (SD = 3) out of 43, with an overall correct rate of 34%. The mean score of total knowledge items was significantly higher (p<0.001) among Masters students and students with family members who have breast cancer. Only one in five students (21%) ever practiced breast self-examination. The mean score of practice towards breast self-examination was significantly higher (p<0.001) among participants who reported having family member of breast cancer. It is noted that the total knowledge score about breast cancer and practice towards breast self-examination are significantly correlated with each other (r = 0.54; p<0.001). About 33% participants had reported that lack of knowledge as the main barrier to practicing breast self-examination followed by I do not have the symptoms (22%), and shyness/ uncomfortable feelings (17%). The study revealed low levels of knowledge about breast cancer and low breast self-examination practices. This implies the need of promotion and implementation of educational interventions programs that are social and culturally appropriate and suitable for specific age groups.

What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

2020 ◽  
Vol 31 (2) ◽  
pp. 33-44
Author(s):  
Simon Francis ◽  
Obadia V. Nyongole
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Positive Family History ◽  
Negative Attitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adult Men ◽  
History Of ◽  
One Year ◽  
High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas

Gut ◽  
2019 ◽  
Vol 69 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Siew C Ng ◽  
Moe Htet Kyaw ◽  
Bing Yee Suen ◽  
Yee Kit Tse ◽  
Martin C S Wong ◽  
...  
Keyword(s):  
Family History ◽  
Colorectal Neoplasms ◽  
Colorectal Neoplasia ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Advanced Adenoma ◽  
Degree Relative ◽  
Cross Sectional ◽  
History Of ◽  
Advanced Adenomas

ObjectiveThe risk associated with a family history of non-advanced adenoma (non-AA) is unknown. We determined the prevalence of colorectal neoplasms in subjects who have a first-degree relative (FDR) with non-AA compared with subjects who do not have an FDR with adenomas.DesignIn a blinded, cross-sectional study, consecutive subjects with newly diagnosed non-AA were identified from our colonoscopy database. 414 FDRs of subjects with non-AA (known as exposed FDRs; mean age 55.0±8.1 years) and 414 age and sex-matched FDRs of subjects with normal findings from colonoscopy (known as unexposed FDRs; mean age 55.2±7.8 years) underwent a colonoscopy from November 2015 to June 2018. One FDR per family was recruited. FDRs with a family history of colorectal cancer were excluded. The primary outcome was prevalence of advanced adenoma (AA). Secondary outcomes included prevalence of all adenomas and cancer.ResultsThe prevalence of AA was 3.9% in exposed FDRs and 2.4% in unexposed FDRs (matched OR (mOR)=1.67; 95% CI 0.72 to 3.91; p=0.238 adjusted for proband sex and proband age). Exposed FDRs had a higher prevalence of any adenomas (29.2% vs 18.6%; mOR=1.87; 95% CI 1.32 to 2.66; p<0.001) and non-AA (25.4% vs 16.2%; mOR=1.91; 95% CI 1.32 to 2.76; p=0.001). A higher proportion of exposed FDRs than unexposed FDRs (4.3% vs 2.2%; adjusted mOR=2.44; 95% CI 1.01 to 5.86; p=0.047) had multiple adenomas. No cancer was detected in both groups.ConclusionA positive family history of non-AA does not significantly increase the risk of clinically important colorectal neoplasia. The data support current guidelines which do not advocate earlier screening in individuals with a family history of non-AA.Trial registration numberNCT0252172.

Nocturnal enuresis among children in Morogoro region in Tanzania: A cross-sectional survey

2020 ◽  
Vol 31 (1) ◽  
pp. 16-29
Author(s):  
Nehemia Kilongo ◽  
Francis F. Furia
Keyword(s):  
Family History ◽  
Demographic Data ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
African Region ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Childhood Disorders ◽  
Factors Affecting ◽  
History Of

Background: Enuresis is common childhood disorders which affecting quality of life of children and causing significant psychosocial disturbances to children and their families. This condition has been widely reported globally with increasing data from sub-Saharan African region. In Tanzania there is no reports on its magnitude and therefore this study was carried out with the aim of determine the prevalence of this condition among children in Tanzania.Methods: This was a community based cross-sectional study conducted among children aged between 5 and 14 years recruited from 12 streets in Morogoro Municipality in Tanzania. Standardized Swahili questionnaire was used to collect data including socio-demographic details of parents,  children and presence of enuresis. Socio-demographic data included age of the child, sex, level of education of the parents, education of the child, presence of bed wetting, history of enuresis in the family.Results: Five hundred and ten children were recruited into this study out of which 271 (53.1%) were females and mean age of study participants was 9±2.8 years. Enuresis was noted in 19% (97/510) of children, 68% (66/97) and 32% (31/97) had primary and secondary enuresis respectively. Significantly higher prevalence rates of enuresis were noted for children aged below 8 years 26.4% (43/162) and those with family history of enuresis 47% (18/38) with p values of 0.01 and < 0.001 respectively. Forty-one (42.3%) out of 97 respondents whose children had enuresis reported to have punished their children and only 21.4% (20/97) reported to have sought treatment for their children.Conclusions: Enuresis is common among children in Tanzania particularly those with positive family history. Punishment to children with enuresis was noted in this study and only one in five parents/guardians sought treatment for their affected children. Therefore, there is a need for initiatives for raising community awareness about enuresis in Tanzania Key words: Enuresis in children, prevalence of enuresis in Tanzania, factors affecting enuresis in children.

scholarly journals Analysis of two groups of young patients with breast cancer

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Matheus de Paula Solino ◽  
Mariana Soares Cardoso ◽  
Marcelo Antonini
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Screening Method ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Clinical Staging ◽  
Cross Sectional ◽  
Hormonal Receptors ◽  
Significant Difference ◽  
History Of

Introduction: Breast cancer is the main type of cancer and the main cause of death by cancer among women worldwide. For Brazil, the National Cancer Institute José Alencar Gomes da Silva (Instituto Nacional de Câncer José Alencar Gomes da Silva – INCA) estimated that breast cancer would be responsible for 29.5% of new cancer cases and 16.2% of cancer deaths in 2019. The incidence of breast cancer in young women has grown worldwide: in developing countries, 25% of breast cancer cases occur in women under 40 years of age. In young women, breast cancer has more aggressive characteristics and is diagnosed later. Mammography is the best screening method, however, it is only started at 40. Objective: To analyze the clinical, pathological, and treatment characteristics among patients with breast cancer diagnosed up to 40 years old and between 41 and 45 years old. Methods: Observational and cross-sectional study, which evaluated patients diagnosed with breast cancer until the age of 45 and who underwent surgical treatment at the Hospital do Servidor Público Estadual between October, 2013 and October, 2017. Data were collected from medical records and patients were divided into two groups: Group 01, up to 40 years old and Group 02, from 41 to 45 years old. Variables were collected regarding age at diagnosis, menarche, number of deliveries, body mass index (BMI), comorbidities, family history of breast cancer, initial clinical staging, type of biopsy, type of histological biopsy result, type of treatment, and surgical results. The variables were analyzed statistically. Results: Fifty patients aged between 29 and 45 years old were evaluated. There was no statistically significant difference in clinical characteristics. Group 02 presented more tumors with hormonal receptors, more cases of axillary emptying after compromised sentinel lymph node, and lower rates of radiotherapy. Conclusion: Young patients aged 41-45 years old present more tumors with hormonal receptors, greater involvement of microscopically locoregional lymph nodes, and less treatment with radiotherapy than young patients under 40 years of age.

scholarly journals Obstructive Sleep Apnea and Associated Factors Among Hypertensive Patients Attending a Tertiary Cardiac Center in Tanzania: a Comparative Cross-sectional Study

2021 ◽  
Author(s):  
Pedro Pallangyo ◽  
Lucy R. Mgopa ◽  
Zabella Mkojera ◽  
Makrina Komba ◽  
Jalack Millinga ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Family History ◽  
Nasal Congestion ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Excess Body Weight ◽  
Cross Sectional ◽  
Obstructive Sleep ◽  
History Of

Abstract Background: There is mounting evidence for a reciprocal yet bidirectional association between sleep-disordered breathing and hypertension. Obstructive sleep apnea (OSA), a common cause of systemic hypertension is an independent risk factor for hypertension-related cardiovascular morbidity and mortality. In this comparative hospital-based cross-sectional study, we sought to explore the burden of obstructive sleep apnea and its associated risk factors among hypertensive patients attending Jakaya Kikwete Cardiac Institute.Methodology: A total of 1974 individuals (i.e. 1289 hypertensive and 685 normotensives) were consecutively enrolled in this study. The Berlin questionnaire and Epworth Sleepiness Scale were utilized in the assessment of OSA and excessive daytime sleepiness (EDS) respectively. Logistic regression analyses were employed in the determination of associated factors for OSA. Results: The mean age was 53.4 years and females constituted the large majority (60.4%) of participants. About three quarters (74.1%) of participants had excess body weight, 11.6% had diabetes, 8.0% had asthma and 18.6% had history of recurrent nasal congestion. Positive family history of snoring was reported by 43.1% of participants and 36.9% had a personal history of snoring. Persons with hypertension displayed a higher frequency (42.1%) of OSA compared to their normotensive counterparts (11.8%), p<0.001. Multivariate logistic regression analyses revealed hypertension (OR 5.1, 95% CI 3.2-8.2, p<0.001), diabetes mellitus (OR 2.2, 95% CI 1.3-3.5, p<0.01), chronic nasal congestion (OR 1.6, 95% CI 1.1-2.5, p = 0.01), obesity (OR 2.4, 95% CI 1.8-3.3, p<0.001), increased neck circumference (OR 2.7, 95% CI 1.2-6.4, p = 0.02), family history of snoring (OR 5.5, 95% CI 4.0-7.5, p<0.001), and working >8hrs/24hr (OR 0.6, 95% CI 0.4-1.0, p = 0.03) to have an independent association for OSA. Furthermore, participants with hypertension displayed superior odds for OSA compared to their normotensive counterparts across all subgroup analyses. Conclusion: OSA is considerably common among hypertensives in a tertiary health care setting in Tanzania. Positive family history of snoring was the strongest associated factor; however, excess body weight proved to be the strongest modifiable risk factor. In view of its pervasiveness, OSA should be an integral part of the medical evaluation in hypertensive individuals.

scholarly journals Breast Cancer Knowledge and Screening Behaviour among Women with a Positive Family History: A Cross Sectional Study

2013 ◽  
Vol 14 (11) ◽  
pp. 6783-6790 ◽  
Author(s):  
Pathmawathi Subramanian ◽  
Nelson Ositadimma Oranye ◽  
Azimah Mohd Masri ◽  
Nur Aishah Taib ◽  
Nora Ahmad
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Cancer Knowledge ◽  
Sectional Study ◽  
Cross Sectional ◽  
Breast Cancer Knowledge

Prophylactic Mastectomy

2000 ◽  
Vol 124 (3) ◽  
pp. 378-381 ◽  
Author(s):  
Kamal K. Khurana ◽  
Anne Loosmann ◽  
Patricia J. Numann ◽  
Seema A. Khan
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Prophylactic Mastectomy ◽  
Positive Family History ◽  
Reduction Mammoplasty ◽  
Malignant Neoplasms ◽  
Atypical Lobular Hyperplasia ◽  
Pathologic Findings ◽  
History Of ◽  
The Mean

Abstract Background.—According to recently published data, prophylactic mastectomy (PM) appears to prevent about 90% of the expected malignant neoplasms in women with a family history of breast cancer. Objectives.—To identify the frequency of high-risk lesions in PM specimens and to determine occurrence of any new primary breast cancer following PM. Design.—We performed a retrospective study of women undergoing unilateral or bilateral PM. Medical charts and pathologic findings of 35 patients who underwent bilateral mastectomies at University Hospital, Syracuse, NY, from 1989 to 1996 were reviewed. Patients with biopsy-proven bilateral breast cancer were excluded. Patients were divided into 3 groups: (A) positive family history and no known breast cancer (n = 9), (B) positive family history and contralateral neoplasia (n = 13), and (C) negative family history and contralateral neoplasia (n = 13). These findings were compared with those found in reduction mammoplasty specimens from 10 women at standard risk of breast cancer. Results.—The mean age of the control group of women undergoing reduction mammoplasty was 38 years. The pathologic specimens demonstrated no significant pathologic findings in 9 and fibrocystic change in 1. In group A, the mean number of affected relatives was 3.1, and the mean age was 38 years. Two of these 9 women had atypical duct hyperplasia and 1 had atypical lobular hyperplasia in their breasts (ie, 33% with high-risk pathologic findings). Of the 13 group B women (mean age, 46.6 years; mean of 2.5 affected relatives and unilateral breast cancer), the contralateral PM specimen contained duct carcinoma in situ in one and invasive ductal cancer in a second (15% with occult malignant neoplasms). In 13 group C patients (mean age, 47.1 years), 3 (23.1%) of the contralateral PM specimens displayed atypical duct hyperplasia or atypical lobular hyperplasia. At a mean follow-up of 4.8 years, there have been no new breast malignant neoplasms in these 45 women. Conclusions.—The occurrence of unilateral cancer in patients with family history of breast cancer is associated with a 15.4% probability of simultaneous occult malignant neoplasms in the contralateral breast. Patients with a strong family history but no evidence of breast cancer have a substantially similar rate of proliferative disease in their PM specimens as those women who have unilateral cancer but no significant family history.

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