High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men

Background: Transient tachypnea of newborn (TTN) is a common cause of respiratory distress in newborns with estimated incidence of 1-2% of all newborns. Although a self-limiting transient condition but it may cause severe morbidities. This study was conducted to find association of serum vitamin D levels in neonates who develop TTN as compared to normal healthy neonates.Methods: With thorough history with structured questionnaire and lab tests, serum vitamin D levels of 45 neonates who develop TTN were compared with 56 healthy neonates in control group.Results: Out of 45 neonates who develop TTN 39(86.7%) were deficient in vitamin D as compared to control group where 33(58.9%) out of 56 healthy neonates were deficient in vitamin D.Conclusions: Lower vitamin D levels at birth in term neonates is associated with increased risk of developing TTN and vitamin D may have a role in its pathogenesis.

Download Full-text

Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

Download Full-text

Relationship between serum vitamin D levels and angiographic severity and extent of coronary artery disease

European Journal of Clinical Investigation ◽

10.1111/eci.12490 ◽

2015 ◽

Vol 45 (9) ◽

pp. 940-948 ◽

Cited By ~ 12

Author(s):

Yakup Alsancak ◽

Atiye Cengel ◽

Ahmet Akyel ◽

Selcuk Ozkan ◽

Burak Sezenoz ◽

...

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Artery Disease

Download Full-text

Relationship of serum vitamin D deficiency with coronary artery disease severity using multislice CT coronary angiography

Clínica e Investigación en Arteriosclerosis (English Edition) ◽

10.1016/j.artere.2021.11.006 ◽

2021 ◽

Vol 33 (6) ◽

pp. 289-295

Author(s):

Mostafa El Mokadem ◽

Hesham Boshra ◽

Yasser Abd el Hady ◽

Alshimaa Saber Abd el Hameed

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Serum Vitamin ◽

Multislice Ct ◽

Ct Coronary Angiography ◽

Serum Vitamin D ◽

Coronary Artery Disease Severity ◽

Artery Disease ◽

Relationship Of

Download Full-text

Serum Vitamin D Level in Patients with Coronary Artery Disease and Association with Sun Exposure: Experience from a Tertiary Care, Teaching Hospital in India

Advances in Medicine ◽

10.1155/2019/6823417 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Tauseef Akhtar ◽

Ramesh Aggarwal ◽

Sachin Kumar Jain

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Vitamin D Deficiency ◽

Tertiary Care ◽

Serum Vitamin ◽

Sun Exposure ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Artery Disease

Background. Vitamin D, a fat-soluble vitamin, has various extraskeletal effects, and several human and animal studies have suggested that vitamin D deficiency may be a contributory factor in the pathogenesis of coronary artery disease (CAD). However, such studies in the Indian subcontinent are either lacking or have shown conflicting results. Methods. This was a descriptive cross-sectional study involving 121 patients with CAD from a tertiary care center and their 80 age-matched healthy controls. Serum vitamin D levels along with serum and urine chemistries were measured in both the groups. The average duration of sun exposure/day and use of sunscreen were also considered in the study cohort using a questionnaire. Serum vitamin D levels were categorized into deficient (<30 nmol/lit), insufficient (30–75 nmol/lit), and sufficient (>75 nmol/lit) groups. Results. Among the cases, 51.2% of the patients were vitamin D deficient and 44.6% patients had insufficient vitamin D levels, whereas among controls, 40% and 31% of the population had deficient and insufficient levels of vitamin D, respectively. However, the mean value of the serum vitamin D level was not statistically different in the cases as compared to that of the controls (34.06 vs 40.19 nmol/lit) (P=0.08). Corrected serum calcium (9.26 vs 9.59 mg%) (P≤0.0001) and serum albumin levels (4.21 vs 4.75 gm%) (P≤0.0001) were lower in the cases than those of the controls. The average sun exposure/day was higher among the cases than that among the controls (2.93 vs 1.85 hours) (P=0.001). Conclusion. Vitamin D deficiency is widely prevalent in Indian population despite abundant sunshine, and the duration of sun exposure is not correlated with serum vitamin D levels. Vitamin D deficiency is not associated with CAD. However, serum calcium is deficient in CAD patients as compared to the controls. Large-scale studies are required to explore the association further to evaluate the benefits of screening and correction of vitamin D deficiency in patients with CAD.

Download Full-text

Serum vitamin D levels correlate to coronary artery disease severity: a retrospective chart analysis

Expert Review of Cardiovascular Therapy ◽

10.1080/14779072.2016.1190273 ◽

2016 ◽

Vol 14 (8) ◽

pp. 977-982 ◽

Cited By ~ 5

Author(s):

Robert Sogomonian ◽

Hassan Alkhawam ◽

JoshPaul Jolly ◽

Neil Vyas ◽

Sumair Ahmad ◽

...

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Disease Severity ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Coronary Artery Disease Severity ◽

Vitamin D Levels ◽

Artery Disease

Download Full-text

Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

Journal of Clinical Oncology ◽

10.1200/jco.2015.65.1463 ◽

2016 ◽

Vol 34 (12) ◽

pp. 1345-1349 ◽

Cited By ~ 22

Author(s):

Yaw A. Nyame ◽

Adam B. Murphy ◽

Diana K. Bowen ◽

Gregory Jordan ◽

Ken Batai ◽

...

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Radical Prostatectomy ◽

Univariate Analysis ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Cancer Aggressiveness ◽

Increased Risk ◽

Vitamin D Levels ◽

The Relationship

Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low- or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study.

Download Full-text