scholarly journals Prenatal prediction and typing of placental invasion using MRI deep and radiomic features

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Rongrong Xuan ◽  
Tao Li ◽  
Yutao Wang ◽  
Jian Xu ◽  
Wei Jin
Keyword(s):  
Placental Tissue ◽  
Objective Evaluation ◽  
Regions Of Interest ◽  
Diagnostic Methods ◽  
Multi Layer Perceptron ◽  
Mr Image ◽  
New Approach ◽  
Average Accuracy ◽  
Therapeutic Measures ◽  
Placental Invasion

Abstract Background To predict placental invasion (PI) and determine the subtype according to the degree of implantation, and to help physicians develop appropriate therapeutic measures, a prenatal prediction and typing of placental invasion method using MRI deep and radiomic features were proposed. Methods The placental tissue of abdominal magnetic resonance (MR) image was segmented to form the regions of interest (ROI) using U-net. The radiomic features were subsequently extracted from ROI. Simultaneously, a deep dynamic convolution neural network (DDCNN) with codec structure was established, which was trained by an autoencoder model to extract the deep features from ROI. Finally, combining the radiomic features and deep features, a classifier based on the multi-layer perceptron model was designed. The classifier was trained to predict prenatal placental invasion as well as determine the invasion subtype. Results The experimental results show that the average accuracy, sensitivity, and specificity of the proposed method are 0.877, 0.857, and 0.954 respectively, and the area under the ROC curve (AUC) is 0.904, which outperforms the traditional radiomic based auxiliary diagnostic methods. Conclusions This work not only labeled the placental tissue of MR image in pregnant women automatically but also realized the objective evaluation of placental invasion, thus providing a new approach for the prenatal diagnosis of placental invasion.

scholarly journals Magnetic resonance imaging and bone scintigraphy in bone metastasis detection: A comparative study

2010 ◽  
Vol 67 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Silvija Lucic ◽  
Katarina Nikoletic ◽  
Andrea Peter ◽  
Milos Lucic ◽  
Dusan Jovanovic
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Bone Metastasis ◽  
Bone Scintigraphy ◽  
Regions Of Interest ◽  
Diagnostic Methods ◽  
Whole Body ◽  
Resonance Imaging ◽  
Mutual Correlation ◽  
Diagnostic Potential

Background/Aim. Bone scintigraphy is well-known method for the detection of neoplastic lesions with a high sensitivity and, at the same time, a lower specificity. On the other hand magnetic resonance imaging (MRI) is previously established noninvasive imaging method regarding its diagnostic specificity. The aim of this study was to determine the possibilities and to correlate two different diagnostic methods - bone scintigraphy and MRI in the detection of bone metastasis in the spine and pelvic bones. Methods. A total of 123 patients who underwent both bone scintigraphy and spine and pelvic MRI on 1.5 T MR imager were enrolled in this study. Scans were subsequently analyzed in total and divided in regions of interest (cervical, upper, middle and lower thoracic, upper and lower lumbar and pelvic region, which includes sacral spinal segment); afterwards the total number of 585 matching regions were compared and statistically analyzed. Results. The statistical analysis demonstrated significant correlation between the findings of both methods in total. Divided by regions of interest, significant degrees of correlation were demonstrated in all of them, except in the cervical spine region where the r-value was in the range of low correlation. Conclusion. Having a high mutual correlation, bone scintigraphy and MRI are to be considered as the complementary diagnostic methods in the detection of bone metastases. Still, increased diagnostic potential of MRI may highlights negative bone scintigraphy findings in the patients with solitary metastatic lesions or diffuse vertebral infiltration. Advances in the bone scintigraphy (single photon emission tomography - SPECT, SPECTcomputed tomography - SPECT-CT) and MRI (whole body MRI, diffusion MRI), make it possible the diagnostic potential of both methods will result in a further improvement in bone metastasis detection.

Orthodontically induced root resorption – a literature review

2019 ◽  
Vol 24 (2) ◽  
Author(s):  
Anna Pogorzelska ◽  
Anna Stróżyńska-Sitkiewicz ◽  
Kazimierz Szopiński
Keyword(s):  
Orthodontic Treatment ◽  
Root Resorption ◽  
Dental Treatment ◽  
Diagnostic Methods ◽  
Cone Beam ◽  
Permanent Teeth ◽  
Therapeutic Measures ◽  
Cervical Area ◽  
Periapical Radiography

Root resorption in moved teeth is a common undesirable side effect of orthodontic treatment. This pathology usually affects permanent teeth. Although any part of the root may be involved, the apical or cervical area is usually affected. The formation and development of these changes are a long-term process and depend on various factors. The etiology of resorptive changes associated with orthodontic treatment has been widely discussed by many authors, who proposed numerous classifications. Particularly noteworthy are the works on techniques for the treatment of malocclusion and their potential adverse effects. Modern diagnostic methods allow for an early detection of this pathology and the implementation of appropriate therapeutic measures. These techniques include periapical radiography (paralleling technique) combined with cone-beam computed tomography. Dentists not only notice the need to achieve a beautiful smile, but they also take into account possible root shortening. This process is not fully understood, but realizing its existence is important for planning and implementing both orthodontic and general dental treatment.

scholarly journals New approach for diagnostic of Facioscapulohumeral muscular dystrophy based on PCR

2019 ◽  
pp. 3-9
Author(s):  
Н.В. Зернов ◽  
А.А. Гуськова ◽  
М.Ю. Скоблов
Keyword(s):  
Muscular Dystrophy ◽  
Molecular Genetic ◽  
Facioscapulohumeral Muscular Dystrophy ◽  
Diagnostic Methods ◽  
Pulse Field ◽  
Agarose Gel ◽  
New Approach ◽  
Pulse Field Gel Electrophoresis ◽  
Pcr Products ◽  
The Moment

Актуальность. Миодистрофия Ландузи-Дежерина (МЛД) является одной из наиболее часто встречающихся мышечных дистрофий. В 95% случаев заболевание связано с частичной делецией массива повторов D4Z4 на одном из аллелей 4-й хромосомы. Существующие диагностические методики гибридизации по Саузерну и молекулярного комбинга являются ресурсо- и времязатратными. В настоящее время в Российской Федерации молекулярно-генетическая диагностика МЛД не проводится. Цель. Поиск новых подходов к диагностике МЛД для использования в молекулярно-генетических лабораториях. Методы. ДНК выделялась в агарозных блоках и подвергалась обработке эндонуклеазой EcoRI. Полученные фрагменты ДНК разделялись методом пульс-электрофореза в агарозном геле, после этого агарозный гель фрагментировался согласно маркеру молекулярного веса и использовался в качестве матрицы для полимеразной цепной реакции (ПЦР). Принадлежность полученных ПЦР-продуктов к последовательностям повторов D4Z4 4-й хромосомы подтверждалась секвенированием по Сэнгеру. Результаты. Протокол пульс-электрофореза оптимизирован таким образом, что после всех этапов ДНК в агарозном геле пригодна для использования в качестве матрицы для ПЦР. Разработана ПЦР-система специфичной амплификации контрольных ДНК-матриц 4-й хромосомы и подтверждена секвенированием принадлежность получаемых ПЦР-продуктов к последовательности повторов D4Z4 4-й хромосомы. Выводы. Показана возможность использования ДНК в агарозном геле после пульс-электрофореза в качестве матрицы для детекции повторов D4Z4 методом ПЦР. Представленная ПЦР-система специфично амплифицирует последовательности D4Z4 4-й хромосомы. Используя данную ПЦР-систему и геномную ДНК пациента с известной длиной массива повторов D4Z4 проведена успешная диагностика МЛД. Таким образом разработан новый подход к диагностике МЛД для использования в молекулярно-генетических лабораториях. Relevance. Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common muscular dystrophies. In 95% of cases, the disease is associated with partial deletion of the array of the D4Z4 repeats on one of the alleles of the 4th chromosome. The existing diagnostic methods of Southern blotting and molecular combing are quite resource-and time-consuming. At the moment, molecular genetic diagnostic of FSHD is not provided on the territory of the Russian Federation. Aim: to find new approaches for molecular genetic diagnostic of FSHD acceptable for use in standard molecular genetic laboratories Materials and methods: DNA isolated in agarose plugs and treated by the EcoRI restriction enzyme. DNA fragments then were separated by pulse field gel electrophoresis (PFGE) in agarose gel. After PFGE, the agarose gel was fragmented and used as a matrix for PCR. The identity of the obtained PCR products to the sequence of the D4Z4 repeats of the 4th chromosome was confirmed by sequencing by Sanger. Results. The PFGE protocol is optimized in such a way that, after all stages, DNA in agarose gel is suitable for use as a matrix for PCR. We achieve a specific amplification of the control DNA matrices of the 4th chromosome and confirm belonging of the PCR products to the sequence of D4Z4 repeats of the 4th chromosome by the Senger sequencing. Conclusions. This paper shows the possibility of using DNA in agarose gel after PFGE as a matrix for detection of D4Z4 repeats by PCR. The presented PCR system specifically amplify sequence of the 4th chromosome D4Z4 repeats. Using this PCR system and genomic DNA of a patient with a known length of the D4Z4 repeats array, a successful diagnosis of FSHD was performed. Thus, we propose a new approach for FSHD diagnostic, acceptable for use in standard molecular genetic laboratories.

scholarly journals Differential Evaluation of Crew Functional Effectiveness

2017 ◽  
Vol 4 (1) ◽  
pp. 88-95
Author(s):  
Viktors Feofanovs
Keyword(s):  
Theoretical Model ◽  
Functional Performance ◽  
Probabilistic Approach ◽  
Statistical Processing ◽  
Objective Evaluation ◽  
Operator Training ◽  
Evaluation Standards ◽  
New Approach ◽  
Differential Evaluation ◽  
High Degree

Abstract The aim of this article is the development of the system and methodology of complex control and evaluation of vehicle operators performance during multifunctional simulation. In order to achieve the above-stated aim it is necessary to solve the following principal tasks: to elaborate a theoretical model of differentiated evaluation of vehicle operator training degree according to different kinds of their functional performance; to develop the method of the differential evaluation of crew performance on full-scale aviation simulators with due consideration of the probabilistic approach on the basis of statistical processing of the data of recorded flight information. The offered theoretical model of the differential evaluation of operator performance and the methodology of standards determination developed on its basis represent a new approach to the creation of automated systems for the objective evaluation of the trainees’ qualification degree. The elaborated system of differential evaluation standards ensures a high degree of objectiveness when evaluating the degree of the vehicle operator qualification and makes it possible to carry out a comparative analysis of the operators’ qualification.

Laser micro-dissection microscopy of single Cell-compartments from human placental tissue: A new approach to study trophoblast differentiation

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A108-A109
Author(s):  
Matthias Ruebner ◽  
Christine Henke ◽  
Pamela L. Strissel ◽  
Fabian B. Fahlbusch ◽  
Florian Faschingbauer ◽  
...  
Keyword(s):  
Single Cell ◽  
Placental Tissue ◽  
Trophoblast Differentiation ◽  
New Approach ◽  
Cell Compartments ◽  
Human Placental Tissue

scholarly journals The Effect of Labeled/Unlabeled Prior Information for Masseter Segmentation

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Yousef Rezaei Tabar ◽  
Ilkay Ulusoy
Keyword(s):  
Prior Information ◽  
Automatic Segmentation ◽  
Magnetic Resonance Images ◽  
Target Tissue ◽  
Mr Images ◽  
Mr Image ◽  
Seed Point ◽  
New Approach ◽  
Segmentation Methods ◽  
The Common

Several segmentation methods are implemented and applied to segment the facial masseter tissue from magnetic resonance images. The common idea for all methods is to take advantage of prior information from different MR images belonging to different individuals in segmentation of a test MR image. Standard atlas-based segmentation methods and probabilistic segmentation methods based on Markov random field use labeled prior information. In this study, a new approach is also proposed where unlabeled prior information from a set of MR images is used to segment masseter tissue in a probabilistic framework. The proposed method uses only a seed point that indicates the target tissue and performs automatic segmentation for the selected tissue without using labeled training set. The segmentation results of all methods are validated and compared where the influences of labeled or unlabeled prior information and initialization are discussed particularly. It is shown that if appropriate modeling is done, there is no need for labeled prior information. The best accuracy is obtained by the proposed approach where unlabeled prior information is used.

scholarly journals Examples of acquisition and application of biooptical signals

2019 ◽  
Vol 11 (2) ◽  
pp. 25
Author(s):  
Anna Romana Cysewska-Sobusiak
Keyword(s):  
Pulse Oximetry ◽  
Light Transmission ◽  
Medical Engineering ◽  
Objective Evaluation ◽  
Short Review ◽  
Scientific Activity ◽  
Diagnostic Methods ◽  
Sensor Technology ◽  
Arterial Blood ◽  
Light Flicker

Scientific activity of Division of Metrology and Optoelectronics with Poznan University of Poland (PUT) includes methods and systems used in modern electronic, optoelectronic, and biomedical metrology. Noninvasive diagnostic methods applied in medical engineering, with special interest in optoelectronic sensor technology and advanced methods of imaging, are considered in the paper. The author who was the Head of the Division presents the short review of some selected former results of studies related to biophotonics. Full Text: PDF ReferencesA. Cysewska-Sobusiak, "Powers and Limitations of Noninvasive Measurements Implemented in Pulse Oximetry", Biocybernetics and Biomedical Engineering 22 (2002). DirectLink J.G. Webster, Design of pulse oximeters (Bristol, IOP Publishing Ltd 1997). CrossRef T. Aoyagi, "Pulse oximetry: its invention, theory, and future", Journal of Anesthesia 17, 4 (2003). CrossRef A.A. Alian and K.H Shelley, "Photoplethysmography", Anesthesiology 28, 4 (2014). CrossRef F.A. Duck, Physical properties of tissue: a comprehensive reference book (San Diego, Academia Press 1990). CrossRef Z. Krawiecki, A. Cysewska-Sobusiak, G. Wiczyński, and A. Odon, "Modeling and measurements of light transmission through human tissues", Bull. Pol. Ac. Tech. 56, 2 (2008). DirectLink A. Cysewska-Sobusiak, "One-dimensional representation of light-tissue interaction for application in noninvasive oximetry", Opt. Eng. 36, 4 (1997). CrossRef D. Prokop, A. Cysewska-Sobusiak, and A. Hulewicz, "Monitoring of the Arterial Blood Waveforms with a Multi-Sensor System", Procedia Eng. 47 (2012). CrossRef A. Cysewska-Sobusiak, P. Skrzywanek, and A. Sowier, "Utilization of Miniprobes in Modern Endoscopic Ultrasonography", IEEE Sensors Journal 6, 5 (2006). CrossRef A. Cysewska-Sobusiak, G. Wiczyński, Z. Krawiecki, and A. Sowier, "Role of optical techniques in combined use of selected methods of medical imaging", Opto-Electron. Rev. 16, 2 (2008). CrossRef A. Cysewska-Sobusiak, M. Bołtrukiewicz, and J. Parzych, "Evaluation of fluorescence images acquired from oligonucleotide libraries", Optica Applicata 38, 2 (2008). DirectLink M. Jukiewicz and A. Cysewska-Sobusiak, "Stimuli design for SSVEP-based brain computer-interface", Intl. Journal of Electronics and Telecommunications 62, 2 (2016). CrossRef G. Wiczyński, "Inaccuracy of Short-Term Light Flicker Pst Indicator Measuring With a Flickermeter", IEEE Trans. on Power Delivery, 27, 2 (2012). CrossRef A. Hulewicz, "A New Approach to Objective Evaluation of Human Visual Acuity", Phot. Lett. Poland 6, 4 (2014). CrossRef A. Zielińska, K. Kiluk, M. Wojtkowski, and K. Komar, "System for psychophysical measurements of two-photon vision", Phot. Lett. Poland 11, 1 (2019). CrossRef

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