Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential

Abstract Background The biomedical field has used gold nanorods (GNRs) for decades; however, clinical trials and translation is limited except gold nanoshells. The preparation of gold nanoshells is more complex than that of polyethylene glycol-modified GNRs (PEG-GNRs), and it is difficult to ensure uniform thickness. It is important to encourage and broaden the use of the star member (PEG-GNRs) of gold nanoparticles family for clinical translation. Existing studies on PEG-GNRs are limited with no relevant systematic progression in non-human primates. Herein, we assessed the systematic biocompatibility of PEG-GNRs in rats and clinically relevant Macaca fascicularis. Results In this small animal study, we administrated multiple doses of PEG-GNRs to rats and observed good biocompatibility. In the non-human primate study, PEG-GNRs had a longer blood half-life and produced a negligible immune response. Histological analysis revealed no significant abnormality. Conclusions PEG-GNRs were well-tolerated with good biocompatibility in both small animals and large non-human primates. The information gained from the comprehensive systemic toxicity assessment of PEG-GNRs in M. fascicularis will be helpful for translation to clinical trials. Graphical abstract

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Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy

Journal of Nanobiotechnology ◽

10.1186/s12951-020-00754-8 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Beilei Gong ◽

Yuanbing Shen ◽

Huiyan Li ◽

Xiaojun Li ◽

Xia Huan ◽

...

Keyword(s):

Gold Nanorods ◽

Biomedical Applications ◽

Continuous Wave ◽

Continuous Wave Laser ◽

Tumour Site ◽

Polymer Shell ◽

Potential System ◽

Responsive Polymer ◽

Good Biocompatibility ◽

Spr Effect

AbstractOwing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

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Translational Animal Models for Liver Cancer

American Journal of Interventional Radiology ◽

10.25259/ajir-11-2017 ◽

2018 ◽

Vol 2 ◽

pp. 2 ◽

Cited By ~ 4

Author(s):

Michele Obeid ◽

Ramzy C. Khabbaz ◽

Kelly D. Garcia ◽

Kyle M. Schachtschneider ◽

Ron C. Gaba

Keyword(s):

Hepatocellular Carcinoma ◽

Cancer Research ◽

Animal Models ◽

Liver Cancer ◽

Small Animal ◽

Large Animal ◽

Starting Point ◽

Perfect Model ◽

Small Animal Models ◽

Human Primate

Animal models have become increasingly important in the study of hepatocellular carcinoma (HCC), as they serve as a critical bridge between laboratory-based discoveries and human clinical trials. Developing an ideal animal model for translational use is challenging, as the perfect model must be able to reproduce human disease genetically, anatomically, physiologically, and pathologically. This brief review provides an overview of the animal models currently available for translational liver cancer research, including rodent, rabbit, non-human primate, and pig models, with a focus on their respective benefits and shortcomings. While small animal models offer a solid starting point for investigation, large animal HCC models are becoming increasingly important for translation of preclinical results to clinical practice.

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Thermo-Responsive Polymer Encapsulated Gold Nanorods for Single Continuous Wave Laser-Induced Photodynamic/ Photothermal Tumour Therapy

10.21203/rs.3.rs-41731/v1 ◽

2020 ◽

Author(s):

Beilei Gong ◽

Yuanbing Shen ◽

Huiyan Li ◽

Xiaojun Li ◽

Xia Huan ◽

...

Keyword(s):

Gold Nanorods ◽

Biomedical Applications ◽

Continuous Wave ◽

Continuous Wave Laser ◽

Tumour Imaging ◽

Tumour Site ◽

Polymer Shell ◽

Potential System ◽

Good Biocompatibility ◽

Spr Effect

Abstract Gold nanoparticles have been proven suggested to be a versatile platform for a broad range of biomedical applications owing to their strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility. In this study, a new nanoplatform composed of thermo-responsivepolymer encapsulated gold nanorods incorporating ICG was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG for enhanced photodynamic/photothermal combination therapy (PDT/PTT). For the nanoplatform, in addition to significantly increasing theICG payload with the additional benefit of enhancing ICG photostability, the polymer shell also has thermo-responsive characteristics, which can control the release of drugs at tumour sites afterlaser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improvedthe photothermal/photodynamic therapeutic efficacy by inhibiting the growth of tumours in mice aftermild laser irradiation. These results suggest that thisnanoplatform is a great potential system for tumour imaging and antitumour therapy.

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Gold Nanorods as Drug Delivery Vehicles for Rifampicin Greatly Improve the Efficacy of Combating Mycobacterium tuberculosis with Good Biocompatibility with the Host Cells

Bioconjugate Chemistry ◽

10.1021/acs.bioconjchem.6b00430 ◽

2016 ◽

Vol 27 (10) ◽

pp. 2486-2492 ◽

Cited By ~ 27

Author(s):

Hala R. Ali ◽

Moustafa R. K. Ali ◽

Yue Wu ◽

Salah A. Selim ◽

Hazem F. M. Abdelaal ◽

...

Keyword(s):

Drug Delivery ◽

Mycobacterium Tuberculosis ◽

Gold Nanorods ◽

Host Cells ◽

Drug Delivery Vehicles ◽

Good Biocompatibility ◽

Delivery Vehicles

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Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)-8-O-Debutanoylthapsigargin

Biomolecules ◽

10.3390/biom10121640 ◽

2020 ◽

Vol 10 (12) ◽

pp. 1640

Author(s):

Tomáš Zimmermann ◽

Pavel Drašar ◽

Silvie Rimpelová ◽

Søren Brøgger Christensen ◽

Vladimir A. Khripach ◽

...

Keyword(s):

Clinical Trials ◽

Side Effects ◽

Sesquiterpene Lactone ◽

Large Scale ◽

Active Principle ◽

Chemotherapeutic Drug ◽

Limited Access ◽

General Toxicity ◽

Clinical Potential

In spite of the impressing cytotoxicity of thapsigargin (Tg), this compound cannot be used as a chemotherapeutic drug because of general toxicity, causing unacceptable side effects. Instead, a prodrug targeted towards tumors, mipsagargin, was brought into clinical trials. What substantially reduces the clinical potential is the limited access to Tg and its derivatives and cost-inefficient syntheses with unacceptably low yields. Laser trilobum, which contains a structurally related sesquiterpene lactone, trilobolide (Tb), is successfully cultivated. Here, we report scalable isolation of Tb from L. trilobum and a transformation of Tb to 8-O-(12-aminododecanoyl)-8-O-debutanoylthapsigargin in seven steps. The use of cultivated L. trilobum offers an unlimited source of the active principle in mipsagargin.

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Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis)

Reproductive Toxicology ◽

10.1016/j.reprotox.2014.10.004 ◽

2015 ◽

Vol 53 ◽

pp. 105-118 ◽

Cited By ~ 9

Author(s):

Christopher J. Bowman ◽

Mark Evans ◽

Thomas Cummings ◽

Satoru Oneda ◽

Mark Butt ◽

...

Keyword(s):

Monoclonal Antibody ◽

Nerve Growth Factor ◽

Growth Factor ◽

Macaca Fascicularis ◽

Developmental Toxicity ◽

Toxicity Assessment ◽

Nerve Growth ◽

Cynomolgus Monkeys

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TH-C-BRC-02: Lung Injury From Stereotactic Radiosurgery and Efficacy of Amifostine: A Small Animal Study On Helical TomoTherapy

Medical Physics ◽

10.1118/1.3182616 ◽

2009 ◽

Vol 36 (6Part27) ◽

pp. 2798-2798

Author(s):

K Sheng ◽

J Mata ◽

J Cai ◽

J Larner ◽

P Read

Keyword(s):

Lung Injury ◽

Stereotactic Radiosurgery ◽

Animal Study ◽

Helical Tomotherapy ◽

Small Animal ◽

Small Animal Study

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TH-C-204B-07: Development of Image-Guided Radiosurgery with Novalis TX for Small Animal Study

Medical Physics ◽

10.1118/1.3469500 ◽

2010 ◽

Vol 37 (6Part13) ◽

pp. 3456-3456

Author(s):

H Yan ◽

B Koontz ◽

M Kimura ◽

Z Vujaskovic ◽

F Yin

Keyword(s):

Animal Study ◽

Small Animal ◽

Image Guided ◽

Small Animal Study

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Clinical potential of new antiestrogens.

Journal of Clinical Oncology ◽

10.1200/jco.1997.15.2.840 ◽

1997 ◽

Vol 15 (2) ◽

pp. 840-852 ◽

Cited By ~ 83

Author(s):

W J Gradishar ◽

V C Jordan

Keyword(s):

Breast Cancer ◽

Clinical Trials ◽

Bone Density ◽

Clinical Experience ◽

Advanced Disease ◽

Adjuvant Therapies ◽

Laboratory Development ◽

Medical Indications ◽

Clinical Potential

PURPOSE Based on the data and clinical experience derived from tamoxifen usage, the properties of an ideal antiestrogen is described that could have applications as a breast cancer preventative agent, long-term adjuvant therdpy, or as a treatment for osteoporosis. Each of the new antiestrogens currently being tested is discussed in terms of laboratory development, toxicology, pharmacology, endocrinology, and clinical evaluation. And each new compound is assessed according to the properties of an ideal antiestrogen. METHODS A review of all published reports was facilitated by the use of Medline computer searches. RESULTS Numerous compounds are being evaluated in clinical trials and can be categorized as triphenylethylenes or tamoxifen analogs, pure antiestrogens, and targeted antiestrogens. Several of these compounds may have fewer uterotropic properties and greater effects on maintaining bone density compared with tamoxifen; however, the clinical experience (ie, patient-years of treatment) with any of these compounds is minimal. CONCLUSION Although many of these compounds appear promising, further evaluation will be necessary to determine the role these compounds may serve as preventive agents, adjuvant therapies, treatments for advanced disease, or other medical indications such as osteoporosis.

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