scholarly journals Intrinsic nucleus-targeted ultra-small metal–organic framework for the type I sonodynamic treatment of orthotopic pancreatic carcinoma

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Zhang ◽  
Yu Sun ◽  
Jing Cao ◽  
Jiali Luo ◽  
Jing Wang ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Metal Organic Framework ◽  
Phase Cell ◽  
Great Promise ◽  
Type I ◽  
Type Ii ◽  
Independent Manner ◽  
Low Intensity ◽  
Metal Organic ◽  
Organic Framework

Abstract Background Sonodynamic therapy (SDT) strategies exhibit a high tissue penetration depth and can achieve therapeutic efficacy by facilitating the intertumoral release of reactive oxygen species (ROS) with a short lifespan and limited diffusion capabilities. The majority of SDT systems developed to date are of the highly O2-dependent type II variety, limiting their therapeutic utility in pancreatic cancer and other hypoxic solid tumor types. Results Herein, a nucleus-targeted ultra-small Ti-tetrakis(4-carboxyphenyl)porphyrin (TCPP) metal–organic framework (MOF) platform was synthesized and shown to be an effective mediator of SDT. This MOF was capable of generating large quantities of ROS in an oxygen-independent manner in response to low-intensity ultrasound (US) irradiation (0.5 W cm−2), thereby facilitating both type I and type II SDT. This approach thus holds great promise for the treatment of highly hypoxic orthotopic pancreatic carcinoma solid tumors. This Ti-TCPP MOF was able to induce in vitro cellular apoptosis by directly destroying DNA and inducing S phase cell cycle arrest following US irradiation. The prolonged circulation, high intratumoral accumulation, and nucleus-targeting attributes of these MOF preparations significantly also served to significantly inhibit orthotopic pancreatic tumor growth and prolong the survival of tumor-bearing mice following Ti-TCPP + US treatment. Moreover, this Ti-TCPP MOF was almost completely cleared from mice within 7 days of treatment, and no apparent treatment-associated toxicity was observed. Conclusion The nucleus-targeted ultra-small Ti-TCPP MOF developed herein represents an effective approach to the enhanced SDT treatment of tumors in response to low-intensity US irradiation. Graphic abstract

A novel multifunction photochromic metal–organic framework for rapid ultraviolet light detection, amine-selective sensing and inkless and erasable prints

2019 ◽  
Vol 6 (11) ◽  
pp. 3077-3082 ◽  
Author(s):  
Li Li ◽  
Zu-Ming Tu ◽  
Yang Hua ◽  
Xiao-Nan Li ◽  
Hai-Yu Wang ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Metal Organic Framework ◽  
Light Detection ◽  
Low Intensity ◽  
Metal Organic ◽  
Organic Framework

The system shows efficient and fast low intensity ultraviolet light detection, amine-selective sensing and also be used as inkless and erasable print.

Metal–organic framework based nanozymes: promising materials for biochemical analysis

2020 ◽  
Vol 56 (77) ◽  
pp. 11338-11353 ◽  
Author(s):  
Xiangheng Niu ◽  
Xin Li ◽  
Zhaoyuan Lyu ◽  
Jianming Pan ◽  
Shichao Ding ◽  
...  
Keyword(s):  
Biochemical Analysis ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Great Promise ◽  
Metal Organic ◽  
Organic Framework

Metal–organic frameworks with enzyme-like catalytic features (MOF nanozymes) exhibit great promise in detecting various analytes with amplified signal outputs.

scholarly journals The impact of crystal size and temperature on the adsorption-induced flexibility of the Zr-based metal–organic framework DUT-98

2019 ◽  
Vol 10 ◽  
pp. 1737-1744 ◽  
Author(s):  
Simon Krause ◽  
Volodymyr Bon ◽  
Hongchu Du ◽  
Rafal E Dunin-Borkowski ◽  
Ulrich Stoeck ◽  
...  
Keyword(s):  
Crystal Size ◽  
Metal Organic Framework ◽  
Adsorption Behavior ◽  
Switching Behavior ◽  
Type I ◽  
X Ray Diffraction ◽  
X Ray ◽  
Metal Organic ◽  
The Impact ◽  
Organic Framework

In this contribution we analyze the influence of adsorption cycling, crystal size, and temperature on the switching behavior of the flexible Zr-based metal–organic framework DUT-98. We observe a shift in the gate-opening pressure upon cycling of adsorption experiments for micrometer-sized crystals and assign this to a fragmentation of the crystals. In a series of samples, the average crystal size of DUT-98 crystals was varied from 120 µm to 50 nm and the obtained solids were characterized by X-ray diffraction, infrared spectroscopy, as well as scanning and transmission electron microscopy. We analyzed the adsorption behavior by nitrogen and water adsorption at 77 K and 298 K, respectively, and show that adsorption-induced flexibility is only observed for micrometer-sized crystals. Nanometer-sized crystals were found to exhibit reversible type I adsorption behavior upon adsorption of nitrogen and exhibit a crystal-size-dependent steep water uptake of up to 20 mmol g−1 at 0.5 p/p 0 with potential for water harvesting and heat pump applications. We furthermore investigate the temperature-induced structural transition by in situ powder X-ray diffraction. At temperatures beyond 110 °C, the open-pore state of the nanometer-sized DUT-98 crystals is found to irreversibly transform to a closed-pore state. The connection of crystal fragmentation upon adsorption cycling and the crystal size dependence of the adsorption-induced flexibility is an important finding for evaluation of these materials in future adsorption-based applications. This work thus extends the limited amount of studies on crystal size effects in flexible MOFs and hopefully motivates further investigations in this field.

scholarly journals Paralyzed membrane: Current-driven synthesis of a metal-organic framework with sharpened propene/propane separation

2018 ◽  
Vol 4 (10) ◽  
pp. eaau1393 ◽  
Author(s):  
Sheng Zhou ◽  
Yanying Wei ◽  
Libo Li ◽  
Yifan Duan ◽  
Qianqian Hou ◽  
...  
Keyword(s):  
Large Scale ◽  
Metal Organic Framework ◽  
Great Promise ◽  
Cubic Phase ◽  
Membrane Composition ◽  
Zeolitic Imidazolate Framework ◽  
Metal Organic ◽  
Dynamics Simulations ◽  
Molecular Sieving ◽  
Organic Framework

Metal-organic framework (MOF) membranes show great promise for propene/propane separation, yet a sharp molecular sieving has not been achieved due to their inherent linker mobility. Here, zeolitic imidazolate framework ZIF-8–type membranes with suppressed linker mobility are prepared by a fast current–driven synthesis (FCDS) strategy within 20 min, showing sharpened molecular sieving for propene/propane separation with a separation factor above 300. During membrane synthesis, the direct current promotes the metal ions and ligands to assemble into inborn-distorted and stiffer frameworks with ZIF-8_Cm (a newly discovered polymorph of ZIF-8) accounting for 60 to 70% of the membrane composition. Molecular dynamics simulations further verify that ZIF-8_Cm is superior to ZIF-8_I 4¯3m (the common cubic phase) for propene/propane separation. FCDS holds great potential to produce high-quality, ultrathin MOF membranes on a large scale.

Titanium-Based Nanoscale Metal–Organic Framework for Type I Photodynamic Therapy

2019 ◽  
Vol 141 (10) ◽  
pp. 4204-4208 ◽  
Author(s):  
Guangxu Lan ◽  
Kaiyuan Ni ◽  
Samuel S. Veroneau ◽  
Xuanyu Feng ◽  
Geoffrey T. Nash ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Framework ◽  
Type I ◽  
Metal Organic ◽  
Organic Framework

Surface-supported metal–organic framework thin films: fabrication methods, applications, and challenges

2017 ◽  
Vol 46 (19) ◽  
pp. 5730-5770 ◽  
Author(s):  
Jinxuan Liu ◽  
Christof Wöll
Keyword(s):  
Thin Films ◽  
Energy Storage ◽  
Water Splitting ◽  
Metal Organic Framework ◽  
Electronic Devices ◽  
Great Promise ◽  
Metal Organic ◽  
Organic Framework ◽  
Supported Metal

Surface-supported metal–organic framework thin films are receiving increasing attention as a novel form of nanotechnology, which hold great promise for photovoltaics, electronic devices, CO2 reduction, energy storage, water splitting and membranes.

scholarly journals The impact of crystal size and temperature on the adsorption-induced flexibility of the Zr-based metal-organic framework DUT-98

2019 ◽  
Author(s):  
Simon Krause ◽  
Volodymyr Bon ◽  
Hongchu Du ◽  
Rafal E Dunin-Borkowski ◽  
Ulrich Stoeck ◽  
...  
Keyword(s):  
Crystal Size ◽  
Metal Organic Framework ◽  
Type I ◽  
Adsorption Behaviour ◽  
X Ray Diffraction ◽  
Transmission Electron ◽  
Adsorption Of Nitrogen ◽  
Metal Organic ◽  
The Impact ◽  
Organic Framework

In this contribution we analyse the influence of adsorption cycling, crystal size, and temperature on the switching behaviour of the flexible Zr-based metal-organic framework DUT-98. We observe a shift in the gate opening pressure upon cycling of adsorption experiments of micro meter-sized crystals and assign this to a fragmentation of the crystals. In a series of modulated syntheses we downsize the average crystal size of DUT-98 crystals from 120 µm to 50 nm and characterize the obtained solids by X-ray diffraction, infrared spectroscopy, as well as scanning and transmission electron microscopy. We analyse the adsorption behaviour by nitrogen and water adsorption at 77 K and 298 K, respectively and show that adsorption-induced flexibility is only observed for micro meter-sized crystals. Nanometer-sized crystals were found to exhibit reversible type I adsorption behaviour upon adsorption of nitrogen and exhibit a crystal-size dependent steep water uptake of up to 20 mmol g-1 at 0.5 p/p 0 with potential for water harvesting and heat pump applications. We furthermore investigate the temperature-induced structural transition by in situ PXRD. At temperatures beyond 110 °C the open pore state of nano meter-sized DUT-98 crystals are found to irreversibly transform in a closed pore state. The connection of crystal fragmentation upon adsorption cycling and the crystal size-dependence of the adsorption-induced flexibility is an important finding for evaluation of these materials in future adsorption-based applications. This work thus extends the limited amount of studies on crystal size effects in flexible MOFs and hopefully motivates further investigations into this field.

scholarly journals High Performance of UiO-66 Metal-Organic Framework Modified with Melamine for Uptaking of Lead and Cadmium from Aqueous Solutions

2021 ◽  
Author(s):  
alaaS Abdelmoaty ◽  
Shaimaa El-Wakeel ◽  
Nady Fathy ◽  
AdlyA Hanna
Keyword(s):  
Metal Ion ◽  
Active Sites ◽  
High Performance ◽  
Metal Organic Framework ◽  
Ion Concentration ◽  
Great Promise ◽  
Order Kinetic ◽  
Lead And Cadmium ◽  
Metal Organic ◽  
Organic Framework

Abstract In this paper, UiO-66 metal-organic framework (MOF) was prepared by a hydrothermal method and modified consequently with melamine (MUiO-66), as so as enhance the adsorption properties of these materials in liquid-phase adsorption. With respect to this, the adsorption of lead and cadmium divalent ions was performed under varying conditions of pH, metal ion concentration, contact time, adsorbent dose and temperature. Morphology, texture properties, functional groups, crystallinity and thermal properties of both MOFs were examined. UiO-66 composed of sphere-like particles and covered by layers of melamine with enhancing in crystallinity and active sites as well as the total surface area increased from 1080 to 1160 m2/g. The modified UiO-66 with melamine (MUiO-66) showed a notable adsorption capacity of 177.5 and 146.6 mg/g for Pb and Cd (II) ions, respectively. Adsorption of both metals fitted well with the pseudo-second-order kinetic and Langmuir models and controlled by a physisorption mechanism at pH of 5. Also, adsorption process is an endothermic in nature and desorption is achieved well for three cycles by MUiO-66. Therefore, UiO-66 and MUiO-66 obtained in this work have a great promise in adsorption of heavy metals such as Pb and Cd(II) ions from wastewater.

scholarly journals Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Li-Chun Zhao ◽  
Mei Tang ◽  
Qian-Hua Zhang ◽  
Zhi-Yi Hu ◽  
Hong-Wei Gao ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Loading ◽  
Window Size ◽  
Great Promise ◽  
Osteosarcoma Cell ◽  
Impregnation Method ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Metal Organic ◽  
Organic Framework

As an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery. In this study, a new porous MOF, [[Dy2(H2O)3(SDBA)3](DMA)6] (1, H2SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N,N-dimethylacetamide (C4H9NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition. The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement. Due to the suitable window size and polar atom functionalized 1D channels, the activated 1 (1a) compound was used for the anticancer drug 5-fluorouracil (5-Fu, C4H3FN2O2) loading by a simple impregnation method. A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a. Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63.

Sign in / Sign up

Export Citation Format

Share Document