scholarly journals The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Kyle R. Cesareo ◽  
Justin R. Mason ◽  
Patrick G. Saracino ◽  
Margaret C. Morrissey ◽  
Michael J. Ormsbee
Keyword(s):  
Muscular Strength ◽  
Perceived Exertion ◽  
Bench Press ◽  
Time Trial ◽  
Endurance Performance ◽  
Rating Of Perceived Exertion ◽  
Power Performance ◽  
Double Blind ◽  
Tea Plants ◽  
Repetitions To Failure

Abstract Background TeaCrine® is the synthetic version to naturally occurring theacrine (1, 3, 7, 9-tetramethyluric acid) found in the leaves of Camellia kucha tea plants. A few studies have examined the effects of TeaCrine® on cognitive perception, but no research exists examining its effects on resistance exercise performance. The purpose of this study was to determine the efficacy of TeaCrine®, a caffeine-like compound, on maximal muscular strength, endurance, and power performance in resistance-trained men. Methods Twelve resistance-trained men participated in a randomized, double-blind, cross-over designed study. Each participant performed one-repetition maximum (1RM) bench press, 1RM squat, bench press repetitions to failure (RTF) at 70% 1RM, squat RTF at 70% 1RM, and 2-km rowing time trial 90 min after consumption of: (1) Caffeine 300 mg (CAFF300); (2) TeaCrine® 300 mg (TEA300); (3) TeaCrine® + Caffeine (COMBO; 150 mg/150 mg); (4) Placebo 300 mg (PLA). Power and velocity were measured using a TENDO Power Analyzer. Visual analogue scales for energy, focus, motivation to exercise, and fatigue were administered at baseline and 90 min post-treatment ingestion (pre-workout). Rating of perceived exertion was assessed after bench press RTF and squat RTF. Results There were no differences between groups for 1RM, RTF, and power in the bench press and squat exercises. Only CAFF300 resulted in significant increases in perceived energy and motivation to exercise vs. TEA300 and PLA (Energy: + 9.8%, 95% confidence interval [3.3–16.4%], p < 0.01; + 15.3%, 95% CI [2.2–28.5%], p < 0.02; Motivation to exercise: + 8.9%, 95% CI [0.2–17.6%], p = 0.04, + 14.8%, 95% CI [4.7–24.8%], p < 0.01, respectively) and increased focus (+ 9.6%, 95% CI [2.1–17.1%], p = 0.01) vs. TEA300, but there were no significant differences between CAFF300 and COMBO (Energy + 3.9% [− 6.9–14.7%], Focus + 2.5% [− 6.3–11.3%], Motivation to exercise + 0.5% [− 11.6–12.6%]; p > 0.05). Conclusion Neither TEA300, CAFF300, COMBO, or PLA (when consumed 90 min pre-exercise) improved muscular strength, power, or endurance performance in resistance-trained men. Only CAFF300 improved measures of focus, energy, and motivation to exercise.

Improved Cycling Time-Trial Performance after Ingestion of a Caffeine Energy Drink

2009 ◽  
Vol 19 (1) ◽  
pp. 61-78 ◽  
Author(s):  
John L. Ivy ◽  
Lynne Kammer ◽  
Zhenping Ding ◽  
Bei Wang ◽  
Jeffrey R. Bernard ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Time Trial ◽  
Endurance Performance ◽  
Energy Drink ◽  
Rating Of Perceived Exertion ◽  
Double Blind ◽  
Time Trial Performance ◽  
Cycling Time Trial ◽  
Cycling Time ◽  
Trial Performance

Context:Not all athletic competitions lend themselves to supplementation during the actual event, underscoring the importance of preexercise supplementation to extend endurance and improve exercise performance. Energy drinks are composed of ingredients that have been found to increase endurance and improve physical performance.Purpose:The purpose of the study was to investigate the effects of a commercially available energy drink, ingested before exercise, on endurance performance.Methods:The study was a double-blind, randomized, crossover design. After a 12-hr fast, 6 male and 6 female trained cyclists (mean age 27.3 ± 1.7 yr, mass 68.9 ± 3.2 kg, and VO2 54.9 ± 2.3 ml · kg–1 · min–1) consumed 500 ml of either flavored placebo or Red Bull Energy Drink (ED; 2.0 g taurine, 1.2 g glucuronolactone, 160 mg caffeine, 54 g carbohydrate, 40 mg niacin, 10 mg pantothenic acid, 10 mg vitamin B6, and 10 μg vitamin B12) 40 min before a simulated cycling time trial. Performance was measured as time to complete a standardized amount of work equal to 1 hr of cycling at 70% Wmax.Results:Performance improved with ED compared with placebo (3,690 ± 64 s vs. 3,874 ± 93 s, p < .01), but there was no difference in rating of perceived exertion between treatments. β-Endorphin levels increased during exercise, with the increase for ED approaching significance over placebo (p = .10). Substrate utilization, as measured by open-circuit spirometry, did not differ between treatments.Conclusion:These results demonstrate that consuming a commercially available ED before exercise can improve endurance performance and that this improvement might be in part the result of increased effort without a concomitant increase in perceived exertion.

scholarly journals Caffeine improves biochemical and specific performance after judo training: a double-blind crossover study in a real judo training situation

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Kelvin Euton Oliveira Carmo ◽  
Diego Ignácio Valenzuela Pérez ◽  
Charles Nardelli Valido ◽  
Jymmys Lopes dos Santos ◽  
Bianca Miarka ◽  
...  
Keyword(s):  
Heart Rate ◽  
Uric Acid ◽  
Body Mass ◽  
Perceived Exertion ◽  
Rating Of Perceived Exertion ◽  
Power Performance ◽  
Double Blind ◽  
Biochemical Effect ◽  
Plasma Uric Acid ◽  
Hemodynamic Variables

Abstract Background Nutritional ergogenic aids are foods or nutrients that can improve physical performance. Among these foods with ergogenic properties, caffeine has shown that it can increase the fat catabolism, strength, and improve the cognition and time reaction of an athlete, therefore, it is hoped that it can improve the performance of judokas. This study through a double-blind crossover (supplement X placebo) protocol, investigated the effects caffeine supplementation (single capsule containing 5 mg/kg body mass intake 60 min before the session) on biochemical, anthropometrical, physical, subjective and hemodynamic variables measured before, during and after two typical judo trainingcxs sessions (120-min: 40-min of gymnastics; 40-min of specific technics and; 40-min of judo combat). Methods 8 high-level athletes (21.4 ± 2.0 years; 83.6 ± 15.2 kg; 1.8 ± 0.1 m; 17.9 ± 7.0 Fat%) were evaluated before and after each training for body mass, hydration, upper and lower limb power, performance in the special judo fitness test (SJFT), free fatty acids (FFA) in plasma, uric acid, glucose, lactate, heart rate, and pain. In addition, heart rate, FFA in plasma, uric acid, glucose, lactate, rating of perceived exertion and pain were assessed during the training. Results At 120 min, supplementation resulted in a higher concentration of plasma FFA (1.5 ± 0.5 vs. 1.0 ± 0.3 mmol/L; p = 0.047) and lactate (4.9 ± 1.8 vs. 3.0 ± 1.2 mmol/L; p = 0.047), and a lower concentration of uric acid (5.4 ± 0.9 vs. 7.0 ± 1.5 mg/dL; p = 0.04). Supplementation also resulted in performance maintenance (fatigue index) in the SJFT (Δ0.3 ± 2.0 vs Δ1.7 ± 2.5, for caffeine and placebo respectively, p = 0.046). No adverse effects were observed. Conclusion Based on the applied dose, intake time, and sample of this study, we can conclude that caffeine produces an ergogenic biochemical effect, and improves performance in judo athletes.

Carbohydrate mouth rinsing improves resistance training session performance

2018 ◽  
Vol 13 (5) ◽  
pp. 804-809 ◽  
Author(s):  
Luciana S Decimoni ◽  
Victor M Curty ◽  
Livia Almeida ◽  
Alexander J Koch ◽  
Jeffrey M Willardson ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Exercise Performance ◽  
Repeated Measures ◽  
Perceived Exertion ◽  
Bench Press ◽  
Statistical Significance ◽  
Training Session ◽  
Rating Of Perceived Exertion ◽  
Double Blind ◽  
Mouth Rinsing

We investigated the effect of carbohydrate mouth rinsing on resistance exercise performance. Fifteen recreationally trained women (age 26 ± 4 y; height 1.61.9 ± 5.1 m; weight 59.5 ± 8.2 kg) completed two resistance exercise bouts consisting of three sets of five exercises (half-squat, leg press, bench press, military press, and seated row) to volitional fatigue with a 10 repetition-maximum load. Immediately prior to and during the middle of each exercise bout, subjects mouth rinsed for 10 s with 100 mL of either a 6% maltodextrin solution (CHO) or an artificially flavored solution (PLA) in a randomized, double-blind, counterbalanced fashion. Heart rate and perceived exertion were compared between conditions using a 2 (conditions) × 15 (time points) repeated measures ANOVA. Significant main effects were further analyzed using pairwise comparisons with Bonferroni post hoc tests. Total volume (exercises * sets * repetitions * load) between sessions was compared with a Student’s t-test. Statistical significance was set at p ≤ 0.05 level of confidence. The CHO resulted in more repetitions performed during half-squat, bench press, military press, and seated row, for a significantly greater (∼12%) total volume load lifted versus PLA ( p = 0.039, ES: 0.49). Rating of perceived exertion was also significantly lower in the CHO versus PLA ( p = 0.020, ES: 0.28). These data indicate that CHO mouth rinsing can enhance high-volume resistance exercise performance and lower ratings of perceived exertion.

On- Versus Off-Bike Power Training in Professional Cyclists: A Randomized Controlled Trial

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Pedro L. Valenzuela ◽  
Jaime Gil-Cabrera ◽  
Eduardo Talavera ◽  
Lidia B. Alejo ◽  
Almudena Montalvo-Pérez ◽  
...  
Keyword(s):  
Body Composition ◽  
Muscle Strength ◽  
Perceived Exertion ◽  
Ventilatory Threshold ◽  
Controlled Trial ◽  
Time Trial ◽  
Endurance Performance ◽  
Rating Of Perceived Exertion ◽  
Power Training ◽  
Sprint Training

Purpose: To compare the effectiveness of resistance power training (RPT, training with the individualized load and repetitions that maximize power output) and cycling power training (CPT, short sprint training) in professional cyclists. Methods: The participants (20 [2] y, peak oxygen uptake 78.0 [4.4] mL·kg−1·min−1) were randomly assigned to perform CPT (n = 8) or RPT (n = 10) in addition to their usual training regime for 7 weeks (2 sessions/wk). The training loads were continuously registered using the session rating of perceived exertion. The outcomes included endurance performance (8-min time trial and incremental test), as well as measures of muscle strength/power (1-repetition maximum and mean maximum propulsive power on the squat, hip thrust, and lunge exercises) and body composition (assessed by dual-energy X-ray absorptiometry). Results: No between-group differences were found for training loads or for any outcome (P > .05). Both interventions resulted in increased time-trial performance, as well as in improvements in other endurance-related outcomes (ie, ventilatory threshold, respiratory compensation point; P < .05). A significant or quasi-significant increase (P = .068 and .047 for CPT and RPT, respectively) in bone mineral content was observed after both interventions. A significant reduction in fat mass (P = .017), along with a trend (P = .059) toward a reduced body mass, was observed after RPT, but not CPT (P = .076 for the group × time interaction effect). Significant benefits (P < .05) were also observed for most strength-related outcomes after RPT, but not CPT. Conclusion: CPT and RPT are both effective strategies for the improvement of endurance performance and bone health in professional cyclists, although the latter tends to result in greater improvements in body composition and muscle strength/power.

Increased Cardiorespiratory Stress During Submaximal Cycling After Ketone Monoester Ingestion in Endurance-Trained Adults

2021 ◽  
Author(s):  
Devin Goddard McCarthy ◽  
William Bostad ◽  
Fiona Jane Powley ◽  
Jonathan P. Little ◽  
Douglas Richards ◽  
...  
Keyword(s):  
Body Mass ◽  
Ketone Body ◽  
Perceived Exertion ◽  
Bolus Dose ◽  
Ventilatory Threshold ◽  
Time Trial ◽  
Rating Of Perceived Exertion ◽  
Threshold Intensity ◽  
Double Blind ◽  
And Performance

There is growing interest in the effect of exogenous ketone body supplementation on exercise responses and performance. The limited studies to date have yielded equivocal data, likely due in part to differences in dosing strategy, increase in blood ketones, and participant training status. Using a randomized, double-blind, counterbalanced design, we examined the effect of ingesting a ketone monoester (KE) supplement (600 mg/kg body mass) or flavour-matched placebo in endurance-trained adults (n=10 males, n=9 females; VO2peak=57±8 ml/kg/min). Participants performed a 30-min cycling bout at ventilatory threshold intensity (71±3% VO2peak), followed 15 min later by a 3 kJ/kg body mass time-trial. KE versus placebo ingestion increased plasma [β-hydroxybutyrate] before exercise (3.9±1.0 vs 0.2±0.3 mM, p<0.0001, dz=3.4), ventilation (77±17 vs 71±15 L/min, p<0.0001, dz=1.3) and heart rate (155±11 vs 150±11 beats/min, p<0.001, dz=1.2) during exercise, and rating of perceived exertion at the end of exercise (15.4±1.6 vs 14.5±1.2, p<0.01, dz=0.85). Plasma [β-hydroxybutyrate] remained higher after KE vs placebo ingestion before the time-trial (3.5±1.0 vs 0.3±0.2 mM, p<0.0001, dz=3.1), but performance was not different (KE: 16:25±2:50 vs placebo: 16:06±2:40 min:s, p=0.20; dz=0.31). We conclude that acute ingestion of a relatively large KE bolus dose increased markers of cardiorespiratory stress during submaximal exercise in endurance-trained participants. Novelty bullets: •Limited studies have yielded equivocal data regarding exercise responses after acute ketone body supplementation. •Using a randomized, double-blind, placebo-controlled, counterbalanced design, we found that ingestion of a large bolus dose of a commercial ketone monoester supplement increased markers of cardiorespiratory stress during cycling at ventilatory threshold intensity in endurance-trained adults.

Caffeinated Chewing Gum Improves Bicycle Motocross Time-Trial Performance

2020 ◽  
Vol 30 (6) ◽  
pp. 427-434 ◽  
Author(s):  
Amin Daneshfar ◽  
Carl J. Petersen ◽  
Majid S. Koozehchian ◽  
Daniel E. Gahreman
Keyword(s):  
Perceived Exertion ◽  
Weight Ratio ◽  
Time Trial ◽  
Rating Of Perceived Exertion ◽  
Repeated Measure ◽  
Chewing Gum ◽  
Placebo Condition ◽  
Double Blind ◽  
Measure Analysis ◽  
Repeated Measure Analysis

This study aimed to identify the acute effects of caffeinated chewing gum (CAF) on bicycle motocross (BMX) time-trial (TT) performance. In a randomized, placebo-controlled, double-blind cross-over design, 14 male BMX riders (age = 20.0 ± 3.3 years; height = 1.78 ± 0.04 m; body mass = 72 ± 4 kg), consumed either (300 mg; 4.2 ± 0.2 mg/kg) caffeinated (300 mg caffeine, 6 g sugars) or a placebo (0 mg caffeine, 0 g sugars) gum, and undertook three BMX TTs. Repeated-measure analysis revealed that CAF has a large ergogenic effect on TT time, F(1, 14) = 33.570, p = .001, ; −1.5% ± 0.4 compared with the placebo. Peak power and maximal power to weight ratio also increased significantly compared with the placebo condition, F(1, 14) = 54.666, p = .001, ; +3.5% ± 0.6, and F(1, 14) = 57.399, p = .001, ; +3% ± 0.3, respectively. Rating of perceived exertion was significantly lower F(1, 14) = 25.020, p = .001, in CAF (6.6 ± 1.3) compared with the placebo (7.2 ± 1.7). Administering a moderate dose (300 mg) of CAF could improve TT time by enhancing power and reducing the perception of exertion. BMX coaches and riders may consider consuming CAF before a BMX race to improve performance and reduce rating of perceived exertion.

scholarly journals Pre-Sleep Low Glycemic Index Modified Starch Does Not Improve Next-Morning Fuel Selection or Running Performance in Male and Female Endurance Athletes

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2888
Author(s):  
Monique D. Dudar ◽  
Emilie D. Bode ◽  
Karly R. Fishkin ◽  
Rochelle A. Brown ◽  
Madeleine M. Carre ◽  
...  
Keyword(s):  
Glycemic Index ◽  
Perceived Exertion ◽  
Time Trial ◽  
Substrate Utilization ◽  
Rating Of Perceived Exertion ◽  
Endurance Running ◽  
Double Blind ◽  
Baseline Measure ◽  
Running Performance ◽  
Low Glycemic Index

To determine the effects of pre-sleep supplementation with a novel low glycemic index (LGI) carbohydrate (CHO) on next-morning substrate utilization, gastrointestinal distress (GID), and endurance running performance (5-km time-trial, TT). Using a double-blind, randomized, placebo (PLA) controlled, crossover design, trained participants (n = 14; 28 ± 9 years, 8/6 male/female, 55 ± 7 mL/kg/min) consumed a LGI, high glycemic index (HGI), or 0 kcal PLA supplement ≥ 2 h after their last meal and <30 min prior to sleep. Upon arrival, resting energy expenditure (REE), substrate utilization, blood glucose, satiety, and GID were assessed. An incremental exercise test (IET) was performed at 55, 65, and 75% peak volume of oxygen consumption (VO2peak) with GID, rating of perceived exertion (RPE) and substrate utilization recorded each stage. Finally, participants completed the 5-km TT. There were no differences in any baseline measure. During IET, CHO utilization tended to be greater with LGI (PLA, 56 ± 11; HGI, 60 ± 14; LGI, 63 ± 14%, p = 0.16, η2 = 0.14). GID was unaffected by supplementation at any point (p > 0.05). Performance was also unaffected by supplement (PLA, 21.6 ± 9.5; HGI, 23.0 ± 7.8; LGI, 24.1 ± 4.5 min, p = 0.94, η2 = 0.01). Pre-sleep CHO supplementation did not affect next-morning resting metabolism, BG, GID, or 5-km TT performance. The trend towards higher CHO utilization during IET after pre-sleep LGI, suggests that such supplementation increases morning CHO availability.

scholarly journals Gastrointestinal Symptoms Related to Potato Ingestion During Cycling in Trained Athletes (P23-012-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Susannah Scaroni ◽  
Amadeo Salvador ◽  
Colleen McKenna ◽  
Rafael Alamilla ◽  
Isabel Martinez ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Mixed Model ◽  
Gastrointestinal Symptoms ◽  
Time Trial ◽  
Endurance Performance ◽  
Rating Of Perceived Exertion ◽  
Random Factor ◽  
Mixed Model Analysis ◽  
Gi Symptoms ◽  
Significant Difference

Abstract Objectives Carbohydrate (CHO) ingestion is an established nutritional strategy to improve endurance performance, yet currently available products may contribute to gastrointestinal (GI) distress. Potatoes have a high-glycemic index, indicating that their CHO content is readily available. We aimed to compare the effects of ingesting potato purée (POT), commercial CHO gel (GEL), or a control (water, CTL) during cycling on GI Symptoms and affective indices in trained athletes. Methods In a randomized crossover study, twelve trained cyclists (9 M and 3F; 30.5 ± 8.7y; 70.6 ± 7.6 kg; 1.70 ± 7 cm; 60.7 ± 8.9 mL/kg/min) completed a 2 h cycling challenge (60–85%VO2max) followed by a 6 kJ/kg time trial. Cyclists were randomly assigned to consume POT, GEL, or CTL during the challenge. Rating of perceived exertion (RPE), GI symptoms, and affective responses (Feeling Scale −5/+5) were collected throughout the challenge via visual analog scales. Differences between treatments were assessed by mixed model analysis of variance using time and condition as a fixed factor and subject as a random factor. All data represent mean ± standard deviation. Results RPE was not different between POT, GEL, or CTL condition at the end of the cycling challenge (POT: 17 ± 1; GEL: 17 ± 1, CTL: 18 ± 1, P > 0.05). Higher GI symptoms (P < 0.01) were observed at the end of the challenge during POT condition (15 ± 3%) when compared to GEL (8 ± 3%) and CTL (7 ± 3%), with no significant difference in these symptoms prior to this time. FS response significantly increased (P = 0.04) during POT trial (2 ± 2) compared to GEL (0 ± 0.2) and CTL (0 ± 2) conditions at end of the challenge. Conclusions While POT ingestion resulted in greater GI distressed compared to CHO gel, cyclists perceived the exertion to be similar and even reported feeling more pleasant after POT ingestion in endurance exercise. Funding Sources Alliance for Potato Research and Education.

The Effect of Siberian Ginseng (Eleutherococcus Senticosus) on Substrate Utilization and Performance during Prolonged Cycling

2000 ◽  
Vol 10 (4) ◽  
pp. 444-451 ◽  
Author(s):  
L. Christopher Eschbach ◽  
Michael J. Webster ◽  
Joseph C. Boyd ◽  
Patrick D. McArthur ◽  
Tammy K. Evetovich
Keyword(s):  
Steady State ◽  
Perceived Exertion ◽  
Time Trial ◽  
Cycling Performance ◽  
Substrate Utilization ◽  
Rating Of Perceived Exertion ◽  
Time Interval ◽  
Double Blind ◽  
Eleutherococcus Senticosus ◽  
Siberian Ginseng

It has been suggested that Eleutherococcus senticosus (ES). also known as Siberian ginseng or ciwuija. increases fat utilization in humans. The purpose of this study was to examine the physiological responses to supplementation with ES in endurance cyclists. Using arandomized. double-blind crossover design. 9 highly-trained men (28 ± 2 years. V̇O2max 57.3±2.0 ml · kg−1 · min−1) cycled for 120 min at 60% V̇O2max followed by a simulated 10-km lime trial. Diet was controlled, and ES (1,200 mg · day−1) or a placebo (P) were administered for 7 days prior to each of the two trials. Oxygen consumption, respiratory exchange ratio, and heart rate were recorded every 30 min, and rating of perceived exertion. plasma [lactate], and plasma [glucose j were recorded every 20 min during the 120 min of steady state cycling. There were no significant differences (p > .05) between the ES and P groups at any steady-state time interval or during the cycling time trial (ES = 18.10 ± 0.42, P = 17.83 ± 0.47 min). In contrast with previous reports, the results of this study suggest that ES supplementation does not alter steady-state substrate utilization or 10-km cycling performance time.

scholarly journals Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
S. C. Broome ◽  
A. J. Braakhuis ◽  
C. J. Mitchell ◽  
T. L. Merry
Keyword(s):  
Perceived Exertion ◽  
Average Power ◽  
Time Trial ◽  
Cycling Performance ◽  
Rating Of Perceived Exertion ◽  
Middle Aged ◽  
Double Blind ◽  
Nutritional Strategy ◽  
Exercise Induced ◽  
Respiratory Gases

Abstract Background Exercise increases skeletal muscle reactive oxygen species (ROS) production, which may contribute to the onset of muscular fatigue and impair athletic performance. Mitochondria-targeted antioxidants such as MitoQ, which contains a ubiquinone moiety and is targeted to mitochondria through the addition of a lipophilic triphenylphosphonium cation, are becoming popular amongst active individuals as they are designed to accumulate within mitochondria and may provide targeted protection against exercise-induced oxidative stress. However, the effect of MitoQ supplementation on cycling performance is currently unknown. Here, we investigate whether MitoQ supplementation can improve cycling performance measured as time to complete an 8 km time trial. Method In a randomized, double-blind, placebo-controlled crossover study, 19 middle-aged (age: 44 ± 4 years) recreationally trained (VO2peak: 58.5 ± 6.2 ml·kg− 1·min− 1, distance cycled per week during 6 months prior to study enrollment: 158.3 ± 58.4 km) male cyclists completed 45 min cycling at 70% VO2peak followed by an 8 km time trial after 28 days of supplementation with MitoQ (20 mg·day− 1) and a placebo. Free F2-isoprostanes were measured in plasma samples collected at rest, after 45 min cycling at 70% VO2peak and after completion of the time trial. Respiratory gases and measures of rating of perceived exertion (RPE) were also collected. Results Mean completion time for the time trial was 1.3% faster with MitoQ (12.91 ± 0.94 min) compared to placebo (13.09 ± 0.95 min, p = 0.04, 95% CI [0.05, 2.64], d = 0.2). There was no difference in RPE during the time trial between conditions (p = 0.82) despite there being a 4.4% increase in average power output during the time trial following MitoQ supplementation compared to placebo (placebo; 270 ± 51 W, MitoQ; 280 ± 53 W, p = 0.04, 95% CI [0.49, 8.22], d = 0.2). Plasma F2-isoprostanes were lower on completion of the time trial following MitoQ supplementation (35.89 ± 13.6 pg·ml− 1) compared to placebo (44.7 ± 16.9 pg·ml− 1p = 0.03). Conclusion These data suggest that MitoQ supplementation may be an effective nutritional strategy to attenuate exercise-induced increases in oxidative damage to lipids and improve cycling performance.

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