scholarly journals A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Hamed Jafari-Vayghan ◽  
Parisa Varshosaz ◽  
Fatemeh Hajizadeh-Sharafabad ◽  
Hamid Reza Razmi ◽  
Mahdi Amirpour ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Blood Sugar ◽  
Animal Studies ◽  
Serum Levels ◽  
First Century ◽  
Glutamine Supplementation ◽  
Weight Changes ◽  
Metabolic Variables

Abstract Diabetes mellitus is one of the most important threats to human health in the twenty-first century. The use of complementary and alternative medicine to prevent, control, and reduce the complications of diabetes mellitus is increasing at present. Glutamine amino acid is known as a functional food. The purpose of this systematic review is to determine the potential role of glutamine supplementation on metabolic variables in diabetes mellitus. For this review, PubMed, SCOPUS, Embase, ProQuest, and Google Scholar databases were searched from inception through April 2020. All clinical trial and animal studies assessing the effects of glutamine on diabetes mellitus were eligible for inclusion. 19 studies of 1482 articles met the inclusion criteria. Of the 19 studies, nine studies reported a significant increase in serum GLP-1 levels. Also, eight studies showed reducing in serum levels of fasting blood sugar, four studies reducing in postprandial blood sugar, and triglyceride after glutamine supplementation. Although glutamine resulted in a significant increase in insulin production in seven studies, the findings on Hb-A1c levels were inconclusive. In addition to, despite of the results was promising for the effects of glutamine on weight changes, oxidative stress, and inflammation, more precise clinical trials are needed to obtain more accurate results. In conclusion, glutamine supplementation could improve glycemic control and levels of incretins (such as GLP-1 and GIP) in diabetes mellitus. However, more studies are needed for future studies.

scholarly journals The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Natural Products ◽  
Promising Therapeutic Target ◽  
Prevalent Disease ◽  
Bibliographic Search ◽  
Treatment Of Diabetes ◽  
Definition Of ◽  
Diabetes Mellitus Treatment

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.

scholarly journals The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Joshua A. David ◽  
William J. Rifkin ◽  
Piul S. Rabbani ◽  
Daniel J. Ceradini
Keyword(s):  
Diabetes Mellitus ◽  
Oxidative Damage ◽  
Therapeutic Target ◽  
Type Ii Diabetes ◽  
Animal Studies ◽  
Cell Types ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
And Oxidative Stress

Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide, and prevalence continues to rise. Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. Only recently, however, has the role of the Nrf2/Keap1/ARE master antioxidant pathway in diabetic dysfunction begun to be elucidated. There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. In this review, we outline the role of oxidative damage and the Nrf2/Keap1/ARE pathway in TIIDM, focusing on current and future efforts to utilize this relationship as a therapeutic target for prevention, prognosis, and treatment of TIID.

Role of yoga for patients with type II diabetes mellitus: A systematic review and meta-analysis

2016 ◽  
Vol 25 ◽  
pp. 104-112 ◽  
Author(s):  
Vinod Kumar ◽  
Aarti Jagannathan ◽  
Mariamma Philip ◽  
Arun Thulasi ◽  
Praveen Angadi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type Ii Diabetes ◽  
Meta Analysis ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

scholarly journals Increased Serum Levels of Uric Acid Are Associated with Sudomotor Dysfunction in Subjects with Type 2 Diabetes Mellitus

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
N. Papanas ◽  
M. Demetriou ◽  
N. Katsiki ◽  
K. Papatheodorou ◽  
D. Papazoglou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Colour Change ◽  
Serum Levels ◽  
Group A ◽  
Group B

The aim of this paper was to assess serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) with or without sudomotor dysfunction (evaluated by the Neuropad test). We included 36 T2DM patients with sudomotor dysfunction (group A: mean age63.1±2.6years) and 40 age-, gender-, renal function- and T2DM duration-matched patients without sudomotor dysfunction (group B: mean age62.1±3.1years). SUA was significantly higher in group A (P<0.001). There was a significant correlation between SUA and Neuropad time to colour change in both groups (group A:rs=0.819,P<0.001; group B:rs=0.774,P<0.001). There was also a significant positive correlation between SUA and CRP in both groups (group A:rs=0.947,P<0.001; group B:rs=0.848,P<0.001). In conclusion, SUA levels were higher in T2DM patients with sudomotor dysfunction than those without this complication. The potential role of SUA in sudomotor dysfunction merits further study.

scholarly journals Family's Ability to Take Care The Patient of Type 2 Diabetes Mellitus in Tasikmalaya

2020 ◽  
Vol 3 (3) ◽  
pp. 150
Author(s):  
Bayu Brahmantia ◽  
Miftahul Falah ◽  
Lilis Lismayanti ◽  
Vina Erviana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Education ◽  
Blood Sugar ◽  
Metabolic Disorder ◽  
Sampling Method ◽  
The Family

Diabetes Mellitus is a metabolic disorder disease characterized by a rise of blood sugar due to a decrease of insulin by the pancreas. The role of the family in caring for the patient with type 2 diabetes mellitus is crucial in treatment. this study was aimed to know the ability of family in caring. a purposive sampling method was applied in this research. a total of 31 respondents were selected. the results showed that the majority of family's ability to recognize as a problem was good with 16 people ( 51,6 % ), in taking decisions for treatment was positive as much as 19 people (61.3%), in treatment of type 2 Diabetes Mellitus patients were positive 25 people (80,6%), in modifying the environment for Treatment was negative  18 people (58.1%). therefore, Health education for the family related to modifying the environment for treatment was required to recover the patient.

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