scholarly journals The relationship of C-reactive protein/interleukin-6 concentrations between serum and synovial fluid in the diagnosis of periprosthetic joint infection

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Bao-Zhan Yu ◽  
Rui Li ◽  
Xiang Li ◽  
Wei Chai ◽  
Yong-Gang Zhou ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Periprosthetic Joint Infection ◽  
Interleukin 6 ◽  
Joint Infection ◽  
C Reactive Protein ◽  
Musculoskeletal Infection ◽  
Reactive Protein ◽  
Serum Crp ◽  
Relationship Of ◽  
The Relationship

Abstract Background The relationship of C-reactive protein (CRP)/interleukin-6 (IL-6) concentrations between serum and synovial fluid and whether synovial CRP/IL-6 testing in addition to serum CRP/IL-6 testing would result in a benefit in the diagnosis of periprosthetic joint infection (PJI) deserves to be investigated. Methods From June 2016 to July 2019, 139 patients were included in the study. Synovial CRP and IL-6 were tested by ELISA. The serum CRP and IL-6 were obtained from medical records. The definition of PJI was based on the modified Musculoskeletal Infection Society (MSIS) criteria. The relationship of serum and synovial CRP and IL-6 and the value of each index in the diagnosis of PJI were evaluated. Results The receiver operating characteristic (ROC) curves showed that synovial IL-6 had the highest area under the curve (AUC) at 0.935, which was followed by synovial CRP, serum IL-6 and serum CRP 0.861, 0.847 and 0.821, respectively. When combining serum CRP and synovial CRP to diagnose PJI, the AUC was 0.849, which was slightly higher than the result obtained when using serum CRP alone. In contrast, when combining serum IL-6 and synovial IL-6 to diagnose PJI, the AUC increased to 0.940, which was significantly higher than that obtained using serum IL-6 alone. Conclusion The synovial IL-6 has the highest diagnostic accuracy for PJI. However, inferring the level of CRP/IL-6 in the synovial fluid from the serum level of CRP/IL-6 was not feasible. Synovial CRP testing did not offer an advantage when combined with an existing serum CRP result to diagnose PJI, while additional synovial IL-6 was worthy of testing even if there was an existing serum IL-6 result.

scholarly journals The Relationship of C-reactive Protein/interleukin-6 Concentrations Between Serum and Synovial Fluid in the Diagnosis of Periprosthetic Joint Infection

2021 ◽  
Author(s):  
Bao-Zhan Yu ◽  
Rui Li ◽  
Xiang Li ◽  
Wei Chai ◽  
Yong-Gang Zhou ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Periprosthetic Joint Infection ◽  
Interleukin 6 ◽  
Joint Infection ◽  
C Reactive Protein ◽  
Musculoskeletal Infection ◽  
Reactive Protein ◽  
Serum Crp ◽  
Relationship Of ◽  
The Relationship

Abstract Background: The relationship of C-reactive protein (CRP)/interleukin-6 (IL-6) concentrations between serum and synovial fluid and whether synovial CRP/IL-6 testing in addition to serum CRP/IL-6 testing would result in a benefit in the diagnosis of periprosthetic joint infection (PJI) deserves to be investigated.Methods: From June 2016 to July 2019, 139 patients were included in the study. Synovial CRP and IL-6 were tested by ELISA. The serum CRP and IL-6 were obtained from medical records. The definition of PJI was based on the modified Musculoskeletal Infection Society (MSIS) criteria. The relationship of serum and synovial CRP and IL-6 and the value of each index in the diagnosis of PJI were evaluated.Results: The Receiver operating characteristic（ROC）curves showed that synovial IL-6 had the highest area under the curve（AUC） at 0.935, which was followed by synovial CRP, serum IL-6 and serum CRP 0.861, 0.847 and 0.821, respectively. When combining serum CRP and synovial CRP to diagnose PJI, the AUC was 0.849, which was slightly higher than the result obtained when using serum CRP alone. In contrast, when combining serum IL-6 and synovial IL-6 to diagnose PJI, the AUC increased to 0.940, which was significantly higher than that obtained using serum IL-6 alone.Conclusion: The synovial IL-6 has the highest diagnostic accuracy for PJI. However，inferring the level of CRP/IL-6 in the synovial fluid from the serum level of CRP/IL-6 was not feasible. Synovial CRP testing did not offer an advantage when combined with an existing serum CRP result to diagnose PJI, while additional synovial IL-6 was worthy of testing even if there was an existing serum IL-6 result.

scholarly journals Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection

2016 ◽  
Vol 129 (16) ◽  
pp. 1987-1993 ◽  
Author(s):  
Chi Wang ◽  
Qi Wang ◽  
Rui Li ◽  
Jin-Yan Duan ◽  
Cheng-Bin Wang
Keyword(s):  
Synovial Fluid ◽  
Periprosthetic Joint Infection ◽  
Diagnostic Marker ◽  
Joint Infection ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Investigation of the Relationship of Systemic Immune-Inflammation Index, C-Reactive Protein and Interleukin-6 with Viral Dynamics in Patients with COVID-19

2021 ◽  
Vol 55 (4) ◽  
pp. 539-552
Author(s):  
Emrah Salman ◽  
Nevreste Çelikbilek ◽  
Sibel Aydoğan ◽  
Birsen Özdem ◽  
Sibel Gökay ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Viral Dynamics ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immune Inflammation ◽  
Relationship Of ◽  
The Relationship

scholarly journals The role of serum C-reactive protein in the diagnosis of periprosthetic shoulder infection

2021 ◽  
Author(s):  
Doruk Akgün ◽  
Mats Wiethölter ◽  
Paul Siegert ◽  
Victor Danzinger ◽  
Marvin Minkus ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Joint Infection ◽  
Receiver Operating Curve ◽  
C Reactive Protein ◽  
Level Of Evidence ◽  
Reactive Protein ◽  
Median Serum ◽  
Cutibacterium Acnes ◽  
Serum Crp ◽  
Receiver Operating

Abstract Introduction There is a paucity of literature regarding serum C-reactive protein (CRP) in the evaluation of a shoulder periprosthetic joint infection (PJI). The purpose of the current study was to establish cutoff values for diagnosing shoulder PJI and evaluate the influence of the type of infecting microorganism and the classification subgroups according to last proposed International Consensus Meeting (ICM) criteria on the CRP level. Materials and methods A retrospective analysis of all 136 patients, who underwent septic or aseptic revision shoulder arthroplasty in our institution between January 2010 and December 2019, was performed. Shoulder PJI was defined according to the last proposed definition criteria of the ICM. Serum CRP levels were compared between infected and non-infected cases, between infection subgroups, as well as between different species of infecting microorganisms. A receiver-operating characteristic (ROC) analysis was performed to display sensitivity and specificity of serum CRP level for shoulder PJI. Results A total of 52 patients (38%) were classified as infected, 18 meeting the criteria for definitive infection, 26 for probable infection and 8 for possible infection. According to the ROC curve, an optimized serum CRP threshold of 7.2 mg/l had a sensitivity of 69% and specificity of 74% (area under curve = 0.72). Patients with definitive infection group demonstrated significantly higher median serum CRP levels (24.3 mg/l), when compared to probable, possible infection groups and PJI unlikely group (8 mg/l, 8.3 mg/l, 3.6 mg/l, respectively, p < 0.05). The most common isolated microorganism was Cutibacterium acnes in 25 patients (48%) followed by coagulase-negative staphylococci (CNS) in 20 patients (39%). Patients with a PJI caused by high-virulent microorganisms had a significantly higher median serum CRP level compared to patients with PJI caused by low-virulent microorganisms (48 mg/l vs. 11.3 mg/l, p = 0.04). Conclusions Serum CRP showed a low sensitivity and specificity for the diagnosis of shoulder PJI, even applying cutoffs optimized by receiver-operating curve analysis. Low-virulent microorganisms and patients with probable and possible infections are associated with lower CRP levels compared to patients with definitive infection and infections caused by high-virulent microorganisms. Level of evidence Diagnostic Level III.

Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

2010 ◽  
Vol 69 (11) ◽  
pp. 1976-1982 ◽  
Author(s):  
Hanneke J M Kerkhof ◽  
Sita M A Bierma-Zeinstra ◽  
Martha C Castano-Betancourt ◽  
Moniek P de Maat ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Genetic Variation ◽  
Body Mass ◽  
Analysis Of Covariance ◽  
C Reactive Protein ◽  
Knee Oa ◽  
Reactive Protein ◽  
Serum Crp ◽  
The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

The relationship between serum and tumoral CRP, Akt, MAPK, and survival in patients undergoing potentially curative resection for colorectal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14110-e14110
Author(s):  
Arfon Powell ◽  
Scott Shepherd ◽  
Clare Orange ◽  
Donald C. Mcmillan ◽  
Paul G Horgan ◽  
...  
Keyword(s):  
Map Kinase ◽  
Patient Survival ◽  
C Reactive Protein ◽  
Tumour Heterogeneity ◽  
Cancer Specific Survival ◽  
Colorectal Tumour ◽  
Reactive Protein ◽  
Membrane Bound ◽  
Serum Crp ◽  
The Relationship

e14110 Background: Serum CRP was previously reported in myeloma to activate membrane bound Fcγ receptors which in turn activated Akt, and MAP kinase and inhibited caspase cascade activation resulting in increased tumour cell proliferation and inhibition of apoptosis. This study investigated the hypothesis that serum C-reactive protein (CRP) may activate signalling pathways in colorectal tumour cells. Methods: A cohort of 147 colorectal tumours was established and immunohistochemistry performed to assess protein expression of CRP, MAP kinase and Akt phosphorylated at serine 473 (pAkt). In addition, reverse transcriptase PCR for CRP mRNA expression was performed on 31 malignant colorectal specimens, 20 non-malignant colorectal specimens and 30 liver specimens. Results: No association between patient survival and tumour expression of CRP, pAkt and MAPK was observed, but serum CRP was independently associated with cancer-specific survival (p<0.001). When analysed according to tumour site, cytoplasmic CRP expression was associated with cancer specific survival in left sided tumours (p=0.022) and cytoplasmic pAkt was associated with cancer specific survival (p=0.029) in rectal tumours. No correlations were observed between serum CRP and tumour expression of CRP, pAkt and MAPK in the cohort as a whole or when subdivided by site. Conclusions: No link was established between serum CRP and signalling within the tumour. However, our results do support the concept of colorectal tumour heterogeneity, as different proteins were associated with patient survival depending on site. Further work is therefore required to elucidate the mechanisms underlying colorectal development and progression in tumour subtypes.

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