scholarly journals The mechanism of electroacupuncture for depression on basic research: a systematic review

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xuke Han ◽  
Yang Gao ◽  
Xuan Yin ◽  
Zhangjin Zhang ◽  
Lixing Lao ◽  
...  
Keyword(s):  
Animal Studies ◽  
Data Extraction ◽  
Basic Research ◽  
The Other ◽  
Mild Stress ◽  
Inclusion Criteria ◽  
China National Knowledge Infrastructure ◽  
Search Terms ◽  
Knowledge Infrastructure ◽  
Treatment Of Depression

Abstract Background Electroacupuncture (EA) is generally accepted as a safe and harmless treatment option for alleviating depression. However, there are several challenges related to the use of EA. Although EA has been shown to be effective in treating depression, the molecular mechanism is unclear. Objective To reveal the therapeutic effect of EA and its possible mechanism in the treatment of depression. Search strategy We performed a systematic search according to PRISMA guidelines. We electronically searched PubMed, Web of Science (WOS), the China National Knowledge Infrastructure (CNKI), Wanfang Data Information Site and the VIP information database for animal studies in English published from the inception of these databases to December 31, 2019. Inclusion criteria Electronic searches of PubMed, WOS, the CNKI, Wanfang and the VIP database were conducted using the following search terms: (depression OR depressive disorder OR antidepressive), (rat OR mouse) AND (acupuncture OR EA). Data extraction and analysis The data were extracted primarily by one author, and a follow-up review was conducted by the other authors. Results Twenty-eight articles met the inclusion criteria. The most commonly used method for inducing depression in animal models was 21 days of chronic unpredictable mild stress. For the depression model, the most commonly selected EA frequency was 2 Hz. Among the 28 selected studies, 11 studies observed depression-related behaviors and used them as indicators of EA efficacy. The other 17 studies focused on mechanisms and assessed the indexes that exhibited abnormalities that were known to result from depression and then returned to a normal range after EA treatment. Treatment of depression by EA involves multiple therapeutic mechanisms, including inhibition of HPA axis hyperactivity and inflammation, regulation of neuropeptides and neurotransmitters, modulation of the expression of particular genes, restoration of hippocampal synaptic plasticity, increased expression of BDNF, and regulation of several signaling pathways. Conclusions This review reveals that the mechanisms underlying the effect of acupuncture involve multiple pathways and targets, suggesting that acupuncture is a wholistic treatment for people rather than for diseases. Our findings also explain why acupuncture can treat various disorders in addition to depression.

scholarly journals A Systematic Review of the World of Validated Suprapubic Catheter Insertion Simulation Trainers: From ‘Head-Blocks' to ‘Lunch Boxes'

2019 ◽  
Vol 13 (4) ◽  
pp. 179-188
Author(s):  
James Nonde ◽  
Abdullah Ebrahim Laher ◽  
Jared McDowall ◽  
Ahmed Adam
Keyword(s):  
Animal Studies ◽  
Web Of Science ◽  
Median Number ◽  
Catheter Insertion ◽  
Cochrane Library ◽  
Suprapubic Catheter ◽  
Training Curriculum ◽  
Inclusion Criteria ◽  
Search Terms ◽  
The World

Purpose: Various suprapubic catheter insertion simulators have been described to aid in the training of this fundamental skill. The purpose of this review was to evaluate and critically appraise all validated simulators. Methods: The PubMed, Web of Science, Cochrane Library, Scopus, British Medical Journal and the Embase databases were searched (March 2018), by using key search terms “suprapubic trainer”, “suprapubic model”, “suprapubic simulation” and “suprapubic simulator”. Results: A total of 196 articles were identified; 117 unrelated, 53 animal studies and 20 duplications. Only 6 articles met the inclusion criteria for this review. The median number of participants per study was 30.5. Material costs ranged from 1.71 to 60 dollars per model. Only 2 studies incorporated the use of ultrasound. Conclusion: Despite validated suprapubic catheter insertion models being a specially needed learning resource, only few have been described-mostly for not resourceful environments. There exists a general lack of guidelines on model validation processes. There is a need to develop, appropriately validate and integrate models into training curriculum.

scholarly journals Chinese Herbal Formula Xiao Yao San for Treatment of Depression: A Systematic Review of Randomized Controlled Trials

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Yuqing Zhang ◽  
Mei Han ◽  
Zhijun Liu ◽  
Jie Wang ◽  
Qingyong He ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Methodological Quality ◽  
Randomized Clinical Trials ◽  
Data Extraction ◽  
International Standards ◽  
Inclusion Criteria ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
Study Selection ◽  
Treatment Of Depression

Objectives.To assess the beneficial and adverse effects of Xiaoyaosan for depression.Search Strategy. Electronic databases were searched until December 2009.Inclusion Criteria.We included randomized clinical trials testing Xiaoyaosan against placebo, antidepressants, or combined with antidepressants against antidepressants alone.Data Extraction and Analyses.Study selection, data extraction, quality assessment, and data analyses were conducted according to the Cochrane standards.Results.26 randomized trials (involving 1837 patients) were included and the methodological quality was evaluated as generally low. The pooled results showed that Xiaoyaosan combined with antidepressants was more effective in comprehensive effect, the score of HAMD and the score of SDS compared with antidepressants alone. Xiaoyaosan was superior to antidepressants for the score of HAMD. However, Xiaoyaosan was not different from placebo for the score of SDS. There was no adverse effects reported in the trials from Xiaoyaosan.Conclusions.Xiaoyaosan appears to be effective on improving symptoms in patients with depression. However, due to poor methodological quality in the majority of included trials, the potential benefit from Xiaoyaosan need to be confirmed in rigorous trials and the design and reporting of trials should follow international standards.

scholarly journals Status and Trend of Research on the Funding and Management of Basic Research in China: An Analysis Based on Knowledge Maps of Core Journal Database of China National Knowledge Infrastructure in 1992-2019

2021 ◽  
Vol 16 (06) ◽  
pp. 201
Author(s):  
Yang Yang ◽  
Xiangyu Zhu
Keyword(s):  
Basic Research ◽  
Development Trend ◽  
Research Field ◽  
Current Status ◽  
Core Journal ◽  
China National Knowledge Infrastructure ◽  
Knowledge Maps ◽  
Knowledge Infrastructure ◽  
Visualization Software ◽  
Content Mining

This paper aims to clarify the current status, hotspots, historical evolution and development trend of the research on funding and management of basic research in China. Firstly, 736 relevant papers indexed during 1992-2019 in the core journal database of China National Knowledge Infrastructure (CNKI) were analyzed in details. Using the information visualization software CiteSpaceV5.6.R3, the institutional cooperation co-occurrence map, author cooperation co-occurrence map, keyword co-occurrence map, and keyword timeline view maps were plotted through content mining. The results show that: the research institutions in the research field of basic research funding and management have formed three core cooperation networks, and the institutions in Beijing attract the most attention; most of the prolific and active authors choose teamwork over independent research; the research topics mainly fall into four aspects of basic research: input, subjects, results, and talents; the research hotspots are in line with policies and demands, and evolve through three stages: exploration and gradual progress, adjustment and development, and expansion and acceleration. The research results open up a new direction for relevant studies, and provide a reference for innovative parties to implement basic research.

scholarly journals External application of Ruyi Jinhuang powder for phlebitis: A systematic review and meta-analysis

2021 ◽  
Vol 18 (3) ◽  
pp. 647-667
Author(s):  
Qian Yang ◽  
Chunyan Yang ◽  
Yongqiong Deng ◽  
Qunhua Ma
Keyword(s):  
Meta Analysis ◽  
Relevant Literature ◽  
Onset Time ◽  
Healing Time ◽  
Cochrane Central Register ◽  
China National Knowledge Infrastructure ◽  
External Application ◽  
Search Terms ◽  
Knowledge Infrastructure ◽  
Central Register

Purpose: To systematically review the effectiveness of the external application, Ruyi Jinhuang powder, on phlebitis Methods: Relevant literature was retrieved from Medline, Embase, China National Knowledge Infrastructure database (CNKI), Cochrane Central Register, Chongqing Vip, Wanfang Data and SinoMed using the search terms “Ruyi Jinhuang San”, “Ruyi Jinhuang powder”, “Ruyi Jinhuang cream”, “Agreeable golden powder”, “satisfactory golden powder”, “Jinhuang cream”, “phlebitis”, “prevention and (or) treatment”, “randomized controlled trials” and “RCRs”. Two researchers independently arranged and analyzed the data. Results: Significant differences were observed in the total effectiveness rate of Ruyi Jinhuang powder [relative risk (RR) = 1.27, 95% confidence interval (CI) = 1.19 to 1.36, and p < 0.0001). Ruyi Jinhuang powder can reduce the incidence of phlebitis versus conventional therapy in preventing phlebitis (RR = 0.32, 95 % CI 0.24 to 0.42, and p < 0.0001). Shorten the average healing time [mean difference (MD) =- 32.17, 95 % CI= -48.39 to -15.94, and p = 0.0001). Reduced pain relief time for phlebitis (MD = -3.29, 95% CI -5.42 to -1.16, and p = 0.002). However, no statistical difference was observed with regard to the onset time of phlebitis (MD = -0.62, 95 % CI -1.76 to 0.52, and p = 0.29). Conclusion: Clinicians consider Ruyi Jinhuang powder a viable complementary and alternative medicine for phlebitis following the stronger evidence being offered.

scholarly journals UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis

ISRN Oncology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Marce-Amara Kpoghomou ◽  
Joella Eldie Soatiana ◽  
Fatch W. Kalembo ◽  
Ghose Bishwajit ◽  
Wei Sheng
Keyword(s):  
Prostate Cancer ◽  
Outcome Measure ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Prostate Cancer Susceptibility ◽  
Increased Risk ◽  
Subgroup Analyses

Objective. Recent studies on the association between uridine diphosphosglucuronosyltransferases (UGTs) 2B17 polymorphism and risk of prostate cancer (PCa) showed inconclusive results. To clarify this possible association, we conducted a meta-analysis of published studies. Methods. We searched the published literature from PubMed, Embase, Google Scholar, and China National Knowledge Infrastructure (CNKI). According to our inclusion criteria, studies that observed the association between UGT2B17 polymorphism and PCa risk were included. The principal outcome measure was the adjusted odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with UGT2B17 polymorphism. Results. A total of 6 studies with 7,029 subjects (3,839 cases and 3,190 controls) were eligible for inclusion in the meta-analysis. Overall, there was a significant association between UGT2B17 polymorphism and increased risk of prostate cancer (, 95% CI 1.14–2.64, ). Similar results were found in the subgroup analyses by ethnicity and types of controls. Conclusion. This meta-analysis demonstrates that UGT2B17 polymorphism is associated with prostate cancer susceptibility, and it contributes to the increased risk of prostate cancer.

scholarly journals Clinical Effect of Preservation or Nonpreservation of Left Colic Artery in Total Mesorectal Excision under Laparoscopy: A Meta-analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jiefeng Liu ◽  
Yujing Gong ◽  
Miao He ◽  
Xinyu Zeng ◽  
Yiping Liu
Keyword(s):  
Total Mesorectal Excision ◽  
Clinical Effect ◽  
Data Extraction ◽  
Meta Analysis ◽  
Colic Artery ◽  
Left Colic Artery ◽  
Mesorectal Excision ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Duration Of Surgery

Background and Aims. To investigate the clinical effect of preservation or nonpreservation of the left colic artery (LCA) in total mesorectal excision (TME) under laparoscopy. Methods. The words, like “rectal cancer,” “left colonic artery,” and “laparoscopy,” were used as the retrieval terms, and the keyword retrieval method was adopted. The retrieval period was set as from January 1, 2013, to June 1, 2018. We searched databases including PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) to collect randomized and controlled trials which compared the effect of preservation or nonpreservation of the LCA in TME under laparoscopy. Two researchers independently carried out literature screening, data extraction, and literature quality evaluation; Review Manager 5.3 was used for the meta-analysis. Results. Seven studies including 1467 cases were identified for the meta-analysis. As showed by the meta-analysis, compared with the LCA nonpreservation group, the LCA preservation group had significantly reduced incidence of anastomotic leakage (OR=0.44, CI=0.30,0.65, P<0.0001) and postoperative urinary and sexual dysfunction (OR=0.26, CI=0.09,0.78, P=0.02) and significantly shorter time for intestinal function recovery (WMD=−0.26, CI=−0.41,−0.11, P=0.0008). There were no significant differences between the two groups in the duration of surgery, blood loss, number of dissected lymph nodes, or postoperative hospital stay. Conclusions. From the results, the LCA preservation group seems to achieve comparable success with acceptable safety outcomes. Therefore, this surgical method can be recommended in the clinical practice.

Rethinking Carbapenems: A Pharmacokinetic Approach for Antimicrobial Selection in Infected Necrotizing Pancreatitis

2020 ◽  
pp. 106002802097012
Author(s):  
Christina Maguire ◽  
Deepak Agrawal ◽  
Mitchell J. Daley ◽  
Elizabeth Douglass ◽  
Dusten T. Rose
Keyword(s):  
Animal Studies ◽  
Data Extraction ◽  
Necrotizing Pancreatitis ◽  
Pancreatic Tissue ◽  
Search Terms ◽  
Study Selection ◽  
Optimal Drug ◽  
Dosing Regimens ◽  
History Of ◽  
Key Terms

Objective: To provide an overview of pathophysiological changes to the pancreas during infected necrotizing pancreatitis (INP), optimal drug properties needed to penetrate the pancreas, human and animal studies supporting the use of antimicrobials, and carbapenem-sparing strategies in INP. Data Sources: A literature analysis of PubMed/MEDLINE was performed (from 1960 to September 2020) using the following key terms: infected necrotizing pancreatitis, necrotizing acute pancreatitis, and infected pancreatitis antimicrobial concentration. Individual antimicrobials were investigated with these search terms. Study Selection and Data Extraction: All relevant studies describing the management of INP, and human and animal pharmacokinetic (PK) data supporting antimicrobial use in the pancreas were reviewed for possible inclusion regardless of sample size or study design. Data Synthesis: Piperacillin/tazobactam and cefepime achieve adequate pancreatic tissue concentrations in INP studies. A majority of the literature supporting carbapenem use in INP involves imipenem, and meropenem Monte Carlo simulations suggest that standard dosing regimens of meropenem may not achieve PK targets to eradicate Pseudomonas aeruginosa. Relevance to Patient Care and Clinical Practice: Carbapenems are often utilized for INP treatment based on guideline recommendations. This review discusses PK data, the history of carbapenem use in INP, and the pathophysiology of pancreatitis to suggest carbapenem-sparing strategies and provides stewardship tactics such as when to start antimicrobials, which empirical antimicrobial to use, and when to discontinue antimicrobials in the INP setting. Conclusions: Noncarbapenem antipseudomonals, such as piperacillin/tazobactam and cefepime, are appropriate carbapenem-sparing options in INP, based on PK data, spectrum of activity, and risk of collateral damage.

scholarly journals Is Ultrasound an Accurate Alternative for Mammography in Breast Cancer Screening in an Asian Population? A Meta-Analysis

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 985
Author(s):  
Jing Wang ◽  
Senshuang Zheng ◽  
Lanjun Ding ◽  
Xuan Liang ◽  
Yuan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Data Extraction ◽  
Meta Analysis ◽  
Asian Population ◽  
Asian Women ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Prisma Statement

In Asian countries, ultrasound has been proposed as a possible alternative for mammography in breast cancer screening because of its superiority in dense breasts, accessibility and low costs. This research aimed to meta-analyze the evidence for the diagnostic performance of ultrasound compared to mammography for breast cancer screening in Asian women. PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched for studies that concurrently compared mammography and ultrasound in 2000–2019. Data extraction and risk of bias were performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) statement. The primary outcome was the sensitivity and specificity. Bivariate random models were used to generate pooled estimates of diagnostic parameters and 95% confidence intervals (95% CI). In total, 4424 studies were identified of which six studies met the inclusion criteria with a sample size of 124,425 women. The pooled mean prevalence of the included studies was 3.7‰ (range: 1.2–5.7‰). The pooled sensitivity of mammography was significantly higher than that of ultrasound (0.81 [95% CI 0.71–0.88] versus 0.65 [95% CI 0.58–0.72], p = 0.03), but no significant differences were found in specificity (0.98 [95% CI: 0.94–1.00] versus 0.99 [95% CI: 0.97–1.00], p = 0.65). In conclusion, based on the currently available data on sensitivity alone, there is no indication that ultrasound can replace mammography in breast cancer screening in Asian women.

The Anti-depressant Effect of Nelumbinis Semen on Rats Under Chronic Mild Stress Induced Depression-like Symptoms

2005 ◽  
Vol 33 (02) ◽  
pp. 205-213 ◽  
Author(s):  
Moonkyu Kang ◽  
Dongwon Shin ◽  
Jung-Wan Oh ◽  
Chongwoon Cho ◽  
Hwa-Jin Lee ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
Chronic Mild Stress ◽  
The Other ◽  
Herbal Extract ◽  
Mild Stress ◽  
Test Results ◽  
Traditional Herbal Medicine ◽  
Treatment Of Depression ◽  
Corni Fructus ◽  
Nelumbinis Semen

Nelumbinis Semen is a well-known traditional herbal medicine frequently used in treatment of depression in many Asian countries. In this study, its anti-depression effects in rats were investigated by comparing the test results of those treated with Nelumbinis Semen to those treated with other herbal anti-depressants, including Rehmanniae Radix Preparat, Corni Fructus, Lycii Fructus, Pinelliae Rhizoma and Hypericum Perforatum. In order to induce depression-like symptoms, the animals were placed under chronic mild stress in the form of overnight illumination for 2 consecutive days. They were treated with the respective herbal extract and forced swimming tests were conducted afterwards. The anti-depression effects of each extract were then evaluated based on a measured index, which consisted of struggling time, first latency and first rest duration. These test results show that Nelumbinis Semen provides greater anti-depression effects than the other herbal extracts. Specifically, only the rats treated with Nelumbinis Semen showed significant increases in struggling time (43.9%, p <0.005, p =0.0037) and in first latency time (90.2%, p <0.05, p =0.0116). However, the first rest duration for Nelumbinis Semen treated rats was not significantly different from the other rats. It appears that Nelumbinis Semen provides even greater anti-depression effects than Hypericum Perforatum (commonly referred to as St. John's Wort, perhaps the most widely used natural anti-depressant today). The anti-depression effects of Nelumbinis Semen might be due to the modulation of the amount of neurotransmitters involved in depression.

scholarly journals Current Studies of Acupuncture in Cancer-Induced Bone Pain Animal Models

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hee Kyoung Ryu ◽  
Yong-Hyeon Baek ◽  
Yeon-Cheol Park ◽  
Byung-Kwan Seo
Keyword(s):  
Animal Models ◽  
Cancer Pain ◽  
Mammary Cancer ◽  
Animal Studies ◽  
Bone Pain ◽  
Bone Cancer ◽  
Inclusion Criteria ◽  
Specific Mechanism ◽  
Search Terms ◽  
Pubmed Database

Acupuncture is generally accepted as a safe and harmless treatment option for alleviating pain. To explore the pain mechanism, numerous animal models have been developed to simulate specific human pain conditions, including cancer-induced bone pain (CIBP). In this study, we analyzed the current research methodology of acupuncture for the treatment of CIBP. We electronically searched the PubMed database for animal studies published from 2000 onward using these search terms: (bone cancer OR cancer) AND (pain OR analgesia) AND (acupuncture OR pharmacopuncture OR bee venom). We selected articles that described cancer pain in animal models. We analyzed the methods used to induce cancer pain and the outcome measures used to assess the effects of acupuncture on CIBP in animal models. We reviewed articles that met our inclusion criteria. Injection of mammary cancer cells into the cavity of the tibia was the most frequently used method for inducing CIBP in the animal models. Among the eight selected studies, five studies demonstrated the effects of electroacupuncture on CIBP. The effects of acupuncture were assessed by measuring pain-related behavior. Future researches will be needed to ascertain the effectiveness of acupuncture for treating CIBP and to explore the specific mechanism of CIBP in animal models.

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