scholarly journals A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort

Critical Care ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Björn Ahlström ◽  
Ing-Marie Larsson ◽  
Gunnar Strandberg ◽  
Miklos Lipcsey
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Nationwide Study ◽  
Prevalence Of Dementia

Acute kidney injury following coronary angiography: a nationwide study of incidence, risk factors and long-term outcomes

2018 ◽  
Vol 31 (5) ◽  
pp. 721-730 ◽  
Author(s):  
Dadi Helgason ◽  
Thorir E. Long ◽  
Solveig Helgadottir ◽  
Runolfur Palsson ◽  
Gisli H. Sigurdsson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Coronary Angiography ◽  
Kidney Injury ◽  
Long Term Outcomes ◽  
Nationwide Study ◽  
Incidence Risk

scholarly journals Hydroxychloroquine-Induced Creatine Kinase Elevation

2020 ◽  
Vol 25 (4) ◽  
pp. 599-602
Author(s):  
Sinem Bayrakçı ◽  
Nursel Sürmelioğlu ◽  
Ezgi Özyılmaz
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Creatine Kinase ◽  
Intensive Care ◽  
General Condition ◽  
Creatine Kinase Level ◽  
Loading Dose ◽  
Term Administration ◽  
Drug Cessation

Long-term administration of hydroxychloroquine and chloroquine leads to deposition in the tissues including muscles, nerves and retina. Here, we report a case of hydroxychloroquine induced creatine kinase elevation after loading dose. An 80-year-old man with comorbidities, presented with a dry cough, high fever, diarrhea and general condition disorder ongoing for the last 3 days. The patient was admitted to the intensive care unit. The treatment was commenced with hydroxychloroquine. On the first day of treatment, the loading dose of hydroxychloroquine was started as 400 mg q12h, and treatment was continued as 200 mg q12h from the 3rd dose. After the hydroxychloroquine loading dose, the patient’s creatine kinase level increased, and after drug cessation, the level decreased. Hydroxychloroquine-induced creatine kinase elevated may be on not only long-term use but also acute period. Clinicians should have a high suspicion for hydroxychloroquine toxicity in patients with risk factors.

Risk factors for nosocomial intensive care infection: a long-term prospective analysis

2001 ◽  
Vol 45 (6) ◽  
pp. 710-719 ◽  
Author(s):  
P. Appelgren ◽  
I. Hellström ◽  
E. Weitzberg ◽  
V. Söderlund ◽  
L. Bindslev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Prospective Analysis

scholarly journals A systematic review of the impact of intensive care admissions on post discharge cognition in children

2021 ◽  
Author(s):  
Ana Sánchez-Moreno Royer ◽  
Jamiu O. Busari
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Cognitive Development ◽  
High Risk ◽  
Pediatric Patients ◽  
Post Discharge ◽  
Icu Stay ◽  
Short And Long Term ◽  
Length Of Icu Stay

AbstractUnderstanding how hospitalization affects cognitive development is crucial to safeguard children’s cognition; however, there is little research evaluating the associations between NICU or PICU hospitalization and survivors’ cognition. The objective of this study is to identify and characterize the associations between a neonatal or pediatric ICU hospitalization and the short- and long-term cognition of survivors. The databases Cochrane Library, Medline, EBSCO, Embase, and Google Scholar and the journals JAMA Pediatrics, Journal of Pediatrics, Pediatrics, Archives of Disease in Childhood, Academic Pediatrics, Pediatric Critical Care Medicine and Child Development were searched until April 2021. Retrieved article references were analyzed. Included articles investigated cognition as an outcome of ICU hospitalization in non-preterm neonatal or pediatric patients. Case studies and studies analyzing diagnosis or treatment interventions were excluded. Four prospective cohort or case-control studies and two retrospective cohort studies were included, totaling 2172 neonatal and 42368 pediatric patients. Quality assessment using the BMJ Criteria and Cochrane Collaboration’s Risk-of-Bias tool displayed good results. Significant negative associations were found between neonatal cognition and length-of-ICU-stay at 9- (p<0.001) and 24 months (p<0.01), and between pediatric cognition and length-of-ICU-stay at discharge (p<0.001). Additional weeks on the neonatal ICU increased odds of impairment at 9- (OR 1.08, 95%CI 1.034–1.112) and 24 months (OR 1.11, 95%CI 1.065–1.165).Conclusion: There is a significant negative correlation between NICU and PICU hospitalization and the short- and long-term cognitive status. Future research must identify patient- and hospital-related risk factors and develop management strategies. What is Known:• Cognitive development relies on the presence of stimulating factors and absence of risk factors, and is hypothesized to be directly and indirectly affected by hospitalization in the short and long term.• No research examines the relation between survivor cognition post-discharge of a general pediatric hospitalization, and scarcely more of a neonatal or pediatric intensive care hospitalization. What is New:• NICU and PICU hospitalization is independent risk factors for survivor impaired cognition in the short and in the long term with a dose-response effect. High risk patients for cognitive impairment should be identified and appropriately followed-up.• Patients with an ICU hospitalization of over 2.5 days and two or more of the following factors should be considered high risk: increased mortality risk, invasive interventions, neurological or oncological diagnosis, postnatal complications or decreased maternal mental health status.

Prolonged Intensive Care Unit Stay in Cardiac Surgery: Risk Factors and Long-Term-Survival

2006 ◽  
Vol 81 (3) ◽  
pp. 880-885 ◽  
Author(s):  
Ortrud Vargas Hein ◽  
Jürgen Birnbaum ◽  
Klaus Wernecke ◽  
Michael England ◽  
Wolfgang Konertz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Cardiac Surgery ◽  
Intensive Care ◽  
Intensive Care Unit Stay ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Risk Factors for Invasive Aspergillosis in Patients Admitted to the Intensive Care Unit With Coronavirus Disease 2019: A Multicenter Retrospective Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Jiqian Xu ◽  
Xiaobo Yang ◽  
Zheng Lv ◽  
Ting Zhou ◽  
Hong Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Invasive Mechanical Ventilation ◽  
Invasive Pulmonary Aspergillosis ◽  
Corticosteroid Treatment ◽  
Clinical Criteria ◽  
Increased Risk ◽  
Life Threatening ◽  
Vasopressor Use

Background: Invasive pulmonary aspergillosis (IPA) is a life-threatening complication in coronavirus disease 2019 (COVID-19) patients admitted to intensive care units (ICUs), but risk factors for COVID-19-associated IPA (CAPA) have not been fully characterized. The aim of the current study was to identify factors associated with CAPA, and assess long-term mortality.Methods: A retrospective cohort study of adult COVID-19 patients admitted to ICUs from six hospitals was conducted in Hubei, China. CAPA was diagnosed via composite clinical criteria. Demographic information, clinical variables, and 180-day outcomes after the diagnosis of CAPA were analyzed.Results: Of 335 critically ill patients with COVID-19, 78 (23.3%) developed CAPA within a median of 20.5 days (range 13.0–42.0 days) after symptom onset. Compared to those without CAPA, CAPA patients were more likely to have thrombocytopenia (50 vs. 19.5%, p &lt; 0.001) and secondary bacterial infection prior to being diagnosed with CAPA (15.4 vs. 6.2%, p = 0.013), and to receive vasopressors (37.2 vs. 8.6%, p &lt; 0.001), higher steroid dosages (53.9 vs. 34.2%, p = 0.002), renal replacement therapy (37.2 vs. 13.6%, p &lt; 0.001), and invasive mechanical ventilation (57.7 vs. 35.8%, p &lt; 0.001). In multivariate analysis incorporating hazard ratios (HRs) and confidence intervals (CIs), thrombocytopenia (HR 1.98, 95% CI 1.16–3.37, p = 0.012), vasopressor use (HR 3.57, 95% CI 1.80–7.06, p &lt; 0.001), and methylprednisolone use at a daily dose ≥ 40 mg (HR 1.69, 95% CI 1.02–2.79, p = 1.02–2.79) before CAPA diagnosis were independently associated with CAPA. Patients with CAPA had longer median ICU stays (17 days vs. 12 days, p = 0.007), and higher 180-day mortality (65.4 vs. 33.5%, p &lt; 0.001) than those without CAPA.Conclusions: Thrombocytopenia, vasopressor use, and corticosteroid treatment were significantly associated with increased risk of incident IPA in COVID-19 patients admitted to ICUs. The occurrence of CAPA may increase the likelihood of long-term COVID-19 mortality.

Osteomyelitis in the Neonate

2002 ◽  
Vol 21 (1) ◽  
pp. 9-22 ◽  
Author(s):  
Deanna McPherson
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Bacterial Infection ◽  
Intensive Care Units ◽  
Musculoskeletal System ◽  
Gestational Age ◽  
Clinical Presentation ◽  
Long Term Outcomes

Osteomyelitis is defined as a bacterial infection of the musculoskeletal system. Osteomyelitis in the newborn is relatively rare, but if missed can have devastating, lifelong consequences for the growing infant. Those of us who care for neonates in intensive care units should have an understanding of this disease and be equipped to recognize it and begin treatment quickly to prevent long-term sequelae.This article reviews the pathophysiology of osteomyelitis and explains why the neonate is at an extraordinary risk for this disease. It reviews risk factors, clinical presentation, etiology and pathophysiology, diagnostic evaluation, treatment and monitoring of treatment, and long-term outcomes. A case study of a 27-week gestational age infant who presented with osteomyelitis and septic hip is presented, looking at the infant’s hospital course and outcome.

scholarly journals Risk Factors and Outcomes of Methicillin-resistant Staphylococcus Aureus Bacteraemia in Critically Ill Patients: A Case Control Study

2009 ◽  
Vol 37 (3) ◽  
pp. 457-463 ◽  
Author(s):  
K. M. Ho ◽  
J. O. Robinson
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Critically Ill Patients ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Case Control Study ◽  
Case Control ◽  
Mrsa Infection ◽  
Control Study

Methicillin-resistant Staphylococcus aureus (MRSA) infection is an increasing threat to critically ill patients in many intensive care units. MRSA bacteraemia is an extreme form of MRSA infection and is a significant cause of morbidity and mortality. This case control study aimed to assess the risk factors and outcomes of MRSA bacteraemia compared to methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. A total of 21 MRSA bacteraemia and 60 randomly selected MSSA bacteraemia episodes, admitted to the intensive care unit at Royal Perth Hospital between 1997 and 2007, were considered. There was a suggestion that hospitalisation within the preceding six months (P=0.087) and residence in a long-term care facility (P=0.065) were associated with a higher risk of MRSA bacteraemia. MRSA bacteraemia was more often treated with antibiotics to which the pathogen was not susceptible in vitro (38.1% vs 0%, P=0.001), resulting in a longer duration of fever (median 7.0 vs 2.0 days, P=0.009) and bacteraemia (mean 3.2 vs 0.6 days, P=0.005) and a higher incidence of metastatic seeding of infection (52.4% vs 21.7%, P=0.012) as compared to MSSA bacteraemia. While in-hospital mortality between MRSA and MSSA was similarly high (47.6% vs 38.3% for MRSA and MSSA respectively, P=0.607), a significant proportion of the patients who had MRSA bacteraemia died within five years of hospital discharge (36.4%, hazard ratio 26.0, 95% confidence interval 1.90 to 356.7, P=0.015). Infections contributed to 75% of the deaths after hospital discharge in patients who had an episode of MRSA bacteraemia. MRSA bacteraemia carries a much worse long-term prognosis than MSSA bacteraemia and that could be explained by recurrent MRSA infections and residual confounding.

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