scholarly journals Design and rationale of a randomized control trial testing the effectiveness of combined therapy with STAtin plus FENOfibrate and statin alone in non-diabetic, combined dyslipidemia patients with non-intervened intermediate coronary artery disease - STAFENO study

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Taek-Geun Kwon ◽  
Albert Youngwoo Jang ◽  
Sang Wook Kim ◽  
Young Joon Hong ◽  
Jang-Ho Bae ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Randomized Control Trial ◽  
Combined Therapy ◽  
Trial Testing ◽  
Randomized Control ◽  
Artery Disease

scholarly journals Effect of Lifestyle Modification Intervention on Health Status of Coronary Artery Disease Patients: Randomized Control Trial

2018 ◽  
Vol 3 (3) ◽  
pp. 127
Author(s):  
Manal Hamed Mahmoud ◽  
Sabah Nazeh Elderiny
Keyword(s):  
Coronary Artery Disease ◽  
Health Status ◽  
Coronary Artery ◽  
Life Style ◽  
Randomized Control Trial ◽  
Lifestyle Modification ◽  
Bodily Pain ◽  
Randomized Control ◽  
Artery Disease ◽  
Modification Intervention

Background: Coronary artery disease is a major cause of morbidity and mortality throughout the world. Modification of life style can be achieved by patients' education to improve their health status. Aim: To evaluate effect of lifestyle modification intervention on health status of coronary artery disease patients. Design: Randomized control trial used to achieve the aim of this study. Setting: The current study conducted at the coronary care unit and cardiology out-patient clinics of Benha University Hospital, Benha City. Subjects: Purposive sample of 92 coronary artery disease patients (study and control) were included in the study. Tools: Two tools used in this study 1) Interview questionnaire. 2) Health status questionnaire. Results: Significant percentage of the study participants from both groups were adhered to unhealthy life-style practices as smoking, eating salty and fatty foods, drinking tea and coffee as well as they didn't practice exercises and recreational activities. After lifestyle modification intervention, there were significant statistical differences between the two groups favoring the study group regarding all aspects of health status; physical function, bodily pain, social function, role limitation due to physical or emotional problems and mental health (P<0.05). Conclusion and recommendations: This study concluded that life style modification intervention for coronary artery disease patients is effective and useful for enhancing their health status. This study recommended that coronary artery patients` education should be held in permanent approach, because it is a crucial part of their treatment.

scholarly journals Potential benefits of ticagrelor plus aspirin in Chinese patients with stable coronary artery disease and diabetes

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
W Sun ◽  
B Yan
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Absolute Risk ◽  
Combined Therapy ◽  
Stable Coronary Artery Disease ◽  
Public Hospitals ◽  
Chinese Patients ◽  
Number Needed To Treat ◽  
History Of ◽  
Artery Disease

Abstract Purpose Ticagrelor plus aspirin has been shown to reduce the incidence of cardiovascular (CV) events compared to asprin alone in patients with stable coronary artery disease and diabetes in the THEMIS trial. This study aimed to estimate the potential CV benefit of adding ticagrelor to aspirin among a THMEIS-like Chinese population. Methods We retrospectively analyzed 13,322 patients with stable coronary artery disease and diabetes from 16 public hospitals in Hong Kong between August 2015 and July 2020. 5,642 (42.4%) patients who met inclusion and exclusion criteria of the THEMIS trial were included in final analysis. Estimated absolute risk reduction (eARR) in major adverse CV event (MACE, composite of myocardial infarction (MI), ischemic stroke or CV death) and number needed to treat (eNNT) were extrapolated based on results of the THEMIS trial. Results Of 5,642 THEMIS-like patients (62.1% male; mean age 69.6±10.4 years), 26.5% had history of percutaneous coronary intervention (PCI). During a median follow-up of 17.5 (IQR: 9.3–41.3) months, rates of MACE, MI, stroke and CV-death were 10.7% (n=605), 5.3% (n=298), 2.5% (n=139) and 5.5% (n=308), respectively. Kaplan-Meier estimates at 36 months stratified by history of PCI or not were 16.9% vs. 14.0% for MACE and 9.0% vs 6.7% for MI (both Log-rank p&lt;0.01). Among THEMIS-like and THEMIS-PCI-like patients, eARR with ticagrelor plus aspirin was 1.4% (eNNT=71) and 1.6% (eNNT=63) for MACE and 1.5% (eNNT=67) and 1.9% (eNNT=53) for MI, respectively. Conclusion Approximately one third of Chinese patients with stable coronary artery disease and diabetes met THEMIS trial criteria. Combined therapy of ticagrelor and aspirin might provide similar clinical benefit in our population observed in the THEMIS trial, with low number needed to treat, especially in patients with previous PCI. FUNDunding Acknowledgement Type of funding sources: None.

Comparison of the effects of rosuvastatin monotherapy and atorvastatin-ezetimibe combined therapy on the structure of erythrocyte membranes in patients with coronary artery disease

2018 ◽  
Vol 70 (2) ◽  
pp. 258-262 ◽  
Author(s):  
Małgorzata Olszewska-Banaszczyk ◽  
Paulina Jackowska ◽  
Paulina Gorzelak-Pabiś ◽  
Edyta Pytel ◽  
Maria Koter-Michalak ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Combined Therapy ◽  
Erythrocyte Membranes ◽  
Artery Disease

scholarly journals The influence of statin monotherapy and statin-ezetimibe combined therapy on FoxP3 and IL 10 mRNA expression in patients with coronary artery disease

2019 ◽  
Vol 28 (9) ◽  
pp. 1243-1248
Author(s):  
Paulina Jackowska ◽  
Maciej Chałubiński ◽  
Emilia Łuczakl ◽  
Katarzyna Wojdan ◽  
Paulina Gorzelak-Pabis ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Mrna Expression ◽  
Combined Therapy ◽  
Statin Monotherapy ◽  
Artery Disease

Inhibition by combined therapy with ticlopidine and aspirin of enhanced platelet aggregation during physical exercise in patients with coronary artery disease

2001 ◽  
Vol 142 (2) ◽  
pp. 5A-12A ◽  
Author(s):  
Tamaki Kitai ◽  
Masakatsu Nishikawa ◽  
Takashi Tanigawa ◽  
Tsutomu Okinaka ◽  
Hideo Wada ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Platelet Aggregation ◽  
Physical Exercise ◽  
Combined Therapy ◽  
Artery Disease

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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