Feasibility and efficacy of diabetic retinopathy screening among youth with diabetes in a pediatric endocrinology clinic: a cross-sectional study

OBJECTIVE: To assess the usefulness of corneal esthesiometry for screening diabetic retinopathy. METHODS: A cross-sectional study was carried out comprising 575 patients attending a diabetic retinopathy-screening program in the city of São Paulo. Corneal esthesiometry was assessed with the Cochet-Bonnet esthesiometer. The presence of diabetic retinopathy was detected with indirect fundoscopy. The validity of corneal esthesiometry in identifying diabetic retinopathy was evaluated by the Receiver Operating Characteristic (ROC) curve. RESULTS: Sensitivity and specificity analyses of the corneal esthesiometry for detecting the stages of diabetic retinopathy using different cut-offs showed values less than 80%. The best indices (72.2% sensitivity and 57.4% specificity) were obtained for the identification of patients with proliferative diabetic retinopathy. CONCLUSIONS: In the study series, corneal esthesiometry was not a good indicator of diabetic retinopathy.

Download Full-text

Association between myopia and diabetic retinopathy in Saudi diabetics - A cross sectional study

International Journal of Advanced Life Sciences ◽

10.26627/ijals/2017/10.02.0013 ◽

2017 ◽

Vol 10 (02) ◽

pp. 239-246

Author(s):

Khalid Alabdulwahhab ◽

Keyword(s):

Diabetic Retinopathy ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Association between Diabetic Retinopathy and Chronic Periodontitis—A Cross-Sectional Study

Medical Sciences ◽

10.3390/medsci6040104 ◽

2018 ◽

Vol 6 (4) ◽

pp. 104 ◽

Cited By ~ 1

Author(s):

Veena H. R. ◽

Sribhargava Natesh ◽

Sudhir Patil

Keyword(s):

Diabetic Retinopathy ◽

Serum Creatinine ◽

Glycated Haemoglobin ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Chronic Inflammatory Condition ◽

The Mean

Periodontal disease (PD), a chronic inflammatory condition characterized by destruction of the supporting tissues of the teeth, increases the risk of complications in diabetics. Diabetic retinopathy (DR) is a microvascular complication of prolonged hyperglycaemia. There appears to be a similarity in the pathogenesis of DR and PD. Hence, this study aimed to investigate the association, if any, between DR and PD, correlate the severity of DR with the severity of PD, and investigate the association between glycated haemoglobin (HbA1c), serum creatinine and periodontal variables. The periodontal status of 200 adult diabetic patients in the age group of 30–65 years with varying severity of DR was assessed. Evaluation of the severity of PD was assessed by recording clinical parameters. Haematological investigations including glycated haemoglobin (HbA1c) and serum creatinine were estimated before the initiation of treatment for DR. A statistically significant association between the mean duration of diabetes mellitus (DM) and the severity of DR and PD was found. The severity of PD was directly correlated with the severity of DR. There was a significant association between the levels of HbA1c and serum creatinine and severity of DR and PD. There could be a plausible relationship between DR and PD. Further prospective studies on a larger population with longer follow-ups are required to ascertain whether PD and its severity directly affect the progression and severity of DR.

Download Full-text

DOES INSULIN LIKE GROWTH FACTOR-1 (IGF-1) DEFICIENCY HAVE A “PROTECTIVE” ROLE IN THE DEVELOPMENT OF DIABETIC RETINOPATHY IN THALASSEMIA MAJOR PATIENTS?

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2015.038 ◽

2015 ◽

Vol 7 ◽

pp. e2015038 ◽

Cited By ~ 4

Author(s):

Vincenzo De Sanctis

Keyword(s):

Diabetic Retinopathy ◽

Growth Factor ◽

Cross Sectional Study ◽

Protective Role ◽

Dependent Diabetes Mellitus ◽

Diabetic Patients ◽

Italian Population ◽

Sectional Study ◽

Cross Sectional ◽

Number Of Patients

Objective: This cross-sectional study was designed to give insights into relationship between Insulin-Growth-Factor 1 (IGF-1) levels and diabetic retinopathy (DR) in a sample of thalassaemia major(TM) patients with insulin dependent diabetes mellitus (IDDM). Τhis relation was not previously evaluated, despite the fact that both diseases co-exist in the same patient. The study also describes the clinical and biochemical profile of the associated complications in TM patients with and without IDDM. Design: A population-based cross-sectional study. Participants:The study includes 19 consecutive TM patients with IDDM and 31 age- and sex-matched TM patients without IDDM who visited our out-patient clinics for an endocrine assessment Methods: An extensive medical history, with data on associated complications and current medications, was obtained. Blood samples were drawn in the morning after an overnight fast to measure the serum concentrations of IGF-1, glucose, fructosamine , free thyroxine (FT4), thyrotropin (TSH) and biochemical analysis . Serologic screening assays for hepatitis C virus seropositivity (HCVab and HCV-RNA) were also evaluated, applying routine laboratory methods.Plasma total IGF-1 was measured by a chemiluminescent immunometric assay (CLIA) method. Ophthalmology evaluation was done by the same researcher using stereoscopic fundus biomicroscopy through dilated pupils. DR was graded using the scale developed by the Global Diabetic Retinopathy Group. Iron stores were assessed by direct and indirect methods. Results:Eighteen TM patients with IDDM (94.7 %) and 10 non-diabetic patients (32.2 %) had IGF-1 levels below the 2.5th percentile of the normal values for the Italian population. The mean serum IGF-1 concentrations were significantly lower in the diabetic versus the non-diabetic TM groups (p < 0.001). DR was present in in 4 (21 %) of 19 TM patients with IDDM and was associated with the main classical risk factors, namely inefficient glycemic control and duration of disease but not hypertension. Using the scale developed by the Global Diabetic Retinopathy Group, the DR in our patients was classified as non proliferative diabetic retinopathy (NPDR). Only few numbers of microaneurysms [1-3] were detected. Our data also confirm the strong association of IDDM in TM patients with other endocrine and non-endocrine complications.Conclusions: These results , although on a small number of patients, suggest a possible ‘protective’ role of low IGF-1 in the development of DR in TM patients

Download Full-text

Prevalence and Risk Factors of Diabetes and Diabetic Retinopathy in Liaoning Province, China: A Population-Based Cross-Sectional Study

PLoS ONE ◽

10.1371/journal.pone.0121477 ◽

2015 ◽

Vol 10 (3) ◽

pp. e0121477 ◽

Cited By ~ 22

Author(s):

Yuedong Hu ◽

Weiping Teng ◽

Limin Liu ◽

Kang Chen ◽

Lei Liu ◽

...

Keyword(s):

Risk Factors ◽

Diabetic Retinopathy ◽

Population Based ◽

Cross Sectional Study ◽

Liaoning Province ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Sex-Gender Differences in Diabetic Retinopathy

Diabetology ◽

10.3390/ijd1010001 ◽

2020 ◽

Vol 1 (1) ◽

pp. 1-10

Author(s):

Sara Cherchi ◽

Alfonso Gigante ◽

Maria Anna Spanu ◽

Pierpaolo Contini ◽

Gisella Meloni ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Sectional Study ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Large Sample ◽

Male Sex ◽

Type 2 Diabetic

Diabetic retinopathy (DR) is one of the main causes of visual loss in individuals aged 20–64 years old. The aim of this study was to investigate, in a multicenter retrospective cross-sectional study, sex-gender difference in DR in a large sample of type 2 diabetic patients (T2DM). 20,611 T2DM regularly attending the units for the last three years were classified as having: (a) No DR (NDR), (b) nonproliferative DR (NPDR), or (c) preproliferative/proliferative DR (PPDR). DR of all grades was present in 4294 T2DM (20.8%), with a significant higher prevalence in men as compared to women (22.0% vs. 19.3% p < 0.0001). Among DR patients, both NPDR and PPDR were significantly more prevalent in men vs. women (p = 0.001 and p = 0.0016, respectively). Women had similar age and BMI, but longer diabetes duration, worse glycemic metabolic control, and more prevalence of hypertension and chronic renal failure (CRF) of any grade vs. men. No significant differences between sexes were evident in term of drug therapy for diabetes and associate pathologies. Conclusions: In this large sample of T2DM, men show higher prevalence of DR vs. women, in spite of less represented risk factors, suggesting that male sex per se might be a risk factor for DR development.

Download Full-text

Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes: a cross-sectional study

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2017-000404 ◽

2017 ◽

Vol 5 (1) ◽

pp. e000404 ◽

Cited By ~ 9

Author(s):

Tatsuya Fukuda ◽

Ryotaro Bouchi ◽

Takato Takeuchi ◽

Yujiro Nakano ◽

Masanori Murakami ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Cross Sectional Study ◽

Muscle Quality ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Serum high sensitivity C reactive protein levels in patients with diabetic retinopathy: a cross sectional study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20200483 ◽

2020 ◽

Vol 7 (3) ◽

pp. 391

Author(s):

Harishchandra R. Chaudhari ◽

Gaurav A. Chaudhari

Keyword(s):

Diabetic Retinopathy ◽

Blood Glucose ◽

High Sensitivity ◽

Cross Sectional Study ◽

Postprandial Blood Glucose ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Hs Crp

Background: Diabetic retinopathy (DR) is one of the major visual morbidities associated with diabetes. This study determined the levels of serum high-sensitivity C-reactive protein (hs-CRP) in patients with DR and to correlate the estimated levels of serum hs-CRP with the severity of DR and other coexisting factors.Methods: This was a cross-sectional study conducted between March 2009 and August 2010 and included patients with type 2 diabetes mellitus (T2DM) with or without DR. A detailed fundus evaluation was performed using direct and indirect ophthalmoscopy. The retinopathies were observed and documented in accordance with the Kanski's system of classification as background DR (BDR), pre-proliferative DR (PPDR), and proliferative DR (PDR). Laboratory investigations determined the levels of fasting blood glucose (FBG), postprandial blood glucose (PPBG), glycosylated hemoglobin, urine albumin excretion, and serum hs-CRP levels.Results: In total, 80 patients with T2DM were included (DR group, n=40 [BDR, n=22; PDR, n=11; PPDR, n=7]; control group, n=40). Highest serum hs-CRP levels were found in PDR group (6.68 mg/L), followed by PPDR and BDR group (3.2 mg/L and 1.56 mg/L, respectively). The PDR group showed the longest duration of diabetes (16 years), highest FBG (221.8 mg/dL) and HbA1c (6.68 mg/L). The incidence of albuminuria and maculopathy was higher in PDR group (72.7% and 54.54%, respectively). A significant association of hs-CRP levels with DR in patients with T2DM was observed. A significantly (<0.005) positive correlation of hs-CRP was also observed with age, duration of disease, FBG, PPBG, and HbA1c.Conclusions: Patients with severe grades of retinopathy had significantly higher hs-CRP levels than patients with the milder grades.

Download Full-text