scholarly journals Microbial keratinase and the bio-economy: a three-decade meta-analysis of research exploit

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nonso E. Nnolim ◽  
Uchechukwu U. Nwodo
Keyword(s):  
Environmental Sustainability ◽  
Research Productivity ◽  
Research Output ◽  
Meta Analysis ◽  
Research Direction ◽  
Future Research ◽  
Collaboration Networks ◽  
Survey Period ◽  
Scientific Impact ◽  
Total Citation

AbstractMicrobial keratinase research has been on an upward trajectory due to the robustness and efficiency of the enzyme toward various green technological processes that promote economic development and environmental sustainability. A compendium of research progression and advancement within the domain was achieved through a bibliometric study to understand the trend of research productivity, scientific impacts, authors' involvement, collaboration networks, and the advancement of knowledge gaps for future research endeavours. A three-decade (1990 to 2019) scholarly published articles were retrieved from the web of science database using a combination of terms "keratinas* or keratinolytic proteas* or keratinolytic enzym*", and subsequently analyzed for bibliometric indicators. A collection of 330 peer-reviewed, research, articles were retrieved for the survey period and authored by 1063 researchers with collaboration index of 3.27. Research productivity was most in 2013 with total research output of 28 articles. The top three authors' keywords were keratinase, keratin and protease with a respective frequency of 188, 26 and 22. India, China and Brazil ranked top in terms of keratinase research outputs and total citation with respective article productivity (total citations) of 85 (1533), 57 (826), and 36 (764). This study evaluated the trend of keratinase research outputs, scientific impact, collaboration networks and biotechnology innovations. It has the potentials to influence positively decision making on future research direction, collaborations and development of products for the bio-economy.

Endoscopic Sinus Surgery Improves Sleep Quality in Chronic Rhinosinusitis: A Systematic Review and Meta-analysis

2017 ◽  
Vol 158 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Daniel C. Sukato ◽  
Jason M. Abramowitz ◽  
Marina Boruk ◽  
Nira A. Goldstein ◽  
Richard M. Rosenfeld
Keyword(s):  
Systematic Review ◽  
Sleep Quality ◽  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
Meta Analysis ◽  
Research Direction ◽  
Sinus Surgery ◽  
Future Research ◽  
Apnea Hypopnea Index ◽  
Poor Sleep

Objective Up to 75% of patients with chronic rhinosinusitis (CRS) suffer with poor sleep quality and reduced quality of life. Endoscopic sinus surgery has demonstrated encouraging results in improving sleep function. The aim of this systematic review is to assess the change in sleep quality after surgery for CRS. Data Sources PubMed, Web of Science, EMBASE. Review Methods An electronic search was conducted with the keywords “sinusitis” or “rhinosinusitis” and “sleep.” Studies were included only when adults underwent endoscopic sinus surgery and were evaluated pre- and postoperatively by the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI), the Apnea-Hypopnea Index (AHI), the sleep domain of Sino-Nasal Outcome Test–22, or the sleep domain of Rhinosinusitis Disability Index. Results The database search yielded 1939 studies, of which 7 remained after dual-investigator screening. The standardized mean differences (95% CI) for the ESS, PSQI, and AHI were −0.94 (−1.63 to −0.26), −0.80 (−1.46 to −0.14), and −0.20 (−0.32 to −0.07), indicating large, moderate to large, and small improvements, respectively. All analyses displayed high heterogeneity ( I2 = 95%-99%). Conclusion Sleep quality, as measured by the ESS and PSQI surveys, shows substantial improvement after surgery for CRS, with smaller improvement seen for AHI. Generalizability of our results is limited by high heterogeneity among studies and by broad confidence intervals that cannot exclude small to trivial changes. The findings of this meta-analysis provide insight into the effect of CRS-related endoscopic sinus surgery on sleep quality, which should guide future research direction and counseling of patients in the clinical setting.

scholarly journals Comparative Safety of Therapies for Hyperthyroidism Planning Pregnancy: A Network Meta-analysis

2020 ◽  
Author(s):  
Xiaohua Fang ◽  
Huibin Huang ◽  
Wei Lin ◽  
Jixing Liang ◽  
Junping Wen ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Cohort Studies ◽  
Lower Risk ◽  
Birth Defect ◽  
Meta Analysis ◽  
Research Direction ◽  
Future Research ◽  
Retrospective Cohort Studies ◽  
Comparative Safety ◽  
Future Pregnancy

Objective: Our intention was to compare the pregnancy safety in women with hyperthyroidism seeking future pregnancy after ATD, RAI or thyroidectomy treatment and to explore the optimum treatment strategy. We hope the results will guide the choice for endocrinologists and patients, and be beneficial for promoting eugenics. Methods: We searched multiple databases though December 2019. The outcome indicators were abortion, preterm birth, IUGR and birth defect. We conducted a frequency-framework network meta-analysis by using Stata and R software. The results of the intervention comparison were expressed as OR with 95%CI, and ranking was assessed using surface under the cumulative ranking (SUCRA) probabilities. Results: The network meta-analysis included 4 retrospective cohort studies with a total enrollment of 480 patients. 1)Thyroidectomy had a lower risk of abortion than RAI [OR=0.77, 95%CI (0.23, 2.56)] and ATD [OR=0.68, 95%CI (0.21, 2.21)]. RAI had a lower risk of abortion than ATD [OR=0.88, 95%CI (0.45, 1.75)]. Based on SUCRA results, thyroidectomy (0.698) was followed by RAI (0.494), ATD (0.308). Thyroidectomy (60.7%) had the highest probability of being first compared to RAI (27.0%) and ATD (12.4%). 2)Thyroidectomy had a lower risk of preterm birth than RAI [OR=0.80, 95%CI (0.26, 2.44)] and ATD [OR=0.79, 95%CI (0.39, 1.59)]. RAI had a lower risk of preterm birth than ATD [OR=0.98, 95%CI (0.42, 2.33)]. Based on SUCRA results, thyroidectomy (0.703) was followed by RAI (0.430), ATD (0.367). Thyroidectomy (57.8%) had the highest probability of being first compared with RAI (30.5%) and ATD (11.8%). 3)Thyroidectomy had a lower risk of IUGR than RAI [OR=0.28, 95%CI (0.03, 3.02)] and ATD [OR=0.83, 95%CI (0.14, 4.86)]. RAI had a higher risk of IUGR than ATD [OR=3.02, 95%CI (0.60, 15.27)]. Based on SUCRA results, thyroidectomy (0.717) was followed by ATD (0.663), RAI (0.120). Thyroidectomy (56.6%) had the highest probability of being first compared with RAI (5.4%) and ATD (37.9%). 4)Thyroidectomy had a lower risk of birth defect than RAI [OR=0.70, 95%CI (0.02, 30.34)] and ATD [OR=0.23, 95%CI (0.01, 4.52)]. RAI had a lower risk of birth defect than ATD [OR=0.32, 95%CI (0.03, 3.12)] (Table 2). Based on SUCRA results, thyroidectomy (0.70) was followed by RAI (0.629), ATD (0.171). Thyroidectomy (55.9%) had the highest probability of being first compared with RAI (41.3%) and ATD (2.8%). Conclusion: Thyroidectomy was the optimum option for women with hyperthyroidism seeking near future pregnancy. The future research direction is to include more samples to conduct head-to-head randomized controlled trials or prospective cohort studies, establish inclusion criteria for various pre-pregnancy conditions or further subgroup analysis, and develop more acceptable, safer, and more manageable treatments that allow for the remission of both thyroid function and autoimmune abnormalities.

scholarly journals Mapping Evidence on Global Perceptions of Environmental Sustainability amidst the COVID-19 Pandemic: A Systematic Review Protocol

2021 ◽  
Author(s):  
PETER ANSU-MENSAH ◽  
Monica Ansu-Mensah ◽  
Desmond Kuupiel
Keyword(s):  
Scoping Review ◽  
Environmental Sustainability ◽  
Data Extraction ◽  
Meta Analysis ◽  
World Health ◽  
Future Research ◽  
Regulatory Bodies ◽  
Review Protocol ◽  
Government Websites ◽  
Health Organization

Abstract Background: Identifying and addressing research gaps on environmental sustainability in this striving time of COVID-19, it is imperative to ensure proper waste management disposal, efficient use of energy as well as judicious use of transport in order to achieve the SDGs 2030.Aim: The proposed scoping review is aimed at mapping evidence on global perceptions of environmental sustainability amidst COVID-19 pandemic. Methods: The proposed study will be guided by the enhanced version of Arksey and O’Malley’s scoping review framework, and Levac et al. 2010 recommendations together with the 2015 Joanna Briggs Institute guidelines. A comprehensive keywords search for relevant studies presenting evidence of environmental sustainability during COVID-19 pandemic will be conducted with the following databases: SCOPUS, Google Scholar, EBSCOhost, and PubMed. Literature from university repositories and international organization such as the World Health Organization (WHO) and government websites relevant to the proposed study will also be retrieved. The proposed review will use the Preferred Reporting Items for Systematic Reviews and Meta-analysis: Extension for Scoping Review (PRISMA-ScR) to present the results of the study. For data extraction in a content thematic manner of analysis, NVivo version 11 software package will be used. A mixed methods appraisal tool (MMAT) version 2018 will be employed to appraise the quality of all the included studies. Discussion: We are hopeful that the results of the proposed study will inform future research and unveil evidence-based information to report potential environmental sustainability issues that may arise in this new phase of COVID-19 pandemic. It also anticipated that the proposed study will enable policy and regulatory bodies to implement new strategies to achieve the SDGs inclusive of COVID-19 pandemic.

scholarly journals Identifying the Superior Reperfusion Technique in Liver Transplantation: A Network Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Yao Yao ◽  
Ping Wu ◽  
Tao Guo
Keyword(s):  
Liver Transplantation ◽  
Meta Analysis ◽  
Vena Cava ◽  
Research Direction ◽  
Current Evidence ◽  
Future Research ◽  
Clinical Effects ◽  
Bayesian Theorem ◽  
Icu Stay ◽  
Parametric Data

Objective. To investigate the clinical effects of different reperfusion techniques in liver transplantation based on network meta-analysis. Method. Literature retrieval was conducted in globally recognized databases, namely, MEDLINE, EMBASE, and Cochrane Central, to address relative randomized controlled trials (RCTs) investigating the clinical effects of respective reperfusion techniques in liver transplantation. Short- and long-term parametric data, including ICU stay, dysfunction rate (DFR), biliary complications (BC), 1-year graft survival (GS), and patient survival (PS), were quantitatively pooled and estimated based on the Bayesian theorem. The P values of surface under the cumulative ranking (SUCRA) probabilities regarding each parameter were calculated and ranked by various techniques. The Grades of Recommendations Assessment, Development and Evaluation (GRADE) criteria were utilized for the recommendations of evidence from pairwise direct comparisons. Results. Seven RCTs containing 6 different techniques were finally included for network meta-analysis. The results indicated that retrograde vena cava (RVC) reperfusion possessed the highest possibility of revealing the best clinical effects on DFR (SUCRA, P=0.93), ICU stay (SUCRA, P=0.76), and GS (SUCRA, P=0.44), while portal-arterial reperfusion (simultaneous initialize) seemed to exhibit the most benefits in reducing BC (SUCRA, P=0.67) and enhancing PS rate (SUCRA, P=0.48). Moreover, sensitivity analysis with the inconsistency approach clarified the reliability of the main results, and the evidence of the most direct comparisons was ranked low or very low. Conclusions. Current evidence demonstrated that RVC and portal-arterial reperfusion (simultaneously initialized) revealed superior clinical effects, compared to other interventions. Investigation of these 2 techniques should be a future research direction, and more high-quality RCTs are expected.

scholarly journals Mapping evidence on the burden and distribution of childhood obesity in sub-Saharan Africa: a scoping review protocol

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Frederick I. Danquah ◽  
Matilda Yeboah ◽  
Vitalis Bawontuo ◽  
Desmond Kuupiel
Keyword(s):  
Childhood Obesity ◽  
Scoping Review ◽  
Data Extraction ◽  
Meta Analysis ◽  
Research Direction ◽  
Sub Saharan Africa ◽  
Future Research ◽  
Adverse Health Outcomes ◽  
Unpublished Studies ◽  
Sub Saharan

Abstract Background Obesity in childhood is associated with adverse health outcomes and complications throughout the life-span of a child. Available evidence suggests a dramatic increase in childhood obesity in sub-Saharan Africa (SSA) over the past two decades. The health risks associated with obesity/overweight are particularly problematic in children due to the potential for long-term health concerns. The researchers propose to conduct a systematic scoping review to map evidence on the burden and distribution of childhood obesity in SSA. Methods The study will be guided by the scoping review framework proposed by Arksey and O’Malley. A comprehensive literature search will be performed in the following electronic databases: PubMed, Web of Science, African Index Medicus, and CINAHL with full text via EBSCOhost platform. Primary studies both published in peer-reviewed journals and gray literature such as unpublished studies, thesis, and studies in press addressing the research topic will be included. One reviewer will conduct title screening, and the results will be exported to Mendeley Desktop library. Two independent reviewers will perform both abstract and full article screening in parallel as well as data extraction from eligible studies. The Preferred Reporting Items for Systematic Reviews and Meta-analysis: Extension for Scoping Review (PRISMA-ScR) will be utilized to present the study findings of the proposed scoping review. NVivo version 11.0 will be used to extract the relevant outcomes from the included studies, a content thematic analysis performed, and the results reported using a narrative approach. The Mixed Method Quality Appraisal Tool Version 2018 will be used to assess the methodological quality of all included studies. Discussion We anticipate that the proposed study will contribute to the existing body of knowledge on childhood obesity, identify gaps in knowledge on the topic, inform future research direction, and provide evidence-based information to strengthen health systems and policies on childhood obesity towards achieving the WHO global target of halting the rise in obesity by 2025.

Research productivity of accounting academics in changing and challenging times

2013 ◽  
Vol 9 (1) ◽  
pp. 4-25 ◽  
Author(s):  
Debbie Wills ◽  
Gail Ridley ◽  
Helena Mitev
Keyword(s):  
Research Productivity ◽  
Research Output ◽  
Meta Analysis ◽  
Global Market ◽  
Individual Characteristics ◽  
International Studies ◽  
Content Type ◽  
Proposed Model ◽  
Data Driven Approach ◽  
The Impact

PurposeThe aim of this study is to investigate factors considered to impact on the research productivity of accounting academics, and identify how the factors were related. The study aims to set itself within an international context of increased workloads, and revenue‐driven research and teaching.Design/methodology/approachA meta‐analysis was conducted of international studies from accounting and related business fields, published between 1988 and 2008, that examined factors influencing the research productivity of academics. A data‐driven approach to thematic analysis was used to synthesise the results, which were categorised into two time periods.FindingsThree clusters of factors that accounted for researcher productivity were found to have had most focus in related studies over the period. These were “Institutional characteristics”, “Intrinsic motivation” and “Knowledge, skills and other individual characteristics”. Hierarchical clusters of factors operating at government, institution and individual levels appeared to influence the research output of accounting academics.Practical implicationsIncreased understanding of the factors that affect the research productivity of accounting academics, and how they are related, has potential to benefit individual researchers and their institutions.Originality/valueModels identified in previous studies have not considered the impact of the relatively recent global market pressures on accounting academics. As the proposed model was developed from a meta‐analysis of many international studies it is likely to accommodate current global pressures better than previous models.

scholarly journals Plastic Pollution Research in Indonesia: State of Science and Future Research Directions to Reduce Impacts

2021 ◽  
Vol 9 ◽  
Author(s):  
Paul Vriend ◽  
H. Hidayat ◽  
J. van Leeuwen ◽  
M. R. Cordova ◽  
N. P. Purba ◽  
...  
Keyword(s):  
Research Output ◽  
Meta Analysis ◽  
Mitigation Strategies ◽  
Future Research ◽  
Plastic Pollution ◽  
Marine Research ◽  
Pollution Research ◽  
Spatial Coverage ◽  
Terrestrial Environments ◽  
Environmental Compartments

Several studies have suggested Indonesia to be among the top plastic polluting countries globally. Data on the presence and amounts of plastic pollution are required to help design effective plastic reduction and mitigation strategies. Research quantifying plastic pollution in Indonesia has picked up in recent years. However, a lack of central coordination in this research has led to research output with different goals, methods, and data formats. In this study we present a meta-analysis of studies published on plastic pollution in Indonesia to uncover gaps and biases in current research, and to use these insights to suggest ways to improve future research to fill these gaps. Research gaps and biases identified include a clear preference for marine research, and a bias toward certain environmental compartments within the marine, riverine, and terrestrial systems that have easy to apply methods. Units of measurement used to express results vary greatly between studies, making it difficult to compare data effectively. Nevertheless, we identify polypropylene (PP) and polyethylene variants (PE, HDPE, LDPE) to be among the most frequently found polymers in both macro- and microplastic pollution in Indonesia, though polymer identification is lacking in a large part of the studies. Plastic research is mostly done on Java (59% of the studies). We recommend research methods used to quantify plastic pollution to be harmonized. Moreover, we recommend a shift in focus of research toward the riverine and terrestrial environments and a shift of focus of environmental compartments analyzed within these systems, an increase in spatial coverage of research across Indonesia, and lastly, a larger focus on polymer characterization. With these changes we envision future research which can aid with the design of more effective and targeted reduction and mitigation strategies.

scholarly journals Global Research Trends on the Use of Nanotechnology to Boost Meat Production: A Scientometric Analysis

2022 ◽  
Vol 6 ◽  
Author(s):  
Emrobowansan Monday Idamokoro ◽  
Yiseyon Sunday Hosu
Keyword(s):  
Research Work ◽  
Research Direction ◽  
Future Research ◽  
Meat Production ◽  
Scientometric Analysis ◽  
Annual Growth Rate ◽  
Total Citation ◽  
Production Research ◽  
Work Done ◽  
Scientometric Study

Meat production plays a vital socioeconomic role for sustainable development and for promoting food security in most countries. However, not much is known about research agendas done globally and the advancement of knowledge-generating networks in this area of study. The present study aims to reveal and analyze scientific research outputs on meat production linked with recent nanotechnology research work done till date. A compilation of research advancement and development within the sphere was realized through a scientometric study to comprehend the trend of research outputs, scientific impacts, authors' involvement, collaboration networks, and the advancement of knowledge gaps for future research endeavors on the current subject matter. Scholarly published articles were retrieved from the web of science (WOS) and Scopus databases from 1985 to 2020 and they were merged together using bibliometric package in R studio. All duplicated articles (438) from both data bases were excluded. A combination of terms (nano* AND (livestock* OR meat* OR beef* OR mutton* OR pork* OR chevon* OR chicken* OR turkey*)), and conversely analyzed for scientometric indices. A collection of 656 peer-reviewed, research articles were retrieved for the study period and authored by 2,133 researchers with a collaboration index of 3.31. The research outputs were highest in the year 2020 with total research outputs of 140 articles. The topmost three authors' keywords commonly used by authors were nanoparticles, meat, and chitosan with a respective frequency of 75, 62, and 57. China, Iran, and India ranked top in terms of meat production research outputs linked to nanotechnology and total citation with respective article productivity (total citations) of 160 (3,193), 111 (1,765), and 37 (552). Our findings revealed an increasing trend in research (with an annual growth rate of 25.18%) tending toward advancing meat production with the use of nanotechnology. Likewise, there is an increasing pointer to the fact that research work on nanotechnology and meat production has the prospect to influence positively, decision-making on research direction, and collaborations, hereby increasing the production of meat and its products in the future.

At the Mercy of Facebook

2019 ◽  
pp. 129-149
Author(s):  
Nirupama R. Akella
Keyword(s):  
Social Networking Sites ◽  
Teenage Pregnancy ◽  
Brain Research ◽  
Meta Analysis ◽  
Research Direction ◽  
Future Research ◽  
Media Technology ◽  
Active Video ◽  
Brain Structure And Function ◽  
And Function

This chapter is a meta-analysis of teen brain research and social media technology such as Facebook that could result in spiraling rates of teenage pregnancy. The author discusses contemporary theories of brain circuitry including teen brain structure and function as one of the plausible reasons for rising teenage pregnancy rates. The author argues that the challenge is to control the quality and influence of Facebook on teen behaviors, actions, and decisions to minimize the growing influence of social networking sites. In the conclusive section of the chapter, the author focuses on the expansion and extension of instructional and non-instructional physical activities, exergames, and active video games strategies to control the quality and influence of Facebook content by presenting research that advocates use of such activities and games within the Facebook interface. The author ends the chapter by mapping a future research direction of cross-cultural empirical investigation. The author wraps the chapter with a summative conclusion.

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