scholarly journals Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: protocol for a mixed-methods systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Dikshyanta Rana ◽  
Sophie Westrop ◽  
Evi Germeni ◽  
Arlene McGarty ◽  
Louisa Ells ◽  
...  
Keyword(s):  
Systematic Review ◽  
Learning Disabilities ◽  
Mixed Methods ◽  
Lifestyle Modification ◽  
Realist Synthesis ◽  
Risk Of Bias ◽  
The Body ◽  
Lifestyle Interventions ◽  
Adults With Learning Disabilities ◽  
Underlying Mechanisms

Abstract Background Adults with learning disabilities have an increased disposition to unhealthy lifestyle behaviours which often occur simultaneously. Existing studies focus on complex interventions targeting unhealthy diet, physical inactivity, sedentary behaviour, smoking, and alcohol use to reduce health risks experienced. It is essential to understand how well these interventions work, what works, for whom, in what context and why. This study aims to investigate the effectiveness and underlying mechanisms of lifestyle modification interventions for adults with learning disabilities. Methods This is a mixed-methods systematic review consisting of a network meta-analysis (NMA) and realist synthesis. Electronic databases (ASSIA, CINAHL, EMBASE, MEDLINE, and PsycINFO) will be searched from inception to 14 January 2021 with no language restriction. Additionally, trial registries, grey literature databases and references lists will be searched. Studies related to lifestyle modification interventions on the adult population (>18 years) with learning disabilities will be eligible for inclusion. Two independent researchers will screen studies, extract data and assess its quality and risk of bias using the Cochrane Collaboration’s Risk of Bias Assessment Tool (RoB Version 2) and ROBINS-I. The strength of the body of evidence will be assessed based on the GRADE approach. The NMA will incorporate results from RCTs and quasi-experimental studies to estimate the effectiveness of various lifestyle interventions. Where appropriate, a component NMA (CNMA) will be used to estimate effectiveness. The realist synthesis will complement and explain the findings of NMA and CNMA by including additional qualitative and mixed-methods studies. Studies will be included based on their relevance to the programme theory and the rigour of their methods, as determined by quality appraisal tools appropriate to the study design. Results from both syntheses will be incorporated into a logic model. Discussion The paucity of population-specific lifestyle interventions contributes to the challenges of behaviour change in adults with learning disabilities. This study will provide an evidence-base from which various stakeholders can develop effective interventions for adults with learning disabilities. The evidence will also help prioritise and inform research recommendations for future primary research so that people with learning disabilities live happier, healthier and longer lives. Trial registration PROSPERO CRD 42020223290

Association between muscle strength and risk factors for metabolic syndrome in children and adolescents: a systematic review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Tiago R. de Lima ◽  
Priscila C. Martins ◽  
Giuseppe L. Torre ◽  
Alice Mannocci ◽  
Kelly S. Silva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Metabolic Syndrome ◽  
Muscle Strength ◽  
Children And Adolescents ◽  
Lower Risk ◽  
Preliminary Evidence ◽  
Risk Of Bias ◽  
The Body ◽  
Reference List

AbstractThe aim of this systematic review was to identify and summarize evidence for the association between muscle strength (MS) and metabolic syndrome (MetS), and MS and combinations of risk factors for MetS in children and adolescents. Five databases (Medline/PubMed, EBSCO, Scielo, Scopus, and Web of Knowledge) were searched up to November 2019 with complementary reference list searches. Inclusion criteria were studies that investigated the relationship between MS and MetS or MS and combinations of risk factors for MetS in children and adolescents (≤19 years of age). Risk of bias was assessed using standard procedures. From the total of 15,599 articles initially identified, 13 articles were included, representing 11,641 children and adolescents. Higher MS values were associated with lower risk for MetS or combinations of risk factors for MetS (n=11/13 studies). Of the total of included studies, about 23.1% (03/13) were longitudinal and all included studies were classified as having a moderate risk of bias. This review provides preliminary evidence for a beneficial relationship between MS and MetS among children and adolescents. Additionally, although the body of evidence points to the beneficial relationship between higher MS and lower risk for combination of factors for MetS in children and adolescents, this relationship is inconclusive.

scholarly journals Sella Turcica Morphology in Patients With Genetic Syndromes: Protocol for a Systematic Review

10.2196/16633 ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. e16633
Author(s):  
Imaan Amina Roomaney ◽  
Manogari Chetty
Keyword(s):  
Systematic Review ◽  
Pathological Condition ◽  
Sella Turcica ◽  
Open Access Journal ◽  
Risk Of Bias ◽  
The Body ◽  
Biomedical Science ◽  
Western Cape ◽  
Genetic Syndromes ◽  
Craniofacial Complex

Background The sella turcica is an important anatomical reference used in orthodontics and the evaluation of craniofacial growth. Studies have found an association between variations in sella turcica morphology in patients with certain syndromes affecting the craniofacial complex. It is hypothesized that each related syndrome or pathological condition is associated with a specific pattern of malformation of the sella turcica. Objective This study outlines the protocol for a systematic review that aims to determine if genetic syndromes involving the craniofacial complex are associated with abnormal radiographic sella turcica morphology and if there is a pattern of malformation that is consistent with each syndrome. Methods An electronic database search was conducted using a planned search strategy to identify relevant studies. We included primary studies evaluating the morphology of the sella turcica based on imaging from a lateral view. Specifically, only studies with postnatal human participants with genetic syndromes involving the craniofacial complex were included in this review. We placed no restrictions on the language or time frame of these studies. Based on the search findings, studies were further screened for relevance and eligibility by two independent reviewers. Data were extracted from the selected studies. We assessed the selected studies for risk of bias and quality by using risk of bias tools from the Joanna Briggs Institute. We will provide a narrative synthesis of our findings and a structured summary based on prespecified themes. Results The protocol is registered with PROSPERO (#CRD42019148060) and approved by the University of Western Cape Biomedical Science Research Ethics Committee (BM205/3). The literature search was conducted in September 2019 and updated in July 2020. The study was completed in August 2020, and the findings will be published in an open-access journal. Conclusions The results of this systematic review are expected to provide a comprehensive list of morphological variations of the sella turcica, which will aid in the identification of syndromes associated with the craniofacial complex. We also expect to identify patterns of sella turcica morphology that highlight genotype-phenotype correlations, thus adding to the body of evidence relating to genetics and craniofacial malformations. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42019148060; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=148060 International Registered Report Identifier (IRRID) RR1-10.2196/16633

scholarly journals Corrigendum: Bariatric surgery, lifestyle interventions and orlistat for severe obesity: the REBALANCE mixed-methods systematic review and economic evaluation

2020 ◽  
Vol 22 (68) ◽  
pp. 247-250
Author(s):  
Alison Avenell ◽  
Clare Robertson ◽  
Zoë Skea ◽  
Elisabet Jacobsen ◽  
Dwayne Boyers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Economic Evaluation ◽  
Mixed Methods ◽  
Severe Obesity ◽  
Lifestyle Interventions ◽  
Competing Interests

Abstract Correction to Declared competing interests of authors.

Neurodevelopmental Treatment (Bobath) for Children With Cerebral Palsy: A Systematic Review

2019 ◽  
Vol 34 (11) ◽  
pp. 679-686 ◽  
Author(s):  
Márcia Andréa Zanon ◽  
Rafael Leite Pacheco ◽  
Carolina de Oliveira Cruz Latorraca ◽  
Ana Luiza Cabrera Martimbianco ◽  
Daniela Vianna Pachito ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Cerebral Palsy ◽  
Physical Therapy ◽  
Randomized Clinical Trials ◽  
Risk Of Bias ◽  
The Body ◽  
Current Evidence ◽  
Children With Cerebral Palsy ◽  
Protocol Registration

Aim: To assess the effects of neurodevelopmental treatment for children with cerebral palsy. Methods: We conducted a systematic review following the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions and reported in accordance to PRISMA Statement. Through a comprehensive literature search we considered all randomized clinical trials that compared neurodevelopmental treatment with conventional physical therapy for children with cerebral palsy. We used the Cochrane Risk of Bias Table to assess the risk of bias of the included randomized clinical trial, and the GRADE approach to evaluate the certainty of the body of the evidence. Results: We found 3 randomized clinical trials (2 published and 1 ongoing) comprising 66 children. Published randomized clinical trials presented methodological and reporting limitations and only 1 provided data for outcomes of interest. No difference between neurodevelopmental treatment and conventional physical therapy was found for gross motor function (mean difference 1.40; 95% confidence interval –5.47 to 8.27, low certainty evidence). Conclusion: This review found that the effects of neurodevelopmental treatment for children with cerebral palsy are still uncertain. Further studies are required to assess the efficacy and safety of neurodevelopmental treatment for this purpose and until there, current evidence do not support its routinely use in practice. Number of protocol registration in PROSPERO database: CRD42017082817 (available from https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=82817 ).

scholarly journals Electronic Health Records, Interoperability and Patient Safety in Health Systems of High-income Countries: A Systematic Review Protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e044941
Author(s):  
Edmond Li ◽  
Jonathan Clarke ◽  
Ana Luisa Neves ◽  
Hutan Ashrafian ◽  
Ara Darzi
Keyword(s):  
Systematic Review ◽  
Patient Safety ◽  
Electronic Health Records ◽  
Health Systems ◽  
Risk Of Bias ◽  
High Income ◽  
The Body ◽  
Health Records ◽  
Electronic Health ◽  
The Impact

IntroductionThe availability and routine use of electronic health records (EHRs) have become commonplace in healthcare systems of many high-income countries. While there is an ever-growing body of literature pertaining to their use, evidence surrounding the importance of EHR interoperability and its impact on patient safety remains less clear. There is, therefore, a need and opportunity to evaluate the evidence available regarding this relationship so as to better inform health informatics development and policies in the years to come. This systematic review aims to evaluate the impact of EHR interoperability on patient safety in health systems of high-income countries.Methods and analysisA systematic literature review will be conducted via a computerised search through four databases: PubMed, Embase, Health Management Information Consortium and PsycInfo for relevant articles published between 2010 and 2020. Outcomes of interest will include impact on patient safety and the broader effects on health systems. Quality of the randomised quantitative studies will be assessed using Cochrane Risk of Bias Tool. Non-randomised papers will be evaluated with the Risk of Bias In Non-Randomised Studies—of Interventions tool. Drummond’s Checklist will be used for publications pertaining to economic evaluation. The National Institute for Health and Care Excellence quality appraisal checklist will be used to assess qualitative studies. A narrative synthesis will be conducted for included studies, and the body of evidence will be summarised in a summary of findings table.Ethics and disseminationThis review will summarise published studies with non-identifiable data and, thus, does not require ethical approval. Findings will be disseminated through preprints, open access peer-reviewed publications, and conference presentations.PROSPERO registration numberCRD42020209285.

scholarly journals Associations between lifestyle interventions during pregnancy and childhood weight and growth: a systematic review and meta-analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Roxana Raab ◽  
Sophie Michel ◽  
Julia Günther ◽  
Julia Hoffmann ◽  
Lynne Stecher ◽  
...  
Keyword(s):  
Systematic Review ◽  
Childhood Obesity ◽  
Healthy Lifestyle ◽  
Meta Analysis ◽  
The Body ◽  
Analytical Models ◽  
Lifestyle Interventions ◽  
Childhood Weight ◽  
Z Scores ◽  
Meta Analyses

Abstract Background Maternal health and lifestyle during pregnancy may be critical for the onset and progression of childhood obesity. Prenatal lifestyle interventions have been shown to positively affect maternal behaviors, gestational weight gain, and anthropometric outcomes in infants at birth. The influence of such interventions on child weight or growth beyond birth is unknown. We therefore examined the association between lifestyle interventions during pregnancy and anthropometric outcomes during childhood. Methods A systematic literature search was conducted in three electronic databases, two clinical trial registers and further sources, without language or publication status restrictions. Additionally, 110 study authors were contacted to obtain unpublished data. Randomized controlled trials comparing any antenatal lifestyle or behavioral intervention to standard prenatal care, in women of any body mass index (BMI), with offspring anthropometric data at 1 month of age or older, were considered. Two reviewers independently extracted data and assessed the risk of bias using the Cochrane Collaboration’s updated tool. Data on weight, length, and BMI, and corresponding z-scores, were stratified into six age ranges and weighted mean differences (WMD) with 95% confidence intervals (CI) were calculated in univariate and multivariate random-effects meta-analytical models. Results Twenty trials comprising 11,385 women were included in this systematic review, of which 19 were combined in meta-analyses. Overall, lifestyle interventions during pregnancy were not associated with differences in weight, length, BMI, or corresponding z-scores, in children aged 1 month to 7 years (e.g. weight in 5 to 6 month old children, WMD: 0.02 kg; 95% CI: − 0.05 to 0.10 kg, I2 = 38%; 13 studies, 6667 participants). Findings remained consistent when studies were stratified by maternal baseline BMI or other risk factors, and intervention content and duration. Based on the GRADE criteria, the strength of the body of evidence was considered moderate. Conclusion Prenatal lifestyle interventions were not shown to influence childhood weight or growth. Nevertheless, women should be encouraged to pursue a healthy lifestyle during pregnancy. Further efforts to establish early prevention strategies for childhood obesity are urgently needed. Thus, large, high-quality studies with pre-planned, long-term follow-ups are warranted. Trial registration PROSPERO CRD42018118678.

BIM-enabled construction innovation through collaboration: a mixed-methods systematic review

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Hui Liu ◽  
Miroslaw J. Skibniewski ◽  
Qianqian Ju ◽  
Junjie Li ◽  
Hongbing Jiang
Keyword(s):  
Systematic Review ◽  
Mixed Methods ◽  
Conceptual Framework ◽  
Construction Projects ◽  
The Body ◽  
Information Modeling ◽  
Content Type ◽  
Body Of Knowledge ◽  
Building Information ◽  
Innovative Capabilities

PurposeThis study aims to explore the innovative capabilities of building information modeling (BIM) in construction projects. The objectives are to construct an inclusive conceptual framework of BIM-enabled construction innovation, identify the status and trends of innovation-related research in BIM publications, synthesize research pertaining to BIM-enabled construction innovation and discover core research requirements in the related body of knowledge.Design/methodology/approachThis study proposes a comprehensive theoretical framework, named innovation pyramid, comprising context, actor, artifact, process, structure and innovative task for exploring and analyzing the innovative capability of BIM in construction projects. Accordingly, mixed methods were used to perform a systematic review of research on the topic of BIM-enabled construction innovation.FindingsThe findings reveal that BIM innovation-related articles have predominantly considered BIM as an innovation from a technological standpoint, while the innovative capabilities of BIM have remained under-researched with a fragmented research focus. Fertile grounds for research have emerged and call for research pertaining to entities of “structure” and “innovative task” as well as interaction, interrelations and mutually adjusting effect among the entities.Practical implicationsThe framework proposed may be useful for subsequent research design and for assisting project management practitioners in the use of BIM to achieve innovation more efficiently.Originality/valueThis research provides an insight into the innovative capabilities of BIM based on the BIM–collaboration–construction innovation logic chain. It contributes to the body of knowledge by devising an inclusive conceptual framework of BIM-enabled construction innovation, synthesizing the state of the art and exposing the research needs in this area.

scholarly journals Sella Turcica Morphology in Patients With Genetic Syndromes: Protocol for a Systematic Review (Preprint)

2019 ◽  
Author(s):  
Imaan Amina Roomaney ◽  
Manogari Chetty
Keyword(s):  
Systematic Review ◽  
Pathological Condition ◽  
Sella Turcica ◽  
Open Access Journal ◽  
Risk Of Bias ◽  
The Body ◽  
Biomedical Science ◽  
Western Cape ◽  
Genetic Syndromes ◽  
Craniofacial Complex

BACKGROUND The sella turcica is an important anatomical reference used in orthodontics and the evaluation of craniofacial growth. Studies have found an association between variations in sella turcica morphology in patients with certain syndromes affecting the craniofacial complex. It is hypothesized that each related syndrome or pathological condition is associated with a specific pattern of malformation of the sella turcica. OBJECTIVE This study outlines the protocol for a systematic review that aims to determine if genetic syndromes involving the craniofacial complex are associated with abnormal radiographic sella turcica morphology and if there is a pattern of malformation that is consistent with each syndrome. METHODS An electronic database search was conducted using a planned search strategy to identify relevant studies. We included primary studies evaluating the morphology of the sella turcica based on imaging from a lateral view. Specifically, only studies with postnatal human participants with genetic syndromes involving the craniofacial complex were included in this review. We placed no restrictions on the language or time frame of these studies. Based on the search findings, studies were further screened for relevance and eligibility by two independent reviewers. Data were extracted from the selected studies. We assessed the selected studies for risk of bias and quality by using risk of bias tools from the Joanna Briggs Institute. We will provide a narrative synthesis of our findings and a structured summary based on prespecified themes. RESULTS The protocol is registered with PROSPERO (#CRD42019148060) and approved by the University of Western Cape Biomedical Science Research Ethics Committee (BM205/3). The literature search was conducted in September 2019 and updated in July 2020. The study was completed in August 2020, and the findings will be published in an open-access journal. CONCLUSIONS The results of this systematic review are expected to provide a comprehensive list of morphological variations of the sella turcica, which will aid in the identification of syndromes associated with the craniofacial complex. We also expect to identify patterns of sella turcica morphology that highlight genotype-phenotype correlations, thus adding to the body of evidence relating to genetics and craniofacial malformations. CLINICALTRIAL PROSPERO International Prospective Register of Systematic Reviews CRD42019148060; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=148060 INTERNATIONAL REGISTERED REPORT RR1-10.2196/16633

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