Polymorphisms in DNA repair and oxidative stress genes associated with pre-treatment cognitive function in breast cancer survivors: an exploratory study

Purpose: The purpose of this study was to examine the effects of a smart-care services program for breast cancer survivors on cognitive function and physical health. Methods: A quasi-experimental control group pretest posttest design was used. Subjects were recruited in D city, and data were collected from July 2017 to February 2018. The experimental group (n=24) participated in the smart-care services program, whereas the control group (n=26) received conventional management. The smart-care services program consisted of addressing cognitive function problems arising from chemotherapy, diet, exercise, head/neck massage and self-monitoring using smartphone applications and smart bands. All participants underwent assessments at baseline, at 6 weeks, and at 12 weeks. Data were analyzed using descriptive statistics (frequency, percentage, mean and standard deviation), a chi-squared test, t-test, and repeated measures ANOVA. Results: After the smart-care services program, significant differences were found between the groups in cognitive function (F=18.91, p<.001) and sleep time (F=9.25, p<.001). No significant differences were found between the groups in caloric consumption after the program. Conclusion: The smart-care services program significantly improved the level of cognitive function and sleep time for breast cancer survivors. The use of this smart-care services program for breast cancer survivors might be an effective nursing intervention tool for improving cognitive function and health behaviors.

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Abstract P2-14-10: Self Reported Cognitive Function in Breast Cancer Survivors: A 12 Month Longitudinal Descriptive Study

10.1158/0008-5472.sabcs10-p2-14-10 ◽

2010 ◽

Author(s):

D Barton ◽

K Burger ◽

P Novotny ◽

J. Sloan

Keyword(s):

Breast Cancer ◽

Cognitive Function ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Descriptive Study

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Exploratory Study of Breast Cancer Survivors’ Lived Experience: Activity Engagement During and After Breast Cancer Treatment

American Journal of Occupational Therapy ◽

10.5014/ajot.2016.70s1-po2069 ◽

2016 ◽

Vol 70 (4_Supplement_1) ◽

pp. 7011505122p1

Author(s):

Anne Fleischer ◽

Max Ito

Keyword(s):

Breast Cancer ◽

Cancer Survivors ◽

Cancer Treatment ◽

Lived Experience ◽

Exploratory Study ◽

Breast Cancer Survivors ◽

Breast Cancer Treatment ◽

Activity Engagement

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Exploratory Study of Associations Between DNA Repair and Oxidative Stress Gene Polymorphisms and Cognitive Problems Reported by Postmenopausal Women With and Without Breast Cancer

Biological Research For Nursing ◽

10.1177/1099800418799964 ◽

2018 ◽

Vol 21 (1) ◽

pp. 50-60

Author(s):

John D. Merriman ◽

Susan M. Sereika ◽

Yvette P. Conley ◽

Theresa A. Koleck ◽

Yehui Zhu ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Dna Repair ◽

Depressive Symptoms ◽

Postmenopausal Women ◽

Systemic Therapy ◽

Gene Polymorphisms ◽

Latent Subgroups ◽

Cognitive Problems ◽

And Oxidative Stress

Purpose: Women with breast cancer report varying frequencies of cognitive problems during adjuvant systemic therapy. This variability suggests latent subgroups. Therefore, we identified latent subgroups of self-reported cognitive problems among postmenopausal women with and without breast cancer. We explored associations between membership in these subgroups and (a) demographic, clinical, and symptom characteristics and (b) variations in candidate gene polymorphisms. Methods: We evaluated frequency of cognitive problems using the Patient Assessment of Own Functioning Inventory. Growth mixture modeling identified latent subgroups over 18 months of adjuvant systemic therapy and at matched time points for women without cancer ( N = 331). We evaluated for differences among subgroups in demographic, clinical, and symptom characteristics and in 41 single nucleotide polymorphisms in 10 candidate genes involved in DNA repair and oxidative stress pathways ( n = 199). We modeled associations between genotypes and subgroup membership using multinomial logistic regression. Results: We identified three latent subgroups: more frequent, persistent, and almost never. Receipt of chemotherapy plus anastrozole, depressive symptoms, and baseline neuropathic symptoms increased the odds of belonging to the more frequent subgroup. Anxiety and depressive symptoms increased the odds of belonging to the persistent subgroup. With covariates controlled for, carrying the ERCC5 rs873601 G minor allele increased the odds of reporting more frequent cognitive problems. Conclusions: Chemotherapy plus anastrozole, depressive symptoms, and presence of neuropathic symptoms may predict more frequent cognitive problems during systemic therapy that later resolve. Mood dysregulation before therapy may predict persistent cognitive problems during therapy. ERCC5 genotype may influence frequency of cognitive problems after controlling for these risk factors.

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Interaction Effects of Vitamin D Receptor Polymorphisms and Vitamin D3 Supplementation on Plasma Oxidative Stress and Apoptotic Biomarkers Among Breast Cancer Survivors (P05-027-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz030.p05-027-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Elham Kazemin ◽

Yasaman Jamshidi-naeini ◽

Mohammad Esmaeil Akbari ◽

Nariman Moradi ◽

Safoora Gharibzadeh ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Vitamin D ◽

Linear Regression ◽

Cancer Survivors ◽

Vitamin D Receptor ◽

Vitamin D3 ◽

Multiple Testing ◽

Breast Cancer Survivors ◽

Vitamin D3 Supplementation

Abstract Objectives Interactions of human genes and environmental exposures play a crucial role in cancer etiology and prognosis. We investigated whether response to vitamin D3 supplementation in terms of plasma oxidative stress (OS) and apoptotic biomarkers were mediated by the vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) among breast cancer survivors. Methods Two hundred and fourteen women who were diagnosed with breast cancer (invasive or in situ) and had completed all treatment regimens received 4000 IU of vitamin D3 daily for 12 weeks. Anthropometric, dietary, sun exposure, physical activity, as well as laboratory assessments including plasma superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and Bcl2 were performed at enrolment and post-intervention. VDR genotyping was performed at ApaI, TaqI, FokI, BsmI, and Cdx-2. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was modulated by the selected VDR SNPs. Results Linear regression analysis adjusted for age, BMI, on-study plasma 25(OH)D changes, and baseline circulating 25(OH)D indicated that the AA genotype of the ApaI on VDR was associated with greater increase and decrease in plasma Bcl2 [0.21, 95% Confidence Interval (CI) (0.03, 0.39)] and MDA [−0.68, 95% CI (−1.35, −0.02)] compared to aa respectively. This association did not remain statistically significant after correction for multiple testing. Overall, we found no statistically significant interaction of the VDR SNPs and inferred haplotypes with the circulating OS and apoptotic biomarkers except for the FokI BsmI ApaIhaplotype and circulating MDA (p-value for global score = 0.02) after multiple testing correction. Conclusions Our findings indicate a weak interaction between the VDR haplotypes and responses of plasma OS and apoptotic biomarkers to vitamin D3 supplementation. However, further assessments of additional genes and biomarkers with longer intervention periods may further explain the complex interplay between genes and nutrients. Funding Sources Cancer Research Center, National Nutrition and Food Technology Research Institute, and the Endocrine Research Center of Shahid Beheshti University of Medical Sciences.

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