scholarly journals Development and validation of a formula for objective assessment of cervical vertebral bone age

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Raghavan Chandrasekar ◽  
Shyamala Chandrasekhar ◽  
K. K. Shantha Sundari ◽  
Poornima Ravi
Keyword(s):  
Cervical Vertebrae ◽  
Objective Assessment ◽  
Bone Age ◽  
Chronological Age ◽  
Strong Positive Correlation ◽  
Vertebral Bone ◽  
Indian Patients ◽  
South Indian ◽  
Lateral Cephalograms ◽  
Significant Difference

Abstract Background and aim Determination of skeletal maturity and bone age from cervical vertebrae has been well documented. Most methods described use subjective evaluation of morphological characteristics of cervical vertebrae and may be prone to variability and error. A few objective methods have also been developed, specific for certain populations and genders. The aim of this study was to establish and validate an objective method to determine cervical vertebral bone age from lateral cephalometric radiographs, for Asian South Indian patients of both genders. Methods Ninety boys and 90 girls between 9 and 15 years of age were recruited, and their lateral cephalograms were taken. Using measurements made from the third and fourth cervical vertebrae, a formula to determine cervical vertebral bone age was derived using stepwise regression analysis. To validate the formula, a separate sample of 30 boys and 30 girls was chosen, and hand-wrist radiographs and lateral cephalograms were obtained. Cervical vertebral bone age (CVBA) was determined by applying the formula derived. Bone age was also calculated using the Tanner-Whitehouse 3 method. The bone ages determined by both methods were compared to each other and chronological age, using one-way ANOVA, Tukey’s post hoc analysis, and Pearson’s correlation coefficient. Results The formulae derived in the current study to determine CVBA differed for both genders. No statistically significant difference was found between CVBA, bone age derived by the Tanner-Whitehouse 3 method, and chronological age for both boys (p value = 0.425) and girls (p value = 0.995). A moderate to strong positive correlation was found between CVBA, bone age, and chronological age. Conclusion The formulae derived in this study were validated and are reliable for objectively determining cervical vertebral bone age and skeletal maturation from lateral cephalograms for Asian South Indian patients of both genders.

scholarly journals Objective Evaluation of Cervical Vertebral Bone Age— Its Reliability in Comparison with Hand-Wrist Bone Age: By TW3 Method

2013 ◽  
Vol 14 (5) ◽  
pp. 806-813
Author(s):  
Vamsi Nilay Reddy ◽  
Gojja Sreedevi ◽  
CMS Krishna Prasad ◽  
Swaroopa Rani Ponnada ◽  
K Padma Priya ◽  
...  
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Bone Age ◽  
Objective Evaluation ◽  
Ease Of Use ◽  
Skeletal Maturation ◽  
Potential Growth ◽  
Vertebral Bone ◽  
Therapeutic Decisions ◽  
Lateral Cephalograms

ABSTRACT Aim The aim of this study was to establish the validity of a new method for evaluating skeletal maturation by assessing the 3rd and 4th cervical vertebrae seen in the cephalometric radiograph. Materials and methods This study consisted of a sample of 50 patients in the age group of 8 to 14 years of age. Chronologically, they were divided into six groups, based on the age consisting of a minimum of six to a maximum of 10 subjects. All the patients included in the study were females. The selected subjects were clinically examined and then age and date of birth of the patient in years and months was noted. Then lateral cephalograms and hand-wrist radiographs of the patient were taken on the same day with good clarity and contrast. Results The results suggested that cervical vertebral bone age on cephalometric radiographs calculated with this method is as reliable at estimating bone age as is the Tanner-Whitehouse 3 (TW3) method on hand-wrist radiographs. By determining the cervical vertebral bone age, skeletal maturity can be evaluated in a detailed and objective manner with cephalometric radiographs. Conclusion The ability to accurately appraise skeletal maturity from cervical vertebral maturation, without the need for additional radiographs, has the potential to improve orthodontic diagnostic and therapeutic decisions. The technique's simplicity and ease of use should encourage this method as a first level diagnostic tool to assess skeletal maturation. Clinical significance This study revealed that the timing and sequence of ossification of the bones in hand and wrist and cervical vertebrae were able to relate the skeletal development of the various skeletal maturity indicators to a child's development. This method provided a mean with which one can determine the skeletal maturity of a person and thereby determine whether the possibility of potential growth existed. How to cite this article Prasad CMSK, Reddy VN, Sreedevi G, Ponnada SR, Priya KP, Naik BR. Objective Evaluation of Cervical Vertebral Bone Age—Its Reliability in Comparison with Hand-Wrist Bone Age: By TW3 Method. J Contemp Dent Pract 2013;14(5):806-813.

scholarly journals New formula to objectively evaluate skeletal maturation using lateral cephalometric radiographs

2007 ◽  
Vol 21 (4) ◽  
pp. 330-335 ◽  
Author(s):  
Maria de Paula Caldas ◽  
Gláucia Maria Bovi Ambrosano ◽  
Francisco Haiter Neto
Keyword(s):  
Statistical Difference ◽  
Cervical Vertebrae ◽  
Bone Age ◽  
Dental School ◽  
Skeletal Maturation ◽  
Chronological Age ◽  
Oral Radiology ◽  
Vertebral Bone ◽  
Vertebral Bodies ◽  
New Formula

The aim of this study was to establish two new formulas for objectively evaluating skeletal maturation of cervical vertebrae in female and male Brazilian subjects using lateral cephalometric radiographs. The sample included 128 girls and 110 boys, aged 7.0 to 15.9 years, from the files of the Oral Radiology Clinic, Piracicaba Dental School, University of Campinas (Unicamp), SP, Brazil. The cervical vertebral bodies of C3 and C4 were traced and measured and regression formulas were developed in order to determine cervical vertebral bone age. Another sample of lateral teleradiographs and hand-wrist radiographs of 55 girls and 54 boys (aged 7.0 to 15.9 years) was used to verify the reliability of the developed regression formulas, as compared with bone age assessed using the Tanner et al.15 (2001) Method (TW3) in hand-wrist radiographs. The analysis of both the boys’ and girls’ data (ANOVA) showed no statistical difference between cervical vertebral bone age, bone age, and chronological age, indicating that these formulas can be used in this population (p = 0.5721 and p = 0.6007 for girls and boys, respectively). Female cervical vertebral bodies of C3 and C4 increased in an accelerated manner from 10 to 13 years. Analysis of the male sample showed that C3 measurements increased in an accelerated manner from 12 to 15 years. The C4 measurements, however, did not increase at all. Using cervical vertebral bone age it is possible to evaluate skeletal maturation objectively in cephalometric radiographs.

Assessment of bruise age on dark-skinned individuals using tristimulus colorimetry

2011 ◽  
Vol 52 (1) ◽  
pp. 6-11 ◽  
Author(s):  
D Thavarajah ◽  
P Vanezis ◽  
D Perrett
Keyword(s):  
Objective Assessment ◽  
B Value ◽  
Forensic Analysis ◽  
Control Area ◽  
Sri Lankan ◽  
Colour Difference ◽  
Tristimulus Colorimetry ◽  
South Indian ◽  
Colour Measurements ◽  
Significant Difference

Introduction Studies on the ageing of bruises have been reported on Caucasians or individuals of fair ethnicity. This study focuses on bruise changes in dark-skinned individuals using tristimulus colorimetry for forensic analysis in such individuals. Methods Eighteen subjects of South Indian or Sri-Lankan ethnicity were recruited. Subjects were bruised using a vacuum pump and then daily colour measurements were taken of the bruise using a tristimulus colorimeter. The L* a* b* readings were recorded of a control area and of the bruise until it disappeared. Two Caucasians were used for comparison. Results This study showed that, using colorimetry, bruises on dark-skinned individuals can be measured and analysed even if the bruises are unclear visually. As the bruise is beneath the skin, the colour difference Δ L*, Δ a* and Δ b* were calculated. All values showed a trend, indicating that the L* a* b* measuring technique is a reliable method to analyse bruises on dark-skinned individuals. Comparisons of Asian subjects and Caucasian subjects were performed. The largest difference was seen in the b* value. Statistical analysis showed that Δ L* colour difference was the most consistent (95% CI −4.05 to −2.49) showing a significant difference between days 1–4 and 5–8. Conclusion Objective assessment of bruises on dark-skinned individuals using the L* a* b* method of measuring gave reproducible results. Furthermore, the study showed that the yellowing of a bruise cannot be seen or measured with a tristimulus colorimeter on dark-skinned individuals due to the pigmentation of the skin. With further studies and more subjects, the age of bruises could potentially be assessed for use in forensic analysis.

Prevalence of Upper Cervical Vertebrae Anomalies in Patients with Cleft Lip and/or Palate and Noncleft Patients

2009 ◽  
Vol 46 (5) ◽  
pp. 481-486 ◽  
Author(s):  
Marta Cunha Lima ◽  
Eduardo Jacomino Franco ◽  
Guilherme Janson ◽  
Izabel Maria Marchi Carvalho ◽  
Carlos Ferreira Santos ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cervical Vertebrae ◽  
Sao Paulo ◽  
Posterior Arch ◽  
São Paulo ◽  
Craniofacial Anomalies ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Upper Cervical ◽  
School Of Dentistry

Objectives: To investigate the prevalence of upper cervical vertebrae anomalies in patients with isolated cleft lip, isolated cleft palate, and complete cleft lip and palate, as well as to compare the prevalence of these anomalies between groups, between genders, and with noncleft patients. Design: Retrospective cross-sectional study of randomly selected patients. Setting: Radiology Section, Hospital for Rehabilitation of Craniofacial Anomalies and Department of Orthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil. Participants: The sample comprised 300 lateral cephalograms of cleft patients, aged 12 to 13 years, of both genders, from the files of the Hospital for Rehabilitation of Craniofacial Anomalies–University of São Paulo and 300 lateral cephalograms from noncleft patients of the Department of Orthodontics, Bauru School of Dentistry. Cephalograms of patients with syndromes were not included. Method: Radiographs were interpreted on a film viewer by a single examiner; the profiles of vertebrae were traced on acetate paper, and cervical vertebrae anomalies were registered and categorized into posterior arch deficiencies, fusion, and association of both. Main Outcome Measures: Statistical comparison of groups using the chi-square test. Results: In the cleft group, 38.67% of the patients had cervical vertebrae anomalies. Of those in the noncleft sample, 31% showed anomalies of the cervical spine. This difference was statistically significant. There was no statistically significant difference when the types of clefts were compared with each other or when both genders were compared in both samples. Conclusions: This study confirms the association between clefts and cervical anomalies. Additional research on this topic is necessary.

scholarly journals Evaluation of the degree of fusion of midpalatal suture at various stages of cervical vertebrae maturation

2019 ◽  
Vol 9 ◽  
pp. 235-240
Author(s):  
Khyati Narula ◽  
Siddarth Shetty ◽  
Nandita Shenoy ◽  
N. Srikant
Keyword(s):  
Cervical Vertebrae ◽  
Skeletal Age ◽  
Kappa Statistics ◽  
Kendall’S Tau ◽  
Kendall's Tau ◽  
Midpalatal Suture ◽  
Rapid Palatal Expansion ◽  
South Indian ◽  
Lateral Cephalograms ◽  
B Test

Introduction: Rapid palatal expansion was initially done during circumpubertal age. However, the correct evidence suggests visualizing the patency of midpalatal suture (MPS) radiologically at different chronological age as there can be early or late fusion of suture in some cases. Objective: This study was aimed at assessing the fusion of MPS at different stages of cervical vertebrae maturation and to find any correlation between them from the patients of two South Indian districts. Design and Setting: A total of 144 subjects aged 10–20 years were included in our study. Materials and Methods: Skeletal age based on cervical vertebrae was assessed from lateral cephalograms. MPS staging was done by two observers using cone-beam computed tomography at 2-time intervals. Inter- and intra- examiner reliability for suture staging was analyzed by kappa statistics. Correlation of skeletal age to sutural maturation was done using Kendall’s tau-b test. Results: A fair agreement was obtained by kappa test for inter (0.313) and intraexaminer reliability (0.219 for first and 0.451 for the second observer) for 144 subjects. Kendall’s tau-b test showed a significant correlation between skeletal age and suture maturation, with the maximum association between CS 4 skeletal age and Stage C of MPS, with P < 0.001. Conclusion: A strong correlation was found between skeletal age and sutural fusion. Predominantly, Stage C coincided with CS 4 with greater gender predilection toward females.

scholarly journals Cephalometric Comparison of Wits Appraisal and APP-BPP to the ANB Angle

2020 ◽  
Vol 10 (1) ◽  
pp. 40-43
Author(s):  
Sanzee Silwal ◽  
Rabindra Man Shrestha ◽  
Ujjwal Pyakurel ◽  
Sanjeev Bhandari
Keyword(s):  
Treatment Planning ◽  
Descriptive Statistics ◽  
Diagnosis And Treatment ◽  
Strong Positive Correlation ◽  
Mean Values ◽  
Positive Correlation ◽  
Skeletal Class ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Gender Groups

Introduction: Great emphasis has been given to the evaluation of sagittal apical base relationship in orthodontic diagnosis and treatment planning. Supposedly, the most commonly used parameter is “ANB angle”; however its accuracy and reliability have been questioned. Many authors have alternatively introduced linear parameters like Wits appraisal and APP-BPP. The objective of the study was to compare Wits appraisal and APP-BPP with the ANB angle. Materials & Method: This study was conducted on patients visiting the Department of Orthodontics, Kantipur Dental College, Kathmandu. The sample included 100 lateral cephalograms of subjects of the age group 18–30 years with skeletal Class I relation. Parameters like ANB angle, Wits appraisal and APP-BPP were measured to assess the sagittal jaw relationship. Descriptive statistics were calculated for each parameter. Spearman’s test was done to evaluate the correlation between the parameters. Mann-Whitney U test was done to compare the parameters between male and female subjects. Result: Descriptive statistics showed that the mean values of ANB, Wits appraisal and APP-BPP were 2.26±1.19°, 0.38±0.87mm and 3.25±1.20mm respectively. Mann-Whitney U test showed no significant difference among the parameters between the gender groups (p>0.05). Spearman’s test showed significant correlation among the parameters ANB angle, Wits appraisal and APP-BPP. The parameters had strong positive correlation as r value was greater than 0.7. Conclusion: The strong positive correlation between ANB angle, Wits appraisal and APP-BPP indicates that these parameters can be used as better adjunct to ANB angle in orthodontic diagnosis and treatment planning.

scholarly journals Correlation between chronological age and skeletal age using CVMI and modified MP3 methods

2020 ◽  
Vol 16 (12) ◽  
pp. 1045-1050
Author(s):  
Ravindra Kumar Jain ◽  
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Skeletal Age ◽  
Chronological Age ◽  
Accurate Estimation ◽  
P Value ◽  
Positive Correlation ◽  
Lateral Cephalograms ◽  
Rough Approximation ◽  
Method R

Chronological age conveys only a rough approximation of the maturational status of a person whereas skeletal maturity indicators give a more accurate estimation. Therefore, it is of interest to document the correlation between chronological and skeletal age using CVMI and modified MP3 methods. A total of 39 subjects between the age ranges of 9-16 years were selected for this study. Pre-treatment lateral cephalograms and hand-wrist radiographs of the subjects were used. The skeletal age was analyzed by the Cervical Vertebrae Maturity Index (CVMI) and modified MP3 methods. The data was analyzed with SPSS software version 23.00. Kendall’s Tau correlation test was performed to estimate the correlation between chronological age and skeletal age among the subjects and a linear regression test was also performed. Positive correlation was found between chronological age and skeletal age assessed by CVMI method (r= 0.398) and modified MP3 method (r=0.382) with p value <0.003. Thus it can be concluded that there was a positive correlation between chronological age and skeletal age among all the subjects.

scholarly journals Position of the Hyoid Bone in Anteroposterior Skeletal Patterns

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Rabia Bilal
Keyword(s):  
Hyoid Bone ◽  
Cervical Vertebrae ◽  
Multiple Comparisons ◽  
Growth Patterns ◽  
Class Iii ◽  
Linear Measurements ◽  
Pharyngeal Airway ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
The Relationship

Introduction. Hyoid bone plays a vital role in the craniofacial dynamics. From the maintenance of pharyngeal airway to phonation, deglutition, and mandibular movements, it has multifactorial roles to fulfill. The hyoid bone has a spatial relationship with cranial base, mandible, and cervical vertebrae. This study was performed to determine the position of the hyoid bone in different anteroposterior growth patterns. Materials and Methods. 75 lateral cephalograms belonging to all three sagittal skeletal patterns were evaluated in the study. The angular and linear measurements using 10 variables were made to determine the relationship of the hyoid bone with different craniofacial structures. SPSS was used to calculate the descriptive statistics, mean, and standard deviation of all the linear and angular variables. The analysis of variance (ANOVA) and post hoc test were used to compare the means of linear and angular measurement and multiple comparisons, respectively, at p < 0.05 significance level. Results. There was no significant difference in the mean angular measurements (NSH and MPH) between the 3 groups ( p > 0.05 ). Also, the multiple comparisons showed no significant difference between the linear measurements (H-FH, H-MP, H-H′, and H-N). However, there was a significant difference in three linear measurements: H-Rgn, RGN-C3, and C3-H. The values were more in class III subjects, compared to class I and class II. Conclusion. The linear millimetric distance between points H-RGN, RGN-C3, and C3-H which determine the relationship and spatial position of the hyoid bone with the mandible and third cervical vertebrae was statistically significant among groups. The values were more in class III subjects inferring the anterior position of the hyoid bone.

The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy

2020 ◽  
Vol 33 (1) ◽  
pp. 113-120
Author(s):  
Nursel Muratoglu Sahin ◽  
Havva Nur Peltek Kendirci ◽  
Semra Çetinkaya ◽  
Şenay Savaş Erdeve ◽  
Zehra Aycan
Keyword(s):  
Growth Velocity ◽  
Standard Deviation Score ◽  
Central Precocious Puberty ◽  
Bone Age ◽  
Chronological Age ◽  
Gnrh Analogue ◽  
Pubertal Stage ◽  
Ovarian Volume ◽  
Significant Difference ◽  
High Level

AbstractBackgroundSome studies have examined the effect of gonadal suppression on insulin-like growth factor-1 (IGF-1) levels and the growth velocity (GV) with conflicting results.MethodsForty-four girls treated with gonadotropin-releasing hormone analogue (GnRHa) for central precocious puberty (CPP) were included in the study. IGF-1 levels were examined at the beginning and after 12 months of treatment.ResultsIGF-1 and IGF-1 standard deviation score (SDS) according to chronological age (CA-IGF-1 SDS) at diagnosis were positively correlated with chronological age (CA), anthropometric measurements, stage of puberty, bone age (BA), BA-CA, follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, uterus length, endometrium thickness and ovarian volume (OV) at diagnosis (p < 0.05). There was no significant difference in IGF-1 levels after treatment. However, there was a negative correlation between ΔIGF-1 SDS and IGF-1 level, CA-IGF-1 SDS and BA-IGF-1 SDS at diagnosis (p < 0.05). There was no correlation between GV and IGF-1, ΔIGF-1. GV was negatively correlated with basal LH level at diagnosis (p = 0.008, r = −0.397). Peak LH levels of the patients who had GV-SDS < 0 were more suppressive than those of the patients who had GV-SDS > 0 after 12 months of treatment.ConclusionsIt was determined that the IGF-1 level and CA-IGF-1 SDS at baseline were correlated with more advanced pubertal stage prior to treatment. Initiation of treatment with a relatively high level of IGF-1 increased the risk of a decrease in the IGF-1 level. Likewise, the initiation of treatment with a relatively high LH level may increase the risk of low GV, but low GV was not related to the IGF-1 level. Increased sex steroid suppression may increase the risk of low GV.

scholarly journals Evaluation and development of a bone age assessment method in patients with Down syndrome

2013 ◽  
Vol 10 (2) ◽  
pp. 41-45
Author(s):  
Michelle BM BM ◽  
Mari Eli LM ◽  
Fernando VR ◽  
Simone MRG ◽  
Déborah H
Keyword(s):  
Down Syndrome ◽  
Bone Age ◽  
Assessment Method ◽  
Control Group ◽  
Age Assessment ◽  
Male And Female ◽  
Vertebral Bone ◽  
Significant Difference ◽  
Bone Age Assessment ◽  
Female Control

The objective of this paper was to evaluate the applicability of the method developed by Caldas to measure the vertebral bone age of Brazilians suffering from Down syndrome. A database comprised of 57 case records of individuals with this syndrome, both male and female, with ages ranging between 5 and 18 years, was used for this purpose. These records had lateral cephalometric radiographs and radiographs of hand and wrist, all of which had been obtained on the same date. There were 48 other records of individuals who did not suffer from Down syndrome. The Tanner and Whitehouse (TW3) method was used to perform the hand and wrist radiographs for obtaining bone age. The Caldas method was employed on the lateral cephalometric radiographs in order to obtain the vertebral bone age. From the information acquired on bone age, vertebral bone age and chronological age, it could be concluded that there is a statistically significant difference between the three ages for both the male and the female control group and for the female Down syndrome group. Therefore, this method was employed only on male Down syndrome individuals. Based on the results, a formula was developed to obtain the bone age for Down syndrome individuals.

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