scholarly journals Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Samantha L. Fousse ◽  
William D. Tyrrell ◽  
Mariellen E. Dentino ◽  
Frances L. Abrams ◽  
Steven L. Rosenthal ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pedigree Analysis ◽  
Dominant Mode ◽  
Future Research ◽  
Phenotype Data ◽  
High Prevalence ◽  
High Heritability ◽  
Environmental Causes ◽  
Genetic Contributions ◽  
Mode Of Inheritance

Abstract Background Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices. Results There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8 years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50–0.86). The pedigree was consistent with a dominant mode of inheritance. Conclusion Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted.

Gender-Based Violence Among HIV-Positive Women in Kazakhstan: Prevalence, Types, and Associated Risk and Protective Factors

2017 ◽  
Vol 24 (13) ◽  
pp. 1570-1590 ◽  
Author(s):  
Tina Jiwatram-Negrón ◽  
Nabila El-Bassel ◽  
Sholpan Primbetova ◽  
Assel Terlikbayeva
Keyword(s):  
Protective Factors ◽  
Partner Violence ◽  
Risk And Protective Factors ◽  
Future Research ◽  
Hiv Positive ◽  
Gender Based Violence ◽  
Hiv Positive Women ◽  
High Prevalence ◽  
Gender Based ◽  
Partner Gender

This article examines the prevalence and associated multilevel risk and protective factors of intimate and nonintimate partner violence among a sample of 249 HIV-positive women in Kazakhstan. We found high prevalence of both lifetime intimate partner violence (52%) and nonintimate partner violence (30%). Together, nearly 60% experienced at least one incident of violence by either an intimate or nonintimate partner (gender-based violence [GBV]). In the multivariate analyses, we found associations between several individual, interpersonal, and socio-structural risk factors and GBV. Findings provide direction for practice, policy, and future research to address the intersection of GBV and HIV in Kazakhstan.

scholarly journals Prevalence of musculoskeletal injuries among adolescent squash players in the Western Cape

2009 ◽  
Vol 19 (1) ◽  
pp. 3 ◽  
Author(s):  
L Meyer ◽  
L Van Niekerk ◽  
E Prinsloo ◽  
M Steenkamp ◽  
Q Louw
Keyword(s):  
High School ◽  
Sports Medicine ◽  
Traumatic Injury ◽  
Musculoskeletal Injuries ◽  
Future Research ◽  
Western Cape ◽  
Research Areas ◽  
Experienced Pain ◽  
High Prevalence ◽  
Descriptive Survey

Objective. To determine the prevalence of musculoskeletal injuries among adolescent squash players in the Western Cape. Design. A retrospective descriptive survey was conducted during the first week of May 2006. Three schools were randomly selected from a list of the top 10 schools in the Western Cape high school squash league of 2005, with 106 squash players aged 13 - 18 years participating in the study. Setting. Injury data were collected for 106 players at three schools randomly selected from a list of the top 10 schools in the Western Cape high school squash league of 2005. Interventions. An adapted structured self-administered questionnaire based on a previously validated musculoskeletal injury questionnaire was used to collect the data. Main outcome measures. The main variables investigated were prevalence, mechanism and injury site of musculoskeletal squash injuries. Results. Twenty-nine per cent of the players (N = 31) reported that they had sustained a squash injury in the 4 weeks prior to data collection. A total of 48 injuries were reported by the injured players. The most common injuries included those of the thigh (19%), shoulder (13%) and lower back (13%). Forty-two per cent of players reported no specific mechanism of injury, but experienced pain not associated with a traumatic injury only while playing squash. Conclusion. A relatively high prevalence of squash injuries was found. This preliminary study serves as a baseline for future research. Areas for further investigation were identified and this could lead to the implementation of preventive programmes and education to prevent injuries among adolescent squash players. South African Journal of Sports Medicine Vol. 19 (1) 2007: pp. 3-8

scholarly journals Autistic-Like Features in Visually Impaired Children: A Review of Literature and Directions for Future Research

2020 ◽  
Vol 10 (8) ◽  
pp. 507 ◽  
Author(s):  
Anna Molinaro ◽  
Serena Micheletti ◽  
Andrea Rossi ◽  
Filippo Gitti ◽  
Jessica Galli ◽  
...  
Keyword(s):  
Visually Impaired ◽  
Autism Spectrum ◽  
Future Research ◽  
Clinical Impression ◽  
Blind And Visually Impaired ◽  
Current State ◽  
High Prevalence ◽  
The Relationship ◽  
Impaired Children ◽  
Visually Impaired Children

There remains great interest in understanding the relationship between visual impairment (VI) and autism spectrum disorder (ASD) due to the extraordinarily high prevalence of ASD in blind and visually impaired children. The broad variability across individuals and assessment methodologies have made it difficult to understand whether autistic-like symptoms shown by some children with VI might reflect the influence of the visual deficit, or represent a primary neurodevelopmental condition that occurs independently of the VI itself. In the absence of a valid methodology adapted for the visually impaired population, diagnosis of ASD in children with VI is often based on non-objective clinical impression, with inconclusive prevalence data. In this review, we discuss the current state of knowledge and suggest directions for future research.

scholarly journals The May-Hegglin Anomaly: Platelet Function, Ultrastructure and Chromosome Studies

Blood ◽  
1968 ◽  
Vol 32 (6) ◽  
pp. 950-961 ◽  
Author(s):  
JEANNE M. LUSHER ◽  
JOHN SCHNEIDER ◽  
I. MIZUKAMI ◽  
RUTH K. EVANS
Keyword(s):  
Platelet Function ◽  
Autosomal Dominant ◽  
Dominant Mode ◽  
Bleeding Tendency ◽  
Function Defect ◽  
Father And Son ◽  
Mode Of Inheritance

Abstract A father and son with the May-Hegglin anomaly were studied. Both were asymptomatic, although the father had a mild thrombocytopenia and a probable platelet thromboplastic function defect. Possible mechanisms for the bleeding tendency observed in approximately one-fourth of the persons with this anomaly are discussed. The autosomal dominant mode of inheritance is again demonstrated, and both father and son were found to have normal chromosomes.

Self-Directed Approaches to the Treatment of Depression

2016 ◽  
pp. 468-477
Author(s):  
Pim Cuijpers ◽  
Annet Kleiboer
Keyword(s):  
Depressive Disorders ◽  
Future Research ◽  
Evidence Based ◽  
Advantages And Disadvantages ◽  
Self Help ◽  
Treatment Of Depression ◽  
High Prevalence ◽  
Evidence Based Treatments ◽  
The Common

This article examines self-directed approaches to the treatment of depression. It first considers some of the reasons why the uptake of mental health services by depressed people is low, despite the high prevalence of depressive disorders and the availability of evidence-based treatments. It then looks at the role of self-management in increasing access to evidence-based treatments for depression. It also defines what self-directed treatments are and goes on to discuss the different types of self-directed therapy, the common components of self-directed interventions for depression, Internet-based interventions for depression, and the advantages and disadvantages of self-directed interventions. Finally, it summarizes the findings from research on self-directed interventions for depression and suggests directions for future research and development in this area. Some titles of self-help books that can be used in self-directed interventions are presented.

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