scholarly journals A case series of post COVID-19 mucormycosis—a neurological prospective

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Tamer Roushdy ◽  
Eman Hamid
Keyword(s):  
Sinus Thrombosis ◽  
Case Series ◽  
Tertiary Hospital ◽  
Delayed Presentation ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Current Case ◽  
Case Presentation ◽  
First Case ◽  
Uncontrolled Diabetes

Abstract Background Direct neurological manifestations of coronavirus disease whether peripheral or central are reported worldwide. Yet, along the 3rd wave of the pandemic especially in India, an associated angioinvasive opportunistic infection with mucormycosis in COVID-19 cases is emerging. Case presentation The current case series which represents 4 patients with mucormycosis post COVID-19 is one of a few if not the first case series that discusses post COVID-19 mucormycosis from a neurological prospective in a tertiary hospital in Egypt. All cases but one presented with total ophthalmoplegia, and only one was diagnosed as a cavernous sinus thrombosis; meanwhile, orbital cellulitis and orbital apex syndrome were responsible of ophthalmoplegia in two cases. Mortality reached 25%, and the case that died suffered cutaneous as well as rhino-cerebral type with a delayed presentation to hospital. Conclusion A rare but fatal fungal infection is ought to be nowadays kept in mind in COVID-19 active cases as well as in recovered COVID-19 patients, especially those who have comorbid medical conditions as uncontrolled diabetes and who were treated with large doses of corticosteroids.

Hazardous complications of animate foreign bodies in otology practice

2015 ◽  
Vol 129 (6) ◽  
pp. 540-543 ◽  
Author(s):  
K Sikka ◽  
R Agrawal ◽  
K Devraja ◽  
J V Lodha ◽  
A Thakar
Keyword(s):  
Foreign Bodies ◽  
Sinus Thrombosis ◽  
Complete Recovery ◽  
Sigmoid Sinus ◽  
Emergency Setting ◽  
Delayed Presentation ◽  
Cavernous Sinus Thrombosis ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
History Of

AbstractBackground:Animate foreign bodies in the ear are frequent occurrences in otology practice. Such foreign bodies may lead to hazardous complications.Method:This paper describes a retrospective study of six patients with a recent history of an insect in the ear who presented with various complications following intervention received elsewhere.Results:An insect was retrieved from the external auditory canal in four cases and from the antrum in two cases. The patients presented with progressive otological complications: two patients who presented with orbital apex syndrome and cavernous sinus thrombosis succumbed to the disease; three patients suffered sensorineural hearing loss; and two patients had persistent facial palsy. One patient with sigmoid sinus thrombosis, who presented early, experienced complete recovery.Conclusion:Insects in the ear can lead to hazardous complications. Animate foreign bodies should preferably be managed by a trained otologist, even in an emergency setting. Patients with delayed presentation and complications have a guarded prognosis.

scholarly journals Orbital apex syndrome affecting head and neck cancer patients: A case series

2017 ◽  
pp. 0-0
Author(s):  
AC Prado-Ribeiro ◽  
AC Luiz ◽  
MA. Montezuma ◽  
MP Mak ◽  
AR Santos-Silva ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Case Series ◽  
Orbital Apex ◽  
Orbital Apex Syndrome

Orbital Apex Syndrome: A Case Series and Review of the Literature

2014 ◽  
Vol 72 (9) ◽  
pp. e27-e28
Author(s):  
R.E. Warburton ◽  
C. C. Dicus Brookes ◽  
T.A. Turvey
Keyword(s):  
Case Series ◽  
Review Of The Literature ◽  
Orbital Apex ◽  
Orbital Apex Syndrome

scholarly journals Orbital apex syndrome with frontal abscess secondary to sinusitis due to Candida guilliermondii

2021 ◽  
Vol 3 (2) ◽  
pp. 133-138
Author(s):  
Muhd-Syafi Abd Bari ◽  
Mas Edi ◽  
Hudzaifah Nordin ◽  
Rosdan Salim ◽  
Zamzuri Idris ◽  
...  
Keyword(s):  
Immunocompromised Patient ◽  
Opportunistic Pathogen ◽  
Candida Guilliermondii ◽  
Intracranial Extension ◽  
Fungal Sinusitis ◽  
Team Management ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Case Presentation ◽  
Invasive Fungal Sinusitis

Candida guilliermondii is an opportunistic pathogen that rarely causes invasive candidiasis even in immunocompromised humans. We report a case presentation of invasive C. guilliermondii rhinosinusitis causing an orbital and intracranial extension (frontal lobe abscess). An aggressive multidisciplinary team management is a key approach in invasive fungal sinusitis and avoided mortality in this case. When orbital apex syndrome secondary to sinusitis is encountered in an immunocompromised patient, the treating physician should consider fungal infection as a causative agent.

scholarly journals Trichorionic Triamniotic Triplets After Single Embryo Transfer: A Case Series and Literature Review

2018 ◽  
Vol 7 (3) ◽  
pp. 408-411
Author(s):  
Isao Takehara ◽  
Toshifumi Takahashi ◽  
Kuniaki Ota ◽  
Nobuhiko Ohta ◽  
Hideki Mizunuma ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Fetal Heart ◽  
Hormone Replacement ◽  
Case Series ◽  
Single Embryo Transfer ◽  
Heart Beat ◽  
Assisted Hatching ◽  
Triplet Pregnancy ◽  
Case Presentation ◽  
First Case

Objectives: Monozygotic triplet pregnancy very rarely occurs in assisted reproductive technology (ART) treatment. The present study reported two cases of trichorionic triplet pregnancies after single embryo transfer (SET) and reviewed the literature in this regard. Case Presentation: In the first case, a 29-year-old female underwent the long protocol using gonadotropin-releasing hormone analogue and one full blastocyst was transferred in a fresh cycle. At 6 gestational weeks, three gestational sacs were clearly observed, while only one fetus with fetal heart beat was found after one week. In the second case, a 39-year-old female underwent intracytoplasmic sperm injection treatment and seven embryos were frozen accordingly. After assisted hatching, one completely expanded blastocyst was transferred during a hormone replacement cycle. Three gestational sacs with three yolk sacs were observed at 6 gestational weeks. Finally, two fetuses with fetal heart beat were found after one week. Conclusions: Overall, although the developmental mechanisms of monozygotic triplets are unknown, clinicians should be aware of the possibility of multiple pregnancies under SET.

Clinical Characteristics of Elizabethkingia meningoseptica Ophthalmic infections

2020 ◽  
Author(s):  
KAI CHING PETER LEUNG ◽  
TAK CHUEN SIMON KO
Keyword(s):  
Risk Factors ◽  
Contact Lens ◽  
Ocular Surface ◽  
Treatment Duration ◽  
Case Series ◽  
Tertiary Hospital ◽  
Surface Barrier ◽  
Ocular Prosthesis ◽  
First Case ◽  
Elizabethkingia Meningoseptica

Abstract Background: Elizabethkingia is a Gram-negative, obligate aerobic, oxidase positive bacillus that is known to cause a variety of nosocomial infections and has emerged as an important pathogen because of multiple anti-microbial resistance. We present the first case series of Elizabethkingia ophthalmic infections, with specific emphasis on its clinical spectrum, risk factors, treatment and outcome.Method: Microbiological specimens growing Elizabethkingia were reviewed retrospectively at a regional tertiary hospital from 2005-2019. Clinical manifestation, risk factors, treatment including types of antibiotics, treatment duration and clinical outcome were documented. Results: Ten cases of culture positive Elizabethkingia ophthalmic infection were identified, which all cultured E. meningoseptica. Four cases of keratitis, three cases of conjunctivitis, two cases of blepharitis and one case of blepharitis-conjunctivitis were observed. Four cases were found to be associated with contact lens use and were discovered to colonize E. meningoseptica. One case of blepharitis was associated with an ocular prosthesis (scleral shell) in an eviscerated eye. Fluoroquinolone and chloramphenicol were most commonly used topical antibiotics for treatment. The mean treatment duration for all infections were averaged at 6.5 weeks. Conclusion: E. meningoseptica is the predominant species that causes ophthalmological related Elizabethkingia infections and is found most frequently manifested on the ocular surface. Contact lens use and ocular prosthesis appears to be a risk factor for infection due to ocular surface barrier disruption and bacteria colonization. Combination of fluroquinolone and chloramphenicol is a safe and effective treatment against Elizabethkingia ocular infections. Further studies are required to determine the susceptibility of commonly used topical anti-microbial agents to Elizabethkingia species.

scholarly journals Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?

2018 ◽  
Vol 5 (10) ◽  
Author(s):  
Ling-Hong Zhou ◽  
Xuan Wang ◽  
Rui-Ying Wang ◽  
Hua-Zhen Zhao ◽  
Ying-Kui Jiang ◽  
...  
Keyword(s):  
Treatment Options ◽  
Tertiary Hospital ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Fungal Rhinosinusitis ◽  
Significant Difference ◽  
Clinical Considerations ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive

Abstract Background Chronic and granulomatous invasive fungal rhinosinusitis are important causes of blindness and craniocerebral complications. However, the classification of these 2 diseases remains controversial. Methods We retrospectively analyzed patients with chronic and granulomatous invasive fungal rhinosinusitus in a Chinese tertiary hospital from 2009 to 2017, with a focus on classification and comparisons. Results Among 55 patients enrolled in our study, 11 (11/55, 20%) had granulomatous invasive fungal rhinosinusitis (GIFRS) and 44 (44/55, 80%) had chronic invasive fungal rhinosinusitis (CIFRS). Aspergillus fumigatus and Dematiaceous hyphomycetes were identified in 2 patients with GIFRS. Compared with granulomatous type, CIFRS was more frequently encountered in immunocompromised patients (P = .022), and the time from onset to diagnosis was much shorter (P = .001). Proptosis and orbital apex syndrome showed no significant difference between granulomatous and CIFRS in our study. The treatment options and prognosis of both diseases also showed no significant difference. Conclusions Despite the consensus on histopathology, the classification of the chronic and granulomatous types may need further evaluation in clinical considerations.

scholarly journals Covid associated orbital apex syndrome: Madras ENT Research Foundation experience

2021 ◽  
Vol 7 (9) ◽  
pp. 1513
Author(s):  
Manjunatha H. Anandappa ◽  
Sunil Mathews ◽  
Kiran Natarajan ◽  
Raghunandhan S. ◽  
Mohan Kameswaran
Keyword(s):  
Elderly Patients ◽  
Relevant Literature ◽  
Case Series ◽  
Healthy Individuals ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Timely Manner ◽  
Management Protocol ◽  
Life Threatening ◽  
Second Wave

<p class="abstract">The second wave of corona virus pandemic is currently raging through India since last few weeks. Since last year, COVID-19 has brought in a multitude of challenging manifestations in the ENT regions. One such rare and complex entity is OAS (orbital apex syndrome). This case series highlighted our experience in 2020 with managing two such cases of OAS associated with COVID-19 infection. Their clinical and radiological presentation was discussed and their management protocol was explained with references from relevant literature. Although elderly patients with co-morbidities were considered to have highest risk for COVID-19 associated neurologic and ophthalmic complications earlier, now it was found to affect younger healthy individuals as noted in our cases. Knowledge about such virulent complications of COVID-19 is essential for otolaryngologists, to manage this life-threatening entity in a timely manner.</p>

scholarly journals Case Series of Irritated Giant Acrochordons Arising from Skin Folds

2021 ◽  
Vol 9 (C) ◽  
pp. 304-307
Author(s):  
Fiedyawati Kusuma ◽  
Jemie Rudyan
Keyword(s):  
Case Series ◽  
Skin Surface ◽  
Pain Sensation ◽  
Case Presentation ◽  
Endocrine Disorder ◽  
Short Stalk ◽  
First Case ◽  
Skin Fold ◽  
The Right ◽  
Oval Shape

BACKGROUND: Acrochordons are pedunculated papules or nodules with a soft consistency and smooth contour, sometimes apparently growths often hang on thin stalk, with the most acrochordons size was 2–5 mm. Occasionally, due to frictions of the pedicle, acrochordon can become inflamed, tender, and even gangrenous. CASE PRESENTATION: We report a case series of three giant acrochordons, first case, 19-year-old female come to my OPD clinic with a big mass on her left vagina, with pain and hot while being touched, and fever. On examination big nodule on the right labia mayor was found, with diameter 20 × 20 cm, short stalk, firm, warmed, and pain sensation while touched, with several excoriated skin surface. Second case, 23-year-old female presented in my OPD with a mass in her left vagina, associated with pain and several bleeding spots while being touched, with diameter of 5 × 5 cm. Third case, 31-year-old female consulted to OPD clinic with a year of history having a mass on her right buttock, which gradually increases in size and causing a light pain. On examination, short pedunculated nodule was found at the right buttock, diameter 10 × 6 cm, oval shape, firm, and several excoriated plaques. All cases were diagnosed as giant acrochordons and were performed excision. The previous studies state that the larger lesions of acrochordons in the groin or upper thighs maybe associated with diabetes mellitus and obese individuals. Due to the twisting or strangulated of the pedicle, all three cases of giant acrochordons become inflamed, tender, irritated, infarction, and even gangrenous. In general, it was advised to have the acrochordons removed, particularly in the skin fold of axillae, groin, or vagina, since they will gradually develop in size. CONCLUSION: Giant acrochordons usually relate to the growth hormone like activity. Hence, they may associate with endocrine disorder. It may occasionally become inflamed, tender, and even gangrenous due to frictions. General principle is to have the acrochordons removed, particularly in skin fold area.

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