Review on Tablet in Tablet techniques

Abstract Background Among all available dosage form, tablet is most widely used because of its stability and patient acceptability. The better aesthetic quality like color, texture, mouth feel, and taste masking depended on film and sugar coatings, so the coating is an important part in the formulation of the tablet. The present work aims to comprehensively review the formulation, characterization, and challenges in the development of Tablet in Tablet dosage form. Main text Film and sugar coatings have the number of disadvantages; most important one is the utilization of aqueous or organic solvent that leads to toxicity. To overcome this problem in the year 1896, Noyes firstly introduced the compression coating or Tablet in Tablet technique. In the development of Tablet in Tablet dosage form, substantial attention among researchers and various research reports and patents inputs can be found in the literature. Also, we focused on the recent advancements in techniques like one-step dry-coating (OSDrC®) for manufacturing Tablet in Tablet dosage form. Conclusion The current review gathered information on the latest patent, formulation, advantages, and disadvantages of Tablet in Tablet or compression coating. The review also elaborates on the importance of Tablet in Tablet techniques in the development of a modified release system. Graphical abstract

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Spectrophotometric Determination of Some Angiotensin Converting Enzyme Inhibitors By Potassium Dichromate and Potassium Permanganate in Tablet Dosage Form

Asian Journal of Biomedical and Pharmaceutical Sciences ◽

10.15272/ajbps.v4i39.642 ◽

2014 ◽

Vol 4 (39) ◽

pp. 16-24 ◽

Cited By ~ 2

Author(s):

Horria A. Mohamed

Keyword(s):

Angiotensin Converting Enzyme ◽

Potassium Permanganate ◽

Dosage Form ◽

Enzyme Inhibitors ◽

Potassium Dichromate ◽

Angiotensin Converting Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Tablet Dosage

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Novel UV Spectrophotometric Method for the Quantitative Analysis of CefpodoximeProxetil in Pharmaceutical Formulations by First Derivative Technique

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.v8i03.9577 ◽

2017 ◽

Vol 8 (03) ◽

Author(s):

Potdar S. S. ◽

Karajgi S. R. ◽

Simpi C. C. ◽

Kalyane N. V.

Keyword(s):

Quantitative Analysis ◽

Spectrophotometric Method ◽

Dosage Form ◽

Pharmaceutical Formulations ◽

First Derivative ◽

Good Linearity ◽

Beer's Law ◽

Beer’S Law ◽

Tablet Dosage ◽

Ich Guideline

The spectrophotometric method for estimation of CefpodoximeProxetil employed first derivative amplitude UV spectrophotometric method for analysis using methanol as solvent for the drug. CefpodoximeProxetil has absorbance maxima at 235nm and obeys Beer’s law in concentration range 10-50µg/ml with good linearity i.e. r2 about 0.999. The recovery studies established accuracy of the proposed method; result validated according to ICH guideline. Results were found satisfactory and reproducible. The method was successfully for evaluation of CefpodoximeProxetil in tablet dosage form without interference of common excipients.

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Principles of masking organoleptic properties of bitter tasting medicines

10.33920/med-13-2001-02 ◽

2020 ◽

pp. 25-32

Author(s):

Mariya Anurova ◽

Elena Bakhrushina ◽

Anna Moiseyeva ◽

Ivan Krasnyuk

Keyword(s):

Nervous System ◽

Patient Compliance ◽

Dosage Form ◽

Bitter Taste ◽

Drug Uptake ◽

Taste Masking ◽

Pure Substance ◽

High Concentration ◽

Organoleptic Properties ◽

Gel Composition

Patient compliance of drug therapy is the key factor in achieving the pharmaceutical effect. Taste masking is particularly important in pediatrics and geriatrics because the unpleasant taste negatively affects drug uptake. Patient compliance can be improved through balanced organoleptic properties of medicines. It is particularly important to choose optimal correction method for medicines with high concentration of the active substance. Hopantenic acid has been chosen as a model drug due to its bitter taste. Taste masking technologies for creating a new dosage form with optimal organoleptic properties are proposed in the article. The objective is to achieve an experimentally justified choice of technological approach to masking bitter taste of a substance and to create a new dosage form on its basis. Materials and methods. Alternative technologies were considered to solve this problem: granulation, creation of complexes with ion-exchange resins, introduction of a gel composition and taste-masking using sweeteners. Organoleptic properties in dry compositions (pure substance of hopantenic acid, granulate and resinate based on it), and also after preparation of liquid dosage forms and incorporation them into gel, were evaluated by A. I. Tentsova method. Choice of sweetener and its concentration to achieve an optimally balanced taste took place at the final stage. Hopantenic acid was chosen as a model substance. Hopantenic acid is a nootropic drug stimulating cognitive functions, nervous system, enhancing intellectual functioning, decreasing nervous system activity, with anticonvulsant action. The main therapeutic indications are mental retardation, dementia, epilepsy. Results and discussion. The study has shown that optimal technology for masking unpleasant taste of hopantenic acid is its introduction into a gel composition, and a promising dosage form is an oral gel. Compri-Zucker G sweetener (Südzucker АG, Germany) in concentration of 5 % has been chosen to create pleasant taste due to its highest taste rating. Conclusion. It has been determined as a result of the study that oral gel with active drug concentration of 5 % and sweetener concentration of 5 % has optimal organoleptic properties. Thus, this combination of active and additional substances can be considered the most perspective for developing a new dosage form of a medicine.

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