scholarly journals Effect of acute kidney injury on weaning from mechanical ventilation in chronic obstructive pulmonary diseases patients with respiratory failure

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ahmed Gouda El-Gazzar ◽  
Mahmoud Mohamad El-Salahy ◽  
Tarek Samy Essway ◽  
Samar Nasef Mohammed ◽  
Marwa Elsayed Elnaggar
Keyword(s):  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Respiratory Failure ◽  
Kidney Injury ◽  
Pulmonary Diseases ◽  
Chronic Obstructive ◽  
Weaning From Mechanical Ventilation ◽  
Chronic Obstructive Pulmonary Diseases

scholarly journals Hyperuricaemia as a predictor of hospital outcome in patients with sepsis: results of a prospective study

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Mir Nadeem ◽  
Bilal Ahmad Mir ◽  
Mir Waseem ◽  
Tabinda Ayub Shah ◽  
Rameez Raja
Keyword(s):  
Emergency Department ◽  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Uric Acid ◽  
Respiratory Failure ◽  
Serum Uric Acid ◽  
Kidney Injury ◽  
Study Cohort ◽  
Early Management ◽  
Hospital Outcome

Abstract Background Early management of sepsis in the emergency department improves patient outcomes. The identification of at-risk patients for aggressive management by an easily available biomarker could go a long way in the triage of patients in the emergency department. It is postulated that during sepsis, the majority of patients undergo ischaemic reperfusion injury or inflammation, and uric acid with its oxidant and antioxidant properties may be playing some role and, hence, the measurement of uric acid could possibly predict the hospital course in patients with sepsis. We were prompted to undertake this study as serum uric acid estimation is readily available and economical compared to newly evolving biomarkers in sepsis. Estimation of serum uric acid levels on arrival to the emergency department may prove a useful predictor of hospital outcome in patients with sepsis especially in regions with limited resources. Results Of 102 patients, 55 (53.9%) were males. The mean age of the study cohort was 63.2 ± 10.48. Patients with higher qSOFA scores had higher uric acid levels on admission. While 12 (11.8%) patients had a septicaemic shock, acute kidney injury was recorded in 48 (47.1%) patients and 11 (10.8%) patients required dialysis. Thirty-four (33.3%) patients had respiratory failure, and of these, 21 (20.6%) patients required mechanical ventilation. The overall median stay in the medical intensive care (MICU) was 3days (range 2–7 days). The patients with higher uric acid levels had higher rates of respiratory failure but did not reach significant levels. In 15 (14.7%) patients, 7 males expired (mortality rate of 14.7%). There was a significant association between SOFA score and mortality. Patients who succumbed to sepsis had higher serum uric acid levels on arrival. Conclusions Patients with higher qSOFA scores had higher uric acid levels on admission. Hyperuricaemia predicted acute kidney injury, a requirement of mechanical ventilation and mean hospital stay in patients with sepsis. Further studies may be required to confirm the association.

scholarly journals Developing a Differential Zone for Virus Disease Prevention using Phytoterapy

2020 ◽  
Author(s):  
Aleksandra Alekseevna Mukhina
Keyword(s):  
Respiratory Failure ◽  
Disease Prevention ◽  
Chronic Bronchitis ◽  
Respiratory System ◽  
Virus Disease ◽  
Pulmonary Diseases ◽  
Modern World ◽  
Chronic Obstructive ◽  
Airway Patency ◽  
Chronic Obstructive Pulmonary Diseases

Pulmonology is a branch of medicine that treats diseases of the respiratory system. An important problem in the modern world is chronic obstructive pulmonary diseases: bronchial asthma, emphysema, chronic bronchitis, including obstructive and others. This group of diseases with a transient or permanent violation of airway patency with the development and further progression of respiratory failure.

Effect of acute kidney injury on weaning from mechanical ventilation in critically ill patients*

2007 ◽  
Vol 35 (1) ◽  
pp. 184-191 ◽  
Author(s):  
José M. Vieira ◽  
Isac Castro ◽  
Américo Curvello-Neto ◽  
Sérgio Demarzo ◽  
Pedro Caruso ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Kidney Injury ◽  
Weaning From Mechanical Ventilation

scholarly journals Inhaled Nitric Oxide via High-Flow Nasal Cannula in Patients with Acute Respiratory Failure Related to COVID-19

2021 ◽  
Vol 15 ◽  
pp. 117954842110470
Author(s):  
Abhimanyu Chandel ◽  
Saloni Patolia ◽  
Kareem Ahmad ◽  
Shambhu Aryal ◽  
A Whitney Brown ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Respiratory Failure ◽  
Length Of Stay ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Kidney Injury ◽  
High Flow ◽  
High Flow Nasal Cannula

INTRODUCTION Limited evidence exists regarding use of inhaled nitric oxide (iNO) in spontaneously breathing patients. We evaluated the effectiveness of continuous iNO via high-flow nasal cannula (HFNC) in COVID-19 respiratory failure. METHODS We performed a multicenter cohort study of patients with respiratory failure from COVID-19 managed with HFNC. Patients were stratified by administration of iNO via HFNC. Regression analysis was used to compare the need for mechanical ventilation and secondary endpoints including hospital mortality, length of stay, acute kidney injury, need for renal replacement therapy, and need for extracorporeal life support. RESULTS A total of 272 patients were identified and 66 (24.3%) of these patients received iNO via HFNC for a median of 88 h (interquartile range: 44, 135). After 12 h of iNO, supplemental oxygen requirement was unchanged or increased in 52.7% of patients. Twenty-nine (43.9%) patients treated with iNO compared to 79 (38.3%) patients without iNO therapy required endotracheal intubation ( P = .47). After multivariable adjustment, there was no difference in need for mechanical ventilation between groups (odds ratio: 1.53; 95% confidence interval [CI]: 0.74-3.17), however, iNO administration was associated with longer hospital length of stay (incidence rate ratio: 1.41; 95% CI: 1.31-1.51). No difference was found for mortality, acute kidney injury, need for renal replacement therapy, or need for extracorporeal life support. CONCLUSION In patients with COVID-19 respiratory failure, iNO delivered via HFNC did not reduce oxygen requirements in the majority of patients or improve clinical outcomes. Given the observed association with increased length of stay, judicious selection of those likely to benefit from this therapy is warranted.

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