The Expectation of Outcome from Maintenance Therapy in Chronic Schizophrenic Patients

SummaryThe results from a prospective follow-up study of a group of schizophrenic patients suggest that a significant proportion (41 per cent) are likely to relapse during a two-year period despite the prescription of long-acting injectable neuroleptic drugs. Some will relapse because of a failure of the regime, but others (32–37 per cent) because the pharmacological protection of these drugs would appear to be less effective in certain patients. Even with the major advantages of the long-acting injectable neuroleptics over oral medication, the schizophrenic patient population remains a group with a high incidence of psychiatric and social morbidity which continues to require the full resources of both the hospital and community services.

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Schizophrenic Patients Discharged from Hospital—A Follow-up Study

The British Journal of Psychiatry ◽

10.1192/bjp.145.6.586 ◽

1984 ◽

Vol 145 (6) ◽

pp. 586-590 ◽

Cited By ~ 54

Author(s):

Eve C. Johnstone ◽

David G. C. Owens ◽

Aviva Gold ◽

Timothy J. Crow ◽

J. Fiona Macmillan

Keyword(s):

Social Services ◽

Hospital Care ◽

Mental Hospital ◽

Mental States ◽

Community Services ◽

Follow Up Study ◽

Financial Difficulties ◽

Schizophrenic Patients ◽

Psychotic Features

SummaryA cohort of 120 patients, comprising all those who met the St Louis criteria for a diagnosis of schizophrenia, discharged from a mental hospital over a five-year period, were followed-up in the community after an interval of five to nine years; 105 were traced and 94 were alive. Of those, 66 were living in UK, out of hospital, and willing to be seen. Their mental states, and social functioning and circumstances were assessed by interview with the patients and those with whom they lived; 18% had recovered to the extent that they had no significant symptoms and appeared to function satisfactorily. More than 50% had definite psychotic features. No patients and few relatives sought a return to hospital care, but severe emotional, social, and financial difficulties were commonplace; 27% of the sample had no contact with medical or social services, a further 14% saw only community nurses, and 24% only their general practitioners. The findings emphasise the limitations of community services in dealing with the chronicity and severity of the impairments resulting from schizophrenic illness.

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Ten-Year Follow-Up of 100 Patients Admitted to a Mental Hospital

Canadian Psychiatric Association Journal ◽

10.1177/070674377201700605 ◽

1972 ◽

Vol 17 (6) ◽

pp. 429-432

Author(s):

Charles H. Cahn

Keyword(s):

Drug Therapy ◽

Maintenance Therapy ◽

Mental Hospital ◽

Government Support ◽

Follow Up Study ◽

Hospital Beds ◽

Schizophrenic Patients ◽

Organic Psychoses ◽

One Year

A ten-year follow-up study of 100 patients admitted consecutively to a mental hospital revealed the following information. The patients used the hospital beds for an average of one year and two months of the ten years, that is, about. one-eighth of the time. The co-operative schizophrenic patients could be kept out of hospital with proper maintenance therapy. Patients admitted with organic psychoses died after an average of one and three-quarter years. Of the ‘functional’ cases nearly a half were alive after ten years, 8 were dead (2 or 3 suicides) and the rest could not be traced. The patients had an average of 23 physicians but this large number does not appear to have harmed them. Nearly all patients had some drug therapy, the two most frequently prescribed categories being neuroleptics and antidepressants. About half the patients had occupational and work therapy. The condition of the 68 survivors was considered to be: ‘recovered’ or ‘much improved’ in 55 per cent; ‘moderately or slightly improved’ in 40 per cent and ‘unimproved or worse’ in 3 per cent. Their last known vocational status was ‘working or self-sufficient’ in 34 per cent, ‘dependent’ upon relatives or government support in 43 per cent and not known in 23 per cent.

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Current Perspectives on Neonatal Screening for Propionic Acidemia in Japan: An Unexpectedly High Incidence of Patients with Mild Disease Caused by a Common PCCB Variant

International Journal of Neonatal Screening ◽

10.3390/ijns7030035 ◽

2021 ◽

Vol 7 (3) ◽

pp. 35

Author(s):

Go Tajima ◽

Reiko Kagawa ◽

Fumiaki Sakura ◽

Akari Nakamura-Utsunomiya ◽

Keiichi Hara ◽

...

Keyword(s):

Neonatal Screening ◽

Acid Metabolism ◽

Neonatal Period ◽

Propionic Acidemia ◽

Cardiac Complications ◽

Mild Disease ◽

Follow Up Study ◽

Organic Acid Metabolism ◽

High Incidence

Propionic acidemia (PA) is a disorder of organic acid metabolism which typically presents with acute encephalopathy-like symptoms associated with metabolic acidosis and hyperammonemia during the neonatal period. The estimated incidence of symptomatic PA in Japan is 1/400,000. The introduction of neonatal screening using tandem mass spectrometry has revealed a far higher disease frequency of approximately 1/45,000 live births due to a prevalent variant of c.1304T>C (p.Y435C) in PCCB, which codes β-subunit of propionyl-CoA carboxylase. Our questionnaire-based follow-up study reveals that most of these patients remain asymptomatic. However, reports on symptomatic patients exhibiting cardiac complications such as cardiomyopathy and QT prolongation have been increasing. Moreover, there were even cases in which these cardiac complications were the only symptoms related to PA. A currently ongoing study is investigating the risk of cardiac complications in patients with neonatal screening-detected PA caused by this common variant.

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PAROXYSMAL TACHYCARDIA IN INFANCY: FOLLOW-UP STUDY OF 47 SUBJECTS RANGING IN AGE FROM 10 TO 26 YEARS

PEDIATRICS ◽

10.1542/peds.51.1.26 ◽

1973 ◽

Vol 51 (1) ◽

pp. 26-35

Author(s):

Åke Lundberg

Keyword(s):

Physical Education ◽

Maintenance Therapy ◽

Physical Working Capacity ◽

Working Capacity ◽

Paroxysmal Tachycardia ◽

Follow Up Study ◽

The Past ◽

Triggering Factor

A follow-up study of 47 individuals with paroxysmal tachycardia in infancy is reported. The incidence of recurrence decreases from 55% during infancy to 17% up to 10 years of age; a slight increase to 23% is then observed in adolescence. There is a higher incidence of paroxysm in cases with preexcitation in the ECG. Physical overexertion may be a triggering factor in recurrences, but exemption from school physical education and sports should only be granted exceptionally. No signs of reduced physical working capacity were found in this group. The results of maintenance therapy do not appear to have improved in the past decade.

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High incidence of vertebral and non-vertebral fractures in the OSTRA cohort study: a 5-year follow-up study in postmenopausal women with rheumatoid arthritis

Osteoporosis International ◽

10.1007/s00198-010-1517-6 ◽

2011 ◽

Vol 22 (9) ◽

pp. 2413-2419 ◽

Cited By ~ 42

Author(s):

M. Vis ◽

E. A. Haavardsholm ◽

P. Bøyesen ◽

G. Haugeberg ◽

T. Uhlig ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Postmenopausal Women ◽

Vertebral Fractures ◽

Follow Up Study ◽

High Incidence

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Progression of Periodontitis in a Sample of Regular and Irregular Compliers Under Maintenance Therapy: A 3-Year Follow-Up Study

Journal of Periodontology ◽

10.1902/jop.2011.100664 ◽

2011 ◽

Vol 82 (9) ◽

pp. 1279-1287 ◽

Cited By ~ 28

Author(s):

Fernando Oliveira Costa ◽

Luís Otávio Miranda Cota ◽

Eugênio José Pereira Lages ◽

Telma Campos Medeiros Lorentz ◽

Alcione Maria Soares Dutra Oliveira ◽

...

Keyword(s):

Maintenance Therapy ◽

Follow Up Study

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Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update

Blood ◽

10.1182/blood.v62.2.315.315 ◽

1983 ◽

Vol 62 (2) ◽

pp. 315-319 ◽

Cited By ~ 189

Author(s):

HJ Weinstein ◽

RJ Mayer ◽

DS Rosenthal ◽

FS Coral ◽

BM Camitta ◽

...

Keyword(s):

Complete Remission ◽

Maintenance Therapy ◽

Induction Chemotherapy ◽

Acute Myelogenous Leukemia ◽

Myelogenous Leukemia ◽

Kaplan Meier ◽

High Incidence ◽

Acute Myelogenous ◽

Leukemia In Children

Abstract We designed a protocol (VAPA) that featured 14 mo of intensive postremission induction chemotherapy in an effort to improve remission durations for patients with acute myelogenous leukemia (AML). One hundred and seven patients under 50 yr of age were entered into this study. The rate of complete remission is 70%. A Kaplan-Meier analysis of patients entering remission predicts that 56% +/- 7% (+/-SE) of patients less than 18 yr and 45% +/- 9% of patients aged 18–50 yr will remain in remission at 3 yr (median follow-up is 43 mo). Patients with the monocytic subtype had a statistically significant shorter duration of remission (2-sided p less than 0.05). There was a high incidence of primary CNS relapse in children. Thirty-one of 41 patients who completed the regimen remain in remission without maintenance therapy. We conclude that the VAPA protocol continues to offer a promising approach to treatment of AML.

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A Long-term Retrospective Follow-up Study of Patients Treated with Prophylactic Lithium Carbonate

The British Journal of Psychiatry ◽

10.1192/bjp.150.2.175 ◽

1987 ◽

Vol 150 (2) ◽

pp. 175-179 ◽

Cited By ~ 45

Author(s):

C. Page ◽

S. Benaim ◽

F. Lappin

Keyword(s):

Side Effects ◽

Complete Remission ◽

Lithium Carbonate ◽

Favourable Outcome ◽

Lithium Level ◽

Follow Up Study ◽

High Incidence ◽

Average Serum

Patients suffering from unipolar and bipolar affective illness, who began treatment with prophylactic lithium carbonate during a 5-year period, were followed up and 59 out of 101 interviewed. Most had been taking lithium for at least 13 years: 49% had a complete remission, 41% a partial but significant response, and 10% no response. No specific individual or illness factor was found to correlate with favourable outcome, and no correlation between average serum lithium level and outcome. No side-effects could be associated specifically with the long-term use of lithium, but there was a surprisingly high incidence of clinical hypothyroidism.

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