scholarly journals Smoking habits and plasma lipid peroxide and vitamin E levels in never-treated first-episode patients with schizophrenia

2000 ◽  
Vol 176 (3) ◽  
pp. 290-293 ◽  
Keyword(s):  
Body Mass Index ◽  
Lipid Peroxidation ◽  
Vitamin E ◽  
Body Mass ◽  
Smoking Status ◽  
Serum Vitamin ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
First Episode ◽  
Plasma Lipid Peroxide

BackgroundLipid peroxidation may be increased in schizophrenia, due to the illness, lifestyle or medication.AimsTo determine plasma lipid peroxide levels and serum vitamin E and A levels in first-episode never-treated people with schizophrenia and in controls.MethodThirty in-patients with a first episode of schizophrenia or schizophreniform psychosis were recruited, as were controls matched for gender, age, smoking and dietary status. Blood samples were taken, smoking status was recorded and body mass index measured.ResultsThere were no significant differences between patients and controls in plasma lipid peroxide levels. Seventy-three per cent of the patients smoked. Patients who smoked had a higher mean lipid peroxide level than non-smokers. Seventy-seven per cent of patients and 70% of controls had a ratio of vitamin Eto cholesterol of less than 5. Body mass index was lower in patients than in controls.ConclusionsAs a result of the high prevalence of smoking this group shows increased lipid peroxidation. Low serum ratios of vitamin Eto cholesterol in both patients and controls suggest an unsatisfactory diet.

The Nithsdale Schizophrenia Surveys. XIV: Plasma Lipid Peroxide and Serum Vitamin E Levels in Patients with and Without Tardive Dyskinesia, and in Normal Subjects

1995 ◽  
Vol 167 (5) ◽  
pp. 610-617 ◽  
Author(s):  
Robin G. McCreadie ◽  
Elizabeth MacDonald ◽  
David Wiles ◽  
Graham Campbell ◽  
John R. Paterson
Keyword(s):  
Free Radical ◽  
Vitamin E ◽  
Tardive Dyskinesia ◽  
Serum Vitamin ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
Normal Subjects ◽  
Free Radical Damage ◽  
Plasma Lipid Peroxide ◽  
Radical Damage

BackgroundTardive dyskinesia (TD) may be mediated through free radical damage to neurons. Plasma lipid peroxide levels are a measure of radical damage to fats. Vitamin E is a free radical scavenger.MethodOne hundred and twenty-eight schizophrenic patients were examined for TD using the Abnormal Involuntary Movements Scale. Blood samples were taken to measure plasma lipid peroxide, serum vitamin E and cholesterol, and vitamin Exholesterol ratios. Twenty-four patients were also examined in October 1993, January 1994, and April 1994. Biochemical results were compared in 81 patients and 79 normal subjects.ResultsPatients with and without TD did not differ in median plasma lipid peroxide and serum vitamin E levels, or vitamin Exholesterol ratios. Correlations between seasonal change scores in TD and biochemical measurements were low. Lipid peroxide levels were higher and vitamin Exholesterol ratios lower in patients than in normal subjects. Vitamin E levels were lowest in in-patients and in those living in supported accommodation.ConclusionsThe results do not support the hypothesis that TD is mediated through free radical damage to neurons, but suggest increased free radical activity in schizophrenia.

Plasma lipid peroxide and serum vitamin E levels in subjects taking antipsychotic drugs

1996 ◽  
Vol 10 (4) ◽  
pp. 295-297
Author(s):  
R.G. McCreadie ◽  
J. Halliday ◽  
T. MacEwan ◽  
D. Hinselwood ◽  
G. Campbell ◽  
...  
Keyword(s):  
Vitamin E ◽  
Antipsychotic Drugs ◽  
Serum Vitamin ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
Plasma Lipid Peroxide

Increased Lipid Peroxidation in Serum and Low-Density Lipoproteins Associated with Aging in Humans

2002 ◽  
Vol 72 (5) ◽  
pp. 315-320 ◽  
Author(s):  
Jale Balkan ◽  
Öznur Kanbagli ◽  
Güldal Mehmetçik ◽  
Ümit Mutlu-Türkoglu ◽  
Gülçin Aykaç-Toker ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Ldl Cholesterol ◽  
Serum Vitamin ◽  
Lipid Peroxide ◽  
Low Density Lipoproteins ◽  
Elderly Subjects ◽  
Low Density ◽  
Diene Conjugates ◽  
Diene Conjugate

This study was carried out in 140 healthy subjects who were divided into three subgroups of age: young (21–40 years), mature (41–60 years), and elderly ( 61–85 years) to investigate lipid peroxides and the antioxidant system in serum and low-density lipoproteins (LDL). Serum levels of cholesterol and LDL-cholesterol increased with age. The elderly group was found to have higher polyunsaturated fatty acid (PUFA) levels, thiobarbituric acid reactive substances (TBARS), diene conjugates, and lower cholesterol-adjusted vitamin E levels and antioxidant activity (AOA) as compared to the young group. No age-related difference was detected in serum vitamin C levels. Age correlated positively with serum cholesterol, LDL-cholesterol, PUFA, TBARS, diene conjugates, and negatively with cholesterol-adjusted vitamin E levels and AOA. In addition, endogenous LDL diene conjugate levels and the susceptibility of LDL to copper-induced lipid peroxidation increased in elderly subjects as compared with young subjects. In addition, positive correlations were detected between age and LDL endogenous diene conjugate levels and TBARS formation after copper incubation. However, the susceptibility of whole serum to copper-induced lipid peroxidation did not change in young and elderly subjects. Our results show that endogenous lipid peroxide levels in serum and LDL, and the susceptibility of LDL to copper-induced oxidation, increased with aging in humans.

The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community

2005 ◽  
Vol 15 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Kaori Ohmori ◽  
Satoru Ebihara ◽  
Shinichi Kuriyama ◽  
Takashi Ugajin ◽  
Mikiko Ogata ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lipid Peroxidation ◽  
Body Mass ◽  
Plasma Lipid ◽  
Asian Community ◽  
Plasma Lipid Peroxidation ◽  
The Relationship

The Association Between Obstructive Sleep Apnea and Cotton-Wool Spots in Nonproliferative Diabetic Retinopathy

2021 ◽  
pp. 247412642198957
Author(s):  
Halward M.J. Blegen ◽  
Grant A. Justin ◽  
Bradley A. Bishop ◽  
Anthony R. Cox ◽  
James K. Aden ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Obstructive Sleep Apnea ◽  
Diabetic Retinopathy ◽  
Sleep Apnea ◽  
Body Mass ◽  
Smoking Status ◽  
Cotton Wool ◽  
Nonproliferative Diabetic Retinopathy ◽  
Cotton Wool Spots ◽  
Obstructive Sleep

Purpose: This work reports the association of obstructive sleep apnea (OSA) and cotton-wool spots (CWS) seen in patients with nonproliferative diabetic retinopathy (DR). Methods: A random sample of patients diagnosed with DR between January 1, 2015 and December 31, 2018, were selected from medical-billing codes. Dilated funduscopic examination findings and medical history were analyzed by reviewing medical records. Results: CWS were present in 12 of 118 patients without OSA, compared with 11 of 32 patients with OSA (10.2% vs 34.4%, respectively; P = .002). OSA was more common in men (68.8%, P = .03) and associated with a higher body mass index (30.0 ± 5.0 without OSA vs 33.6 ± 5.5 with OSA, P < .001). When comparing those with and without OSA, there was no association with age; glycated hemoglobin A1c; stage of DR; insulin dependence; presence of diabetic macular edema; smoking status; or a history of hypertension, hyperlipidemia, cardiovascular disease, or other breathing disorder. Conclusions: The presence of OSA is associated with CWS in patients with DR, as well as male sex and a higher body mass index. Further research is needed to determine the ophthalmologist’s role in the timely referral of patients with CWS for OSA evaluation.

scholarly journals Pregnancy outcomes related to gestational weight gain in women defined by their body mass index, parity, height, and smoking status

2009 ◽  
Vol 90 (5) ◽  
pp. 1288-1294 ◽  
Author(s):  
Ellen A Nohr ◽  
Michael Vaeth ◽  
Jennifer L Baker ◽  
Thorkild IA Sørensen ◽  
Jorn Olsen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Body Mass ◽  
Pregnancy Outcomes ◽  
Smoking Status ◽  
Gestational Weight
Sign in / Sign up

Export Citation Format

Share Document