scholarly journals Guidelines for the prevention and treatment of benzodiazepine dependence

1993 ◽  
Vol 17 (9) ◽  
pp. 556-557
Author(s):  
Richard Pether

The Substance Misuse Committee of the Mental Health Foundation has produced a booklet called Guidelines for the Prevention and Treatment of Benzodiazepine Dependence. The problem addressed is twofold: encouraging and managing withdrawal, and preventing new cases of dependence. There is no room for complacency because although prescriptions for anxiolytics have halved over the past ten years, prescriptions for hypnotics are unchanged – now twice the number for anxiolytics. The average GP can expect to have about 50 long-term benzodiazepine users on his or her list. The long-term safety of these drugs is uncertain and there are side effects, e.g. memory impairment, ataxia and falls in the elderly, and road traffic accidents.

2017 ◽  
Vol 10 (10) ◽  
pp. 608-613 ◽  
Author(s):  
Jayran Mistry ◽  
Nicola Murray

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Falls, assaults and road traffic accidents are the most common causes, with alcohol precipitating 65% of adult cases. The incidence of TBI is highest in men. As the UK population ages, however, the incidence of TBI in the elderly is rising. Approximately 1 million people affected in the UK have long-term sequelae, and GPs should be aware of the common causes and consequences of TBI. This article will focus primarily on mild TBI in adults.


2013 ◽  
Vol 141 (7) ◽  
pp. 1437-1444 ◽  
Author(s):  
P. J. ATKINS ◽  
P. A. ROBINSON

SUMMARYThe European badger (Meles meles) has been identified as a wildlife reservoir of bovine tuberculosis and a source of transmission to cattle in Britain and Ireland. Both behavioural ecology and statistical ecological modelling have indicated the long-term persistence of the disease in some badger communities, and this is postulated to account for the high incidence of bovine tuberculosis in cattle across large tracts of England and Wales. This paper questions this consensus by using historical cartographic evidence to show that tuberculosis in cattle had a very different spatial distribution before 1960 to the present day. Since few of the badgers collected in road traffic accidents between 1972 and 1990 had tuberculosis in counties such as Cheshire, where the disease had until shortly before that been rife in the cattle population, the role of badgers as reservoirs in spreading disease in similar counties outside the south-west of England has to be questioned.


Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Shernan G. Holtan ◽  
Marcelo Pasquini ◽  
Daniel J. Weisdorf

Abstract Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need.


2010 ◽  
Vol 2 (3) ◽  
pp. 60-66
Author(s):  
Nemunas Abukauskas ◽  
Egidijus Skrodenis

The results of lengthy thorough investigations into traffic safety situation show that the percentage of pedestrians getting involved in road traffic accidents on Lithuanian roads is significantly higher (more than 33 % of the total number of injury and fatal accidents) than that compared to the other European Union member-states. The article studies traffic safety problems and their factors causing the largest influence on the occurrence of these accidents. Considering valuable experience gained by foreign countries, investigation was carried out to establish general and main factors causing insufficient road safety conditions and significance of these factors to road safety. The article also shows the main activity improving road safety in Lithuania and discusses the effectiveness of strategic and local (temporary and long term) measures to improve conditions for pedestrian road safety.


2002 ◽  
Vol 54 (3) ◽  
pp. 205-231 ◽  
Author(s):  
Joseph E. Gaugler ◽  
Robert L. Kane ◽  
Rosalie A. Kane

Family care of the elderly is key to the long-term care system, and its importance has led to an abundance of research over the past two decades. Several methodological and substantive issues, if addressed, could create even more targeted and interpretable research. The present review critically examines methodological topics (i.e., definitions of family caregiving, measurement of caregiving inputs) and conceptual issues (i.e., family involvement in long-term residential settings, and the care receiver's perspective on care) that have received insufficient attention in the caregiving literature. Throughout this review recommendations are offered to improve these areas and advance the state of the art.


2015 ◽  
Vol 61 (3) ◽  
pp. 489-493 ◽  
Author(s):  
H. Etehad ◽  
Sh. Yousefzadeh-Chabok ◽  
A. Davoudi-Kiakalaye ◽  
Dehnadi A. Moghadam ◽  
H. Hemati ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Denise Jochems ◽  
Eveline van Rein ◽  
Menco Niemeijer ◽  
Mark van Heijl ◽  
Michael A. van Es ◽  
...  

AbstractTraumatic brain injury (TBI) is a leading cause of death and disability. Epidemiology seems to be changing. TBIs are increasingly caused by falls amongst elderly, whilst we see less polytrauma due to road traffic accidents (RTA). Data on epidemiology is essential to target prevention strategies. A nationwide retrospective cohort study was conducted. The Dutch National Trauma Database was used to identify all patients over 17 years old who were admitted to a hospital with moderate and severe TBI (AIS ≥ 3) in the Netherlands from January 2015 until December 2017. Subgroup analyses were done for the elderly and polytrauma patients. 12,295 patients were included in this study. The incidence of moderate and severe TBI was 30/100.000 person-years, 13% of whom died. Median age was 65 years and falls were the most common trauma mechanism, followed by RTAs. Amongst elderly, RTAs consisted mostly of bicycle accidents. Mortality rates were higher for elderly (18%) and polytrauma patients (24%). In this national database more elderly patients who most often sustained the injury due to a fall or an RTA were seen. Bicycle accidents were very frequent, suggesting prevention could be an important aspect in order to decrease morbidity and mortality.


Author(s):  
Niranjan Tadvi

<p class="abstract"><strong>Background:</strong> Complex proximal humerus fractures are common injuries are common just because of high incidence of road traffic accidents and old age population. The aim of this study was to evaluate the functional outcome in hemi-replacement in complex 3and 4 part of proximal humerus fracture.</p><p class="abstract"><strong>Methods:</strong> This prospective study was conducted in the Department of Orthopaedics, Sir. T. Hospital, Bhavnagar from August 2010 to April 2014. Out of 30 patients 27 turned up for follow up 3 was lost. Functional and clinical assessments using the age and gender specific Constant-Murley score.<strong></strong></p><p class="abstract"><strong>Results:</strong> Excellent to good outcome as per Constant-Murley score was seen in 16 patients, moderate outcome in 8 patients and poor outcome in 3 patients.</p><p class="abstract"><strong>Conclusions:</strong> To spare proximal humerus in younger patients there should be do osteosynthesis procedure with every effort. In the elderly, especially with more complex four-part fractures and fracture dislocations, hemiarthroplasty and reverse total shoulder arthroplasty are specified to decrease complication rates and improve functional outcomes.</p>


2017 ◽  
Vol 99 (8) ◽  
pp. 637-640 ◽  
Author(s):  
P Singh ◽  
M Khatib ◽  
A Elfaki ◽  
N Hachach-Haram ◽  
E Singh ◽  
...  

Introduction Pretibial lacerations are common injuries, often presenting in the elderly and infirm. Unclear management pathways often result in inappropriate care. We identify patient demographics, morbidity risk factors, injury severity and management options. Materials and methods This retrospective study involved analysing databases and hardcopy notes for patients admitted with pretibial lacerations to Addenbrooke’s Hospital, January to December 2012. Microsoft Excel and Fishers exact test were used to analyse the data with a P-value of less than 0.05 representative of statistical significance. Information on patient demographics, site of lesion, preoperative symptoms, management, operative details and clinical outcomes were collected. Results A total of 36 patients were identified; the mean age was 79 years (± 16 years, 1 standard deviation) with a three to two female to male preponderance; 57% of injuries were caused by mechanical fall, 33% traumatic blunt impact and 7% road traffic accidents. American Society of Anesthesiologists physical status classification was 43% level III, 40% II, 9% I and 9% IV. Dunkin classification of severity was 33% grade III, 30% grade I, 24% grade IV and 12% grade II. Median inpatient duration was 11 days for surgically managed compared with 15 days for conservatively managed patients. Discussion Pretibial lacerations tend to affect the elderly. Management is compounded by polypharmacy and comorbidities. If inadequately managed, such injuries can adopt characteristics of chronic wounds, with lengthy inpatient stays. Surgical intervention may be appropriate where injuries are severe and the patient stable enough for theatre. Conclusions We believe that surgical management with autologous tissue repair, with minimal delay between presentation and theatre, is warranted for extensive injuries wherever possible, with conservative management used for predominantly less extensive pretibial lacerations.


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