scholarly journals College of American Pathologists Cancer Protocols: From Optimizing Cancer Patient Care to Facilitating Interoperable Reporting and Downstream Data Use

2021 ◽  
pp. 47-55
Author(s):  
Vanda F. Torous ◽  
Ross W. Simpson ◽  
Jyoti P. Balani ◽  
Alexander S. Baras ◽  
Michael A. Berman ◽  
...  

The College of American Pathologists Cancer Protocols have offered guidance to pathologists for standard cancer pathology reporting for more than 35 years. The adoption of computer readable versions of these protocols by electronic health record and laboratory information system (LIS) vendors has provided a mechanism for pathologists to report within their LIS workflow, in addition to enabling standardized structured data capture and reporting to downstream consumers of these data such as the cancer surveillance community. This paper reviews the history of the Cancer Protocols and electronic Cancer Checklists, outlines the current use of these critically important cancer case reporting tools, and examines future directions, including plans to help improve the integration of the Cancer Protocols into clinical, public health, research, and other workflows.

2021 ◽  
pp. 263208432110612
Author(s):  
Joseph Grant Brazeal ◽  
Alexander V Alekseyenko ◽  
Hong Li ◽  
Mario Fugal ◽  
Katie Kirchoff ◽  
...  

Objective We evaluate data agreement between an electronic health record (EHR) sample abstracted by automated characterization with a standard abstracted by manual review. Study Design and Setting We obtain data for an epidemiology cohort study using standard manual abstraction of the EHR and automated identification of the same patients using a structured algorithm to query the EHR. Summary measures of agreement (e.g., Cohen’s kappa) are reported for 12 variables commonly used in epidemiological studies. Results Best agreement between abstraction methods is observed among demographic characteristics such as age, sex, and race, and for positive history of disease. Poor agreement is found in missing data and negative history, suggesting potential impact for researchers using automated EHR characterization. EHR data quality depends upon providers, who may be influenced by both institutional and federal government documentation guidelines. Conclusion Automated EHR abstraction discrepancies may decrease power and increase bias; therefore, caution is warranted when selecting variables from EHRs for epidemiological study using an automated characterization approach. Validation of automated methods must also continue to advance in sophistication with other technologies, such as machine learning and natural language processing, to extract non-structured data from the EHR, for application to EHR characterization for clinical epidemiology.


2020 ◽  
Vol 48 (3-4) ◽  
pp. 13-26
Author(s):  
Brandon W. Hawk

Literature written in England between about 500 and 1100 CE attests to a wide range of traditions, although it is clear that Christian sources were the most influential. Biblical apocrypha feature prominently across this corpus of literature, as early English authors clearly relied on a range of extra-biblical texts and traditions related to works under the umbrella of what have been called “Old Testament Pseudepigrapha” and “New Testament/Christian Apocrypha." While scholars of pseudepigrapha and apocrypha have long trained their eyes upon literature from the first few centuries of early Judaism and early Christianity, the medieval period has much to offer. This article presents a survey of significant developments and key threads in the history of scholarship on apocrypha in early medieval England. My purpose is not to offer a comprehensive bibliography, but to highlight major studies that have focused on the transmission of specific apocrypha, contributed to knowledge about medieval uses of apocrypha, and shaped the field from the nineteenth century up to the present. Bringing together major publications on the subject presents a striking picture of the state of the field as well as future directions.


Author(s):  
Leah R. Warner ◽  
Stephanie A. Shields

Intersectionality theory concerns the interdependence of systems of inequality and implications for psychological research. Social identities cannot be studied independently of one another nor separately from the societal processes that maintain inequality. In this chapter we provide a brief overview of the history of intersectionality theory and then address how intersectionality theory challenges the way psychological theories typically conceive of the person, as well as the methods of data gathering and analysis customarily used by many psychologists. We specifically address two concerns often expressed by feminist researchers. First, how to reconcile the use of an intersectionality framework with currently-valued psychological science practices. Second, how intersectionality transforms psychology’s concern with individual experience by shifting the focus to the individual’s position within sociostructural frameworks and their social and political underpinnings. In a concluding section we identify two future directions for intersectionality theory: how psychological research on intersectionality can facilitate social activism, and current developments in intersectionality theory.


Author(s):  
Daniel Massoth

When technology is used for assessment in music, certain considerations can affect the validity, reliability, and depth of analysis. This chapter explores factors that are present in the three phases of the assessment process: recognition, analysis, and display of assessment of a musical performance. Each phase has inherent challenges embedded within internal and external factors. The goal here is not to provide an exhaustive analysis of any or all aspects of assessment but, rather, to present the rationale for and history of using technology in music assessment and to examine the philosophical and practical considerations. A discussion of possible future directions of product research and development concludes the chapter.


Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 185
Author(s):  
Adrian S. Monthony ◽  
Serena R. Page ◽  
Mohsen Hesami ◽  
Andrew Maxwell P. Jones

The recent legalization of Cannabis sativa L. in many regions has revealed a need for effective propagation and biotechnologies for the species. Micropropagation affords researchers and producers methods to rapidly propagate insect-/disease-/virus-free clonal plants and store germplasm and forms the basis for other biotechnologies. Despite this need, research in the area is limited due to the long history of prohibitions and restrictions. Existing literature has multiple limitations: many publications use hemp as a proxy for drug-type Cannabis when it is well established that there is significant genotype specificity; studies using drug-type cultivars are predominantly optimized using a single cultivar; most protocols have not been replicated by independent groups, and some attempts demonstrate a lack of reproducibility across genotypes. Due to culture decline and other problems, the multiplication phase of micropropagation (Stage 2) has not been fully developed in many reports. This review will provide a brief background on the history and botany of Cannabis as well as a comprehensive and critical summary of Cannabis tissue culture. Special attention will be paid to current challenges faced by researchers, the limitations of existing Cannabis micropropagation studies, and recent developments and future directions of Cannabis tissue culture technologies.


1987 ◽  
Vol 18 (2) ◽  
pp. 235-249 ◽  
Author(s):  
Karl L. Hutterer

The purpose of the present essay is not to present a history of Philippine archaeology; several preliminary attempts have been made in this regard which may be consulted. Rather, the aim of this paper is to pause for a moment and look across the landscape of Philippine archaeology to assess what has been accomplished to date, to ponder strength and weaknesses of the field at this time, and to consider future directions. Nevertheless, the shape of any landscape is the result of historical events and processes that need to be taken into account if we want to understand its present form and assess its future potential and development. Thus, it will be necessary to include in the following thoughts historical perspectives which will help to explain how and why certain concepts, methods and research practices arose in the context of Philippine archaeology and came to determine our picture of Philippine prehistory.


2017 ◽  
Vol 5 ◽  
Author(s):  
Kathleen S. Romanowski ◽  
Tina L. Palmieri

Abstract Burn injury is a leading cause of unintentional death and injury in children, with the majority being minor (less than 10%). However, a significant number of children sustain burns greater than 15% total body surface area (TBSA), leading to the initiation of the systemic inflammatory response syndrome. These patients require IV fluid resuscitation to prevent burn shock and death. Prompt resuscitation is critical in pediatric patients due to their small circulating blood volumes. Delays in resuscitation can result in increased complications and increased mortality. The basic principles of resuscitation are the same in adults and children, with several key differences. The unique physiologic needs of children must be adequately addressed during resuscitation to optimize outcomes. In this review, we will discuss the history of fluid resuscitation, current resuscitation practices, and future directions of resuscitation for the pediatric burn population.


Early China ◽  
2016 ◽  
Vol 39 ◽  
pp. 21-52 ◽  
Author(s):  
Anke Hein

AbstractChinese and Western archaeologists (especially those of the anthropologically-oriented tradition) often seem to be talking past each other, not only because they are publishing in different languages, but also because of differences in theory and method. While most of the major theoretical works in Western languages are by now available in Chinese translations, hardly any English-language publications exist that explain Chinese approaches to archaeological method and theory. This article helps to bridge the gap by introducing the history of debates on archaeological method in China to a Western audience, focusing particularly on issues of typology and classification. Discussing in detail the merits—and issues—of approaches suggested by four of the most influential Chinese archaeologists (Li Chi, Xia Nai, Su Bingqi, and K. C. Chang), this article provides a deeper understanding of the preconditions of archaeological research in China. It also suggests future directions for archaeological work by local and foreign archaeologists, including but also going beyond the classification of the rich body of artifacts coming to light in Chinese excavations.


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