scholarly journals Postdiagnosis Body Mass Index, Weight Change, and Mortality From Prostate Cancer, Cardiovascular Disease, and All Causes Among Survivors of Nonmetastatic Prostate Cancer

2020 ◽  
Vol 38 (18) ◽  
pp. 2018-2027 ◽  
Author(s):  
Alyssa N. Troeschel ◽  
Terryl J. Hartman ◽  
Eric J. Jacobs ◽  
Victoria L. Stevens ◽  
Ted Gansler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Weight Change ◽  
Cox Proportional Hazards ◽  
Healthy Weight ◽  
All Cause Mortality

PURPOSE To investigate the association of postdiagnosis body mass index (BMI) and weight change with prostate cancer–specific mortality (PCSM), cardiovascular disease–related mortality (CVDM), and all-cause mortality among survivors of nonmetastatic prostate cancer. METHODS Men in the Cancer Prevention Study II Nutrition Cohort diagnosed with nonmetastatic prostate cancer between 1992 and 2013 were followed for mortality through December 2016. Current weight was self-reported on follow-up questionnaires approximately every 2 years. Postdiagnosis BMI was obtained from the first survey completed 1 to < 6 years after diagnosis. Weight change was the difference in weight between the first and second postdiagnosis surveys. Deaths occurring within 4 years of the follow-up were excluded to reduce bias from reverse causation. Analyses of BMI and weight change included 8,330 and 6,942 participants, respectively. RESULTS Postdiagnosis BMI analyses included 3,855 deaths from all causes (PCSM, n = 500; CVDM, n = 1,155). Using Cox proportional hazards models, hazard ratios (HRs) associated with postdiagnosis obesity (BMI ≥ 30 kg/m2) compared with healthy weight (BMI 18.5 to < 25.0 kg/m2) were 1.28 for PCSM (95% CI, 0.96 to 1.67), 1.24 for CVDM (95% CI, 1.03 to 1.49), and 1.23 for all-cause mortality (95% CI, 1.11 to 1.35). Weight gain analyses included 2,973 deaths (PCSM, n = 375; CVDM, n = 881). Postdiagnosis weight gain (> 5% of body weight), compared with stable weight (± < 3%), was associated with a higher risk of PCSM (HR, 1.65; 95% CI, 1.21 to 2.25) and all-cause mortality (HR, 1.27; 95% CI, 1.12 to 1.45) but not CVDM. CONCLUSION Results suggest that among survivors of nonmetastatic prostate cancer with largely localized disease, postdiagnosis obesity is associated with higher CVDM and all-cause mortality, and possibly higher PCSM, and that postdiagnosis weight gain may be associated with a higher mortality as a result of all causes and prostate cancer.

Effects of Initial Body Mass Index and Weight Change on All-Cause Mortality: A 10-Year Cohort Study in Korea

2018 ◽  
Vol 30 (3) ◽  
pp. 217-226 ◽  
Author(s):  
Susan Park ◽  
Sunmi Pi ◽  
Jinseub Hwang ◽  
Jae-Heon Kang ◽  
Jin-Won Kwon
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Weight Change ◽  
Baseline Body Mass Index ◽  
Healthy Weight ◽  
Risk Of Death ◽  
Hazard Ratios ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Baseline Bmi

We evaluated the effects of baseline body mass index (BMI) and its changes over 4 years on all-cause mortality in Korean population. We analyzed 351 735 participants whose BMI was measured in both 2002/2003 and 2006/2007. Mortality was assessed until 2013. Multivariate hazard ratios for all-cause mortality were estimated. Underweight and severe obesity with BMI >30 kg/m2 were significantly associated with higher mortality. Similarly, >5% decrease or >10% increase of BMI for 4 years was associated with the increased risk of death. Comparing the results between baseline BMI and BMI change, the BMI change showed more stable associations with mortality than the baseline BMI in subgroup analysis such as nonsmokers and healthy participants. This study suggests that BMI change could be a useful health indicator along with obesity level by BMI. In addition, maintaining a healthy weight is needed for longevity, but rapid weight change should be carefully monitored.

scholarly journals Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

Thorax ◽  
2020 ◽  
Vol 75 (4) ◽  
pp. 313-320 ◽  
Author(s):  
Gabriela P Peralta ◽  
Alessandro Marcon ◽  
Anne-Elie Carsin ◽  
Michael J Abramson ◽  
Simone Accordini ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Lung Function ◽  
Body Mass ◽  
Weight Change ◽  
High Weight ◽  
Overweight And Obesity ◽  
Lung Function Decline ◽  
High Weight Gain

BackgroundPrevious studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS).MethodsWe included 3673 participants recruited at age 20–44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991–93, 1999–2003, 2010–14) until they were 39–67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations.ResultsIn individuals with normal BMI, overweight and obesity at baseline, moderate (0.25–1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had −1011 mL (95% CI −1.259 to −763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<−0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline.ConclusionModerate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

scholarly journals Weight change among normal weight, overweight and obese employees and subsequent diagnosis-specific sickness absence: A register-linked follow-up study

2018 ◽  
Vol 48 (2) ◽  
pp. 155-163
Author(s):  
Anna Svärd ◽  
Jouni Lahti ◽  
Minna Mänty ◽  
Eira Roos ◽  
Ossi Rahkonen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Sickness Absence ◽  
Body Mass ◽  
Weight Change ◽  
Rate Ratio ◽  
Musculoskeletal Diseases ◽  
Normal Weight ◽  
Ratio Range

Aims: Obesity and weight change are associated with sickness absence; however, less is known about the diagnoses for sickness absence. We examined the association between stable and changing weight by body mass index groups with sickness absence due to any, musculoskeletal and mental diagnoses among midlife female and male employees. Methods: The Finnish Helsinki Health Study phase 1 survey took place in 2000–2002 (response rate 67%) and phase 2 in 2007 (response rate 83%). Based on self-reported body mass index, we calculated the weight change between phases 1 and 2 (body mass index change ⩾5%). The data were linked with registers of the Social Insurance Institution of Finland, including information on diagnoses (ICD-10) for sickness absence >9 days. We used a negative binom ial model to examine the association with sickness absence among 3140 women and 755 men during the follow-up (2007–2013). Results are presented as rate ratios. Covariates were age, sociodemographic factors, workload, health behaviors and prior sickness absence. Results: Weight-gain (rate ratio range=1.27–2.29), overweight (rate ratio range=1.77–2.02) and obesity (rate ratio range=2.16–2.29) among women were associated with a higher rate of sickness absence due to musculoskeletal diseases, compared to weight-maintaining normal-weight women. Similarly, obesity among men was associated with sickness absence due to musculoskeletal diseases (rate ratio range=1.55–3.45). Obesity among women (rate ratio range=1.54–1.72) and weight gain among overweight men (rate ratio=3.67; confidence interval=1.72–7.87) were associated with sickness absence due to mental disorders. Conclusions: Obesity and weight gain were associated with a higher rate of sickness absence, especially due to musculoskeletal diseases among women. Preventing obesity and weight gain likely helps prevent sickness absence.

scholarly journals Body mass index rebound, weight gain in puberty, and risk of cardiovascular disease

2020 ◽  
Vol 225 ◽  
pp. 281-282
Author(s):  
Osamu Arisaka ◽  
Go Ichikawa ◽  
Satomi Koyama ◽  
Toshimi Sairenchi
Keyword(s):  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass

scholarly journals Relation of FTO to BOLD response to receipt and anticipated receipt of food and monetary reward, food images, and weight gain in healthy weight adolescents

2019 ◽  
Vol 15 (10) ◽  
pp. 1135-1144 ◽  
Author(s):  
Eric Stice ◽  
Sonja Yokum ◽  
Pascale Voelker
Keyword(s):  
Weight Gain ◽  
Body Mass ◽  
Parietal Lobe ◽  
Monetary Reward ◽  
Healthy Weight ◽  
Palatable Food ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Food Images

Abstract Although the fat mass and obesity-associated gene (FTO) correlates with elevated body mass, it is unclear how it contributes to overeating. We tested if individuals with the A allele show greater reward region responsivity to receipt and anticipated receipt of food and money and palatable food images. We also tested if these individuals show greater future weight gain. Initially healthy weight adolescents (Study 1, N = 162; Study 2, N = 135) completed different functional magnetic resonance imaging paradigms and had their body mass measured annually over 3 years. Adolescents with the AA or AT genotypes showed less precuneus and superior parietal lobe response and greater cuneus and prefrontal cortex response to milkshake receipt and less putamen response to anticipated milkshake receipt than those with the TT genotype in separate analyses of each sample. Groups did not differ in response to palatable food images, and receipt and anticipated receipt of money, or in weight gain over 3-year follow-up. Results suggest that initially healthy weight adolescents with vs without the FTO A allele show differential responsivity to receipt and anticipated receipt of food but do not differ in neural response to palatable food images and monetary reward and do not show greater future weight gain.

scholarly journals Body Mass Index and Weight Change in Men with Prostate Cancer: Progression and Mortality.

2015 ◽  
Vol 44 (suppl_1) ◽  
pp. i141-i142
Author(s):  
S. E. Bonn ◽  
F. Wiklund ◽  
A. Sjölander ◽  
R. Szulkin ◽  
P. Stattin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Cancer Progression ◽  
Weight Change ◽  
Prostate Cancer Progression

The association of fitness and body mass index (BMI) on all-cause mortality in cancer survivors: The Henry Ford Exercise Testing Project (The FIT Project).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 7060-7060
Author(s):  
Catherine Handy Marshall ◽  
Paul A McAuley ◽  
Hua-Ling Tsai ◽  
Zeina Dardari ◽  
Mouaz H Al-Mallah ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Cancer Patients ◽  
Body Mass ◽  
Cancer Diagnosis ◽  
Exercise Test ◽  
Normal Weight ◽  
Risk Of Mortality ◽  
All Cause Mortality ◽  
Henry Ford

7060 Background: The obesity paradox –i.e. inverse associations between body mass index (BMI) and mortality – has been reported in patients with cancer, heart failure, and diabetes. However, the influence of cardiorespiratory fitness (CRF) on this relationship is not well established. This study assesses the association of BMI and CRF with all-cause mortality among cancer patients. Methods: The Henry Ford (HF) FIT Project is a retrospective cohort study of 69,885 consecutive patients who underwent physician-referred exercise stress testing from 1991 through 2009. Cancer diagnosis was identified through linkage to the HF tumor registry. We included patients 40-70 years old, with BMI recorded, at time of exercise test, with a history of cancer > 6 months prior. BMI was categorized as normal (18.5-24.9kg/m2), overweight (25-29.9kg/m2), or obese ( > = 30kg/m2). All-cause mortality was obtained from the National Death Index. Because of a significant interaction between BMI and cancer type, patients with breast or prostate cancer were excluded. Multivariable adjusted Cox proportional hazard models were used to evaluate the association of CRF andBMI with all-cause mortality; adjusted for age at exercise test, sex, diabetes, smoking, cancer stage, and time from cancer diagnosis to exercise test. Results: Included were 676 patients with a mean age of 58 years (SD 7.5), 51% female, 70% White, 25% Black, with a median of 4.8 years from diagnosis to exercise test and median follow up time of 10.3 years. Among patients achieving < 10 METs, those who are overweight and obese had a lower risk of mortality HR 0.47 (95% CI 0.25,0.86) and HR 0.44 (95% CI 0.26, 0.74, respectively), compared to those with normal BMI. Among patients with METs > = 10, those who were overweight had the lowest risk of all-cause mortality (HR 0.23, 95% CI 0.09-0.62) compared to normal weight, while no statistically significant different risk of mortality was observed when comparing those who are obese to normal weight (HR 0.37, 95% CI 0.13-1.06). In an analysis combining BMI and fitness groups (four categories), those with BMI > = 25 and METs > = 10 had the lowest risk of all-cause mortality (Table). Conclusions: In non-breast/non-prostate cancer patients, increased BMI is associated with improved overall survival in those with METs < 10, while a U-shaped relationship between BMI and all-cause mortality exists among those with METs > = 10. [Table: see text]

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