Laser therapy for radio-induced oral mucositis and skin dermatitis: Oral medicine, radiotherapy and oncology shared experience from the University of Trieste.

213 Background: Oral mucositis (OM) and dermatitis (RD) are serious side effects of radiotherapy (RT), often leading to its suspension, need for analgesics and enteral/parenteral nutrition. Laser-therapy is becoming a recommended option for mucosal lesions and has also been tested for skin affections. This prospective study investigates the effect of Laser-therapy (HPLT) on RT-induced OM and proposes an off-label use of HPLT to treat RD in breast-cancer patients and in RT-treated anal-carcinoma patients Methods: 53 cancer patients, during/after RT and/or chemotherapy, affected by OM, were treated with HPLT during 4 consecutive days (970nm, 2,5W, 35-6000Hz, 240s). Assessment of OM (WHO-SCALE: Grading objective Scale), pain (VAS: Visual Analogue Scale), functional ability, subjective parameters, site/severity of OM were recorded weekly for 21 days. 27 breast-cancer patients and 2 anal-carcinoma patients affected by RD were treated by HPLT every other day for 2 weeks (970nm/660nm, 2-1000Hz, 6W, 480s) and monitored weekly for one month for grade, discomfort, itching and bleeding. Results: Regarding OM, regressive improvement of WHO- SCALE from day 7 on, and of VAS from day 2 on (p < 0.000) was registered. All patients’ functional capacity improved on day 4 (p < 0.05). All subjective parameters improved on day 14 (p < 0.001) except voice, which improved on day 21 (p < 0.000). Ulcerations’ dimension and erythema’s severity decreased in all sites (p < 0.05). Regarding breast and anal RD, after 6 HPLT’s sessions, complete and progressive resolution of pain, bleeding and itching was registered (p < 0.002). All patients referred maximum satisfaction for receiving HPLT. Conclusions: Regardless of OM grade/site and of kind/site of tumor, HPLT was effective in healing OM. Moreover, HPLT resulted an innovative and highly effective therapy for RD, both in breast and anal lesions. To establish an effective treatment strategy for OM and RD is of paramount importance to improve life-quality of patients but can also be beneficial for the continuation of cancer therapy. Consequently, HPLT may become integral part of everyday-practice in the management of RT adverse effects.

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Observation of the Influence of Continuing Nursing on the Cancer-Related Fatigue and the Life Quality of Postoperative Breast Cancer Patients

2017 International Conference on Materials Science and Biological Engineering (ICMSBE 2017) ◽

10.25236/icmsbe.2017.19 ◽

2017 ◽

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Life Quality ◽

Breast Cancer Patients ◽

Cancer Related Fatigue

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Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis

Journal of lasers in medical sciences ◽

10.15171/jlms.2019.20 ◽

2019 ◽

Vol 10 (2) ◽

pp. 125-130

Author(s):

Soheir Shehata Rezk-Allah ◽

Heba Mohamed Abd Elshafi ◽

Reem Jan Farid ◽

Mohamed Abd Elrahman Hassan ◽

Samy A. Alsirafy

Keyword(s):

Breast Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Laser Therapy ◽

Oral Mucositis ◽

Low Level Laser Therapy ◽

Breast Cancer Patients ◽

Low Level Laser ◽

Level Laser ◽

Tnf Α

Introduction: Oral mucositis (OM) is an unavoidable condition of the oral cavity that accompanies chemotherapy for various malignant cases. Chemotherapy-induced oral Mucositis (COM) is a frequent complication due to mucotoxic drugs and is known to deteriorate the general health significantly, while negatively affecting the quality of life (QOL). Studies have reported that low-level laser therapy (LLLT) promotes the tissue healing. The objective of the present study was to explore the efficacy of gallium-arsenide (GaAs) laser in treating COM and its impact on inflammatory cytokine levels in patients receiving chemotherapy for various malignancies. Methods: A total of 80 patients with COM received LLLT 6 days/week. OM was graded according to the World Health Organization (WHO) grading scale. The outcome parameters were the serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) measured before, during and after administration of LLLT. Results: After LLLT, a significant decrease was found in the mean values of mucositis grade from 2.35 ± 0.695 to 1.13 ± 0.333 after (P < 0.001). A significant reduction in the level of TNF-α was found after LLLT among breast cancer patients (P = 0.0045), but not in head and neck cancer and lymphoma patients. A significant reduction was also found in IL-6 level after treatment among head and neck and breast cancer patients (P = 0.0307 and 0.019, respectively). Conclusion: The use of GaAs LLLT in treating COM in patients with various malignancies is well tolerated by patients, it results in improvement of mucositis, however; mechanism of action does not seem to be completely linked to the change of pro or anti-inflammatory cytokines.

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FACTORS THAT RELEVANT TO THE QUALITY OF LIFE OF BREAST CANCER PATIENTS

Journal of Maternity Care and Reproductive Health ◽

10.36780/jmcrh.v1i2.27 ◽

2018 ◽

Vol 1 (2) ◽

Author(s):

Haris H ◽

Laili Rahayuwati ◽

Ahmad Yamin

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Linear Regression Analysis ◽

Life Quality ◽

Breast Cancers ◽

Breast Cancer Patients ◽

National Breast ◽

Age Factor

Breast cancer is a health problem since so many years ago especially to women. In 2013, Basic Health Research (Riskesdas) showed that the number of national breast cancer prevalence was the second most numerous patients in the world especially attacked women in Indonesia. The common problems experienced by breast cancers patients is the decrease of life quality of the patients. The purpose of this research was to identify factors related to the life quality of the breast cancers patients in Bandung city. This research used cross sectional method. The determination of life quality based on Quality of Life Cancer Survivor Version (QOL-CSV). Accidental sampling was used to choose samples. This research was taken place in four rumah singgah (shelters) of breast cancer located in Bandung city. There were 30 women involved in this study. Inclusive criterion in this research was the patients of breast cancers who are undergoing medications such as surgery, chemotherapy, or radiotherapy, who are willing to be the respondents voluntary. Result of normality test included age factor, marital age and firts time pregnance. Multivariate test used in this research was the linear regression analysis. Based on the result of bivariate analysis, age factor and frequency of pregnancy had positive correlated (p<0.05) to the life quality of breast cancer patients, while menarche had a negative correlated. Regression linear result was determined to life quality factor (p<0,05) including age factor, marital age and pathology anatomy result. Half of the result of coefficient correlation showed a strong relationship in the quality of life of breast cancer patients. This Research showed that some of the reproduction factors related to the quality of life. Some factors are contributed to the quality of life of breast cancer patients such as age of the patient, marital age and result of pathology anatomy (cancer stage). This research needs more in-depths studies toward the quality of life of breast cancers patients as well as efforts of intervention to increase the quality of life of breast cancers patients.Keywords: breast cancer, quality of life, reproductive factors

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Relationship between Needs of Supportive Care with Quality of Life among Breast Cancer Patients in Dr. Wahidin Sudirohusodo Makassar

KnE Life Sciences ◽

10.18502/kls.v4i13.5315 ◽

2019 ◽

Author(s):

Muh. Zukri Malik ◽

Suriyani . ◽

Nur Fajriani

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Supportive Care ◽

Cancer Patients ◽

Life Quality ◽

Sampling Technique ◽

Breast Cancer Patients ◽

Chi Square ◽

The Individual

Background: The need of supportive care is a care to be given in order to enhance the life quality of the patients with a serious life-threatening disease such as breast cancer. Generally, the patients are really worried and have severe anxiety related to their disease. The quality of life becomes really important in curing the breast cancer. The life quality is the ability to have normal life in accordance with the individual perception about the objective and hope of the breast cancer patients. Method: Thisis anobservationalresearchwithcross-sectionalstudydesign.Thestudywasconducted in 2019 and required as many as 40 respondents. The samples were selected by using purposive sampling technique. The data were gathered by questionnaire then processed by SPSS and analyzed by statistical test of Chi-square with the signiﬁcance degree of 95% (α=0,05). Result: The result showed that there was signiﬁcant correlation between the need of supportive care (p<0,000) and the life quality of the breast cancer patients. Conclusion: There was association of the supportive careandthelifequalityofthebreastcancerpatientswiththevalueofp=0,000<α0.05.

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Pengukuran Kualitas Hidup Pasien Kanker Payudara di Kota Denpasar Menggunakan Instrumen EQ-5D-5L

JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ◽

10.22146/jmpf.47192 ◽

2019 ◽

Vol 9 (3) ◽

Author(s):

Abdillah Mursyid ◽

Restu Nur Hasanah Haris ◽

Dwi Endarti ◽

Chairun Wiedyaningsih ◽

Susi Ari Kristina

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Life Quality ◽

Patient Characteristics ◽

Quality Data ◽

Breast Cancer Patients ◽

Utility Value ◽

Significant Difference

Breast cancer is the second most common cancer in the world and is one of the biggest causes of cancer deaths every year. Measurement of the quality of life in breast cancer patients could improve treatment and become a prognosic factor along with medical parameters for the patients. This study aims to measure the life quality of breast cancer patients and observe how it affects the life quality based on patient characteristics. The study was conducted on 93 breast cancer patients. Data were collected form patients in several breast cancer comunities in Denpasar which were carried outh within 3 months (January – March 2019). This study used a cross sectional design using a snowball sampling technique involving breast cancer patients in several cancer communities in Denpasar. The patient's life quality data was obtained using the EuroQol-5 Dimension-5 Level (EQ-5D-5L) generic instrument and conversion to health utility (utility) used the Indonesian value set. The entire data was analyzed using the independent t-test and multivariate regression. The results showed that pain/discomfort and anxiety/depression were the most dominant problem in breast cancer patients (82,7%). The utility value of breast cancer patients was 0.821±0.123 and the VAS value was 74.41±11.67. There was a significant difference in utility value based on patient characteristics of occupation (p=0.035), symptoms (p=0,003), and cancer stadium (p=0.015). Affected 20.5% of the quality of life of breast cancer patients in Denpasar city.

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