Preoperative hemoglobin-to-red cell distribution width ratio as a novel prognostic parameter in hepatocellular carcinoma after curative resection.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15634-e15634
Author(s):  
Ze-xiao Lin ◽  
Dan-yun Ruan ◽  
Yang Li ◽  
Dong-hao Wu ◽  
Tian-tian Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cox Model ◽  
Critical Role ◽  
Red Cell Distribution Width ◽  
Nutrition Status ◽  
Red Cell ◽  
Cell Distribution ◽  
Operating Characteristics ◽  
Distribution Width ◽  
Significant Difference

e15634 Background: Cumulative evidence has demonstrated that interaction between tumor and the inflammatory microenvironment plays a critical role in the development and progression of hepatocellular carcinoma (HCC). This study aims to investigate the prognostic value of hemoglobin to red cell distribution width (RDW) ratio (HRR), as a novel and simple biomarker reflecting both the host inflammatory response and nutrition status, in patients with HCC undergoing curative hepatectomy. Methods: We retrospectively analyzed 373 HCC patients treated with hepatic resection between January 2004 and December 2012. Preoperative complete blood counts were used to calculate HRR. The best cut-off for survival analysis was determined by receiver operating characteristics (ROC) curve analysis. Univariate and multivariate analyses were applied to assess HRR and other clinicopathological variables. Results: The optimal cutoff value of HRR was 1.06 with an area under the curve (AUC) of 0.591 (95% CI, 0.540-0.642, p = 0.0072). A low preoperative HRR level ( < 1.06) was significantly correlated with hypoalbuminemia, female sex, the presence of portal hypertension and elevated level of total bilirubin. After a median follow-up of 48.5 months (range, 2-148.2 months), patients with a low HRR had significantly worse 5-year overall survival (OS) (69.2% vs 83.9%, p = 0.002). However, no significant difference was observed between low and high HRR groups with respect to recurrence free survival. The HRR (p = 0.009), histological differentiation (p = 0.003), Barcelona Clinic Liver Cancer stage (p = 0.003), serum alkaline phosphatase level (p = 0.008) and serum alanine aminotransferase level (p = 0.041) were identified to be independent prognostic factors of OS by multivariate analysis. This cox model was validated by bootstrap resampling, confirming low HRR as an independent predictor of shorter OS after adjustment (p = 0.01). Conclusions: Our study demonstrates for the first time that preoperative HRR can serve as an independent prognostic maker in HCC patients after radical surgery. Incorporation of HRR into other indices may provide better prognostic stratification.

scholarly journals Evaluation of the red cell distribution width as a biomarker of early mortality in hepatocellular carcinoma

2015 ◽  
Vol 47 (6) ◽  
pp. 488-494 ◽  
Author(s):  
Carlo Smirne ◽  
Glenda Grossi ◽  
David J. Pinato ◽  
Michela E. Burlone ◽  
Francesco A. Mauri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Mortality ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

scholarly journals Relationship between red cell distribution width and prognosis of patients with osteosarcoma

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Jian Zheng ◽  
Xiaopin Yuan ◽  
Weichun Guo
Keyword(s):  
Poor Prognosis ◽  
Survival Curve ◽  
Poor Response ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Poor Overall Survival ◽  
Distribution Width ◽  
Significant Difference

Abstract We retrospectively collected the clinical data and follow-up information of patients with osteosarcoma who were admitted to Department of Orthopedics, RenMin Hospital of Wuhan University from January 2010 to December 2016 and explore the relationship between red cell distribution width (RDW) and prognosis of patients with osteosarcoma. The present study finally included 271 patients with osteosarcoma with median follow-up time of 24.2 months (3–69 months). According to the RDW median, 135 patients belong to the low RDW group and 136 patients belong to high RDW group. Compared with low RDW group, the high RDW group tend to have metastasis (50 vs 32.6%, P=0.004), higher poor response rate to chemotherapy compared with the low RDW group (24.3 vs 7.4%, P=0.000) and higher C-reactive protein (CRP) (7.6 ± 4.9 vs 5.5 ± 4.5, t = 3.727, P=0.000). There was slightly significant difference in the types of pathology (χ2 = 8.059, P=0.045). The Kaplan–Meier analysis indicated survival curve of high RDW group was poorer than that in the low RDW group (P=0.020). The univariate cox analysis indicated that patients with RDW ≥ median had higher risk of poor prognosis compared with those who had RDW level &lt; median (HR = 2.41, 95% confidence interval (CI): 1.51–3.83, P=0.000). After adjusting some potential cofounding factors, the elevated RDW was still associated with poor prognosis (HR = 1.66, 95% CI: 1.07–2.56, P=0.024). The elevated pretreatment RDW was associated with poor overall survival (OS) in patients with osteosarcoma and can be an independent predictor of prognosis.

scholarly journals Comparison of Red Cell Distribution Width (RDW) Value in Congestive Heart Failure (CHF) Patients with Normal Persons

2021 ◽  
Vol 8 (8) ◽  
pp. 27-30
Author(s):  
Marhani Yunita ◽  
Herman Hariman
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Dysfunction ◽  
Red Cell Distribution Width ◽  
Hematological Parameter ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Normal People ◽  
Significant Difference

Congestive Heart Failure (CHF) is a complex clinical symptom that is often characterized by structural abnormalities or cardiac dysfunction that impairs the ability of the left ventricle (LV) to fill or pump blood, especially during physical activity. Red Cell Distribution Width (RDW) is a simple, fast, inexpensive and direct hematological parameter, which reflects the level of anisocytosis in vivo. The association between impaired hematopoiesis and cardiac dysfunction is based on the fact that many different conditions are associated with increased heterogeneity of erythrocyte volume, which can be concurrently present in patients with heart failure, while anisocytosis can also directly contribute to the development and worsening of heart failure. This study aims to provide a comparison of RDW values between CHF patients and normal people. This study uses a case control study design where as many as 20 people with CHF will be compared their RDW values with 20 normal people. From a total of 40 patients, the average RDW value in CHF patients was 17.7±2.4 higher than the average RDW value for normal people was 12.6±0.4 and from the results of statistical analysis using the Independent Student t test obtained p value <0.001. There is a significant difference between the RDW values of CHF patients compared to normal people. Keywords: Congestive Heart Failure, CHF, Red Cell Distribution Width, RDW.

scholarly journals The predictive value of red cell distribution width for stroke severity and outcome

2020 ◽  
Author(s):  
Kavous Shahsavarinia ◽  
Younes Ghavam Laleh ◽  
Payman Moharramzadeh ◽  
Mahboob Pouraghaei ◽  
Elyar Sadeghi-Hokmabadi ◽  
...  
Keyword(s):  
Red Cell Distribution Width ◽  
Stroke Severity ◽  
Red Cell ◽  
Cell Distribution ◽  
Stroke Patients ◽  
Distribution Width ◽  
Significant Difference ◽  
Tissue Plasminogen ◽  
Insignificant Difference ◽  
The Mean

Abstract Objectives: In the present study, we sought to investigate the association between red cell distribution width (RDW) and stroke severity and outcome in patients who underwent anti-thrombolytic therapy with tissue plasminogen activator (tPA). Results: In this prospective study, 282 stroke patients who underwent tPA injection were included. The categorization of RDW to <12.9% and >13% values revealed insignificant difference in stroke severity score, accounting for the mean 36-hour NIHSS of 8.19±8.2 in normal RDW values and 9.94±8.28in higher RDW group (p=0.64). In seventh day, NIHSS was 6.46±7.28 in normal RDW group and was 8.52±8.35 in increased RDW group (p=0.058). Neither the thirty-six-hour, nor the seventh day and 3-month mRS demonstrated significant difference between those with normal and higher RDW values.

scholarly journals Red cell distribution width as a prognostic marker in septic neonates versus healthy term newborns

2021 ◽  
Vol 8 (10) ◽  
pp. 1647
Author(s):  
Saran Sarma ◽  
Madhu George ◽  
Abdul Tawab ◽  
Ann Mary Zacharias
Keyword(s):  
Prognostic Marker ◽  
Blood Sampling ◽  
Red Cell Distribution Width ◽  
Control Group ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Significant Difference ◽  
And Control ◽  
Group 1

Background: We evaluated the usefulness of RDW (red cell distribution width) as a diagnostic tool in newborn sepsis. Several biomarkers for sepsis have been studied including CRP (C-reactive protein), procalcitonin, interleukins, total WBC count (TC) absolute neutrophil count (ANC), ratio of immature neutrophils to total neutrophils (I/T ratio). An ideal biomarker for sepsis is still elusive. Hence we evaluated RDW as a sepsis marker as it was cheap and available. The objective of the study was to evaluate the role of RDW as a prognostic marker in newborn sepsis compared to healthy newborns.Methods: The study sample comprised of two groups (cases and control group) each with 40 neonates. Group 1 (cases group) comprised 40 newborns with suspected/probable sepsis based on clinical or laboratory parameters. In group 1 (suspected/probable sepsis) RDW was done at the time of suspicion of sepsis along with other relevant investigations. According to the clinical course these parameters were repeated 24-48 hrs after first value. Group 2 (control group) comprised 40 normal newborns in the postnatal ward. For the control group blood sampling for CBC and RDW was done simultaneously along with blood sampling for newborn screening.Results: On comparing the baseline variables there is no significant difference among cases and control group with respect to gender distribution, age in days, gestational age in weeks and birth weight. The mean RDW among the cases group was significantly higher than among the control group. In ROC analysis we obtained a cut off value of RDW of 17.25 is helpful to diagnose sepsis with reasonable sensitivity (70%) and specificity (60%).Conclusions: This study revealed that RDW may also be included in the diagnosis of sepsis in newborns as it is a simple, inexpensive, available and easily repeated test as it is routinely done with a complete blood count. 

scholarly journals The predictive value of red cell distribution width for stroke severity and outcome

2020 ◽  
Author(s):  
Kavous Shahsavarinia ◽  
Younes Ghavam Laleh ◽  
Payman Moharramzadeh ◽  
Mahboob Pouraghaei ◽  
Elyar Sadeghi-Hokmabadi ◽  
...  
Keyword(s):  
Red Cell Distribution Width ◽  
Stroke Severity ◽  
Red Cell ◽  
Cell Distribution ◽  
Stroke Patients ◽  
Distribution Width ◽  
Significant Difference ◽  
Tissue Plasminogen ◽  
Insignificant Difference ◽  
The Mean

Abstract Objectives: In the present study, we sought to investigate the association between red cell distribution width (RDW) and stroke severity and outcome in patients who underwent anti-thrombolytic therapy with tissue plasminogen activator (tPA). Results: In this prospective study, 282 stroke patients who underwent tPA injection were included. The categorization of RDW to <12.9% and >13% values revealed insignificant difference in stroke severity score, accounting for the mean 36-hour NIHSS of 8.19±8.2 in normal RDW values and 9.94±8.28in higher RDW group (p=0.64). In seventh day, NIHSS was 6.46±7.28 in normal RDW group and was 8.52±8.35 in increased RDW group (p=0.058). Neither the thirty-six-hour, nor the seventh day and 3-month mRS demonstrated significant difference between those with normal and higher RDW values.

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