Understanding the daily needs and challenges of caregivers of patients with lung cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24173-e24173
Author(s):  
Yanyan Zhu ◽  
Fatima Scipione ◽  
Renee Anderson ◽  
Robin Y. DiPaolo ◽  
Ros Miller ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Family Relationships ◽  
Group Discussion ◽  
Treatment Decision ◽  
Well Being ◽  
Advanced Lung Cancer ◽  
Emotional States ◽  
Eligibility Criteria ◽  
Role Shift

e24173 Background: Informal caregivers provide critical support in the management of all aspects of care for patients with cancer. Although caring for loved ones with cancer can be rewarding, it can also have a significant impact on caregivers’ quality of life. The aim of this study was to understand how caring for someone with advanced lung cancer affects caregivers’ lives. Methods: A targeted review of the caregiver literature (Medline, Embase, and Psych Info; year limits 2006-19) using a single search strategy, and qualitative focus group discussion among caregivers (N = 6) who have been or are currently caring for a loved one with advanced lung cancer was conducted. Results: The search identified 99 articles; however, few articles met eligibility criteria (N = 12). Impacts focused on: caring for patient, psycho-social well-being, ability to work, hopes for future, and physical well-being. Several gaps describing the caregiver experience remained based on the results from the literature review alone. Qualitative insights from caregivers included: (1) Caregivers must deal with all aspects of the patient’s experience, as well as the broader physical and emotional well-being of themselves and family members. (2) Disease-related symptoms and treatment-related side effects can result in physical and emotional distress for both caregivers and patients. (3) Caregivers feel hopeless, frustrated, and discouraged regarding side effects, particularly when they cannot perceive the benefits of treatment. (4) Caregivers are often compelled to mask or suppress their feelings to maintain a sense of (relative) normalcy. (5) Negative emotional states directly affect family relationships and dynamics, heightening stress and loneliness for caregivers. (6) Caregivers’ contributions to shared treatment decision-making relative to the patient’s role shift throughout the cancer journey based on their loved one’s ability to cope. Conclusions: These results provide valuable insights into the under-studied experience of caregivers of patients with lung cancer. Future quantitative research will improve understanding of the unique challenges associated with cancer caregiving, as well as facilitate development of personalized, evidence-based support programs and interventions for caregivers.

scholarly journals Socio-psychological features and legal norms of the life of adolescents from distant families of labor migrants

2021 ◽  
Vol 10 (46) ◽  
pp. 79-91
Author(s):  
Zoriana Kovalchuk ◽  
Yana Raievska ◽  
Liudmіla Beheza ◽  
Iryna Ievtushenko ◽  
Halyna Odyntsova
Keyword(s):  
Family Relationships ◽  
Functional Model ◽  
Psychological Adaptation ◽  
Well Being ◽  
Social Institution ◽  
Family Type ◽  
Emotional States ◽  
Labor Migrants ◽  
Low Level ◽  
The Family

The article considers the distant family as a social institution of education, formation and development of personality. The current state of solving the problem of socio-psychological and legal work with children from distant families is analyzed. The sample of the study is described in detail by family type, sex, absence of father / mother and duration of absence. The peculiarities of the functioning of the emotional sphere of adolescents from distant families (anxiety, aggression, hostility), low level of socio-psychological adaptation, low level of emotional well-being in the family have been experimentally determined. The relationship between the degree of socio-psychological adaptation of the adolescent’s personality and emotional states is proved. The dependence of gender differences in the functioning of the family and the emotional sphere of adolescents has been established. The types of groups of adolescents from distant families are determined, in particular: anxious, aggressive-anxious, hostile-anxious, aggressive-hostile, absence of manifestation of negative signs. A structural and functional model of social and psychological support of remote families has been developed, which provides for work with adolescents and their parents with the use of special technologies to ensure the effectiveness of conditions that form harmonious family relationships.

scholarly journals Assessment of Financial Toxicity Among Advanced Lung Cancer Patients in Western China

2021 ◽  
Author(s):  
Tianqi Xu ◽  
Ying Zhou ◽  
Wenhui Yang ◽  
Hangtian Xi ◽  
Liangliang Xing ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Sick Leave ◽  
Univariate Analysis ◽  
Well Being ◽  
Western China ◽  
Psychological Status ◽  
Advanced Lung Cancer ◽  
Financial Toxicity ◽  
Younger Age ◽  
Life Years

Abstract Background: Lung cancer is the primary reason of cancer-caused disability adjusted life years. Medical cost burden impacts patient’s well-being through decreasing income, cutting daily expenses, leisure activities and exhausting savings. De Souza and colleagues developed and validated the COmprehensive Score for Financial Toxicity (COST). Our study aims to quantify the financial burdens of cancer therapy, to explore the relationship between financial toxicity and HRQoL in advanced lung cancer population.Methods: Patients aged ≥ 18 years with confirmed stage III to IV lung cancer were eligible. The COST questionnaire verified by de Souza et al. was used to identify financial toxicity. Multivariable linear regression analysis with log transformation univariate analysis and Pearson correlations were used to performed the analysis.Results: Most of the patients had an income of < ¥50,000 ($7,775) annually (90.8%, n = 138/152). The insurance condition of the cohort was that the majority of the cohort had social insurance (64.5%), 20.4% of them had commercial insurance, 22.0% of them had both. Patients who were younger age (50 ~ 59, P < 0.001), employed but on sick leave, and lower income reported increased levels of financial toxicity (P < 0.05). The risk factors for high financial toxicity: (i) younger age (50 ~ 59), (ii) <1 month of savings, and (iii) being employed but on sick leave. Increased financial toxicity is moderately correlated with a decrease in QoL.Conclusion: Increased financial toxicity(lower COST) is related to poorer psychological status and certain demographics. Financial toxicity is moderately correlated with a HRQoL, and it may have a demonstrable correlation with HRQoL measures.

Consistency of O6-methylguanine-DNA methyltransferase in intracranial and extracranial lesions and the therapeutic effect of temozolomide in patients with advanced lung cancer and brain metastasis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e14001-e14001
Author(s):  
Ying Fan ◽  
Qian Yun Shan ◽  
Jia Li Gong ◽  
Na Han ◽  
Hongyang Lu
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Promoter Methylation ◽  
Dna Methyltransferase ◽  
Methylation Status ◽  
Small Cell ◽  
Advanced Lung Cancer ◽  
Small Cell Lung ◽  
Methylguanine Dna Methyltransferase ◽  
Mgmt Promoter

e14001 Background: Targeted drugs have made a major breakthrough except small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) of brain metastasis (BM) patients with negative driving gene. Because of the difficulty to obtain pathology of intracranial metastases lesions and the low acceptance of patients, the heterogeneity of O6-methylguanine-DNA methyltransferase (MGMT) between extracranial lesions and intracranial metastatic lesions worth exploring. Methods: 10 patients were administered TMZ after the progression of radiotherapy and chemotherapy and included in one group; the efficacy and safety of TMZ were assessed. Moreover, 15 patients who underwent resection of the lung and brain without neoadjuvant therapy formed another cohort. The promoter methylation status of MGMT was analyzed and compared in the paired primary and BM lesions. Results: The overall response (OS) rate of TMZ was 50% and the disease control rate was 80% in patients with BM lesions. The median progression-free survival was 13.6 months, and the median overall survival was 18.9 months after a median follow-up of 120 months. No grade 3 or higher side effects were reported, but grade 1 or 2 side effects, such as leucopenia, nausea, or vomiting, occurred. However, in another cohort, MGMT promoter methylation was detected in 2 patients (with primary lesions; unmethylation was detected in BM lesions, and the methylation status of MGMT promoter was consistent in paired primary and BM lesions).Conclusions: TMZ was effective against SCLC and NSCLC combined with BM having negative driving genes. Whether primary lesions can replace the MGMT methylation level of BM lesions, as well as the consistency of the promoter methylation status of MGMT in patients with advanced lung cancer, needs exploration.[Table: see text]

scholarly journals Assessment of Financial Toxicity Among Patients With Advanced Lung Cancer in Western China

2022 ◽  
Vol 9 ◽  
Author(s):  
Tianqi Xu ◽  
Leidi Xu ◽  
Hangtian Xi ◽  
Yong Zhang ◽  
Ying Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Sick Leave ◽  
Univariate Analysis ◽  
Well Being ◽  
Western China ◽  
Psychological Status ◽  
Advanced Lung Cancer ◽  
Financial Toxicity ◽  
Younger Age ◽  
Life Years

Background: Lung cancer is the leading source of cancer-caused disability-adjusted life years. Medical cost burden impacts the well-being of patients through reducing income, cutting daily expenses, curtailing leisure activities, and depleting exhausting savings. The COmprehensive Score for Financial Toxicity (COST) was created and validated by De Souza and colleagues. Our study intends to measure the financial burdens of cancer therapy and investigate the link between financial toxicity and health-related quality of life (HRQoL) in an advanced lung cancer population.Methods: Patients aged ≥ 18 years with confirmed stage III to IV lung cancer were eligible. The COST questionnaire verified by de Souza et al. was used to identify financial toxicity. Multivariable linear regression analysis with log transformation univariate analysis and Pearson correlations were used to perform the analysis.Results: The majority of the patients (90.8%, n = 138/152) had an annual income of $50,000 ($7,775). The cohort's insurance situation was as follows: 64.5% of the cohort had social insurance, 20.4% had commercial insurance, and 22.0% had both. Patients who were younger age (50–59, P &lt; 0.001), employed but on sick leave, and had lower income reported increased levels of financial toxicity (P &lt; 0.05). The risk factors for high financial toxicity: (i) younger age (50–59), (ii) &lt;1 month of savings, and (iii) being employed but on sick leave. Increased financial toxicity is moderately correlated with a decrease in QoL.Conclusion: Poorer psychological status and specific demographics are linked to increased financial toxicity (lower COST). Financial toxicity has a modest relationship with HRQoL and may have a clear link with HRQoL measurements.

Awareness about EGFR testing and use of TKIs in advanced lung cancer: A questionnaire-based survey of medical oncologists from India.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e19116-e19116 ◽  
Author(s):  
Purvish M. Parikh
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Egfr Mutation ◽  
Egfr Mutations ◽  
Advanced Lung Cancer ◽  
Cancer Center ◽  
Molecular Testing ◽  
Cancer Tissue ◽  
Tissue Samples ◽  
Medical Oncologists

e19116 Background: EGFR is an important driver mutation in lung cancer. The pattern of usage of EGFR mutation testing is not well defined in the Indian population. Methods: A total of 70 medical oncologists from India were interviewed to identify current practices in the management of advanced lung cancer. They were in clinical practice for 2 to 35 (median 9) years. Their affiliation included medical college (21), regional cancer center (6), corporate hospitals (29) and private practice (14). Their collective experience in conducting international clinical trials in lung cancer was significant (range 0 to 35 trials). Results: The number of new patients with lung cancer seen by them in a month was a median of 8 (range 1 to 20). EGFR testing on the lung cancer tissue was recommended in a median of 60 % (range 10 to 100 %) of paients and was actually carried out in a median of 30 % (range 0 to 90 %). Tissue samples were inadequate for EGFR testing in 30 % of cases (range 2 to 95 %). Method of EGFR testing used included IHC by 06, molecular by 52 and both by 12 of the oncologists. The time to obtain a report was 10 days (range 5 to 21 days). EGFR testing showed mutation/ overexpression in approximately 25 % of cases (range 0 to 70 %. In a large national tertiary cancer center with inhouse laboratory that did testing by PCR and sequencing, EGFR mutations were seen in 30 % of 481 samples. The EGFR mutations considered clinically important included del 19 by 56, L858R by 41 and T790M by 31 of the responding oncologists. The first line therapy used in EGFR mutation positive Lung cancer patients was platinum doublet chemotherapy by 7, gefitinib by 55 and erlotinib by 8 oncologists. The side effects of TKIs considered important were diarrhea by 64, mucositis by 47, rash by all 70, paronychea by 50, nausea vomiting by 52, fatigue by 51 and myelosuppression by 6. The common methods of managing these side effects included dose reduction by 22, drug interruption by 50, symptomatic treatment by 49 and counseling by 22. Conclusions: The awareness about EGFR mutation and use of TKIs among medical oncologist is increasing in India. However availability of sufficient tissue for molecular testing remains a problem.

scholarly journals Relationship-based Models for Supporting Young People Transitioning from Out-of-home Care: Two Case Studies from Victoria, Australia

2020 ◽  
pp. 234930032096717
Author(s):  
Philip Mendes ◽  
Jade Purtell
Keyword(s):  
Home Care ◽  
Family Relationships ◽  
Well Being ◽  
Physical And Mental Health ◽  
Eligibility Criteria ◽  
Social And Emotional ◽  
Out Of Home Care ◽  
Professional Workers ◽  
Care Leavers ◽  
Support Programmes

It is evident from the international literature that supportive relationships with professional workers can play a key role in advancing positive transitions from out-of-home care. This article presents findings from the evaluations of two leaving care support programmes in the state of Victoria, Australia, where relationship-based models were introduced to support care leavers during preparation, transition and post transition from care phases. While the programme models varied according to the eligibility criteria, caseload numbers and programme priorities, they were both effective in facilitating positive outcomes in a range of areas, including housing, family relationships, education, employment and income, physical and mental health, and social and emotional well-being and stability. Relationship-based models based on trust and continuity that protect care leavers from social isolation are likely to be even more crucial in the context of COVID-19

Oral nutritional supplement prevents weight loss and reduces side effects in patients in advanced lung cancer chemotherapy

Amino Acids ◽  
2020 ◽  
Vol 52 (3) ◽  
pp. 445-451 ◽  
Author(s):  
Piera Torricelli ◽  
Francesco Antonelli ◽  
Pasquale Ferorelli ◽  
Ilaria Borromeo ◽  
Anna Shevchenko ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Weight Loss ◽  
Side Effects ◽  
Cancer Chemotherapy ◽  
Nutritional Supplement ◽  
Advanced Lung Cancer ◽  
Oral Nutritional Supplement

scholarly journals Relatives of patients with metastatic lung cancer’s views on the achievement of treatment goals and the choice to start treatment: an interview study

2020 ◽  
Author(s):  
Adinda Mieras ◽  
Bregje D. Onwuteaka-Philipsen ◽  
Annemarie Becker-Commissaris ◽  
Jose C.M. Bos ◽  
H.Roeline W. Pasman
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Tumour Size ◽  
Treatment Decision ◽  
Interview Study ◽  
Treatment Choice ◽  
Treatment Goals ◽  
Metastatic Lung Cancer ◽  
Loved One ◽  
Metastatic Lung

Abstract Purpose. Lung cancer has a high impact on both patients and relatives. Previous studies looked into treatment goals patients have before starting a treatment. However, studies on relatives’ perceptions of treatment at the end of life are scarce. Therefore, we studied the perspectives of relatives in hindsight on the achievement of treatment goals and the choice to start treatment for metastatic lung cancer of their loved one.Methods. We conducted a semi-structured telephone interview study in six hospitals across the Netherlands, one academic and five non-academic hospitals between February 2017 and November 2019. We included 118 relatives of deceased patients diagnosed with metastatic lung cancer who started a systemic treatment and who completed a questionnaire on their treatment goals before start of the treatment and when treatment was finished. We asked the relatives about the achievement of patients’ treatment goals and relatives’ satisfaction with the choice to start treatment.Results. Relatives reported the goals ‘quality of life’, ‘decrease tumour size’ and ‘life prolongation’ as achieved in 21%, 37% and 41% respectively. Most of the relatives (78%) were satisfied with the choice to start a treatment. Also, when none of the goals were achieved, 70% of the relatives were satisfied. About one in two relatives who were satisfied with the patient’s choice did mention negative aspects of the treatment choice, such as that the treatment did not work, that there were side effects or that it would not have been the relatives choice. This was four in five for relatives who were not satisfied. Most mentioned positive aspects were that they tried everything and that it was the patient’s choice. Conclusion. Relatives reported patients’ treatment goals as not achieved in a majority of cases. They were, however, in majority of the cases satisfied about the treatment choice. Being satisfied does not provide a full picture of their experience with the treatment decision as a majority mentions negative aspects of this decision. At the time of making the treatment decision it is important to manage expectations about chance of success and possible side effects of the treatment.

Sign in / Sign up

Export Citation Format

Share Document