Objective:
Energy metabolism disorder is one of the causes of Parkinson's disease (PD).
Rodents, such as rats and mice are often used to establish animal models of PD. This paper used a bibliometric
method to analyze the studies of rat and mouse PD models published between 2009 and 2018
in the Web of Science (WOS) database using CiteSpace V software. In addition, we conducted a literature
review on the development status and research hotspots in this field in the past ten years.
Methods:
The related articles on rat and mouse PD models were retrieved from the WOS database, and
an analysis of the keywords in these articles was conducted using CiteSpace V. A timeline graph was
developed by the software in order to show the focus of researchers in the PD field.
Results :
A total of 8,636 articles were obtained. Results of the cluster analysis in the PD field such as
neuroinflammation, oxidative stress, and autophagy, contributed to the systematic review about the
pathogenesis of PD. At the same time, based on the property of the model drug, this review has summarized
and compared different administration techniques and mechanisms of 6-hydroxydopamine (6-
OHDA), 1-methyl-4-phenyl-1, 2, 4, 5-tetrahydropyridine (MPTP), paraquat and rotenone.
Conclusion:
According to the bibliometric analysis, studies on PD were focused on the mechanisms of
oxidative stress, neuroinflammation, and autophagy. Activated microglia releases inflammatory cytokines;
mitochondrial dysfunction is caused by oxidative damage of mitochondrial protein; abnormal
autophagy-lysosome pathway can lead to abnormal protein deposition in dopaminergic neurons. In
addition, although many animal models of PD have been established, there are some limitations of
such models. Therefore, it is necessary to develop models that accurately mimic human PD.
EXPERIMENTAL ANIMAL MODELS OF PARKINSON’S DISEASE: AN OVERVIEW
