Neuroendocrine Host Factors in Susceptibility and Resistance to Autoimmune/Inflammatory Disease

2004 ◽  
pp. 393-415
Author(s):  
Jeanette Webster ◽  
Esther Sternberg
Keyword(s):  
Inflammatory Disease ◽  
Host Factors ◽  
Autoimmune Inflammatory Disease ◽  
Susceptibility And Resistance

scholarly journals Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus

2013 ◽  
Vol 88 (6) ◽  
pp. 913-916 ◽  
Author(s):  
Mônica Santos ◽  
Hannah Monteiro Fonseca ◽  
Alex Panizza Jalkh ◽  
Gabriela Piraice Gomes ◽  
Andrea de Souza Cavalcante
Keyword(s):  
Waist Circumference ◽  
Inflammatory Disease ◽  
Metabolic Diseases ◽  
Life Quality ◽  
Inflammatory Cells ◽  
Chronic Inflammatory Disease ◽  
Dermatology Clinic ◽  
Autoimmune Inflammatory Disease ◽  
Prevalence Of Obesity ◽  
Level Of Significance

BACKGROUND: Psoriasis is a chronic inflammatory disease of multifactorial etiology, with participation of genetic, autoimmune and environmental factors. Recent studies have demonstrated the role of inflammatory cells and mediators in the pathogenesis of psoriasis, which is now defined as a systemic and autoimmune inflammatory disease that may be associated with other diseases of inflammatory nature. OBJECTIVES: To evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus. METHODS: We performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis. Besides the recommended dermatological care, a physical examination was performed to measure weight, height and waist circumference. RESULTS: We included 72 patients, 44 (61.1%) female and 28 (38.9%) male, with a mean age of 51.0 years ± 15.9 years. As for body mass index (BMI), 16 (22.2%) were overweight and 20 (27.8%) were obese. In the analysis of waist circumference in relation to gender, we found that 79.5% of women surveyed had central obesity, a percentage statistically higher than that observed among men (42.9%) at the 5% level of significance (p = 0.001). Regarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile. CONCLUSIONS: The occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory.

scholarly journals Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Ding-Lei Su ◽  
Zhi-Min Lu ◽  
Min-Ning Shen ◽  
Xia Li ◽  
Ling-Yun Sun
Keyword(s):  
Complex Network ◽  
Inflammatory Cytokines ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Immune Homeostasis ◽  
Adaptive Immune ◽  
Adaptive Immune Cells ◽  
Autoimmune Inflammatory Disease ◽  
Anti Inflammatory

SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy.

scholarly journals Targeting TNF and Its Family Members in Autoimmune/Inflammatory Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-2 ◽  
Author(s):  
Sophie Desplat-Jégo ◽  
Linda Burkly ◽  
Chaim Putterman
Keyword(s):  
Inflammatory Disease ◽  
Family Members ◽  
Autoimmune Inflammatory Disease

scholarly journals Multiple Sclerosis Revealed by Anterior Uveitis

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
Sidi Dahi ◽  
Mehdi Khamaily ◽  
Joumany Brahim Salem ◽  
Imane Tarib ◽  
Mounia Bouchaar ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Inflammatory Disease ◽  
Anterior Uveitis ◽  
Oculomotor Nerve ◽  
Ocular Involvement ◽  
Atypical Case ◽  
Autoimmune Inflammatory Disease ◽  
The Central Nervous System

Multiple sclerosis is an autoimmune inflammatory disease of the central nervous system, leading to the formation of foci of demyelination. Ocular involvement is quite frequent and multiple, dominated by inflammatory optic neuropathies, oculomotor nerve damage, nystagmus and uveitis. We report an atypical case of multiple sclerosis revealed by an anterior unilateral synechiatic hypertensive uveitis in a young patient of 27 years.

scholarly journals Protective effect of a germline, IL-17-neutralizing antibody in murine models of autoimmune inflammatory disease

2015 ◽  
Vol 45 (4) ◽  
pp. 1238-1247 ◽  
Author(s):  
Kiran Dallenbach ◽  
Patrik Maurer ◽  
Till Röhn ◽  
Franziska Zabel ◽  
Manfred Kopf ◽  
...  
Keyword(s):  
Protective Effect ◽  
Inflammatory Disease ◽  
Neutralizing Antibody ◽  
Murine Models ◽  
Autoimmune Inflammatory Disease
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