In a relatively short amount of time, significant progress has been made in discovering gene-environment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension. These correlations appear to change genetic vulnerability, which may help researchers better understand the genetic processes that influence CVD development in the future. In order to advance the field, further research is required to confirm initial comparisons, identify the biological processes by which environmental influences modify genetic risk, and investigate strategies that use this knowledge to influence clinical genetic therapy outcomes.