Monitoring: A Fundamental Process to Provide QoS Guarantees in Cloud-Based Platforms

Abstract Cell migration is a multifactorial/multistep process that requires the concerted action of growth and transcriptional factors, motor proteins, extracellular matrix remodeling and proteases. In this review, we focus on the role of transcription factors modulating Epithelial-to-Mesenchymal Transition (EMT-TFs), a fundamental process supporting both physiological and pathological cell migration. These EMT-TFs (Snail1/2, Twist1/2 and Zeb1/2) are labile proteins which should be stabilized to initiate EMT and provide full migratory and invasive properties. We present here a family of enzymes, the deubiquitinases (DUBs) which have a crucial role in counteracting polyubiquitination and proteasomal degradation of EMT-TFs after their induction by TGFβ, inflammatory cytokines and hypoxia. We also describe the DUBs promoting the stabilization of Smads, TGFβ receptors and other key proteins involved in transduction pathways controlling EMT.

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Self-Supported Ultra-Active NiO-Based Electrocatalysts for Oxygen Evolution Reaction by Solution Combustion

Journal of Materials Chemistry A ◽

10.1039/d1ta00072a ◽

2021 ◽

Author(s):

Julio Lloret Fillol ◽

Alberto Bucci ◽

Miguel García-Tecedor ◽

Sacha Corby ◽

Reshma Rao ◽

...

Keyword(s):

Oxygen Evolution ◽

Oxygen Evolution Reaction ◽

Energy Transition ◽

Solution Combustion ◽

Fundamental Process ◽

Sustainable Fuels

Oxygen evolution reaction (OER) is a fundamental process to develop a technology that can drive the energy transition towards renewable and sustainable fuels. Nevertheless, efficient and straightforward methodologies to obtain...

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Site-specific ubiquitylation acts as a regulator of linker histone H1

Nature Communications ◽

10.1038/s41467-021-23636-5 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Eva Höllmüller ◽

Simon Geigges ◽

Marie L. Niedermeier ◽

Kai-Michael Kammer ◽

Simon M. Kienle ◽

...

Keyword(s):

Posttranslational Modifications ◽

Histone H1 ◽

Linker Histone ◽

Active Chromatin ◽

Site Specific ◽

Linker Histone H1 ◽

Fundamental Process ◽

Core Histones ◽

Wide Scale

AbstractDecoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is well studied for PTMs of core histones but not for linker histone H1 in general and its ubiquitylation in particular due to a lack of proper tools. Here, we report on the chemical synthesis of site-specifically mono-ubiquitylated H1.2 and identify its ubiquitin-dependent interactome on a proteome-wide scale. We show that site-specific ubiquitylation of H1 at position K64 modulates interactions with deubiquitylating enzymes and the deacetylase SIRT1. Moreover, it affects H1-dependent chromatosome assembly and phase separation resulting in a more open chromatosome conformation generally associated with a transcriptionally active chromatin state. In summary, we propose that site-specific ubiquitylation plays a general regulatory role for linker histone H1.

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A Review on Tailoring Stiffness in Compliant Systems, via Removing Material: Cellular Materials and Topology Optimization

Applied Sciences ◽

10.3390/app11083538 ◽

2021 ◽

Vol 11 (8) ◽

pp. 3538

Author(s):

Mauricio Arredondo-Soto ◽

Enrique Cuan-Urquizo ◽

Alfonso Gómez-Espinosa

Keyword(s):

Mechanical Properties ◽

Topology Optimization ◽

Evolutionary Process ◽

Cellular Materials ◽

Related Literature ◽

And Topology ◽

Fundamental Process ◽

Compliant Systems ◽

Basic Concepts

Cellular Materials and Topology Optimization use a structured distribution of material to achieve specific mechanical properties. The controlled distribution of material often leads to several advantages including the customization of the resulting mechanical properties; this can be achieved following these two approaches. In this work, a review of these two as approaches used with compliance purposes applied at flexure level is presented. The related literature is assessed with the aim of clarifying how they can be used in tailoring stiffness of flexure elements. Basic concepts needed to understand the fundamental process of each approach are presented. Further, tailoring stiffness is described as an evolutionary process used in compliance applications. Additionally, works that used these approaches to tailor stiffness of flexure elements are described and categorized. Finally, concluding remarks and recommendations to further extend the study of these two approaches in tailoring the stiffness of flexure elements are discussed.

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