scholarly journals Androgen Controls Transforming Growth Factor-β Receptor and Epidermal Growth Factor Receptor Regulation and Surfactant Protein Gene Expression in the Developing Lung

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 50A-50A
Author(s):  
Christiane E L Dammann ◽  
Sujatha M Ramadurai ◽  
Dana D McCants ◽  
Lucia D Pham ◽  
Heber C Nielsen
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Protein Gene ◽  
Growth Factor Receptor ◽  
Transforming Growth Factor Β ◽  
Surfactant Protein ◽  
Receptor Regulation ◽  
Epidermal Growth ◽  
Β Receptor

N-glycans of growth factor receptors: their role in receptor function and disease implications

2016 ◽  
Vol 130 (20) ◽  
pp. 1781-1792 ◽  
Author(s):  
Motoko Takahashi ◽  
Yoshihiro Hasegawa ◽  
Congxiao Gao ◽  
Yoshio Kuroki ◽  
Naoyuki Taniguchi
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Cell Signalling ◽  
Growth Factor Receptor ◽  
Transforming Growth Factor Β ◽  
Cellular Events ◽  
Functional Regulation ◽  
Epidermal Growth ◽  
Β Receptor ◽  
Novel Strategy

Numerous signal-transduction-related molecules are secreted proteins or membrane proteins, and the mechanism by which these molecules are regulated by glycan chains is a very important issue for developing an understanding of the cellular events that transpire. This review covers the functional regulation of epidermal growth factor receptor (EGFR), ErbB3 and the transforming growth factor β (TGF-β) receptor by N-glycans. This review shows that the N-glycans play important roles in regulating protein conformation and interactions with carbohydrate recognition molecules. These results point to the possibility of a novel strategy for controlling cell signalling and developing novel glycan-based therapeutics.

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