New Approach for the Application of USP Apparatus 3 in Dissolution Tests: Case Studies of Three Antihypertensive Immediate-Release Tablets

2018 ◽  
Vol 19 (7) ◽  
pp. 2866-2874 ◽  
Author(s):  
Brenda Espíndola ◽  
Francieli Furlan Bortolon ◽  
Juliana Munari Oliveira Pinto ◽  
Bianca Ramos Pezzini ◽  
Hellen Karine Stulzer
Keyword(s):  
Case Studies ◽  
Immediate Release ◽  
New Approach ◽  
Dissolution Tests ◽  
Apparatus 3 ◽  
Usp Apparatus

scholarly journals Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process

2012 ◽  
Vol 48 (3) ◽  
pp. 379-388 ◽  
Author(s):  
Michele Georges Issa ◽  
Letícia Pessole ◽  
Andrea Ikeda Takahashi ◽  
Newton Andréo Filho ◽  
Humberto Gomes Ferraz
Keyword(s):  
Small Diameter ◽  
Immediate Release ◽  
Physicochemical Characteristics ◽  
The United States ◽  
Dissolution Profile ◽  
Orally Disintegrating Tablets ◽  
Apparatus 3 ◽  
Usp Apparatus ◽  
Extrusion Spheronization

With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated their different binding properties. The pellets were obtained by the extrusion/spheronization process and were subsequently subjected to fluid bed drying. In order to assess drug delivery, the United States Pharmacopeia (USP) apparatus 3 (Bio-Dis) was employed, in conjunction with the method described by the same pharmacopeia for the dissolution of paracetamol tablets (apparatus 1). The pellets were also evaluated for granulometry, friability, true density and drug content. The results indicate that the different binders used are capable of affecting production in different ways, and some of the physicochemical characteristics of the pellets, as well as the dissolution test, revealed that the formulations acted like immediate-release products. The pellets obtained presented favorable release characteristics for orally disintegrating tablets. USP apparatus 3 seems to be more adequate for discriminating among formulations than the basket method.

scholarly journals Evaluation of USP apparatus 3 for dissolution testing of immediate-release products

AAPS PharmSci ◽  
2002 ◽  
Vol 4 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Lawrence X. Yu ◽  
Jin T. Wang ◽  
Ajaz S. Hussain
Keyword(s):  
Immediate Release ◽  
Dissolution Testing ◽  
Apparatus 3 ◽  
Usp Apparatus

The Effect of Different Superdisintegrants and their Concentrations on the Dissolution of Topiramate Immediate Release Tablets

2009 ◽  
Vol 2 (2) ◽  
pp. 531-5366
Author(s):  
V A. Vamshi Priya ◽  
G. Chandra Sekhara Rao ◽  
D. Srinivas Reddy ◽  
V. Prabhakar Reddy
Keyword(s):  
Immediate Release ◽  
Drug Dissolution ◽  
Dissolution Profile ◽  
Dissolution Medium ◽  
Lactose Monohydrate ◽  
Sodium Starch Glycolate ◽  
Tablet Disintegration ◽  
Croscarmellose Sodium ◽  
Model Drug ◽  
Usp Apparatus

The purpose of this study was to investigate the efficiency of superdisintegrants: sodium starch glycolate, croscarmellose sodium and crospovidone in promoting tablet disintegration and drug dissolution of Topiramate immediate release tablets. The efficiency of superdisintegrants was tested, by considering four concentrations, viz., like 2%, 3%, 4% and 5% in the formulations. The dissolution was carried out in USP apparatus II at 50 rpm with distilled water as a dissolution medium. The dissolution rate of the model drug topiramate was found highly dependent on the tablet disintegration, on the particle size of the superdisintegrant, on the solubility of the drug and also on the type of superdisintegrant in the dissolution medium. There was no effect of the diluent (Lactose monohydrate) on the disintegration of different concentrations of superdisintegrants. These results suggest that, as determined by the f2 metric (similarity factor), the dissolution profile of the formulation containing 4% sodium starch glycolate and lactose monohydrate as a diluent was similar to that of a marketed product.

scholarly journals Potential and Comparative Tablet Disintegrant Properties of Pectin Obtained from Five Okra Genotypes in Ghana

Scientifica ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Frederick William Akuffo Owusu ◽  
Mariam El Boakye-Gyasi ◽  
Jacob Kwaku Agbenorhevi ◽  
Marcel Tunkumgnen Bayor ◽  
Kwabena Ofori-Kwakye
Keyword(s):  
Immediate Release ◽  
Dissolution Profile ◽  
Maize Starch ◽  
Dissolution Tests ◽  
The World ◽  
Weight Test ◽  
Pharmaceutical Industries ◽  
Tablet Formulations ◽  
Low Levels ◽  
Paracetamol Tablet

Okra pectin has been studied as a potential excipient in tablet formulations for pharmaceutical industries. Okra is widely grown and available in Ghana and other parts of the world. The prospective use of pectin from okra genotypes grown in Ghana as tablet disintegrants has not been reported. This study aims to determine the potential and comparative disintegrating properties of pectin from five okra genotypes (Abelmoschus esculentus L.) in Ghana using uncoated immediate release paracetamol tablet formulations. The yield of the pectin from the various genotypes ranged between 6.12 and 18.84% w/w. The extracted pectins had pH ranging from slightly acidic to almost neutral (6.39–6.92). Pectin from the various genotypes exhibited good swelling indexes (˃200%), varying solubility in different solvents, and low moisture content (˂20%). Elemental analysis of the extracted pectin from the various genotypes revealed very low levels of toxic metals and micronutrients. Pectin from the various genotypes was evaluated as disintegrants within concentrations of 5–10% w/w (F1–F18). Their disintegrating properties were compared to that of maize starch BP. All the formulated batches of uncoated immediate release paracetamol tablets (F1–F18) passed the following: uniformity of weight test, uniformity of dimensions, hardness, friability (˂1%), and drug content (95–105%). Significant differences ( p ≤ 0.05 ) were observed between the hardness of the maize starch tablets and tablets formulated from pectin of the various genotypes. Pectin from all genotypes other than PC5 exhibited good disintegrating properties (DT ˂ 15 min) and subsequently passed the dissolution profile test (≥70% release in 45 minutes). Tablets formulated with PC5 as disintegrants at all concentrations (5% w/w (F5), 7.5% w/w (F11), and 10% w/w (F17)) failed the disintegration and dissolution tests. Ultimately, pectins extracted from PC1, PC2, PC3, and PC4 can be commercially exploited as disintegrants in immediate release tablets.

scholarly journals Putting resilient sustainability into strategy decisions – case studies

2018 ◽  
Vol 56 (7) ◽  
pp. 1598-1612 ◽  
Author(s):  
Julie Winnard ◽  
Jacquetta Lee ◽  
David Skipp
Keyword(s):  
Case Studies ◽  
Real World ◽  
Design Methodology ◽  
Strategic Decision ◽  
New Approach ◽  
Content Type ◽  
Industrial Companies ◽  
Different Types ◽  
Strategic Decision Support ◽  
Practical Implications

Purpose The purpose of this paper is to report the results of testing a new approach to strategic sustainability and resilience – Sustainable Resilient Strategic Decision-Support (SuReSDS™). Design/methodology/approach The approach was developed and tested using action-research case studies at industrial companies. It successfully allowed the participants to capture different types of value affected by their choices, optimise each strategy’s resilience against different future scenarios and compare the results to find a “best” option. Findings SuReSDS™ enabled a novel integration of environmental and social sustainability into strategy by considering significant risks or opportunities for an enhanced group of stakeholders. It assisted users to identify and manage risks from different kinds of sustainability-related uncertainty by applying resilience techniques. Users incorporated insights into real-world strategies. Research limitations/implications Since the case studies and test organisations are limited in number, generalisation from the results is difficult and requires further research. Practical implications The approach enables companies to utilise in-house and external experts more effectively to develop sustainable and resilient strategies. Originality/value The research described develops theories linking sustainability and resilience for organisations, particularly for strategy, to provide a new consistent, rigorous and flexible approach for applying these theories. The approach has been tested successfully and benefited real-world strategy decisions.

Summary and conclusion

2016 ◽  
Author(s):  
Joseph Gafaranga
Keyword(s):  
Case Studies ◽  
Language Use ◽  
Research Direction ◽  
Code Switching ◽  
Negative Attitudes ◽  
New Approach ◽  
Advanced Level ◽  
Concurrent Use ◽  
Interactional Functions ◽  
New Research

Research in code-switching, undertaken against the backdrop of very negative attitudes towards the concurrent use of two or more languages within the same conversation, has traditionally been geared towards rehabilitating this form of language use. From being seen as a random phenomenon reflecting the user’s lack of competence, code-switching is currently seen as sign of an advanced level of competence in the languages involved and as serving different interactional functions. However, as a result of its success, the research tradition now faces an entirely new challenge: Where to from here? How can research in code-switching continue to be relevant and interesting now it has largely achieved its original purpose? This book has argued that, in order to overcome this challenge, the notion of bilingualism itself must be redefined. Bilingualism must be seen as consisting of diverse interactional practices and be investigated as such. This book has made the case for this new approach, outlined a methodology for investigating bilingualism as interactional practices and illustrated it by means of three case studies. This concluding chapter wraps up the argument and invites other researchers to contribute to this new research direction.

scholarly journals Effect of Sodium Starch Glycolate on Formulation of Fexofenadine Hydrochloride Immediate Release Tablets by Direct Compression Method

2018 ◽  
Vol 10 (1) ◽  
pp. 31-38 ◽  
Author(s):  
S. Karim ◽  
A. Biswas ◽  
A. Bosu ◽  
F. R. Laboni ◽  
A. S. Julie ◽  
...  
Keyword(s):  
Immediate Release ◽  
Direct Compression ◽  
Compression Method ◽  
Release Formulation ◽  
The Core ◽  
Sodium Starch Glycolate ◽  
Zero Order Kinetics ◽  
Speed Up ◽  
Usp Apparatus ◽  
Paddle Apparatus

Present study aspires at the design of an immediate release formulation with prospective use of fexofenadine hydrochloride by exploring the effect of sodium starch glycolate as super disintegrant. Fexofenadine hydrochloride immediate release tablets (Formulations F-1, F-2, F-3, F-4 and F-5) using different ratios of sodium starch glycolate as a disintegrant were prepared by direct compression method. Standard physicochemical tests were performed for all the formulations. Dissolution studies of the formulations were done in phosphate buffer, pH 6.8 using USP apparatus II (paddle apparatus) at 50 rpm. Percent release of fexofenadine hydrochloride of formulations F-1, F-2, F-3, F-4 and F-5 were 89.98%, 90.98%, 92.95, 96.92% and 99.85%, respectively after 1 h and the release pattern followed the zero order kinetics. The release rate in the formulation F-5 was higher compared to other formulations and the studied market products. Sodium starch glycolate speed up the release of the drug from the core tablets, and the release of fexofenadine hydrochloride from tablets was directly proportional to the amount of sodium starch glycolate present in the formulations and there by produced immediate action.

scholarly journals Language Shift and Identity: Exploring Factors Which Condition Identity When a Traditional Language is Lost

MANUSYA ◽  
2018 ◽  
Vol 21 (2) ◽  
pp. 27-51
Author(s):  
David M. Eberhard
Keyword(s):  
Case Studies ◽  
Group Identity ◽  
Language Shift ◽  
Minority Communities ◽  
New Approach ◽  
Language Ecology ◽  
Traditional Language ◽  
Advanced Stages

The loss of a minority group’s language may or may not be accompanied by the loss of the same group’s identity. This study explores the factors that appear to condition identity choices among minority communities. A number of language communities in advanced stages of language shift are chosen as case studies. Based on these case studies, a framework is proposed that organizes the factors involved in group identity choices into either language internal or language ecology factors, each with their own set of relevant characteristics. The benefit of this new approach over previous explanations is its ability to describe identity choices from a wide array of motivations. Such a framework will facilitate future researchers considering this question, providing them with a roadmap to navigate the various identity options.

Sign in / Sign up

Export Citation Format

Share Document