Wide Distribution of the Serum Levels of DHEA and Sex Steroids in Postmenopausal Women – Relative Role of the Ovary?.

2010 ◽  
pp. P2-429-P2-429
Author(s):  
Fernand Labrie ◽  
Celine Martel ◽  
John Balser
Keyword(s):  
Postmenopausal Women ◽  
Sex Steroids ◽  
Serum Levels ◽  
Wide Distribution ◽  
Relative Role

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

2012 ◽  
Vol 167 (2) ◽  
pp. 145-156 ◽  
Author(s):  
Theodora Pappa ◽  
Maria Alevizaki
Keyword(s):  
Vascular Disease ◽  
Postmenopausal Women ◽  
Sex Steroids ◽  
Carotid Artery Disease ◽  
Subclinical Atherosclerosis ◽  
Vascular Diseases ◽  
Future Research ◽  
Postmenopausal Period ◽  
Endogenous Estrogen

ObjectiveCardio- and cerebro-vascular diseases are two leading causes of death and long-term disability in postmenopausal women. The acute fall of estrogen in menopause is associated with increased cardiovascular risk. The relative contribution of androgen to this risk is also being recognized. The use of more sensitive assays for estradiol measurement and the study of receptor and carrier protein gene polymorphisms have provided some new information on the clinical relevance of endogenous sex steroids. We provide an update on the role of endogenous sex steroids on cardio- and cerebro-vascular disease in the postmenopausal period.Design and methodsWe performed a PubMed search using the terms ‘endogenous estrogen’, ‘androgen’, ‘cardiovascular disease’, ‘cerebro-vascular disease’, ‘stroke’, ‘carotid artery disease’, and ‘subclinical atherosclerosis’.ResultsThe majority of studies show a beneficial effect of endogenous estrogen on the vasculature; however, there are a few studies reporting the contrary. A significant body of literature has reported associations of endogenous estrogen and androgen with early markers of atherosclerosis and metabolic parameters. Data on the relevance of endogenous sex steroids in heart disease and stroke are inconclusive.ConclusionsMost studies support a beneficial role of endogenous estrogens and, probably, an adverse effect of androgens in the vasculature in postmenopausal women. However, the described associations may not always be considered as causal. It is possible that circulating estrogen might represent a marker of general health status or alternatively reflect the sum of endogenous androgens aromatized in the periphery. Elucidating the role of sex steroids in cardio- and cerebro-vascular disease remains an interesting field of future research.

Serum CTRP3 Level is Associated with Osteoporosis in Postmenopausal Women

2018 ◽  
Vol 126 (09) ◽  
pp. 559-563 ◽  
Author(s):  
Zhong-Hua Xu ◽  
Xing Zhang ◽  
Hua Xie ◽  
Jin He ◽  
Wen-Chao Zhang ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Dual Energy ◽  
Complex Interaction ◽  
Mineral Density ◽  
X Ray ◽  
Control Study

Abstract Background As a novel adipokine, CTRP3 involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and adipose tissue via the secretion of adipokines. Aims A hospital-based case-control study was conducted to investigate the role of serum CTRP3 in osteoporosis among postmenopausal women. Methods Serum levels of CTRP3 and osteocalcin were measured. Bone mineral density (BMD) was obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry. Results Serum CTRP3 level was lower in subjects with osteoporosis (76.7±22.1 ng/ml) than it in controls (89.4±22.5 ng/ml) (P<0.001). Meanwhile, the frequency of osteoporosis presented a significant decrease (66.4%, 53.9% and 35.9%, P<0.001), in the tertiles of serum CTRP3. Furthermore, serum CTRP3 witnessed an association with a lower risk of osteoporosis (adjusted odds ratio=0.973, 95% confidence interval [0.963–0.983], P<0.001). Lastly, serum CTRP3 level was positively correlated with femoral BMD (r=0.403, P<0.001), lumbar BMD (r=0.368, P<0.001), and HDL-C (r=0.118, P=0.022), among all participants after adjustment. Meanwhile, CTRP3 presented negative correlations with HOMA-IR (r=−0.136, P=0.008) and insulin (r=−0.192, P <0.001). Conclusions It shows that a decreased serum level of CTRP3 was independently associated with osteoporosis.

Effect of sex steroids on body temperature in postmenopausal women. Role of endogenous opioids

Life Sciences ◽  
1992 ◽  
Vol 50 (7) ◽  
pp. 515-521 ◽  
Author(s):  
A. Cagnacci ◽  
G.B. Melis ◽  
R. Soldani ◽  
A.M. Paoletti ◽  
P. Fioretti
Keyword(s):  
Body Temperature ◽  
Postmenopausal Women ◽  
Sex Steroids ◽  
Endogenous Opioids

Influence of nandrolondecanoate on the pituitary-gonadal axis in males

1982 ◽  
Vol 101 (1) ◽  
pp. 108-112 ◽  
Author(s):  
J. W. J. Bijlsma ◽  
S. A. Duursma ◽  
J. H. H. Thijssen ◽  
O. Huber
Keyword(s):  
Rheumatoid Arthritis ◽  
Pilot Study ◽  
Beneficial Effect ◽  
Sex Steroids ◽  
Anabolic Steroids ◽  
Serum Levels ◽  
Inhibitory Effect ◽  
Testosterone Secretion ◽  
Lh Secretion

Abstract. Different anabolic steroids can exercise different effects on the pituitary-gonadal axis in males. During a pilot study regarding the possible beneficial effect of the anabolic steroid nandrolondecanoate (ND) on bone metabolism in patients with rheumatoid arthritis additional endocrinological parameters were studied. A significant decrease was found in the serum levels of testosterone, androstenedione and FSH and the ratio of testosterone/oestradiol. There was a significant increase in the serum levels of oestrone. The levels of oestradiol, SHBG, LH and cortisol remained unchanged. An inhibitory effect of ND on testicular testosterone secretion is assumed. The decrease in androstenedione levels is explained by the diminished testosterone secretion. The rise in oestrone levels is explained by peripheral aromatizing of ND to oestrogens. The presented findings are in accordance with the hypothesis that sex steroids can act directly on the pituitary resulting in selective FSH and LH secretion. The possible role of the ratio testosterone/oestradiol in controlling gonadotrophin output is discussed.

Serum steroids remain within the same normal postmenopausal values during 12-month intravaginal 0.50% DHEA

2015 ◽  
Vol 24 (3) ◽  
Author(s):  
Yuyong Ke ◽  
Renaud Gonthier ◽  
Jean-Nicolas Simard ◽  
David Archer ◽  
Lyne Lavoie ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Sex Steroids ◽  
Normal Values ◽  
Systemic Exposure ◽  
Serum Levels ◽  
Detectable Change ◽  
Serum Samples ◽  
Vulvovaginal Atrophy ◽  
Related Compounds

Abstract: Analyze the serum levels of DHEA (prasterone) and its metabolites after daily intravaginal 0.50% (6.5 mg) DHEA in postmenopausal women with vulvovaginal atrophy (VVA).: Serum samples were obtained at baseline and after 12, 26 and 52 weeks of treatment. The serum levels of DHEA, DHEA-sulfate (DHEA-S), androstene-3β, 17β-diol (5-diol), androstenedione (4-dione), testosterone, dihydrotestosterone (DHT), estrone (E: A total of 435 women were exposed for 52 weeks. All serum steroids remained within normal values with no significant differences between lengths of treatment. For the most relevant estrogen-related compounds, namely E: While confirming that all serum sex steroids originating exclusively from DHEA after menopause are maintained within the normal postmenopausal values, the present data show that the dose of intravaginal DHEA used is free from systemic exposure with no detectable change in metabolism up to 52 weeks of treatment.

scholarly journals High Levels of 17β-Estradiol Are Associated with Increased Matrix Metalloproteinase-2 and Metalloproteinase-9 Activity in Tears of Postmenopausal Women with Dry Eye

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Guanglin Shen ◽  
Xiaoping Ma
Keyword(s):  
Matrix Metalloproteinase ◽  
Mrna Expression ◽  
Postmenopausal Women ◽  
Dry Eye ◽  
Sex Steroids ◽  
Serum Levels ◽  
Matrix Metalloproteinase 2 ◽  
Schirmer Test ◽  
Metalloproteinase 9 ◽  
Estradiol Levels

Purpose. To determine the serum levels of sex steroids and tear matrix metalloproteinases (MMP) 2 and 9 concentrations in postmenopausal women with dry eye.Methods. Forty-four postmenopausal women with dry eye and 22 asymptomatic controls were enrolled. Blood was drawn and analyzed for serum levels of sex steroids and lipids. Then, the following tests were performed: tear collection, Ocular Surface Disease Index (OSDI) questionnaire, fluorescein tear film break-up time (TBUT), corneal fluorescein staining, Schirmer test, and conjunctival impression cytology. The conjunctival mRNA expression and tear concentrations of MMP-2 and MMP-9 were measured.Results. Serum 17β-estradiol levels were significantly higher in the dry eye subjects than in the controls (P=0.03), whereas there were no significant differences in levels of testosterone, dehydroepiandrosterone sulfate (DHEA-S), and progesterone. Tear MMP-2 and MMP-9 concentrations (P<0.001), as well as the MMP-9 mRNA expression in conjunctival samples (P=0.02), were significantly higher in dry eye subjects than in controls. Serum 17β-estradiol levels were positively correlated with tear MMP-2 and MMP-9 concentrations and negatively correlated with Schirmer test values.Conclusions. High levels of 17β-estradiol are associated with increased matrix metalloproteinase-2 and metalloproteinase-9 activity in tears of postmenopausal women with dry eye.

scholarly journals Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease

2000 ◽  
Vol 25 (1) ◽  
pp. 1-16 ◽  
Author(s):  
F Labrie ◽  
V Luu-The ◽  
SX Lin ◽  
J Simard ◽  
C Labrie ◽  
...  
Keyword(s):  
Human Physiology ◽  
Postmenopausal Women ◽  
Sex Steroids ◽  
Sex Steroid ◽  
Peripheral Target ◽  
Adult Men ◽  
Hydroxysteroid Dehydrogenases ◽  
The Family ◽  
Site Of Action

In women and men, an important proportion of estrogens and androgens are synthesized locally at their site of action in peripheral target tissues. This new field of endocrinology has been called intracrinology. In postmenopausal women, 100% of active sex steroids are synthesized in peripheral target tissues from inactive steroid precursors while, in adult men, approximately 50% of androgens are made locally in intracrine target tissues. The last and key step in the formation of all estrogens and androgens is catalyzed by members of the family of 17beta-hydroxysteroid dehydrogenases (17 beta-HSDs) while different 17 beta-HSDs inactivate these steroids in the same cell where synthesis takes place. To date, seven human 17 beta-HSDs have been cloned, sequenced and characterized. The 17 beta-HSDs provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs.

Sign in / Sign up

Export Citation Format

Share Document