Persistence of Hyperinsulinemia, Positive Correlation of Insulin Resistance Indices with Androgen Levels, Increased Visfatin and Decreased PYY Levels in Women with Polycystic Ovary Syndrome after Menopause

2011 ◽  
pp. P2-226-P2-226
Author(s):  
Marios C Markopoulos ◽  
George Valsamakis ◽  
Demetrios Rizos ◽  
George Creatsas ◽  
George Mastorakos
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Positive Correlation ◽  
Androgen Levels

scholarly journals Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Ewelina Kolan′ska-Dams ◽  
Joanna Boinska ◽  
Maciej W. Socha
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Carbohydrate Metabolism ◽  
De Novo ◽  
Polycystic Ovary ◽  
Control Group ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Positive Correlation ◽  
Pcos Group

Introduction: Central obesity appears to play a major role in the pathogenesis of metabolic disorders in polycystic ovary syndrome. Insulin resistance and carbohydrate disorders are associated with dysfunctional secretion of various adipokines by the adipose tissue. Objectives: This study aimed to evaluate leptin, apelin, and visfatin against a background of carbohydrate metabolism parameters in patients diagnosed de novo with polycystic ovary syndrome (PCOS). Material and methods: The study group consisted of 40 patients with PCOS (mean age, 29 years) diagnosed in accordance with the American Society for Reproductive Medicine criteria from 2003. The control group consisted of 37 clinically healthy women (mean age, 26 years). All controls had regular menses and no clinical or biochemical signs of hyperandrogenism. Concentrations of leptin, apelin, visfatin, and insulin were measured by immunoenzymatic methods. Glucose concentrations were determined using spectrophotometry. Results: Significantly higher concentrations of leptin, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) index, and the immunoreactive insulin (IRI)/glucose index were found in the PCOS group than in the control group. Notably, the concentration of apelin was over five times lower in the PCOS group than in the control group. In patients with PCOS, a positive correlation was found between the concentrations of insulin and leptin and concentrations of leptin and IRI/glucose. Patients of the PCOS group with body mass index (BMI) ≥  25 had significantly higher values of leptin, insulin, HOMA-IR index, and IRI/glucose index than patients of the PCOS group with normal BMI. In the PCOS group, a positive correlation was found between BMI and leptin concentration (r = 0.7176; p < 0.0001) and carbohydrate metabolism, such as insulin (r = 0.5524; p = 0.0003), glucose (r = 0.3843; p = 0.0157), HOMA-IR (r = 0.5895; p < 0.0001), and IRI/glucose (r = 0.3872; p = 0.0163). These findings were not observed in the control group. Conclusions: (1) Increased leptin concentration observed in women diagnosed de novo with PCOS as well as positive correlations between leptin and HOMA-IR, and IRI/glucose and BMI may indicate a potential role of leptin in the reduction of tissue sensitivity to insulin. (2) Significantly lower apelin concentration in the PCOS group (>5 fold) than in the control group, associated with a concomitant increase in leptin, may also contribute to carbohydrate metabolism disorders occurring in the course of PCOS.

No changes of peripheral insulin resistance in polycystic ovary syndrome after long-term reduction of endogenous androgens with leuprolide

1995 ◽  
Vol 133 (6) ◽  
pp. 718-722 ◽  
Author(s):  
Antonino Lasco ◽  
Domenico Cucinotta ◽  
Alfonso Gigante ◽  
Giulia Denuzzo ◽  
Marilena Pedulla ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Control Subjects ◽  
Peripheral Insulin Resistance ◽  
Androgen Levels

Lasco A, Cucinotta D, Gigante A, Denuzzo G, Pedulla M, Trifiletti A, Frisina N. No changes of peripheral insulin resistance in polycystic ovary syndrome after long-term reduction of endogenous androgens with leuprolide. Eur J Endocrinol 1995;133:718–22. ISSN 0804–4643 The aim of this study was to investigate the relationship between plasma insulin levels, peripheral insulin sensitivity and androgen secretion in ten patients with polycystic ovary syndrome and in six obese women as compared with six normal-weight control subjects. During a euglycemic–hyperinsulinemic clamp no significant change of testosterone, androstenedione or dehydroepiandrosterone sulfate plasma levels was observed in the two groups of patients or in the control subjects; insulin sensitivity was clearly reduced and was similar in polycystic ovary patients and in obese women, in spite of the different plasma androgen levels. A long-term (5 months) androgen suppression with the gonadotropin-releasing hormone agonist leuprolide was not able to improve significantly the insulin sensitivity. These results demonstrate that the short-term hyperinsulinemia achieved with the clamp technique does not affect androgen secretion and that insulin resistance, measured with the same technique, is not influenced by long-term suppression of plasma androgen levels in polycystic ovary syndrome. A Lasco, Via Faustina e Tertullo 19, 98100 Messina, Italy

scholarly journals MICROCIRCULATORY DISORDERS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

2017 ◽  
Vol 5 ◽  
pp. 953-957
Author(s):  
Daniela Koleva ◽  
Mariana Batzelova ◽  
Julia Nikolova ◽  
Maria Orbetzova
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Microvascular Dysfunction ◽  
Nailfold Capillaroscopy ◽  
Low Grade ◽  
Inverse Association ◽  
Ovary Syndrome ◽  
Positive Correlation ◽  
Healthy Women

: It is believed that microvascular dysfunction plays a major role in the development of insulin resistance (IR). Performing nailfold capillaroscopy wit­h evaluation of microvascular parameters in women with polycystic ovary syndrome (PCOS) would undoubtedly be helpful for the investigation of novel pathophysiological mechanisms in IR occurrence. The aim of the present study was to compare the values of microvascular parameters between PCOS patients and clinically healthy women and to assess its relationship with clinical and metabolic parameters in the PCOS women. Our study included 21 PCOS patients and 22 clinically healthy women (controls). Nailfold capillaroscopy was conducted and the following parameters were assessed: arterial limb diameter (d art), venous limb diameter (d ven), top diameter of loops (top d), length of loops, d art/d ven ratio, d ven/d art ratio, number of capillary loops (n cap), number of abnormal loops (% abn cap) and a presence of perivascular diapedesis. Weight, height, fasting plasma glucose (FPG), immunoreactive insulin (IRI), lipid parameters, total testosterone, systolic (SBP) and diastolic blood pressure (DBP) were measured in the PCOS women. Body mass index (BMI) and homeostasis model of insulin resistance index (HOMA-IR) were calculated. We found significantly higher values of age, BMI and % abn cap in the women with PCOS as compared to the controls. Interestingly, % abn cap showed a negative correlation with age. Furthermore, an inverse association between top d and the values of SBP and DBP was established. We determined a positive correlation between the presence of perivascular diapedesis and the values of FPG, HOMA-IR and testosterone. As a conclusion, the higher % abn cap in the PCOS women might be an early pathophysiological sign of microvascular dysfunction. The positive correlation between perivascular diapedesis and the degree of IR, hyperglycemia, and hyperandrogenemia shows the existence of a chronic low-grade inflammatory process in PCOS.

Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels

2008 ◽  
Vol 89 (4) ◽  
pp. 899-906 ◽  
Author(s):  
Dimitrios Panidis ◽  
Dimitrios Farmakiotis ◽  
David Rousso ◽  
Anargyros Kourtis ◽  
Ilias Katsikis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Effect Of Treatment ◽  
Androgen Levels

scholarly journals Thyroid function in women with polycystic ovary syndrome

2021 ◽  
Vol 10 (3) ◽  
pp. 929
Author(s):  
Bharti Patidar ◽  
Rekha Sapkal
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Significant Positive Correlation ◽  
Polycystic Ovary ◽  
Thyroid Stimulating Hormone ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Significant Difference ◽  
Tsh Levels

Background: This study aimed to assess the serum thyroid stimulating hormone (TSH) levels in women with polycystic ovary syndrome (PCOS), and its variation with obesity, insulin resistance and LH:FSH ratio.Methods: This was a facility based cross sectional study conducted for a period of 18 months on a total of 165 females with PCOS diagnosed based on Rotterdam 2003 criteria. A thorough history and clinical and anthropometric examination was conducted for all females. USG abdomen and serum TSH levels and fT4 were also done and the findings were recorded on questionnaire.Results: Subclinical hypothyroidism was documented in 17% females with PCOS. No statistically significant difference in mean values of LH:FSH ratio, insulin resistance, and obesity parameters were noted among euthyroid and subclinical hypothyroid females with PCOS (p>0.05). TSH levels in present study showed a statsitcally significant positive correlation with BMI.Conclusions: The proportions of thyroid disorders are higher in females with PCOS and they both may present with various similar clinical features. BMI in females with PCOS has significant positive correlation with TSH levels. However, it is not clear whether thyroid dysfunction has significant effect on insulin resistance.

scholarly journals Plasma Ghrelin, Obesity, and the Polycystic Ovary Syndrome: Correlation with Insulin Resistance and Androgen Levels

2002 ◽  
Vol 87 (12) ◽  
pp. 5625-5629 ◽  
Author(s):  
Uberto Pagotto ◽  
Alessandra Gambineri ◽  
Valentina Vicennati ◽  
Mark L. Heiman ◽  
Matthias Tschöp ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Androgen Levels
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