scholarly journals Adiponectin Gene Expression and Plasma Values in Obese Women during Very-Low-Calorie Diet. Relationship with Cardiovascular Risk Factors and Insulin Resistance

2004 ◽  
Vol 89 (2) ◽  
pp. 756-760 ◽  
Author(s):  
Marta Garaulet ◽  
Nathalie Viguerie ◽  
Stefan Porubsky ◽  
Eva Klimcakova ◽  
Karine Clement ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Obese Women ◽  
Adiponectin Gene ◽  
Very Low Calorie Diet ◽  
Plasma Adiponectin ◽  
The Metabolic Syndrome ◽  
Low Calorie Diet ◽  
Calorie Diet

Adiponectin, a newly discovered adipose-tissue-specific protein, is thought to be involved in the regulation of insulin action. The aim of the present study was to determine whether adiponectin contributes to the improvement in insulin sensitivity during very-low-calorie diet (VLCD). Biopsies of sc abdominal adipose tissue and blood sampling for analysis of plasma adiponectin and related hormones and metabolites were performed before and at the end of a 4-wk VLCD in 33 nonmorbidly obese women (body mass index, 34.4 ± 4.1 kg/m2). VLCD produced a decrease in weight (7.1 ± 0.4 kg) and in insulin and leptin levels and led to an improvement in insulin sensitivity. Adiponectin gene expression and plasma levels were not modified during calorie restriction. Before VLCD, we found negative correlations between plasma adiponectin and variables related to the metabolic syndrome. Adiponectin mRNA levels showed a negative correlation with lipoprotein a plasma values. The correlations observed before VLCD were not found after VLCD. The data suggest that adiponectin is related to the protection against the metabolic syndrome but is not involved in the regulation of VLCD-induced improvement of insulin sensitivity.

scholarly journals Adiponectin Gene Expression in Subcutaneous Adipose Tissue of Obese Women in Response to Short-Term Very Low Calorie Diet and Refeeding

2003 ◽  
Vol 88 (12) ◽  
pp. 5881-5886 ◽  
Author(s):  
Yong-Ming Liu ◽  
Jean-Marc Lacorte ◽  
Nathalie Viguerie ◽  
Christine Poitou ◽  
Véronique Pelloux ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Obese Women ◽  
Adiponectin Gene ◽  
Short Term ◽  
Very Low Calorie Diet ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Subcutaneous Adipose

The effects of very low calorie diet and exercise on insulin sensitivity and secretion in obese type 2 diabetics

2000 ◽  
Vol 50 ◽  
pp. 342
Author(s):  
Munehide Matsuhisa ◽  
Shinichi Gorogawa ◽  
Kentaro Ohtoshi ◽  
Rieko Hayaishi ◽  
Tetsuyuki Yasuda ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Type 2 Diabetics ◽  
Diet And Exercise ◽  
Calorie Diet

scholarly journals Lipoprotein Metabolism in Normolipidemic Obese Women during Very Low Calorie Diet

1991 ◽  
Vol 37 (Supplement) ◽  
pp. S57-S64 ◽  
Author(s):  
Tetsuo SHOJI ◽  
Yoshiki NISHIZAWA ◽  
Hidenori KOYAMA ◽  
Satoshi HAGIWARA ◽  
Hideyuki ARATANI ◽  
...  
Keyword(s):  
Lipoprotein Metabolism ◽  
Obese Women ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

A low-calorie diet with or without interval exercise training improves adiposopathy in obese women

2019 ◽  
Vol 44 (10) ◽  
pp. 1057-1064 ◽  
Author(s):  
Nicole M. Gilbertson ◽  
Natalie Z.M. Eichner ◽  
Emily M. Heiston ◽  
Julian M. Gaitán ◽  
Monique E. Francois ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Composition ◽  
Insulin Sensitivity ◽  
Oxygen Uptake ◽  
Peak Oxygen Uptake ◽  
Energy Deficit ◽  
Obese Women ◽  
Interval Exercise ◽  
Low Calorie Diet ◽  
Calorie Diet

The objective of this study was to test if a low-calorie diet plus interval exercise (LCD+INT) improves adiposopathy, an endocrine dysfunction, when compared with an energy-deficit–matched LCD in obese women. Subjects (age: 48.2 ± 2.4 years, body mass index: 37.8 ± 1.3 kg/m2) were randomized to a 13-day LCD (n = 12; mixed meals of ∼1200 kcal/day) or LCD+INT (n = 12; 12 sessions of 60 min/day alternating 3 min at 50% and 90% peak heart rate). Exercise was estimated to expend 350 kcal per oxygen uptake–heart rate regression analysis and individuals were refed calories expended to match energy availability between groups. Absolute (post – pre caloric intake) and relative (total daily and exercise energy expenditure relative to calorie intake) energy deficits were calculated. Fitness (peak oxygen uptake) and body composition (BodPod; Cosmed USA Inc.) were measured and a 120-min, 75g oral glucose tolerance test was performed at pre- and post-intervention to assess adiposopathy (i.e., ratio of high molecular weight–adiponectin to leptin) and estimate insulin sensitivity. LCD and LCD+INT had similar absolute (P = 0.55) and relative (P = 0.76) energy deficits. LCD and LCD+INT had similar reductions in fat mass (both P < 0.001), despite LCD inducing greater weight loss (P = 0.02) than LCD+INT. Both treatments improved adiposopathy (P = 0.003) and peripheral insulin sensitivity (P = 0.02). Absolute energy deficit correlated to improved adiposopathy (r = –0.41, P = 0.05), and absolute and relative energy deficits were associated with increased insulin sensitivity (r = –0.47, P = 0.02; and r = –0.40, P = 0.05, respectively), independent of body composition changes and increased peak oxygen uptake. Taken together, LCD, with or without INT, improves adiposopathy in relation to insulin sensitivity in obese women, suggesting that a short-term energy deficit is key for reducing risk of type 2 diabetes.

scholarly journals Low-Calorie Diet Plus Interval Exercise Training Improves Metabolic Flexibility and Insulin Sensitivity in Obese Women

2018 ◽  
Vol 50 (5S) ◽  
pp. 222
Author(s):  
Nicole M. Gilbertson ◽  
Natalie Z.M. Eichner ◽  
Emily M. Heiston ◽  
Monique Francois ◽  
Julian M. Gaítan ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Exercise Training ◽  
Metabolic Flexibility ◽  
Obese Women ◽  
Low Calorie ◽  
Interval Exercise ◽  
Low Calorie Diet ◽  
Calorie Diet

Catecholamine and insulin control of lipolysis in subcutaneous adipose tissue during long-term diet-induced weight loss in obese women

2012 ◽  
Vol 302 (2) ◽  
pp. E226-E232 ◽  
Author(s):  
Katrien Koppo ◽  
Michaela Siklová-Vitková ◽  
Eva Klimčáková ◽  
Jan Polák ◽  
Marie A. Marques ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Subcutaneous Adipose Tissue ◽  
Dietary Intervention ◽  
Glycerol Concentration ◽  
Obese Women ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Subcutaneous Adipose

The aim of this study was to investigate the evolution of the adrenergic and insulin-mediated regulation of lipolysis during different phases of a 6-mo dietary intervention. Eight obese women underwent a 6-mo dietary intervention consisting of a 1-mo very low-calorie diet (VLCD) followed by a 2-mo low-calorie diet (LCD) and 3-mo weight maintenance (WM) diet. At each phase of the dietary intervention, microdialysis of subcutaneous adipose tissue (SCAT) was performed at rest and during a 3-h hyperinsulinemic euglycemic clamp. Responses of dialysate glycerol concentration (DGC) were determined at baseline and during local perfusions with adrenaline or adrenaline and phentolamine before and during the last 30 min of the clamp. Dietary intervention induced a body weight reduction and an improved insulin sensitivity. DGC progressively decreased during the clamp, and this decrease was similar during the different phases of the diet. The adrenaline-induced increase in DGC was higher at VLCD and LCD compared with baseline condition and returned to prediet levels at WM. In the probe with adrenaline and phentolamine, the increase in DGC was higher than that in the adrenaline probe at baseline and WM, but it was not different at VLCD and LCD. The results suggest that the responsiveness of SCAT to adrenaline-stimulated lipolysis increases during the calorie-restricted phases due to a reduction of the α2-adrenoceptor-mediated antilipolytic action of adrenaline. At WM, adrenaline-stimulated lipolysis returned to the prediet levels. Furthermore, no direct relationship between insulin sensitivity and the diet-induced changes in the regulation of lipolysis was found.

scholarly journals Expression of Inflammation-Related Genes in Gluteal and Abdominal Subcutaneous Adipose Tissue During Weight-Reducing Dietary Intervention in Obese Women

2014 ◽  
pp. 73-82 ◽  
Author(s):  
L. MALIŠOVÁ ◽  
L. ROSSMEISLOVÁ ◽  
Z. KOVÁČOVÁ ◽  
J. KRAČMEROVÁ ◽  
M. TENCEROVÁ ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Dietary Intervention ◽  
Weight Maintenance ◽  
Maintenance Phase ◽  
Obese Women ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Paired Samples ◽  
Low Calorie Diet ◽  
Calorie Diet

Accumulation of adipose tissue in lower body lowers risk of cardiovascular and metabolic disorders. The molecular basis of this protective effect of gluteofemoral depot is not clear. The aim of this study was to compare the profile of expression of inflammation-related genes in subcutaneous gluteal (sGAT) and abdominal (sAAT) adipose tissue at baseline and in response to multiphase weight-reducing dietary intervention (DI). 14 premenopausal healthy obese women underwent a 6 months’ DI consisting of 1 month very-low-calorie-diet (VLCD), subsequent 2 months’ low-calorie-diet and 3 months’ weight maintenance diet (WM). Paired samples of sGAT and sAAT were obtained before and at the end of VLCD and WM periods. mRNA expression of 17 genes (macrophage markers, cytokines) was measured using RT-qPCR on chip-platform. At baseline, there were no differences in gene expression of macrophage markers and cytokines between sGAT and sAAT. The dynamic changes induced by DI were similar in both depots for all genes except for three cytokines (IL6, IL10, CCL2) that differed in their response during weight maintenance phase. The results show that, in obese women, there are no major differences between sGAT and sAAT in expression of inflammation-related genes at baseline conditions and in response to the weight-reducing DI.

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