scholarly journals A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

2008 ◽  
Vol 93 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Olivier Valkenburg ◽  
Regine P. M. Steegers-Theunissen ◽  
Huberdina P. M. Smedts ◽  
Geesje M. Dallinga-Thie ◽  
Bart C. J. M. Fauser ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Atherogenic Lipid Profile ◽  
Control Study ◽  
Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

scholarly journals Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Sahar Mazloomi ◽  
Faranak Sharifi ◽  
Reza Hajihosseini ◽  
Sadroddin Kalantari ◽  
Saideh Mazloomzadeh
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Confounding Factor ◽  
Polycystic Ovary ◽  
Hdl Cholesterol ◽  
Dehydroepiandrosterone Sulfate ◽  
Control Group ◽  
Ovary Syndrome ◽  
25 Oh Vitamin D ◽  
Control Study

Objective. To investigate the possible association of calcium and vitamin D deficiency with hypoadiponectinemia in women with PCOS. Subjects and Methods. In this case-control study, 103 PCOS cases and 103 controls included. The concentrations of calcium, 25-OH-vitamin D (25OHD), adiponectin, insulin, glucose, total cholesterol, HDL-cholesterol, triglyceride (TG), and androgens were measured in fasting blood samples. Results. Adiponectin (8.4±2.7 ng/mL versus 13.6±5 ng/mL in control group, P:0.00), calcium (2±0.1 mmol/L versus 2.55±0.17 mmol/L in controls, P:0.00), and 25-OH-Vit D (30±2.99 nmol/L versus 43.7±5.2 nmol/L in control group, P:0.00) levels were decreased in women with PCOS. Subjects with PCOS had higher concentrations of TG (1.4±0.77 mmol/L versus 1.18±0.75 mmol/L in control group, P:  0.019) and dehydroepiandrosterone sulfate (DHEA-S) (10.7±11 mmol/L versus 9.7±10.4, P:0.02 in control group). There were significant correlations between adiponectin concentrations with calcium (r:0.78, P:0.00) and 25OHD levels (r:0.82, P:0.00). The association of hypoadiponectinemia and PCOS was not significant considering 25OHD as a confounding factor. Conclusion. The present findings indicate that the association of hypoadiponectinemia with PCOS is dependent on vitamin D. A possible beneficiary effect of vitamin D on the metabolic parameters in PCOS may be suggested.

scholarly journals Monosomy for the X-Chromosome Is Associated with an Atherogenic Lipid Profile

2006 ◽  
Vol 91 (8) ◽  
pp. 2867-2870 ◽  
Author(s):  
Phillip L. Van ◽  
Vladimir K. Bakalov ◽  
Carolyn A. Bondy
Keyword(s):  
Particle Size ◽  
Lipid Profile ◽  
X Chromosome ◽  
Premature Ovarian Failure ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Ovarian Failure ◽  
Atherogenic Lipid Profile ◽  
Lipid Particle ◽  
Atherogenic Lipid

Abstract Context and Objective: Men typically have a more atherogenic lipid profile than women characterized by higher low-density lipoprotein (LDL) cholesterol and triglyceride levels and reduced lipid particle size, contributing to a greater risk for coronary disease. To determine whether X-chromosomal gene dosage affects lipid metabolism independent of sex steroid effects, we compared lipid profiles in age- and body mass-matched young women with ovarian failure, differing only in X-chromosome dosage. Design, Setting, and Patients: Women with premature ovarian failure associated with monosomy X or Turner syndrome (TS, n = 118) were compared with women with 46,XX premature ovarian failure (n = 51) in an in-patient clinical research center unit at the National Institutes of Health. These women were normally on estrogen replacement treatment but discontinued the estrogen 2 wk before study. Major Outcomes: Fasting lipid levels and nuclear magnetic resonance lipid particle profiles in the two study groups were the major outcomes. Results: Average age and body mass were similar in the two groups of women, but LDL cholesterol (P = 0.001) and triglyceride levels (P = 0.0005) were higher in the TS group. Also among women with TS, average LDL particle size was reduced (P < 0.0001) and LDL particle concentration increased, with a 2-fold increase in the smallest particle categories (P < 0.0001). Whereas total high-density lipoprotein cholesterol levels were similar, high-density lipoprotein particle size was significantly smaller in women with TS, compared with women with premature ovarian failure (P < 0.0001). Conclusions: Women with 45,X with ovarian failure exhibit a distinctly more atherogenic lipid profile than 46,XX women with ovarian failure, suggesting that the second X-chromosome contributes to a more salutary lipid profile in normal women, independent of sex steroid effects.

scholarly journals Cardiovascular Risk in Reproductive-aged Women With Polycystic Ovary Syndrome According to Body Mass Index: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Chenchen Zhuang ◽  
Qiongying Wang ◽  
Wenjuan Wang ◽  
Runmin Sun ◽  
Xiaofang Zhang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Ldl Cholesterol ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Hypertension Prevalence ◽  
Reproductive Aged Women

Abstract Background: To evaluate the association between cardiovascular risk and reproductive-aged women with polycystic ovary syndrome (PCOS) according to body mass index (BMI) categories.Methods: A literature search was conducted in MEDLINE, EMBASE, Cochrane Library and PubMed. Blood pressure (BP) [including systolic BP (SBP), diastolic BP (DBP) and hypertension prevalence] and plasma lipids [triglyceride, high-density lipoprotein (HDL)-cholesterol, nonHDL-cholesterol and low-density lipoprotein (LDL)-cholesterol] were calculated at different BMI levels.Results: SBP [MD (95% CI): 2.96 mmHg (1.62, 4.30), P < 0.001] and DBP [MD (95% CI): 1.64 mmHg (0.03, 3.24), P = 0.046] increased in reproductive-aged women with PCOS, however, hypertension prevalence had no difference [OR (95% CI): 1.56 (0.76, 3.06), P = 0.198]. HDL-cholesterol were [SMD (95% CI): -0.24 (-0.39, -0.09), P = 0.002] lower and triglyceride [SMD (95% CI): 0.37 (0.26, 0.48), P < 0.001] higher in reproductive PCOS women. Besides, LDL-cholesterol [SMD (95% CI): 0.25 (0.17, 0.34), P < 0.001] and nonHDL-cholesterol [SMD (95% CI): 0.38 (0.29, 0.47), P < 0.001] were higher in reproductive-aged PCOS. In the subgroup analysis, SBP and LDL-cholesterol were increased in BMI of < 25 kg/m2 and BMI of ≥ 30 kg/m2, but had no difference in BMI of 25-< 30 kg/m2. Triglyceride and nonHDL-cholesterol increased in all BMI categories. However, DBP and hypertension prevalence had no difference in all BMI categories.Conclusion: High baseline BP and dyslipidemia is represented in reproductive PCOS. Besides, reproductive PCOS women are significantly associated with increased cardiovascular risk independent of BMI categories.

Carotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study

1996 ◽  
Vol 174 (4) ◽  
pp. 1224-1232 ◽  
Author(s):  
David S. Guzick ◽  
Evelyn O. Talbott ◽  
Kim Sutton-Tyrrell ◽  
Holly C. Herzog ◽  
Lewis H. Kuller ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Carotid Atherosclerosis ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Case Control ◽  
Ovary Syndrome ◽  
Initial Results ◽  
Control Study

scholarly journals Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy

2019 ◽  
Vol 3 (8) ◽  
pp. 1503-1517 ◽  
Author(s):  
Alexandra B Kinzer ◽  
Robert D Shamburek ◽  
Marissa Lightbourne ◽  
Ranganath Muniyappa ◽  
Rebecca J Brown
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Profile ◽  
Cvd Risk ◽  
Lipoprotein Particles ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

Abstract Context Patients with lipodystrophy have dyslipidemia and insulin resistance. Leptin treatment with metreleptin in lipodystrophy decreases insulin resistance and lowers triglycerides without changing high-density lipoprotein. Detailed measurement of lipoprotein particles with nuclear magnetic resonance (NMR) spectroscopy can offer insights into cardiovascular disease (CVD) risk and lipid metabolism beyond a standard lipid panel. We hypothesized that patients with lipodystrophy would have a more atherogenic lipid profile than controls at baseline, which would be ameliorated with metreleptin treatment. Objective To characterize the lipoprotein profile in patients with lipodystrophy compared with controls and to evaluate effects of metreleptin treatment. Design, Setting, Patients, and Intervention Patients with lipodystrophy (N = 17) were studied before and after metreleptin for 2 weeks and 6 months and compared with 51 insulin-sensitive sex-matched controls. Main Outcome Measures Lipoprotein profiles were measured by NMR with the LP4 deconvolution algorithm, which reports triglyceride-rich lipoprotein particles (TRLPs), high-density lipoprotein particles (HDLPs), and low-density lipoprotein particles (LDLPs). Results Patients with lipodystrophy had elevated large TRLPs and smaller HDLPs and LDLPs compared with controls. Five patients with lipodystrophy had chylomicrons, compared with zero controls. Metreleptin decreased the size and concentration of TRLPs, eliminated chylomicrons in all but one patient, decreased LDLPs, and increased LDLP size. Metreleptin treatment did not have major effects on HDLPs. Conclusions Patients with lipodystrophy had an atherogenic lipoprotein profile at baseline consistent with elevated CVD risk, which improved after metreleptin treatment. The presence of fasting chylomicrons in a subset of patients with lipodystrophy suggests saturation of chylomicron clearance by lipoprotein lipase.

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