scholarly journals Cardiovascular Risk in Reproductive-aged Women With Polycystic Ovary Syndrome According to Body Mass Index: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Chenchen Zhuang ◽  
Qiongying Wang ◽  
Wenjuan Wang ◽  
Runmin Sun ◽  
Xiaofang Zhang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Ldl Cholesterol ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Hypertension Prevalence ◽  
Reproductive Aged Women

Abstract Background: To evaluate the association between cardiovascular risk and reproductive-aged women with polycystic ovary syndrome (PCOS) according to body mass index (BMI) categories.Methods: A literature search was conducted in MEDLINE, EMBASE, Cochrane Library and PubMed. Blood pressure (BP) [including systolic BP (SBP), diastolic BP (DBP) and hypertension prevalence] and plasma lipids [triglyceride, high-density lipoprotein (HDL)-cholesterol, nonHDL-cholesterol and low-density lipoprotein (LDL)-cholesterol] were calculated at different BMI levels.Results: SBP [MD (95% CI): 2.96 mmHg (1.62, 4.30), P < 0.001] and DBP [MD (95% CI): 1.64 mmHg (0.03, 3.24), P = 0.046] increased in reproductive-aged women with PCOS, however, hypertension prevalence had no difference [OR (95% CI): 1.56 (0.76, 3.06), P = 0.198]. HDL-cholesterol were [SMD (95% CI): -0.24 (-0.39, -0.09), P = 0.002] lower and triglyceride [SMD (95% CI): 0.37 (0.26, 0.48), P < 0.001] higher in reproductive PCOS women. Besides, LDL-cholesterol [SMD (95% CI): 0.25 (0.17, 0.34), P < 0.001] and nonHDL-cholesterol [SMD (95% CI): 0.38 (0.29, 0.47), P < 0.001] were higher in reproductive-aged PCOS. In the subgroup analysis, SBP and LDL-cholesterol were increased in BMI of < 25 kg/m2 and BMI of ≥ 30 kg/m2, but had no difference in BMI of 25-< 30 kg/m2. Triglyceride and nonHDL-cholesterol increased in all BMI categories. However, DBP and hypertension prevalence had no difference in all BMI categories.Conclusion: High baseline BP and dyslipidemia is represented in reproductive PCOS. Besides, reproductive PCOS women are significantly associated with increased cardiovascular risk independent of BMI categories.

scholarly journals Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Tommy Kyaw Tun ◽  
Anne McGowan ◽  
Niamh Phelan ◽  
Neuman Correia ◽  
Gerard Boran ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Apolipoprotein B ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Postprandial Glucose ◽  
Ovary Syndrome ◽  
Mixed Meal

Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age30.4±1.2years (mean ± SEM), body mass index (BMI)36.8±1.5 kg/m2) and 26 non-PCOS subjects (age34.1±0.9years, BMI31.5±1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (SI), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.

scholarly journals Body Mass Index below Obesity Threshold Implies Similar Cardiovascular Risk among Various Polycystic Ovary Syndrome Phenotypes

2015 ◽  
Vol 25 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Gulay Simsek Bagir ◽  
Okan S. Bakiner ◽  
Emre Bozkirli ◽  
Gulhan Cavlak ◽  
Hulya Serinsoz ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Metabolic syndrome in women with polycystic ovary syndrome: prevalence, characteristics and predictors

2007 ◽  
Vol 51 (6) ◽  
pp. 972-979 ◽  
Author(s):  
José Antonio M. Marcondes ◽  
Sylvia A.Y. Hayashida ◽  
Cristiano R.G. Barcellos ◽  
Michelle P. Rocha ◽  
Gustavo A.R. Maciel ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Hdl Cholesterol ◽  
Morbidly Obese ◽  
Age Difference ◽  
Obese Women ◽  
Ovary Syndrome

The aim of this study was to determine the prevalence of metabolic syndrome in women with polycystic ovary syndrome, as well as its characteristics and predictors. Seventh-three women, with body mass index of 30.4 ± 7.8 kg/m² and 25.0 ± 6.0 years old, subdivided according to body mass index, were studied retrospectively. There was no significant mean age difference among body mass index groups (p = 0.228). Prevalence of metabolic syndrome was 38.4%, with a null prevalence for normal (n = 18), 23.8% for overweight (n = 17), 62.9% for obese (n = 28), and 85.5% for morbidly obese women (n = 7). Women with metabolic syndrome were older than women without metabolic syndrome (27.3 ± 5.3 vs. 24.2 ± 4.6 vs. years old; p = 0.031) and presented a higher body mass index (36.3 ± 7.7 vs. 26.9 ± 5.4; p < 0.001). There was no difference for degree of hirsutism and menstrual patterns between women with and without metabolic syndrome (p = 0.593 and p = 0.119, respectively). Regarding laboratory parameters, DHEAS was lower (1,646 ± 1,007 vs. 2,594 ± 1,563; p = 0.007) and HOMA-IR were higher (9.9 ± 9.7 vs. 4.6 ± 4.7; p = 0.004) in women with metabolic syndrome (p = 0.031 and p < 0.001, respectively). The best predictors of metabolic syndrome were waist circumference > 88 cm, HDL-cholesterol < 50 mg/dL and triglycerides > 150 mg/dL.

Anti-Müllerian hormone as an indicator of reproductive health in women with obesity and concomitant polycystic ovary syndrome

2016 ◽  
Vol 88 (12) ◽  
pp. 41-44
Author(s):  
A K Durmanova ◽  
N K Otarbaev
Keyword(s):  
Body Mass Index ◽  
Lipid Metabolism ◽  
Reproductive Health ◽  
Polycystic Ovary Syndrome ◽  
Abdominal Obesity ◽  
Polycystic Ovary ◽  
Morphometric Parameters ◽  
Ovary Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
Reproductive Aged Women

Aim. To investigate the ovarian reserve and a relationship between the level of anti-Müllerian hormone (AMH) with that of hormones in reproductive-aged women with abdominal obesity concurrent with and without polycystic ovary syndrome (PCOS). Subjects and methods. A total of 157 women aged 18 to 45 years with a body mass index (BMI) of more than 30 kg/m2 were examined. The 157 women with abdominal obesity were conventionally divided into 2 groups: 1) 20 with PCOS and 2) 137 without this condition. Morphometric parameters, the indicators of carbohydrate and lipid metabolism, and the levels of hormones, including AMH, were studied. Results. The patients with PCOS had statistically significantly elevated AMH levels (11.26±2.63 ng/ml; p

scholarly journals A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

2008 ◽  
Vol 93 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Olivier Valkenburg ◽  
Regine P. M. Steegers-Theunissen ◽  
Huberdina P. M. Smedts ◽  
Geesje M. Dallinga-Thie ◽  
Bart C. J. M. Fauser ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Atherogenic Lipid Profile ◽  
Control Study ◽  
Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

scholarly journals Predictive factors of polycystic ovary syndrome in girls with precocious pubarche

2021 ◽  
Author(s):  
Valentina Guarnotta ◽  
Silvia Lucchese ◽  
Mariagrazia Irene Mineo ◽  
Donatella Mangione ◽  
Renato Venezia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Polycystic Ovary Syndrome ◽  
Predictive Factors ◽  
Ldl Cholesterol ◽  
Polycystic Ovary ◽  
Strong Association ◽  
Hdl Cholesterol ◽  
Total Testosterone ◽  
Visceral Adiposity Index ◽  
Ovary Syndrome

Objective: The aim of this study is to clarify, in girls with premature pubarche (PP), the influence of premature androgenization on the prevalence of polycystic ovary syndrome (PCOS). Design and patients: Ninety-nine PP girls, 63 who developed PCOS and 36 who did not develop PCOS, were cross-sectionally included. Clinical, anthropometric, and metabolic parameters were evaluated to find predictive factors of PCOS. Results: Young females with PP showed a PCOS prevalence of 64% and showed higher prevalence of familial history of diabetes (p= 0.004) and lower prevalence of underweight (p= 0.025) than PP-NO-PCOS. In addition, girls with PP-PCOS showed higher BMI (p<0.001), waist circumference (p<0.001), total testosterone (p= 0.026), visceral adiposity index (VAI) (p= 0.013), total cholesterol (p<0.001), LDL-cholesterol (p<0.001), non-HDL-cholesterol (p<0.001) and lower age of menarche (p=0.015), ISI-Matsuda (p<0.001), DIo (p= 0.002), HDL-cholesterol (p= 0.026) than PP-NO-PCOS. Multivariate analysis showed that WC (p=0.049), ISI-Matsuda (p<0.001), oral disposition index (DIo) (p<0.001), VAI (p<0.001), total testosterone (p<0.001) and LDL-cholesterol (p<0.001) are independent predictive factors for PCOS in girls with PP. Conclusions: Our study established a strong association between multiple risk factors and development of PCOS in PP girls. These risk factors are predominantly related to the regulation of glucose, lipid, and androgen metabolism. Among these factors, WC, ISI-Matsuda, DIo, VAI, total testosterone and LDL-cholesterol predict PCOS.

scholarly journals Evidence for an Association between Metabolic Cardiovascular Syndrome and Coronary and Aortic Calcification among Women with Polycystic Ovary Syndrome

2004 ◽  
Vol 89 (11) ◽  
pp. 5454-5461 ◽  
Author(s):  
E. O. Talbott ◽  
J. V. Zborowski ◽  
J. R. Rager ◽  
M. Y. Boudreaux ◽  
D. A. Edmundowicz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Electron Beam Tomography ◽  
Ovary Syndrome ◽  
Increased Risk ◽  
Metabolic Cardiovascular Syndrome

Abstract Women with polycystic ovary syndrome (PCOS) exhibit an adverse cardiovascular risk profile, characteristic of the metabolic cardiovascular syndrome (MCS). The aim of this study was to determine the prevalence of coronary artery (CAC) and aortic (AC) calcification among middle-aged PCOS cases and controls and to explore the relationship among calcification, MCS, and other cardiovascular risk factors assessed 9 yr earlier. This was a prospective study of 61 PCOS cases and 85 similarly aged controls screened in 1993–1994 for risk factors and reevaluated in 2001–2002. The main outcome measures were CAC and AC, measured by electron beam tomography. Women with PCOS had a higher prevalence of CAC (45.9% vs. 30.6%) and AC (68.9% vs. 55.3%) than controls. After adjustment for age and body mass index, PCOS was a significant predictor of CAC (odds ratio = 2.31; P = 0.049). PCOS subjects were also 4.4 times more likely to meet the criteria for MCS than controls. High-density lipoprotein cholesterol and insulin appeared to mediate the PCOS influence on CAC. Interestingly, total testosterone was an independent risk factor for AC in all subjects after controlling for PCOS, age, and body mass index (P = 0.034). We conclude that women with PCOS are at increased risk of MCS and demonstrate increased CAC and AC compared with controls. Components of MCS mediate the association between PCOS and CAC, independently of obesity.

scholarly journals Total cholesterol/HDL cholesterol ratio and monocyte/HDL cholesterol ratio are related with subclinical hypothyroidism in polycystic ovary syndrome

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Isil Cakir ◽  
Yasin Simsek
Keyword(s):  
Polycystic Ovary Syndrome ◽  
High Density Lipoprotein ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Cholesterol Ratio ◽  
Cholesterol Levels ◽  
Atherogenic Indices

Abstract Objectives There is an association between serum thyrotropin (TSH) and lipid profile. However, there is a little information regarding the relation between subclinical hypothyroidism (SCH), atherogenic indices and inflammation in polycystic ovary syndrome (PCOS). Herein, we aimed to evaluate the impact of SCH on lipids and inflammatory markers in newly diagnosed PCOS patients. Methods Two groups were performed for total 99 PCOS patients: SCH (TSH>2.5 mIU/L) and euthyroid groups (TSH<2.5 mIU/L). Complete blood count, lipids, atherogenic indices were evaluated, inflammatory markers as platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), monocyte/high density lipoprotein ratio (MHR) and mean platelet volume/platelet ratio (MPR) were calculated. Results SCH group had higher WBC, PLT, PCT, PLR, MPR and non-high density lipoprotein cholesterol levels. Differences between MHR, total cholesterol/HDL cholesterol (TC/HDL), triglycerides/HDL cholesterol (TG/HDL) and low density lipoprotein/HDL cholesterol (LDL/HDL) levels were significantly higher (p=0.001; 0.01; 0.01; 0.02, respectively), TC/HDL cholesterol levels were positively correlated with TSH (p=0.028, r=0.402) in SCH group. TC/HDL levels were also correlated with WBC, PLT, PDW, PCT, MPR and MHR (p=0.003; 0.011; 0.031; 0.037; 0.006; 0.002; r=0.515; 0.442; −0.382; 0.370; −0.471; 0.523, repectively). Conclusions TC/HDL and MHR may serve as beneficial markers for evaluating the inflammatory state of PCOS with SCH. Screening thyroid hormones and curing SCH in PCOS may lower lipids, decelerate developing hypothyroidism and cardiovascular morbidities.

scholarly journals Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body Mass Index

Children ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Anastasia Garoufi ◽  
Athanasia Pagoni ◽  
Maria Papadaki ◽  
Antonios Marmarinos ◽  
Georgios Karapostolakis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Cardiovascular Risk Factors ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Subclinical Atherosclerosis ◽  
Healthy Weight ◽  
Ovary Syndrome

Polycystic ovary syndrome (PCOS) is the most common endocrine condition affecting 6–18% of adolescents and is strongly associated with obesity and cardiovascular risk factors, enhancing the risk of atherosclerosis. Thirty-two adolescents with newly diagnosed PCOS were evaluated for lipid profile disorders, insulin resistance, inflammation, non-alcoholic fatty liver disease (NAFLD), and subclinical atherosclerosis through measurements of carotid intima–media thickness (cIMT). The relationships of the above markers with increased body mass index and abdominal obesity were investigated. Twenty-three adolescents (72%) were overweight (OW) or obese (OB). The OW/OB group had significantly higher insulin, HOMA-IR, high-sensitive C-reactive protein (hsCRP), visceral adiposity index (VAI), and lipid accumulation product (LAP) levels; and lower glucose-per-insulin ratios and HDL-C levels compared to the healthy weight group. The cIMT and small dense low-density lipoprotein cholesterol (sdLDL-C) levels did not differ between the two groups. Similarly, cIMT and sdLDL-C levels did not differ between PCOS-adolescents and healthy controls. CIMT was positively correlated with systolic blood pressure and waist circumference per height ratio. In conclusion, OW/OB PCOS-adolescents have a cluster of adverse factors predisposing them to atherosclerotic cardiovascular disease. Therefore, early cardiovascular risk assessment, as well as timely and targeted interventions, are necessary for prevention.

Sign in / Sign up

Export Citation Format

Share Document