scholarly journals Body Mass Index (BMI) Trajectories in Infancy Differ by Population Ancestry and May Presage Disparities in Early Childhood Obesity

2015 ◽  
Vol 100 (4) ◽  
pp. 1551-1560 ◽  
Author(s):  
Sani M. Roy ◽  
Alessandra Chesi ◽  
Frank Mentch ◽  
Rui Xiao ◽  
Rosetta Chiavacci ◽  
...  

Context: No consensus definition exists for excess adiposity during infancy. After age 2 years, high body mass index (BMI) is related to adverse cardiometabolic outcomes. Before age 2 years, the utility of BMI as a metric of excess adiposity is unknown. Objectives: The objective of the study was to characterize infant BMI trajectories in a diverse, longitudinal cohort and investigate the relationship between the infancy BMI trajectory and childhood obesity. Subjects: Healthy, nonpreterm infants (n = 2114) in the Genetic Causes for Complex Pediatric Disorders study (The Children's Hospital of Philadelphia) with six or more BMI measurements in the first 13.5 months participated in the study. Design: For each infant, the BMI trajectory was modeled using polynomial regression. Independent effects of clinical factors on magnitude and timing of peak BMI were assessed. The relationship between infancy BMI and early childhood BMI (age 4 y) was examined (n = 1075). Results: The cohort was 53% male and 61% African-American. Peak BMI was 18.6 ± 1.7 kg/m2 and occurred at 8.6 ± 1.4 months. In multivariate analysis, boys had a higher (0.50 kg/m2, P < .001) peak BMI than girls. The peak was higher (0.53 kg/m2, P ≤ .001) and occurred earlier (by 12 d, P < .001) in African-American vs white children. The odds of obesity at age 4 years increased among children with higher (odds ratio 2.02; P < .001) and later (odds ratio 1.26; P = .02) infancy peak BMI. Conclusions: We demonstrate sex- and ancestry-specific differences in infancy BMI and an association of infancy peak BMI with childhood BMI. These findings support the potential utility of infancy BMI to identify children younger than age 2 years with increased risk for later obesity.

2021 ◽  
Author(s):  
Ming Ying ◽  
Xiangming Hu ◽  
Qiang Li ◽  
Zhujun Chen ◽  
Yingling Zhou

Abstract Background: The incidence of metabolic syndrome (MetS) is increasing each year, and MetS is closely related to cardiovascular diseases. Body mass index (BMI) has been widely used to measure obesity, and the relationship between MetS and BMI has been widely reported. However, the relationship between the trajectory of BMI and MetS is still unclear.Methods: Six waves of the cross-sectional China Health and Nutrition Survey (CHNS) were completed in nine provinces in China from 1993 to 2009, with more than 12,000 participants. We enrolled individuals who were aged 10 to 20 years in 1993, and 554 participants were finally included in our study. A latent class growth mixed model was used to identify different BMI trajectory patterns based on the BMI value measured at each follow-up. Participants completed blood tests and a physical examination in 2009 to allow for the diagnosis of MetS. The primary aim was to explore the relationship between different BMI trajectories and the incidence of MetS through logistic regression, adjusting for baseline age, sex, BMI, waist circumference, residence, educational background, smoking status, alcohol consumption, and nutritional intake.Result: During a follow-up of 16 years, 61 (11.01%) participants developed MetS. In multivariate-adjusted models, different BMI trajectories were significantly associated with the occurrence of MetS in early adulthood. Childhood or adolescents with a low-high BMI trajectory or a high-high BMI trajectory showed a significantly higher risk of MetS in early adulthood than those with a low-low trajectory (low-high: OR=3.40, 95% CI: 1.14-10.13, P <0.05; high-high: OR=5.81, 95% CI: 1.63-20.69, P <0.05).Conclusion: Our study identified three BMI trajectories from adolescence through 16 years of follow-up and found that in addition to baseline BMI, BMI trajectories were also an independent risk factor for incident MetS in early adulthood.


Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Michael M Hammond ◽  
Joanne M Murabito ◽  
Ludovic Trinquart ◽  
Emelia J Benjamin ◽  
Honghuang Lin ◽  
...  

Introduction: The prevalence of obesity is rising. Most previous studies that examined the relationship between body mass index (BMI) and physical activity measured BMI at a single time-point, ignoring the time-varying nature of BMI. The relationship between BMI trajectories and habitual physical activity in community settings remains unclear. Objective: To assess the relationship between BMI trajectories and habitual physical activity measured by daily steps from a smartwatch, among participants enrolled in the electronic Framingham Heart Study (eFHS). We hypothesized that participants whose BMI trajectories increased over a 14-year period prior to the step assessment take fewer daily steps, compared to participants who maintained stable BMI trajectories during the same time period. Methods: We used a semiparametric group-based modelling method to identify BMI trajectory patterns. Participants who attended exams 1, 2, and 3 were included in building the trajectories. Daily steps were recorded from the smartwatch provided at exam 3 with “active days” defined as days with ≥ 5watch wear-hours. We excluded participants with <30 active days. The median follow-up period for step count was 357 days (IQR: 467 days). We used generalized linear models that accounted for correlation between daily steps in the same individuals to examine the longitudinal relationship between BMI trajectory groups and daily step counts, adjusting for relevant covariates. Results: We identified three trajectory groups for the 837 eFHS participants. Group 1 included 292 participants (mean age 54 years, 57% women) whose BMI was stable (slope: 0.005, p=0.75); Group 2 included 468 participants (mean age 53 years, 56% women) whose BMI increased slightly (slope: 0.123, p<9.2e-17); and Group 3 included 77 participants (mean age 50 years, 70% women) who had the largest increase of BMI (slope: 0.318, p=2.8e-22).Adjusting for age, sex, wear time and race/ethnicity, participants in group 3 (Δ1437 steps P< 0.0001) and Group 2 (Δ422 steps, P=0.04) took significantly fewer steps, compared to participants in Group 1 (Model 1). The effect sizes were slightly attenuated but remained significant after additionally adjusting for hypertension, type 2 diabetes, current smoking, and cardiovascular disease: Group 3 took 1258 fewer steps, P=0.0001; Group 2 took 406 fewer steps, P=0.04 (Model 2). We further adjusted for sleep apnea, education, and marital status in Model 3 and observed that on average Group 3 took 1120 fewer steps (P= 0.0007) and Group 2 took 382 fewer steps (P= 0.06), compared to Group 1. Conclusion: Participants whose BMI trajectory increased over time took significantly fewer steps compared to participants with more stable BMI trajectories. Our findings suggest that levels of physical activity may correlate with greater weight gain during adulthood.


2003 ◽  
Vol 40 (S1) ◽  
pp. s305-s308 ◽  
Author(s):  
J. Wang ◽  
J. C. Thornton ◽  
S. B. Heymsfield ◽  
R. N. Pierson

1996 ◽  
Vol 4 (5) ◽  
pp. 451-456 ◽  
Author(s):  
Lucile L. Adams-Campbell ◽  
Kyung Sook Kim ◽  
Georgia Dunston ◽  
Amelia E. Laing ◽  
George Bonney ◽  
...  

Author(s):  
Jihyoung Kim

Purpose: The present study aimed to examine the longitudinal associations among maternal employment, breastfeeding duration, and body mass index (BMI) trajectories in early childhood. Drawing from the process model of the determinants of parenting, this study particularly focused on the mediating role of depressive symptoms in these links.Methods: This study analyzed the data of 2,059 mothers and their children from the panel study on Korean children. A latent growth curve analysis was conducted to investigate the paths linking maternal employment to BMI trajectories during the preschool years.Results: Maternal employment was associated with low levels of depressive symptoms, which in turn predicted a longer duration of breastfeeding. Second, maternal employment had direct adverse effects on the breastfeeding duration. We also found that longer duration of breastfeeding contributed to the low levels of BMI in early childhood.Conclusion: The findings highlight the importance of maternal mental health and breastfeeding duration to prevent obesity in early childhood. Moreover, the results suggest that a distinct approach for working and stay-at-home mothers needs to be considered for the promotion of breastfeeding.


2015 ◽  
Vol 3 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Alma D. Guerrero ◽  
Cherry Mao ◽  
Bruce Fuller ◽  
Margaret Bridges ◽  
Todd Franke ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document