Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults

AbstractRecent epidemiological studies show the association of carotenoids with the metabolic syndrome (MetS), but thorough longitudinal cohort studies regarding this association have not been well conducted. The objective of this study was to investigate longitudinally whether serum carotenoids are associated with the risk of developing the MetS and its components in Japanese subjects. We conducted a follow-up study on 1073 men and women aged 30–79 years at the baseline from the Mikkabi prospective cohort study. Those who participated in the baseline and completed follow-up surveys were examined longitudinally. Over the 10-year period, 910 subjects (295 men and 615 women) took part in the follow-up survey at least once. Over a mean follow-up period of 7·8 (sd 2·9) years, thirty-six men and thirty-one women developed new MetS. After adjustments for confounders, the hazard ratio (HR) for the MetS in the highest tertile of serum β-carotene against the lowest tertile was 0·47 (95 % CI 0·23, 0·95). On the other hand, significantly lower risks for dyslipidaemia were observed in the highest tertiles of serum α- and β-carotene and β-cryptoxanthin (HR 0·66; 95 % CI 0·46, 0·96; HR, 0·54; 95 % CI 0·37, 0·79; and HR 0·66; 95 % CI 0·44, 0·99, respectively). Other significant associations between the risks for obesity, high blood pressure and hyperglycaemia with serum carotenoids were not observed. Our results further support the hypothesis that eating a diet rich in carotenoids might help prevent the development of the MetS and its complications in Japanese subjects.

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Type A factors as predictors of changes in the metabolic syndrome precursors in adolescents and young adults: A 3-year follow-up study.

Health Psychology ◽

10.1037/0278-6133.15.1.18 ◽

1996 ◽

Vol 15 (1) ◽

pp. 18-29 ◽

Cited By ~ 27

Author(s):

Niklas Ravaja ◽

Liisa Keltikangas-Järvinen ◽

Pertti Keskivaara

Keyword(s):

Metabolic Syndrome ◽

Young Adults ◽

Type A ◽

Adolescents And Young Adults ◽

Follow Up Study ◽

The Metabolic Syndrome

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CARDIAC I-123 METAIODOBENZYLGUANIDINE IMAGING PREDICTS THE RISK OF CARDIAC DEATH IN PATIENTS WITH CHRONIC HEART FAILURE, IRRESPECTIVE OF THE METABOLIC SYNDROME.: A LONG TERM FOLLOW UP STUDY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(12)61172-3 ◽

2012 ◽

Vol 59 (13) ◽

pp. E1171

Author(s):

Hironori Yamamoto ◽

Takahisa Yamada ◽

Takashi Morita ◽

Yoshio Furukawa ◽

Koji Tanaka ◽

...

Keyword(s):

Heart Failure ◽

Metabolic Syndrome ◽

Chronic Heart Failure ◽

Cardiac Death ◽

Follow Up Study ◽

The Metabolic Syndrome ◽

Long Term Follow Up

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The metabolic syndrome predicts incident congestive heart failure: A 20-year follow-up study of elderly finns

Atherosclerosis ◽

10.1016/j.atherosclerosis.2009.10.042 ◽

2010 ◽

Vol 210 (1) ◽

pp. 237-242 ◽

Cited By ~ 48

Author(s):

Jianjun Wang ◽

Katriina Sarnola ◽

Sanna Ruotsalainen ◽

Leena Moilanen ◽

Päivi Lepistö ◽

...

Keyword(s):

Heart Failure ◽

Metabolic Syndrome ◽

Congestive Heart Failure ◽

Follow Up Study ◽

The Metabolic Syndrome

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Lean Fish Consumption Is Associated with Beneficial Changes in the Metabolic Syndrome Components: A 13-Year Follow-Up Study from the Norwegian Tromsø Study

Nutrients ◽

10.3390/nu9030247 ◽

2017 ◽

Vol 9 (3) ◽

pp. 247 ◽

Cited By ~ 17

Author(s):

Christine Tørris ◽

Marianne Molin ◽

Milada Småstuen

Keyword(s):

Metabolic Syndrome ◽

Fish Consumption ◽

Follow Up Study ◽

Lean Fish ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components

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Abstract P308: The Association of Vitamin K Intake and Status With the Metabolic Syndrome: A 10 Year Follow-Up Study

Circulation ◽

10.1161/circ.131.suppl_1.p308 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Veerle Dam ◽

Geertje W Dalmeijer ◽

Cees Vermeer ◽

Yvonne T van der Schouw ◽

Joline W Beulens

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Vitamin K ◽

Dietary Factors ◽

Matrix Gla Protein ◽

Lower Prevalence ◽

High Intake ◽

High Vitamin ◽

The Metabolic Syndrome

Background: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities and is associated with increased risk of type 2 diabetes, cardiovascular diseases and all-cause mortality. Vitamin K intake (phylloquinone/menaquinones) and vitamin K status are associated with several components of MetS, but the association with MetS has hardly been studied to date. Objective: To examine whether dietary intake and/or status of vitamin K are associated with occurrence of MetS and its components. Design: This study comprised of two cohorts, one of 402 women and one of 400 men (40-80 years). At follow-up 625 participants were still alive and willing to participate. Data were analyzed both cross-sectionally and longitudinally with Poisson and linear regression analyses adjusted for lifestyle and dietary factors. Baseline phylloquinone and menaquinone intake were measured with a validated food frequency questionnaire and dephospho-uncarborxylated matrix Gla protein was used as a marker for vitamin K status. Results: At baseline 285 (35.6%) participants had MetS and 172 (35.7%) at follow-up. Cross-sectionally, a high intake of menaquinones was associated (P trend =0.03) with a lower prevalence of MetS with a prevalence ratio (PR) of 0.70 (95%CI: 0.51-0.96) for the highest versus the lowest tertile. A high vitamin K status was also associated (P trend =0.02) with a reduced prevalence of MetS in cross-sectional analyses (PR T3 vs. T1 =0.73; 0.54-0.98) At follow-up, the highest tertiles of menaquinone intake (PR=0.62; 0.40-0.95) and vitamin K status (PR=0.61; 0.40-0.92) were associated (P trend <0.02) with a lower occurrence of MetS. These associations were mainly driven by relations with lower triglyceride concentrations for menaquinones and lower waist circumference in women for vitamin K status. Phylloquinone intake was not associated with MetS prevalence. Conclusion: This study shows that a high intake of menaquinones and high vitamin K status are associated with a lower prevalence of MetS. This is mainly driven by the associations of high menaquinones intake with lower triglycerides concentrations and high vitamin K status with lower waist circumference in women.

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