scholarly journals High serum carotenoids associated with lower risk for the metabolic syndrome and its components among Japanese subjects: Mikkabi cohort study

2015 ◽  
Vol 114 (10) ◽  
pp. 1674-1682 ◽  
Author(s):  
Minoru Sugiura ◽  
Mieko Nakamura ◽  
Kazunori Ogawa ◽  
Yoshinori Ikoma ◽  
Masamichi Yano
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Lower Risk ◽  
Epidemiological Studies ◽  
High Serum ◽  
Follow Up Study ◽  
The Metabolic Syndrome ◽  
Serum Carotenoids ◽  
Japanese Subjects

AbstractRecent epidemiological studies show the association of carotenoids with the metabolic syndrome (MetS), but thorough longitudinal cohort studies regarding this association have not been well conducted. The objective of this study was to investigate longitudinally whether serum carotenoids are associated with the risk of developing the MetS and its components in Japanese subjects. We conducted a follow-up study on 1073 men and women aged 30–79 years at the baseline from the Mikkabi prospective cohort study. Those who participated in the baseline and completed follow-up surveys were examined longitudinally. Over the 10-year period, 910 subjects (295 men and 615 women) took part in the follow-up survey at least once. Over a mean follow-up period of 7·8 (sd 2·9) years, thirty-six men and thirty-one women developed new MetS. After adjustments for confounders, the hazard ratio (HR) for the MetS in the highest tertile of serum β-carotene against the lowest tertile was 0·47 (95 % CI 0·23, 0·95). On the other hand, significantly lower risks for dyslipidaemia were observed in the highest tertiles of serum α- and β-carotene and β-cryptoxanthin (HR 0·66; 95 % CI 0·46, 0·96; HR, 0·54; 95 % CI 0·37, 0·79; and HR 0·66; 95 % CI 0·44, 0·99, respectively). Other significant associations between the risks for obesity, high blood pressure and hyperglycaemia with serum carotenoids were not observed. Our results further support the hypothesis that eating a diet rich in carotenoids might help prevent the development of the MetS and its complications in Japanese subjects.

scholarly journals High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study

2015 ◽  
Vol 3 (1) ◽  
pp. e000147 ◽  
Author(s):  
Minoru Sugiura ◽  
Mieko Nakamura ◽  
Kazunori Ogawa ◽  
Yoshinori Ikoma ◽  
Masamichi Yano
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Lower Risk ◽  
High Serum ◽  
Serum Carotenoids ◽  
Japanese Subjects

scholarly journals The metabolic syndrome among Danish seafarers: a follow-up study

2016 ◽  
Vol 67 (3) ◽  
pp. 129-136 ◽  
Author(s):  
Jørgen Riis Jepsen ◽  
Hanna B. Rasmussen
Keyword(s):  
Metabolic Syndrome ◽  
Follow Up Study ◽  
The Metabolic Syndrome

Serum Angiopoietin-like Protein 6, Risk of Type 2 Diabetes, and Response to Hyperglycemia: A Prospective Cohort Study

2020 ◽  
Vol 105 (5) ◽  
pp. e1949-e1957 ◽  
Author(s):  
Kang-Chih Fan ◽  
Hung-Tsung Wu ◽  
Jung-Nan Wei ◽  
Lee-Ming Chuang ◽  
Chih-Yao Hsu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
High Serum ◽  
Incident Diabetes ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Diet Induced Obesity ◽  
The Metabolic Syndrome ◽  
Low Incidence ◽  
Human Participants

Abstract Context Angiopoietin-like protein 6 (ANGPTL6) is a hepatokine that improves insulin sensitivity in animals. However, serum ANGPTL6 concentration was found to be higher in human participants with diabetes or metabolic syndrome in cross-sectional studies, implying that ANGPTL6 may be induced to counteract hyperglycemia. Objective To investigate whether serum ANGPTL6 can predict incident diabetes and explore whether glucose or insulin can regulate ANGPTL6 expression and secretion. Design This cohort study included adults without diabetes at baseline who were followed every 2 years for incident diabetes. Serum ANGPTL6 concentrations were measured at baseline and during oral glucose tolerance tests (OGTTs). A hepatic cell line, HepG2, and diet-induced obesity mouse model were used to evaluate the response of ANGPTL6 expression and secretion to hyperglycemia and the metabolic syndrome. Results We recruited 1103 participants without diabetes at baseline. During the 4.22-year follow-up, 113 (10.2%) participants developed incident diabetes. Serum ANGPTL6 was negatively associated with the incidence of diabetes (adjusted hazard ratio, 0.77; P = 0.042). However, serum ANGPTL6 level was higher in participants with prediabetes (P = 0.018) and was elevated during OGTT. In HepG2 cells, treatment with glucose, but not insulin, induced ANGPTL6 expression. Hepatic ANGPTL6 expression and serum ANGPTL6 concentrations were significantly higher in mice fed with a high-fat diet than in those fed with a standard chow (both P < 0.05). Conclusion A high serum ANGPTL6 level is associated with a low incidence of diabetes in humans. ANGPTL6 is expressed and secreted in response to hyperglycemia to maintain glucose homeostasis.

Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults

2015 ◽  
Vol 100 (6) ◽  
pp. 2472-2479 ◽  
Author(s):  
Veerle Dam ◽  
Geertje W. Dalmeijer ◽  
Cees Vermeer ◽  
Nadja E. Drummen ◽  
Marjo H. Knapen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin K ◽  
Follow Up Study ◽  
The Metabolic Syndrome

scholarly journals High serum carotenoids are associated with lower risk for developing elevated serum alanine aminotransferase among Japanese subjects: the Mikkabi cohort study

2016 ◽  
Vol 115 (8) ◽  
pp. 1462-1469 ◽  
Author(s):  
Minoru Sugiura ◽  
Mieko Nakamura ◽  
Kazunori Ogawa ◽  
Yoshinori Ikoma ◽  
Masamichi Yano
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Provitamin A ◽  
Serum Alanine Aminotransferase ◽  
Provitamin A Carotenoids ◽  
Serum Carotenoids ◽  
Japanese Subjects

AbstractMany recent studies have shown that antioxidant vitamins and/or carotenoids may reduce liver disease, but this association has not been well established with thorough longitudinal cohort studies. The objective of this study was to longitudinally investigate whether serum carotenoids at baseline are associated with the risk of developing elevated serum alanine aminotransferase (ALT) among Japanese subjects. We conducted a follow-up study of 1073 males and females aged between 30 and 79 years at baseline from the Mikkabi prospective cohort study. Those who participated in the baseline study and completed follow-up surveys were examined longitudinally. Exclusions included excessive alcohol consumption (≥60 g alcohol/d), hepatitis B and C and having a history of medication use for liver disease. A cohort of 213 males and 574 females free of elevated serum ALT (>30 IU/ml) at baseline was studied. Over a mean follow-up period of 7·4 (sd 3·1) years, thirty-one males and forty-nine females developed new elevated serum ALT. After adjustments for confounders, the hazard ratios for elevated serum ALT in the highest tertiles of basal serum β-carotene, β-cryptoxanthin and total provitamin A carotenoids against the lowest tertiles were 0·43 (95 % CI 0·22, 0·81), 0·51 (CI 0·27, 0·94) and 0·52 (CI 0·28, 0·97), respectively. For α-carotene and lycopene, borderline reduced risks were also observed; however, these were not significant. Our results further support the hypothesis that antioxidant carotenoids, especially provitamin A carotenoids, might help prevent earlier pathogenesis of non-alcoholic liver disease in Japanese subjects.

scholarly journals Associations of serum carotenoid concentrations with the metabolic syndrome: interaction with smoking

2008 ◽  
Vol 100 (6) ◽  
pp. 1297-1306 ◽  
Author(s):  
Minoru Sugiura ◽  
Mieko Nakamura ◽  
Kazunori Ogawa ◽  
Yoshinori Ikoma ◽  
Hikaru Matsumoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Antioxidant Status ◽  
Smoking Status ◽  
Smoking Habit ◽  
Epidemiological Studies ◽  
The Metabolic Syndrome ◽  
Serum Carotenoids ◽  
The Town ◽  
Β Carotene

Recent epidemiological studies show the associations of serum antioxidant status with the metabolic syndrome. Oxidative stress may play an important role in the pathogenesis of diabetes and CVD. Actually, smoking is a potent oxidative stressor in man, but little is known about the interaction of serum carotenoids and the metabolic syndrome with smoking status. In this study, the associations of the serum carotenoids with the metabolic syndrome stratified by smoking habit were evaluated cross-sectionally. A total of 1073 subjects (357 male and 716 female) who had received health examinations in the town of Mikkabi, Shizuoka Prefecture, Japan, participated in the study. Among total subjects, the OR for the metabolic syndrome in the highest tertile of serum β-carotene was 0·41 (95 % CI 0·18, 0·92) after adjusting confounders. In current smokers, significantly lower OR were observed in the middle (OR 0·10; 95 % CI 0·01, 0·72) and highest (OR 0·06; 95 % CI 0·01, 0·73) tertiles of serum β-carotene. Furthermore, lower OR were observed in accordance with tertiles of serum α-carotene and β-cryptoxanthin in current smokers (P for trend 0·042 and 0·036, respectively). In contrast, in non-smokers, a significantly lower OR was observed in the highest tertile of serum β-carotene (OR 0·30; 95 % CI 0·10, 0·89) after multiple adjustment. Inverse associations of serum carotenoids with the metabolic syndrome were more evident among current smokers than non-smokers. These results support that antioxidant carotenoids may have a protective effect against development of the metabolic syndrome, especially in current smokers who are exposed to a potent oxidative stress.

scholarly journals Association Between Dietary Variety Score and Metabolic Syndrome in Korean Women: A Prospective Cohort Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1412-1412
Author(s):  
Dahye Han ◽  
Jiyeon Kim ◽  
Yoonjin Shin ◽  
Yoonjin Lee ◽  
Yangha Kim
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Dietary Quality ◽  
Korean Women ◽  
Epidemiology Study ◽  
Dietary Variety ◽  
Follow Up Study ◽  
Funding Sources ◽  
High Triglyceride

Abstract Objectives Dietary variety is reported to be an indicator to assess dietary quality and reduces the risk of chronic diseases. This study was performed to investigate the association between dietary variety score (DVS) and the risk of developing metabolic syndrome (MS) in Korean women. Methods The data was obtained from the Ansan and Anseoneg Cohort Study which was a part of the Korean Genome and Epidemiology Study. Subjects were 2865 women aged 40–69 years without MS. DVS was defined by counting the number of different food items consumed during a day. When subjects consumed another food item, dietary variety scored 1. Based on the DVS from 0 to 85, subjects were classified into five groups. Results During the 12-years follow-up study, the cumulative incidence of MS was 38.0%. Subjects with higher DVS showed a decreased incidence of MS compared to those with lower DVS. In addition, higher DVS was associated with lower risk of developing MS [hazard ratio (HR) = 0.78, 95% CI: 0.63 – 0.97 for quintile 1 vs. quintile 5, p-trend = 0.008] after adjustment for potential cofounders. Of MS components, high abdominal obesity (HR = 0.82, 95% CI: 0.69 – 0.98, p-trend = 0.004), high blood pressure (HR = 0.79, 95% CI: 0.64 – 0.97, p-trend = 0.014) and high triglyceride (HR = 0.73, 95% CI: 0.57 – 0.92, p -trend = 0.041) were prospectively associated with DVS. Conclusions These results suggested that eating various foods may reduce the risk of MS in Korean women. Funding Sources None.

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