Altered Hydroxylation of Estrogen in Patients with Postmenopausal Osteopenia--Authors' Responseb

Activities of redox enzymes of peripheral blood leukocytes is studied in patients with postmenopausal osteopenia. Neutrophil myeloperoxidase (MP), alkaline phosphatase (AP) and lymphocyte succinate dehydrogenase (SDH), and succinate.cytochrome C oxyreductase (SCOR) activities were measured by the cytochemical method. Densitometric examinations of 49 postmenopausal women without risk of secondary osteoporosis revealed osteoporosis in 15 (31%)) and osteopenia in 24 (49%)); in 10 (20%o) mineral compactness of bones was normal. AP and SDH activities were increased and SCOR and MP activities normal in patients with osteopenia. Changes in the activities of AL and SDH in subjects with different duration of the postmenopausal period indicate that the main factor affecting the activities of these enzymes was osteopenia but not the duration of postmenopause or age. Significant correlations between enzyme values and mineral compactness of the spine were the most numerous during the first three years of postmenopause, and therefore changes in leukocyte enzyme activities are apparently not caused by inflammations associated with chronic macroand microfractures of the vertebrae but by osteopenia. The detected specific correlation between enzyme activities and localization of the pathological process in certain segments of the skeleton permits us to propose that leukocyte AL and SDH values may serve as criteria for optimal choice of skeletal area for subsequent densitometry or x-ray examination.

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Factors Associated With Changes In Bone-Mass Density In Post Menopause Female Patients With Osteopenia

Clinical and Research Journal in Internal Medicine ◽

10.21776/crjim.2021.002.02.3 ◽

2021 ◽

Vol 2 (2) ◽

pp. 177-186

Author(s):

Bagus Suryana ◽

◽

Muhammad Febriliant ◽

Rulli Rosandi ◽

Sukarlin Sukarlin ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Vitamin D ◽

Bone Mass ◽

Significant Relationship ◽

Mass Density ◽

Bone Mass Density ◽

Factors Associated ◽

Vitamin D Levels ◽

Postmenopausal Osteopenia

Background: Many factors can cause changes in bone mass density (BMD) in women with postmenopausal osteopenia. Aim: Determine factors associated with changes in BMD in postmenopausal women with osteopenia with the most influential risk factors within 1 year. Methods: Survey was conducted on 38 patients who were included in the inclusion criteria with a cross-sectional study analysis and had BMD data for the last 2 years, body mass index, and conducted interviews for physical activity, age of menopause, and duration of menopause. Blood samples were also taken to check total calcium levels, vitamin D levels and estrogen levels. Finally, patients are followed for up to 1 week for daily nutrition records. The relationship between these factors and changes in BMD was analyzed using Pearson's or Spearman's test. The analysis result was considered significant if p<0.05. Results: There was no significant relationship between body mass index, menopause duration, physical activity, dietary calcium, serum calcium levels and serum estradiol levels on changes in BMD with p value > 0.05. However, there was a significant relationship between menopause onset and changes in ward mass density (r = 0,321, p = 0,04) and lumbal 1 (r = 0,333, p = 0,04), serum vitamin D levels and changes in great trochanter mass density (r = 0,336, p = 0,036), physical activity score and changes in ward mass density (r = -0,522, p < 0,01). Conclusion: menopause onset, vitamin D and physical activity are significantly associated with changes in BMD in female patients with postmenopausal osteopenia.

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