scholarly journals Diagnostic value of redox leukocyte enzymes in postmenopausal osteopenia

1999 ◽  
Vol 45 (2) ◽  
pp. 31-35
Author(s):  
A. V. Dreval ◽  
L. A. Marchenkova ◽  
O. P. Kuznetsova ◽  
G. A. Onoprienko ◽  
V. I. Shumsky ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Diagnostic Value ◽  
Pathological Process ◽  
Optimal Choice ◽  
Peripheral Blood Leukocytes ◽  
Redox Enzymes ◽  
Blood Leukocytes ◽  
X Ray ◽  
Postmenopausal Osteopenia ◽  
Main Factor

Activities of redox enzymes of peripheral blood leukocytes is studied in patients with postmenopausal osteopenia. Neutrophil myeloperoxidase (MP), alkaline phosphatase (AP) and lymphocyte succinate dehydrogenase (SDH), and succinate.cytochrome C oxyreductase (SCOR) activities were measured by the cytochemical method. Densitometric examinations of 49 postmenopausal women without risk of secondary osteoporosis revealed osteoporosis in 15 (31%)) and osteopenia in 24 (49%)); in 10 (20%o) mineral compactness of bones was normal. AP and SDH activities were increased and SCOR and MP activities normal in patients with osteopenia. Changes in the activities of AL and SDH in subjects with different duration of the postmenopausal period indicate that the main factor affecting the activities of these enzymes was osteopenia but not the duration of postmenopause or age. Significant correlations between enzyme values and mineral compactness of the spine were the most numerous during the first three years of postmenopause, and therefore changes in leukocyte enzyme activities are apparently not caused by inflammations associated with chronic macroand microfractures of the vertebrae but by osteopenia. The detected specific correlation between enzyme activities and localization of the pathological process in certain segments of the skeleton permits us to propose that leukocyte AL and SDH values may serve as criteria for optimal choice of skeletal area for subsequent densitometry or x-ray examination.

scholarly journals METAPHYSEAL FIBROUS DEFECTS AND NONOSSIFYING BONE FIBROMA IN CHILDREN: CLINICAL TYPES AND TREATMENT

2014 ◽  
Vol 2 (2) ◽  
pp. 12-25
Author(s):  
Nikolai Georgievich Chigvariya ◽  
Aleksander Pavlovich Pozdeev ◽  
Artur Nuralievich Bergaliev
Keyword(s):  
Computed Tomography ◽  
Surgical Treatment ◽  
Children And Adolescents ◽  
Diagnostic Value ◽  
Pathological Process ◽  
X Ray ◽  
Medical Aid ◽  
Comprehensive Examination ◽  
X Ray Computed ◽  
Conservative And Surgical Treatment

The paper presents the results of a comprehensive examination and treatment of 158 children and adolescents with nonossifying bone fibroma and skeleton, who referred for specialized medical aid in clinic of Scientific and Research Institute for Children's Orthopedics n. a. G. I. Turner from 1980 to 2013. We defined diagnostic value and the criteria for identifying lesions using X-ray, computed tomography and radionuclide methods. We emphasized the dynamic variability of clinical and radiological manifestations of the pathological process in nonossifying bone fibroma and skeleton and related difficulties in the diagnosis. Accurate indications for the conservative and surgical treatment were pointed out.

FUNCTIONING OF NO-SYNTHASE IN THE PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH ACNE VULGARIS

2018 ◽  
Vol 14 (66) ◽  
pp. 075
Author(s):  
H. S. Lavryk ◽  
O. P. Korniychuk ◽  
Z. Ya. Fedorovych ◽  
Z. D. Vorobets
Keyword(s):  
Peripheral Blood ◽  
Acne Vulgaris ◽  
No Synthase ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes

A Dinucleotide Deletion in the CD24 Gene Is a Potential Risk Factor for Colorectal Cancer

2020 ◽  
Vol 86 (5) ◽  
pp. 480-485
Author(s):  
Lior Segev ◽  
Ilana Naboishchikov ◽  
Diana Kazanov ◽  
Ezra Bernstein ◽  
Meital Shaked ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Peripheral Blood ◽  
Intracellular Signaling ◽  
Genetic Variant ◽  
Colorectal Carcinogenesis ◽  
Polymorphism Analysis ◽  
Peripheral Blood Leukocytes ◽  
Clinical Value ◽  
Blood Leukocytes ◽  
Multistep Process

Background CD24 is a sialoglycoprotein anchored to the cell surface via glycosylphosphatidylinositol and is involved in intracellular signaling processes. It plays an important role in the early stages of the multistep process of colorectal carcinogenesis. Several single nucleotide polymorphisms in the CD24 gene are reported to exert a diverse effect on cancer risk. We aimed to elucidate whether CD24 TG/del genetic variants are associated with susceptibility to colorectal cancer (CRC). Methods The study included 179 subjects, 36 with CRC (prior to surgery) and 143 healthy control subjects. Deoxyribonucleic acid was purified from peripheral blood leukocytes, and by using restriction fragment length polymorphism analysis, the CD24 gene was genotyped for the specific genetic variant, TG deletion. Additionally, CD24 protein expression levels were determined by Western blotting analysis. Results The incidence of the TG/del was higher among the CRC patients compared with healthy controls, 14% and 10%, respectively ( P = .54). CD24 protein levels were significantly higher among CRC patients. There were no significant differences in CD24 expression between CRC patients at different stages of the disease or between patients who carry the mutation and those who did not. Conclusions CD24 genetic variant might be of clinical value for risk assessment as part of cancer prevention programs. Further study on larger populations is needed to validate the importance of this dinucleotide deletion in CRC development. Overexpression of CD24 protein occurs early along the multistep process of CRC carcinogenesis, and a simple blood sample based on CD24 expression on peripheral blood leukocytes can contribute to early diagnosis.

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